Explore the vast range of titles available.

Introduction Corneal biomechanics has been implicated in a variety of ocular diseases. The purpose of this study was to evaluate the relationship between the glaucoma and corneal biomechanical properties, and exploring the value of corneal biomechanics in the diagnosis and follow-up of glaucoma diseases. Methods We searched studies in PubMed, EMBASE, Web of Science and clinicaltrials.gov., as of October 8, 2022. Only English studies were included, without publication time limit. We also searched the reference lists of published reviews. This meta-analysis was conducted with random-effects models, we used mean difference(MD) to evaluate the outcome, and the heterogeneity was assessed with the I 2 statistic. Subgroup analyses were performed under the appearance of high heterogeneity. We used 11 items to describe the characteristics of included studies, publication bias was performed through the Egger’s test. The quality assessment were evaluated by Newcastle–Ottawa Scale(NOS) items. Results A total of 27 eligible studies were identified for data synthesis and assessment. The result of meta-analysis showed that in the comparison of included indicators, the corneal biomechanics values of glaucoma patients were statistically lower than those of normal subjects in a similar age range. The covered indicators included central corneal thickness(CCT) (MD = -8.34, 95% CI: [-11.74, -4.94]; P  < 0.001), corneal hysteresis(CH)(MD = -1.54, 95% CI: [-1.88, -1.20]; P  < 0.001), corneal resistance factor(CRF)( MD = -0.82, 95% CI: [-1.21, -0.44]; P  < 0.001), and intraocular pressure(IOP)( corneal-compensated intraocular pressure (IOPcc): MD = 2.45, 95% CI: [1.51, 3.38]; P  < 0.001); Goldmann-correlated intraocular pressure (IOPg): MD = 1.30, 95% CI: [0.41, 2.20]; P  = 0.004), they all showed statistical difference. While the value of axial length(AL) did not show statistically different(MD = 0.13, 95% CI: [-0.24, 0.50]; P  = 0.48). Conclusion Corneal biomechanics are associated with glaucoma. The findings can be useful for the design of glaucoma screening, treatment and prognosis.

Abscisic acid (ABA) largely promotes leaf senescence and inhibits seed germination in plants. Endogenous ABA content is finely tuned by many transcription factors. In this study, we showed that OsWRKY53 is a positive regulator of leaf senescence and a negative regulator of seed germination in rice. OsWRKY53 expression was induced in leaves under aging, dark, and ABA treatment. The OsWRKY53 -overexpressing ( OsWRKY53 -oe) plants showed early yellowing leaves, while the OsWRKY53 ( oswrky53 ) knockout mutants maintained green leaves than the wild type under natural, dark-induced, and ABA-induced senescence conditions. Transcriptional analysis revealed that ABA catabolic genes, namely, OsABA8ox1 and OsABA8ox2 , two key genes participating in ABA catabolism harboring ABA 8′-hydroxylase activity, were markedly downregulated in OsWRKY53 -oe leaves. Chromatin immunoprecipitation and protoplast transient assays revealed that OsWRKY53 directly bound to the promoters of OsABA8ox1 and OsABA8ox2 to repress their transcription, resulting in elevated endogenous ABA contents that promoted premature leaf senescence in the OsWRKY53 -oe plants. It indicates that OsWRKY53 is a positive regulator through regulating ABA accumulation to promote leaf senescence. In addition, accumulated ABA simultaneously inhibited seed germination and post-germination growth in OsWRKY53 -oe plants. Taken together, OsWRKY53 suppresses the transcript of ABA catabolic genes to promote ABA accumulation to modulate ABA-induced leaf senescence and ABA-mediated inhibition of seed germination.

The sluggish electrochemical kinetics of sulfur species has impeded the wide adoption of lithium-sulfur battery, which is one of the most promising candidates for next-generation energy storage system. Here, we present the electronic and geometric structures of all possible sulfur species and construct an electronic energy diagram to unveil their reaction pathways in batteries, as well as the molecular origin of their sluggish kinetics. By decoupling the contradictory requirements of accelerating charging and discharging processes, we select two pseudocapacitive oxides as electron-ion source and drain to enable the efficient transport of electron/Li + to and from sulfur intermediates respectively. After incorporating dual oxides, the electrochemical kinetics of sulfur cathode is significantly accelerated. This strategy, which couples a fast-electrochemical reaction with a spontaneous chemical reaction to bypass a slow-electrochemical reaction pathway, offers a solution to accelerate an electrochemical reaction, providing new perspectives for the development of high-energy battery systems. The sluggish electrochemical kinetics of sulfur species remains a major hurdle for the broad adoption of lithium-sulfur batteries. Here, the authors construct an energy diagram of sulfur species to unveil their reaction pathways and propose a general strategy to accelerate electrochemical reactions.

