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"Li, Xiangping"
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The hospitality and tourism industry in ASEAN and East Asian destinations : new growth, trends, and developments
\"This new volume addresses the growing interest to understand tourism and hospitality in Southeast and South Asia, two regions that have seen tremendous growth in international tourists in recent years. It explores the current development of hospitality and tourism industry in the regions of Hong Kong, Macao and Taiwan as well as other key countries in Southeast and South Asia. The Hospitality and Tourism Industry in ASEAN and East Asian Destinations: New Growth, Trends, and Developments provides updated findings and case studies that highlight opportunities and issues of tourism and hospitality development in ASEAN. Chapters cover such diverse topics as online marketing strategies, sustainable hospitality development, diversification efforts of the tourism industry Innovations in independent hotels, wildlife tourism in urban destinations, the Vietnamese national park system, consumers' positive and negative images of certain destinations. While academicians will benefit from the updated research findings summarized by the respected scholars, hospitality professionals will also find the book a valuable source of information as the chapters delve into the most recent topical and industry focused issues.\"-- Provided by publisher.
Book
On-chip noninterference angular momentum multiplexing of broadband light
Angular momentum division has emerged as a physically orthogonal multiplexing method in high-capacity optical information technologies. However, the typical bulky elements used for information retrieval from the overall diffracted field, based on the interference method, impose a fundamental limit toward realizing on-chip multiplexing. We demonstrate noninterference angular momentum multiplexing by using a mode-sorting nanoring aperture with a chip-scale footprint as small as 4.2 micrometers by 4.2 micrometers, where nanoring slits exhibit a distinctive outcoupling efficiency on tightly confined plasmonic modes. The nonresonant mode-sorting sensitivity and scalability of our approach enable on-chip parallel multiplexing over a bandwidth of 150 nanometers in the visible wavelength range. The results offer the possibility of ultrahigh-capacity and miniaturized nanophotonic devices harnessing angular momentum division.
Journal Article
Planar chiral metasurfaces with maximal and tunable chiroptical response driven by bound states in the continuum
Optical metasurfaces with high quality factors (Q-factors) of chiral resonances can boost substantially light-matter interaction for various applications of chiral response in ultrathin, active, and nonlinear metadevices. However, current approaches lack the flexibility to enhance and tune the chirality and Q-factor simultaneously. Here, we suggest a design of chiral metasurface supporting bound state in the continuum (BIC) and demonstrate experimentally chiroptical responses with ultra-high Q-factors and near-perfect circular dichroism (CD = 0.93) at optical frequencies. We employ the symmetry-reduced meta-atoms with high birefringence supporting winding elliptical eigenstate polarizations with opposite helicity. It provides a convenient way for achieving the maximal planar chirality tuned by either breaking in-plane structure symmetry or changing illumination angle. Beyond linear CD, we also achieved strong near-field enhancement CD and near-unitary nonlinear CD in the same planar chiral metasurface design with circular eigen-polarization. Sharply resonant chirality realized in planar metasurfaces promises various practical applications including chiral lasers and chiral nonlinear filters.
Here, the authors employ the physics of chiral bound states in the continuum and suggest planar chiral metasurfaces with simultaneous ultrahigh quality factor and near-perfect circular dichroism in both linear regime and nonlinear regime.
Journal Article
Optical storage arrays: a perspective for future big data storage
The advance of nanophotonics has provided a variety of avenues for light–matter interaction at the nanometer scale through the enriched mechanisms for physical and chemical reactions induced by nanometer-confined optical probes in nanocomposite materials. These emerging nanophotonic devices and materials have enabled researchers to develop disruptive methods of tremendously increasing the storage capacity of current optical memory. In this paper, we present a review of the recent advancements in nanophotonics-enabled optical storage techniques. Particularly, we offer our perspective of using them as optical storage arrays for next-generation exabyte data centers.
