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Since the 20th century, due to global warming, permafrost areas have undergone significant changes. The degradation of permafrost has complicated water cycle processes. Taking the upper Yellow River basin (UYRB) as a demonstration, this study discusses the long-term (1960–2019) changes in frozen ground and their hydrological effects with a cryosphere-hydrology model, in particular a permafrost version of the water and energy budget-based distributed hydrological model. The permafrost at the UYRB, with thickening active layer and lengthening thawing duration, has degraded by 10.8%. The seasonally frozen ground has a more pronounced intra-annual regulation that replenishes surface runoff in the warm season, while the degradation of permafrost leads to a runoff increase. The occurrence of extreme events at the UYRB has gradually decreased with the degradation of frozen ground, but spring droughts and autumn floods become more serious. The results may help better understand the hydrological impacts of permafrost degradation in the Tibetan Plateau.

Rainfall erosivity, which signifies the inherent susceptibility of soil erosion induced by precipitation, plays a fundamental role in formulating a comprehensive soil loss equation (RUSLE). It stands as a crucial determinant among the foundational factors considered in a comprehensive soil loss equation’s establishment. Nonetheless, the prediction and quantification of future alterations in rainfall erosivity under the influence of global warming have been relatively limited. In this study, climate change was widely evaluated and 10 preferred global climate models in the Loess Plateau were selected by using the data sets of 27 models simulating climate change and the CN05.1 data set provided by the latest CMIP6. The monthly precipitation forecast data were obtained by using the delta downscaling method. Combined with trend analysis, significance test, and coefficient of variation, the annual rainfall erosivity during 1961–2100 under four SSP scenarios was analyzed and predicted. Among the 27 GCM models used in this paper, the most suitable climate models for simulating monthly precipitation in the Loess Plateau were CMCC-CM2-SR5, CMCC-ESM2, TaiESM1, EC-Earth3, EC-Earth-Veg-LR, INM-CM4-8, CAS-ESM2-0, EC-Earth-Veg, ACCESS-ESM1-5, and IPSL-CM6A-LR. In comparison to the base period (1961–1990), during the historical period (1961–2014), the average annual rainfall erosivity on the Loess Plateau amounted to 1259.64 MJ·mm·hm−2·h−1·a−1, showing an insignificant downward trend. In the northwest of Ningxia, Yulin City and Yanan City showed a significant upward trend. In the future period (2015–2100), the annual rainfall erosivity continues to constantly change and increase. The potential average increase in rainfall erosivity is about 13.48–25.86%. In terms of spatial distribution, most areas showed an increasing trend. Among these regions, the majority of encompassed areas within Shanxi Province, central Shaanxi, and Inner Mongolia increased greatly, which was not conducive to soil and water conservation and ecological environment construction. This study offers a scientific reference for the projected future erosivity characteristics of the Loess Plateau.

Past research has shown that a physical experience can influence metaphorically linked psychological judgment. However, the underlying mechanisms have not been formally tested. This article examines the role of semantic activations underlying such influences, focusing on the effects of a ubiquitous physical experience—“carrying weight”—on consumers’ judgment of importance. Five experiments provide converging evidence that semantic activation is the primary underlying process for the effect. Specifically, physically carrying a load is neither a necessary nor a sufficient condition for processing the concept of importance. The effect is fully mediated by semantic activation of related weight concepts. Moreover, processing the concept of importance does not necessarily influence the physical experience of carrying weight. An affective state such as mental stress (psychological load), however, does have a reciprocal effect on the physical experience of carrying weight, indicating that there might be different pathways between weight experience and its metaphorically linked concepts.