Antimony selenide (Sb2Se3) is an ideal photovoltaic candidate profiting from its advantageous material characteristics and superior optoelectronic properties, and has gained considerable development in recent years. However, the further device efficiency breakthrough is largely plagued by severe open‐circuit voltage (VOC) deficit under the existence of multiple defect states and detrimental recombination loss. In this work, an effective absorber layer growth engineering involved with vapor transport deposition and post‐selenization is developed to grow Sb2Se3 thin films. High‐quality Sb2Se3 with large compact crystal grains, benign [hk1] growth orientation, stoichiometric chemical composition, and suitable direct bandgap are successfully fulfilled under an optimized post‐selenization scenario. Planar Sb2Se3 thin‐film solar cells with substrate configuration of Mo/Sb2Se3/CdS/ITO/Ag are constructed. By contrast, such engineering effort can remarkably mitigate the device VOC deficit, owing to the healed detrimental defects, the suppressed interface and space‐charge region recombination, the prolonged carrier lifetime, and the enhanced charge transport. Accordingly, a minimum VOC deficit of 0.647 V contributes to a record VOC of 0.513 V, a champion device with highly interesting efficiency of 7.40% is also comparable to those state‐of‐the‐art Sb2Se3 solar cells, paving a bright avenue to broaden its scope of photovoltaic applications. A two‐step thermodynamic/kinetic deposition process involving vapor transport deposition and post‐selenization is developed to grow high‐quality Sb2Se3 thin films. Such absorber engineering can heal detrimental defects, prolong carrier lifetime, suppress interface, and space‐charge region recombination. Thus, the substrate structured Mo/Sb2Se3/CdS/ITO/Ag solar cell delivers a record open‐circuit voltage (VOC) of 0.513 V with minimum deficit, and highly competitive efficiency of 7.40%.

Magnetic skyrmion and layer physics have attracted considerable interest for their significance in fundamental research and practical device applications. Here, through symmetry and model analysis, we propose a mechanism for coupling magnetic skyrmion and layer physics in two-dimensional type-I multiferroic heterostructure, which generates the concept of topological layer Hall effect. Distinct from the existing layer Hall effects that are all driven by momentum-space Berry phase relied on fine-tuned bands, topological layer Hall effect correlates to the layer-polarized real-space Berry physics from noncoplanar spin textures of layer-locked magnetic skyrmion with nontrivial topology. Such layer-polarized real-space Berry physics acts as equivalent electromagnetic field and forces conduction electrons to transversely deflect to specific boundary of one given layer, yielding the anomalous Hall conductivity and thus topological layer Hall effect. Moreover, magnetoelectric coupling can enforce topological layer Hall effect being effectively controllable through ferroelectricity and magnetism. Using first-principles calculations and atomic spin model simulations, we also demonstrate this mechanism in two-dimensional multiferroic heterostructure of CrInSe 3 /In 2 S 3 /CrInSe 3 . Our study greatly enriches the researches on magnetic skyrmion and layer Hall effect. This work couples magnetic skyrmions with layer physics in 2D multiferroic heterostructure, revealing a novel topological layer Hall effect driven by real-space Berry curvature.

Terminalia chebula Retz., known for its dried fruit, namely Chebulae Fructus, is a medicinal plant with a long-standing global reputation, which was initially recognized for its therapeutic properties during the Jin Dynasty. This review consolidates current knowledge on the traditional uses, phytochemistry, pharmacological properties, toxicity, and pharmacokinetics of Chebulae Fructus, highlighting its clinical significance and the promising therapeutic potential of its compounds. To date, studies have identified approximately 149 compounds within the plant, including tannins, phenolic acids, lignans, triterpenes, flavonoids, and volatiles. These compounds confer a broad spectrum of biological activities in vitro and in vivo, such as antioxidant, anti-inflammatory, antiviral, anticancer, antibacterial, hepatoprotective, nephroprotective, neuroprotective, and anti-diabetic, some of which are already integrated into clinical practice. However, despite substantial advancements, considerable gaps remain in understanding the complete mechanisms of action, pharmacokinetics, and safety profiles of its extracts and compounds. This paper advocates for enhanced focus on these areas to fully elucidate the therapeutic capacities and facilitate the clinical application of Chebulae Fructus. This comprehensive analysis not only reinforces the ethnopharmacological significance of Chebulae Fructus but also lays a foundation for future pharmacological explorations.

