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"Li, Xiang"
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Credibilistic programming : an introduction to models and applications
It provides fuzzy programming approach to solve real-life decision problems in fuzzy environment. Within the framework of credibility theory, it provides a self-contained, comprehensive and up-to-date presentation of fuzzy programming models, algorithms and applications in portfolio analysis.
BOOK
The effect of Clostridium butyricum on symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial
Irritable bowel syndrome (IBS) is a common disorder in gastrointestinal system and impairs the quality of life of the patients.
Clostridium butyricum
(
CB
) is a probiotics that has been used in several gastrointestinal diseases. The efficacy of
CB
in treating IBS is still unknown. This prospective, multi-centre, randomized, double-blind, placebo-controlled trial aimed to assess the efficacy and safety of
CB
in treating diarrhea-predominant IBS (IBS-D) and analyze the fecal microbiota after treatment. Two hundred patients with IBS-D were recruited and were given
CB
or placebo for 4 weeks. End points included change from baseline in IBS symptoms, quality of life, stool consistency and frequency. Compared with placebo,
CB
is effective in improving the overall IBS-D symptoms (−62.12 ± 74.00 vs. −40.74 ± 63.67,
P
= 0.038) as well as quality of life (7.232 ± 14.06 vs. 3.159 ± 11.73,
P
= 0.032) and stool frequency (−1.602 ± 1.416 vs. −1.086 ± 1.644,
P
= 0.035). The responder rates are found higher in
CB
compared with the placebo (44.76% vs. 30.53%,
P
= 0.042). The change in fecal microbiota was analyzed and function pathways of
CB
in treating IBS-D were predicted. In conclusion,
CB
improves overall symptoms, quality of life and stool frequency in IBS-D patients and is considered to be used as a probiotics in treating IBS-D clinically.
Journal Article
Microbial and metabolomic profiles in correlation with depression and anxiety co-morbidities in diarrhoea-predominant IBS patients
Background
Psychological co-morbidities in irritable bowel syndrome (IBS) have been widely recognized, whereas less is known regarding the role of gut microbial and host metabolic changes in clinical and psychological symptoms in IBS.
Results
A total of 70 diarrhoea-predominant IBS (IBS-D) patients and 46 healthy controls were enrolled in this study. Stool and urine samples were collected from both groups for 16S rRNA gene sequencing and metabolomic analysis.
The results showed that fecal microbiota in IBS-D featured depleted
Faecalibacterium
(adjusted
P =
0.034),
Eubacterium rectale
group (adjusted
P =
0.048),
Subdoligranulum
(adjusted
P =
0.041) and increased
Prevotella
(adjusted
P =
0.041). O-ureido-L-serine, 3,4-dihydroxybenzenesulfonic acid and (R)-2-Hydroxyglutarate demonstrated lower urinary concentrations in IBS-D patients. We further built correlation matrices between gut microbe abundance, differentiated metabolite quantities and clinical parameters.
Dialister
manifested negative association with IBS severity (
r
= − 0.285,
P
= 0.017), anxiety (
r
= − 0.347,
P
= 0.003) and depression level (
r
= − 0.308,
P
= 0.010).
Roseburia
was negatively associated with IBS severity (
r
= − 0.298,
P
= 0.012). Twenty metabolites correlated with anxiety or depression levels, including 3,4-dihydroxymandelaldehyde with SAS (
r
= − 0.383,
P
= 0.001), 1-methylxanthine with SDS (
r
= − 0.347,
P
= 0.004) and 1D-chiro-inositol with SAS (
r
= − 0.336,
P
= 0.005). In analysis of microbe-metabolite relationship, 3,4-dihydroxymandelaldehyde and 1-methylxanthine were negatively correlated with relative abundance of
Clostridium
sensu stricto
.
Conclusions
Our findings demonstrated altered microbial and metabolomic profiles associated with clinically and psychological symptoms in IBS-D patients, which may provide insights for further investigations.
Journal Article
وجوه لا تلتقيها مرتين : حكايات غير عادية عن أبطال عاديين
\"وجوه لا تلتقيها مرتين\" يروي حكايات غير عادية عن أبطال عاديين، ربما تجدهم في مجتمعك بغض النظر عن طبيعة تكوين هذا المجتمع أو نطاقه الجغرافي أو خلفياته الثقافية والاقتصادية، وهو كتاب واقعي غير مثالي، تعرض فيه الصحفية الشهيرة لي يوان تشنغ الأحداث الخفية والتفاصيل المبهمة التي أفرزت التنمية الصينية الهائلة، والنقلة الاجتماعية كتجربة غير مسبوقة، ولكن من منظور إنساني، فهو لا يتطرق إلى استراتيجيات ولا سياسات ولا خطط خمسية، بل يركز على الفرد، كونه إنسانا فحسب.
Book
Relationship of the metabolic score for insulin resistance and the new-onset hypertension: Evidence from CHARLS
Hypertension (HTN) progression is linked to insulin resistance (IR), yet the association between Metabolic Score for Insulin Resistance (METS-IR) and HTN remains underexplored.
This study included 4,051 individuals without a history of HTN from the China Health and Retirement Longitudinal Study (CHARLS). Participants were stratified into four groups according to their baseline METS-IR values. It was the development of incident HTN that was the primary outcome. We used Cox regression to assess this association, conducted subgroup and sensitivity analyses, and evaluated METS-IR's incremental predictive value over conventional risk factors (age, sex, systolic blood pressure) using C-statistic, net reclassification improvement (NRI), integrated discrimination improvement (IDI), and decision curve analysis (DCA).