Data storage: Nanophotonics promise
The science and technology of nanophotonics can help dramatically increase the capacity of optical discs. After reviewing research into next-generation optical data storage, Min Gu, Xiangping Li and Yaoyu Cao from the Swinburne University of Technology in Australia have offered their perspective of the creation of exabyte-scale optical data centers. They report that developments in ’super-resolution recording‚, which allow a light-sensitive material to be exposed to a focal spot that is smaller than the diffraction limit of light, will allow the size of recorded bits to shrink to just a few nanometres in size. This would ultimately allow a single disk to store petabytes of data and thus constitute a key component in optical storage arrays for ultrahigh-capacity optical data centers.
Journal Article
Hypertriglyceridemia and atherosclerosis
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death and it has been confirmed that increased low density lipoprotein cholesterol (LDL-C) is an independent risk factor for atherosclerosis. Recently, the increasing evidence has showed that hypertriglyceridemia is associated with incremental ASCVD risk. But the proatherogenic mechanism of triglyceride (TG) remains unclear. Therefore, this article focuses on the clinical studies and proatherogenic mechanism related to hypertriglyceridemia, in order to provide reference for the prevention and treatment of ASCVD.
Journal Article
Observation of localized magnetic plasmon skyrmions
Optical skyrmions have recently been constructed by tailoring vectorial near-field distributions through the interference of multiple surface plasmon polaritons, offering promising features for advanced information processing, transport and storage. Here, we provide experimental demonstration of electromagnetic skyrmions based on magnetic localized spoof plasmons (LSP) showing large topological robustness against continuous deformations, without stringent external interference conditions. By directly measuring the spatial profile of all three vectorial magnetic fields, we reveal multiple π-twist target skyrmion configurations mapped to multi-resonant near-equidistant LSP eigenmodes. The real-space skyrmion topology is robust against deformations of the meta-structure, demonstrating flexible skyrmionic textures for arbitrary shapes. The observed magnetic LSP skyrmions pave the way to ultra-compact and robust plasmonic devices, such as flexible sensors, wearable electronics and ultra-compact antennas.
The engineering of localized fields is at the base of ultra-compact plasmonic devices. The authors demonstrate that localized plasmon skyrmions provide a unique way to build arbitrarily shaped skyrmionic textures promising high flexibility and robustness for real applications like information processing.
Journal Article
Clinical advances and challenges in targeting FGF/FGFR signaling in lung cancer
Fibroblast growth factors (FGFs) and their receptors regulate numerous cellular processes, such as metabolism and signal transduction, but can also drive tumorigenesis. Specifically, in lung cancer, the overexpression of FGFs, as well as the amplification, mutation and fusion of FGFR genes, are closely linked to the initiation, progression and resistance of the disease, suggesting that targeting FGF/FGFR is an attractive therapeutic strategy for lung cancer treatment. Nintedanib, a multitarget tyrosine kinase inhibitor (TKI) used in combination with docetaxel, has shown some success as a second-line therapy for lung cancer. However, clinical trials evaluating other FGFR inhibitors have yielded mixed results, indicating substantial complexity in targeting aberrant FGF/FGFR signaling. In this review, we describe the aberrations in FGF/FGFR signaling in lung cancer and summarize the clinical efficacy of FGFR inhibitors, such as multitarget TKIs, selective FGFR-TKIs and biological agents. We also discuss various challenges associated with FGFR targeting in lung cancer, including precision patient selection, toxicity and resistance. Finally, we provide perspectives on future directions, namely, developing novel FGFR-targeting drugs, such as FGFR degraders and more specific FGFR-TKIs, adopting combination therapy and targeting FGFs.