Ferroptosis represents an emerging, iron-dependent form of cell death driven by lipid peroxidation. In recent years, it has garnered significant attention in the realm of cancer immunotherapy, particularly in studies involving immune checkpoint inhibitors. This form of cell death not only enhances our comprehension of the tumor microenvironment but is also considered a promising therapeutic strategy to address tumor resistance, investigate immune activation mechanisms, and facilitate the development of cancer vaccines. The combination of immunotherapy with ferroptosis provides innovative targets and fresh perspectives for advancing cancer treatment. Nevertheless, tumor cells appear to possess a wider array of ferroptosis evasion strategies compared to CD8 + T cells, which have been conclusively shown to be more vulnerable to ferroptosis. Furthermore, ferroptosis in the TME can create a favorable environment for tumor survival and invasion. Under this premise, both inducing tumor cell ferroptosis and inhibiting T cell ferroptosis will impact antitumor immunity to some extent, and even make the final result run counter to our therapeutic purpose. This paper systematically elucidates the dual-edged sword role of ferroptosis in the antitumor process of T cells, briefly outlining the complexity of ferroptosis within the TME. It explores potential side effects associated with ferroptosis-inducing therapies and critically considers the combined application of ferroptosis-based therapies with ICIs. Furthermore, it highlights the current challenges faced by this combined therapeutic approach and points out future directions for development.

To evaluate the corneal biomechanical properties of phacoemulsification in the treatment of cataract patients. Pertinent studies were searched in PubMed, EMBASE, Web of Science and clinicaltrials.gov., as of November 05, 2024. The reference lists of related published reviews were included as well. This meta-analysis was performed with Stata Software and Review Manager, we used mean difference (MD) to evaluate the statistical consequence, using I2 statistic to assess the heterogeneity. Subgroup analysis were performed under the occurrences of high heterogeneity. We used eleven items to describe the characteristics of included studies, publication bias was performed with Egger's test. The quality assessment were evaluated with 3 items by Newcastle-Ottawa Scale (NOS) items. Thirteen eligible studies were identified for data synthesis and assessment. According to the result of meta-analysis, the central corneal thickness(CCT) (MD = 10.50, 95% CI: [5.01, 15.98]; P<0.05) and intraocular pressure(IOPg)(MD = -0.73, 95% CI: [-1.26, -0.19]; P<0.05) of cataract patients after phacoemulsification was significantly higher than the control groups. The values of corneal hysteresis(CH) (MD = -0.43, 95% CI: [-0.62, -0.23]; P<0.05) and corneal resistance factor(CRF) (MD = -0.49, 95% CI: [-0.64, -0.33]; P<0.05) after phacoemulsification surgery were statistically lower than the control groups. While the values of IOPcc did not show statistically different (MD = -0.13, 95% CI: [-0.67, 0.41]; P = 0.64). Included data analysis indicated that the values of CCT, CH, CRF and IOPg showed statistical change in cataract patients after phacoemulsification surgeries compared with control groups. There is a correlation between corneal biomechanics and phacoemulsification surgeries.

Objective Amid population aging and migration, social isolation among older migrants in megacities has increasingly become a public health challenge. This study explores how grandparental childcare affects social isolation via social participation, and the moderating role of settlement intention in this path, offering a new perspective on older migrants’ social integration. Methods Using survey data of older migrants in Shenzhen, a Chinese megacity, this study applies PROCESS macro Model 4 to test the mediating role of social participation in the association between grandparental childcare and social isolation, and moderated mediation Model 14 to analyze the moderating role of settlement intention in the ‘social participation → social isolation’ association. Results Grandparental childcare frequency is significantly associated with higher LSNS-6 scores (indicating lower social isolation) ( β  = 2.841, t  = 3.018, P  < 0.01). Social participation partially mediates the association between grandparental childcare and social isolation, accounting for 34.53% of the total effect. Settlement intention significantly moderates the association in the second half of the mediating pathway ( β =−1.016, t =−2.675, P  < 0.01). Specifically, the strength of the association between social participation and LSNS-6 scores (indicating lower social isolation) was stronger among older migrants without settlement intention ( B  = 2.222, t  = 7.072, P  < 0.01) than among those with settlement intention ( B  = 1.206, t  = 5.376, P  < 0.01). Conclusions This study shows grandparental childcare alleviates older migrants’ social isolation (as reflected by higher LSNS-6 scores) by enhancing social participation, with settlement intention moderating the link between social participation and social isolation. Notably, temporary residence mentality may strengthen social participation’s positive effect, offering new evidence for explaining migrants’ “cultural barriers.” Future research should examine mediating variables like language ability and cultural identity to inform differentiated social integration policies.

MXene is a new family of two-dimensional nanomaterials with outstanding electrical conductivity, tunable structure, biocompatibility, and a large surface area. Thanks to these unique physicochemical properties, MXene has been used for constructing electrochemical sensors (MECSens) with excellent performance. In particular, the abundant surface termination of MXene can contribute to greatly enhancing the analytical sensitivity and selectivity of MECSens. Recently, MECSens have been widely applied in many fields including clinical diagnosis, infectious disease surveillance, and food security. However, not all MXene materials are suitable for building electrochemical sensors. In this article, we present an overview of different MECSens that have been developed so far. We begin with a short summary of the preparation and characterization of MECSens. Subsequently, the electrochemical performance, detection strategies, and application scenarios of MECSens are classified and briefly discussed. The article ends with a short conclusion and future perspectives. We hope this article will be helpful for designing and constructing MECSens with outstanding activity for electrochemical analysis.