Over the 9-year follow-up, 1,572 participants (38.81%) experienced their first incident of HTN. Participants were categorized into quartiles (Q1-Q4) based on their METS-IR levels. After full adjustment for confounders, the hazard ratio (HR) with a 95% confidence interval (CI) for incident HTN demonstrated a progressive increase across ascending METS-IR quartiles, with Q1 as reference: Q2, 0.99 (0.85-1.15); Q3, 1.17 (1.01-1.36); Q4, 1.31 (1.13-1.52). The restricted cubic spline (RCS) model revealed a linear dose-response relationship between METS-IR and the incidence of HTN (P for overall trend < 0.001; P for nonlinear = 0.310). Adding METS-IR to a base model (age/sex/systolic blood pressure) improved HTN prediction (C-statistic Δ= + 0.004; NRI = 16.58%, IDI = 0.75%; all P < 0.001). DCA confirmed greater net benefit across risk thresholds. Subgroup and sensitivity analyses consistently supported the primary findings.
Elevated METS-IR independently predicts HTN risk in Chinese adults, suggesting METS-IR as a potential indicator.
Journal Article
RNA sequencing reveals the expression profiles of circRNA and indicates that circDDX17 acts as a tumor suppressor in colorectal cancer
Background
Circular RNA (circRNA) is a novel class of noncoding RNAs with functions in various pathophysiological activities. However, the expression profiles and functions of circRNAs in colorectal cancer (CRC) remain largely unknown.
Methods
High-throughput RNA sequencing (RNA-seq) was performed to assess circRNA expression profiles in 4 paired CRC tissues, and significantly dysregulated circRNAs were validated by quantitative real-time polymerase chain reaction (qRT-PCR). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to predict the potential functions of dysregulated circRNAs. Target miRNAs of circRNAs were predicted using miRanda software, and were further analyzed combining DIANA-miRPath v.3 platform (Reverse Search module) with KEGG pathways of COLORECTAL CANCER and MicroRNAs in cancer (Entry: map05210 and map05206). CircRNA-miRNA interaction networks were constructed using Cytoscape software. Expression levels of a significantly down-regulated circRNA, circDDX17 (hsa_circ_0002211), was detected by qRT-PCR in 60 paired CRC tissues. CircDDX17 was knockdown by siRNA, and the biological functions of circDDX17 were examined in CRC cell lines.
Results
Totally 448 differentially expressed circRNAs were identified, including 394 up-regulated and 54 down-regulated circRNAs. qRT-PCR validation confirmed the reliability of the RNA-Seq data. GO and KEGG analyses revealed that these dysregulated circRNAs were potentially implicated in CRC pathogenesis. Analyses by combining miRanda and miRPath softwares with KEGG pathways suggested that the miRNAs targeted by the top 10 dysregulated circRNAs were associated with the KEGG pathways of COLORECTAL CANCER and MicroRNAs in cancer, indicating that circRNA-miRNA interactions might play important functional roles in the initiation and progression of CRC. The results of qRT-PCR for circDDX17 in 60 paired CRC tissues showed that circDDX17 was significantly down-regulated in CRC tissues and associated with unfavorable clinicopathological parameters. In vitro experiments showed that silencing of circDDX17 promoted CRC cell proliferation, migration, invasion, and inhibited apoptosis.
Conclusions
In conclusion, we have identified numerous circRNAs that are dysregulated in CRC tissues compared with adjacent normal mucosa tissues. Bioinformatic analyses suggested that these dysregulated circRNAs might play important functional roles in CRC tumorigenesis. CircDDX17 functions as a tumor suppressor and could serve as a potential biomarker and a therapeutic target for CRC.
Journal Article
Research trends on nanomaterials in gastric cancer: a bibliometric analysis from 2004 to 2023
Background
Gastric cancer is one of the leading causes of cancer-related deaths worldwide. In recent years, an increasing number of studies aimed at designing and developing nanomaterials for use in diagnosing and treating gastric cancer have been conducted. In this study, we aimed to comprehensively assess the current status and trends of the research on the application of nanomaterials in gastric cancer through a bibliometric analysis.
Methods
Studies focusing on nanomaterials and gastric cancer were retrieved from the Web of Science Core Collection database and relevant articles were selected for inclusion in the study according to the inclusion criteria. Bibliometric and visual analysis of the included publications was performed using VOSviewer and CiteSpace.
Results
A total of 793 studies were included. An increase in annual publications was observed from 2004 to 2023. China, Iran and the USA were the dominant countries in this field, accounting for 66.1%, 11.5% and 7.2% of publications, respectively. Shanghai Jiao Tong University and Cui DX were the most influential institution and author, respectively. The International Journal of Nanomedicine was the most prolific journal; Biomaterials was the most cited and most cocited journal. Nanomaterial-related drug delivery and anticancer mechanisms were found to be the most widely researched aspects, and green synthesis and anticancer mechanisms are recent research hotspots.
Conclusion
In this study, we summarized the characteristics of publications and identified the most influential countries, institutions, authors, journals, hot topics and trends regarding the application of nanomaterials in gastric cancer.
Graphical Abstract
Journal Article