With the increasing production and application of engineered amorphous silica nanoparticles (aSiNPs), people have more opportunities to be exposed to aSiNPs. However, the knowledge of its adverse health effects and related mechanisms is still limited, compared with the well-studied crystalline micron-sized silica. Since small differences in the physical-chemical properties of nanoparticles could cause significant differences in the toxic effect, it is important to distinguish how these variations influence the outcoming toxicity. Notably, particle size, as one of the essential characterizations of aSiNPs, is relevant to its biological activities. Thus, the aim of this systematic review was to summarize the relationship between the particle size of aSiNPs and its adverse biological effects. In order to avoid the influence of complicated in vivo experimental conditions on the toxic outcome, only in vitro toxicity studies which reported on the cytotoxic effect of different sizes aSiNPs were included. After the systematic literature retrieval, selection, and quality assessment process, 76 eligible scientific papers were finally included in this review. There were 76% of the studies that concluded a size-dependent cytotoxicity of aSiNPs, in which smaller-sized aSiNPs possessed greater toxicity. However, this trend could be modified by certain influence factors, such as the synthetic method of aSiNPs, particle aggregation state in cell culture medium, toxicity endpoint detection method, and some other experimental conditions. The effects of these influence factors on the size-dependent cytotoxicity of aSiNPs were also discussed in detail in the present review.

Aptamer-based lateral flow analysis (Apt-LFAs) has promising applications in many fields. Nanozymes have demonstrated high potential in improving the performance of Apt-LFAs and have been increasingly utilized in recent studies. In this study, we developed a nanozyme-based Apt-LFA for the rapid and sensitive detection of kanamycin by using a novel dual-functionalized AuNPs@polyA-DNA/GpG-Cu2+ nanozyme as a nanoprobe. In the nanoprobe design, the polyA-cDNA strand can discriminate a kanamycin aptamer from the kanamycin/aptamer complex, and the GpG-Cu2+ complex can amplify the detection signal by catalyzing the chromogenic reaction. The nanozyme Apt-LFA can quantify kanamycin in the range of 1–250 ng/mL with an LOD of 0.08 ng/mL, which demonstrated a 4-fold sensitivity improvement and had a wider linear range than the conventional AuNP-based LFA. The Apt-LFA was successfully applied to the detection of kanamycin in honey with good recoveries. Our dual-functionalized AuNP nanoprobe is easily prepared and can be highly compatible with the conventional AuNP-DNA-based LFA platform; thus, it can be extended to the application of Apt-LFAs for other small molecules.

Three studies were conducted to examine how embarrassment influences consumer preferences for brand conspicuousness. We predict that consumers with different levels of self-esteem will have distinct coping strategies when they feel embarrassed, resulting in differences in their preference changes related to brand conspicuousness. The results show that when feeling embarrassed, consumers with low self-esteem (high self-esteem) are more likely to have increased motivation to avoid social attention to the self in general (to repair their self-image). Thus, relatively speaking, consumers with low self-esteem (high self-esteem) prefer a more conspicuous product design over a less conspicuous one to a lesser (greater) extent when they are embarrassed than when they are not embarrassed. In addition, we demonstrate that the interaction between self-esteem and embarrassment is more likely when consumers form a strong connection with the brand.

Vegetation dynamics are sensitive to climate change and human activities, as vegetation interacts with the hydrosphere, atmosphere, and biosphere. The Yarlung Zangbo River (YZR) basin, with the vulnerable ecological environment, has experienced a series of natural disasters since the new millennium. Therefore, in this study, the vegetation dynamic variations and their associated responses to environmental changes in the YZR basin were investigated based on Normalized Difference Vegetation Index (NDVI) and Global Land Data Assimilation System (GLDAS) data from 2000 to 2016. Results showed that (1) the YZR basin showed an obvious vegetation greening process with a significant increase of the growing season NDVI (Zc = 2.31, p < 0.05), which was mainly attributed to the wide greening tendency of the downstream region that accounted for over 50% area of the YZR basin. (2) Regions with significant greening accounted for 25.4% of the basin and were mainly concentrated in the Nyang River and Parlung Tsangpo River sub-basins. On the contrary, the browning regions accounted for <25% of the basin and were mostly distributed in the urbanized cities of the midstream, implying a significant influence of human activities on vegetation greening. (3) The elevation dependency of the vegetation in the YZR basin was significant, showing that the vegetation of the low-altitude regions was better than that of the high-altitude regions. The greening rate exhibited a significantly more complicated relationship with the elevation, which increased with elevated altitude (above 3500 m) and decreased with elevated altitude (below 3500 m). (4) Significantly positive correlations between the growing season NDVI and surface air temperature were detected, which were mainly distributed in the snow-dominated sub-basins, indicating that glaciers and snow melting processes induced by global warming play an important role in vegetation growth. Although basin-wide non-significant negative correlations were found between precipitation and growing season NDVI, positive influences of precipitation on vegetation greening occurred in the arid and semi-arid upstream region. These findings could provide important information for ecological environment protection in the YZR basin and other high mountain regions.