Journal Article
Poincaré sphere trajectory encoding metasurfaces based on generalized Malus’ law
As a fundamental property of light, polarization serves as an excellent information encoding carrier, playing significant roles in many optical applications, including liquid crystal displays, polarization imaging, optical computation and encryption. However, conventional polarization information encoding schemes based on Malus’ law usually consider 1D polarization projections on a linear basis, implying that their encoding flexibility is largely limited. Here, we propose a Poincaré sphere (PS) trajectory encoding approach with metasurfaces that leverages a generalized form of Malus’ law governing universal 2D projections between arbitrary elliptical polarization pairs spanning the entire PS. Arbitrary polarization encodings are realized by engineering PS trajectories governed by either arbitrary analytic functions or aligned modulation grids of interest, leading to versatile polarization image transformation functionalities, including histogram stretching, thresholding and image encryption within non-orthogonal PS loci. Our work significantly expands the encoding dimensionality of polarization information, unveiling new opportunities for metasurfaces in polarization optics for both quantum and classical regimes.
Polarization serves as an excellent information encoding carrier. Here, authors expand the metasurface encoding dimensionality of polarization information by engineering the Poincaré Sphere trajectory with generalized Malus’ law, unveiling new opportunities for advanced polarization optics.
Journal Article
Near infrared emissions from both high efficient quantum cutting (173%) and nearly-pure-color upconversion in NaY(WO4)2:Er3+/Yb3+ with thermal management capability for silicon-based solar cells
Raising photoelectric conversion efficiency and enhancing heat management are two critical concerns for silicon-based solar cells. In this work, efficient Yb3+ infrared emissions from both quantum cutting and upconversion were demonstrated by adjusting Er3+ and Yb3+ concentrations, and thermo-manage-applicable temperature sensing based on the luminescence intensity ratio of two super-low thermal quenching levels was discovered in an Er3+/Yb3+ co-doped tungstate system. The quantum cutting mechanism was clearly decrypted as a two-step energy transfer process from Er3+ to Yb3+. The two-step energy transfer efficiencies, the radiative and nonradiative transition rates of all interested 4 f levels of Er3+ in NaY(WO4)2 were confirmed in the framework of Föster-Dexter theory, Judd-Ofelt theory, and energy gap law, and based on these obtained efficiencies and rates the quantum cutting efficiency was furthermore determined to be as high as 173% in NaY(WO4)2: 5 mol% Er3+/50 mol% Yb3+ sample. Strong and nearly pure infrared upconversion emission of Yb3+ under 1550 nm excitation was achieved in Er3+/Yb3+ co-doped NaY(WO4)2 by adjusting Yb3+ doping concentrations. The Yb3+ induced infrared upconversion emission enhancement was attributed to the efficient energy transfer 4I11/2 (Er3+) + 2F7/2 (Yb3+) → 4I15/2 (Er3+) + 2F5/2 (Yb3+) and large nonradiative relaxation rate of 4I9/2. Analysis on the temperature sensing indicated that the NaY(WO4)2:Er3+/Yb3+ serves well the solar cells as thermos-managing material. Moreover, it was confirmed that the fluorescence thermal quenching of 2H11/2/4S3/2 was caused by the nonradiative relaxation of 4S3/2. All the obtained results suggest that NaY(WO4)2:Er3+/Yb3+ is an excellent material for silicon-based solar cells to improve photoelectric conversion efficiency and thermal management.The Yb3+ emissions from both the quantum cutting and nearly-pure infrared upconversion and excellent temperature detection were realized in Er3+/Yb3+ co-doped NaY(WO4)2 phosphors.
Journal Article
Metformin in patients with and without diabetes: a paradigm shift in cardiovascular disease management
With an increasing global burden of coronary artery disease (CAD), early detection and timely management of risk factors are crucial to reduce morbidity and mortality in such patients. Diabetes mellitus (DM) is considered an independent risk factor for the development of CAD. Metformin, an anti-diabetic drug, has been shown in pre-clinical and clinical studies, to lower the cardiovascular events in the DM patients. Growing evidence suggests that metformin has a protective effect on coronary artery beyond its hypoglycemic effects. Given its global availability, route of administration and cost, metformin provides an alternate/additional therapeutic option for primary and secondary prevention of CAD in DM and non-diabetics alike. Future prospective cohort-based studies and randomized clinical trials are needed to identify ‘at-risk’ population who may potentially benefit from metformin.
Journal Article