EDA is a tumor necrosis factor (TNF) family member, which functions together with its cognate receptor EDAR during ectodermal organ development. Mutations of EDA have long been known to cause X‐linked hypohidrotic dysplasia in humans characterized by primary defects in teeth, hair and sweat glands. However, the structural information of EDA interaction with EDAR is lacking and the pathogenic mechanism of EDA variants is poorly understood. Here, we report the crystal structure of EDA C-terminal TNF homology domain bound to the N-terminal cysteine-rich domains of EDAR. Together with biochemical, cellular and mouse genetic studies, we show that different EDA mutations lead to varying degrees of ectodermal developmental defects in mice, which is consistent with the clinical observations on human patients. Our work extends the understanding of the EDA signaling mechanism, and provides important insights into the molecular pathogenesis of disease-causing EDA variants. EDA variants are associated with X-linked hypohidrotic dysplasia. Here, the authors report the crystal structure of the human EDA-EDAR complex, reveal the important role of this complex in ectodermal development and uncover the structural mechanism of disease-related mutations in EDA.

Seed weight, measured as mass per seed, is an important yield component of soybean and is generally positively correlated with seed yield (Burton et al, Crop Sci 27:1093, 1987). In previous reports, quantitative trait loci (QTL) associated with seed weight, were identified in single genetic background. The objective of the present study was to identify QTL and epistatic QTL underlying soybean seed weight in three RIL populations (with one common male parent ‘Hefeng25’) and across three different environments. Overall, 18, 11, and 17 seed weight QTL were identified in HC (‘Hefeng25’ × ‘Conrad’), HM (‘Hefeng25’ × ‘Maple Arrow’), and HB (‘Hefeng25’ × ‘Bayfield’) populations, respectively. The amount of phenotypic variation explained by a single QTL underlying seed weight was usually less than 10 %. The environment and background-independent QTL often had higher additive (a) effects. In contrast, the environment or background-dependent QTL were probably due to weak expression of QTL. QTL by environment interaction effects were in the opposite direction of a effects and/or epistasis effects. Four QTL and one QTL could be identified (2.0 < LOD < 9.06) in the HC and HB populations, respectively, across three environments (swHCA2-1, swHCC2-1, swHCD1b-1, swHCA2-2 (linked to Satt233, Satt424, Satt460, Satt428, respectively) and swHBA1-1(Satt449). Seven QTL could be identified in all three RIL populations in at least one location. Two QTL could be identified in the three RIL populations across three environments. These two QTL may have greater potential for use in marker-assisted selection of seed weight in soybean.

Aged microglia display augmented inflammatory activity after neural injury. Although aging is a risk factor for poor outcome after brain insults, the precise impact of aging-related alterations in microglia on neural injury remains poorly understood. Microglia can be eliminated via pharmacological inhibition of the colony–stimulating factor 1 receptor (CSF1R). Upon withdrawal of CSF1R inhibitors, microglia rapidly repopulate the entire brain, leading to replacement of the microglial compartment. In this study, we investigated the impact of microglial replacement in the aged brain on neural injury using a mouse model of intracerebral hemorrhage (ICH) induced by collagenase injection. We found that replacement of microglia in the aged brain reduced neurological deficits and brain edema after ICH. Microglial replacement-induced attenuation of ICH injury was accompanied with alleviated blood-brain barrier disruption and leukocyte infiltration. Notably, newly repopulated microglia had reduced expression of IL-1β, TNF-α and CD86, and upregulation of CD206 in response to ICH. Our findings suggest that replacement of microglia in the aged brain restricts neuroinflammation and brain injury following ICH.