Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
83,275
result(s) for
"Li, Yi"
Sort by:
The Bioactivities of Phycocyanobilin from Spirulina
Phycocyanobilin (PCB) is a linear open-chain tetrapyrrole chromophore that captures and senses light and a variety of biological activities, such as anti-oxidation, anti-cancer, and anti-inflammatory. In this paper, the biological activities of PCB are reviewed, and the related mechanism of PCB and its latest application in disease treatment are introduced. PCB can resist oxidation by scavenging free radicals, inhibiting the activity of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, and delaying the activity of antioxidant enzymes. In addition, PCB can also be used as an excellent anti-inflammatory agent to reduce the proinflammatory factors IL-6 and IFN-γ and to up-regulate the production of anti-inflammatory cytokine IL-10 by inhibiting the inflammatory signal pathways NF-κB and mitogen-activated protein kinase (MAPK). Due to the above biological activities of phycocyanobilin PCB, it is expected to become a new effective drug for treating various diseases, such as COVID-19 complications, atherosclerosis, multiple sclerosis (MS), and ischaemic stroke (IS).
Journal Article
Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing
CRISPR-Cas9 has emerged as a powerful technology that relies on Cas9/sgRNA ribonucleoprotein complexes (RNPs) to target and edit DNA. However, many therapeutic targets cannot currently be accessed due to the lack of carriers that can deliver RNPs systemically. Here, we report a generalizable methodology that allows engineering of modified lipid nanoparticles to efficiently deliver RNPs into cells and edit tissues including muscle, brain, liver, and lungs. Intravenous injection facilitated tissue-specific, multiplexed editing of six genes in mouse lungs. High carrier potency was leveraged to create organ-specific cancer models in livers and lungs of mice though facile knockout of multiple genes. The developed carriers were also able to deliver RNPs to restore dystrophin expression in DMD mice and significantly decrease serum PCSK9 level in C57BL/6 mice. Application of this generalizable strategy will facilitate broad nanoparticle development for a variety of disease targets amenable to protein delivery and precise gene correction approaches.
Therapeutic targets of CRISPR-Cas can often not be accessed due to lack of carriers to deliver RNPs systematically. Here, the authors engineer modified lipid nanoparticles for delivery of gene editing proteins to specific tissues.
Journal Article
Lun yu = The Analects of Confucius
Ben shu cai yong ying han dui zhao de xing shi shou lu. shi zhong guo gu dai ru jia de yi bu zhong yao jing dian, Shi kong zi di zi ji qi zai chuan di zi guan yu kong zi yan xing de ji lu.
Book
Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control
Cleavage of transfer (t)RNA and ribosomal (r)RNA are critical and conserved steps of translational control for cells to overcome varied environmental stresses. However, enzymes that are responsible for this event have not been fully identified in high eukaryotes. Here, we report a mammalian tRNA/rRNA-targeting endoribonuclease: SLFN13, a member of the Schlafen family. Structural study reveals a unique pseudo-dimeric U-pillow-shaped architecture of the SLFN13 N′-domain that may clamp base-paired RNAs. SLFN13 is able to digest tRNAs and rRNAs in vitro, and the endonucleolytic cleavage dissevers 11 nucleotides from the 3′-terminus of tRNA at the acceptor stem. The cytoplasmically localised SLFN13 inhibits protein synthesis in 293T cells. Moreover, SLFN13 restricts HIV replication in a nucleolytic activity-dependent manner. According to these observations, we term SLFN13 RNase S13. Our study provides insights into the modulation of translational machinery in high eukaryotes, and sheds light on the functional mechanisms of the Schlafen family.
Translation inhibition is a strategy for organisms to overcome various environmental stresses including viral infections. Here the authors show that a tRNA/rRNA-targeting RNase Schlafen13 inhibits protein synthesis by directly digesting cytoplasmic tRNA and rRNA with the ability to restrict viral propagation.
Journal Article
Best 10 : 20th Asia-Pacific interior design awards = Di er shi jie Ya Tai shi nei she ji da jiang ji huo jiang zuo pin ji
Asia Pacific Interior Design Awards (APIDA) is organised by the Hong Kong Interior Design Association. It aims to give recognition to outstanding interior design projects and designers, promoting professional standards and ethics among interior design practices operating in the Asia Pacific region. The awards accept the interior design projects completed in the Asia/Pacific Region, including Hong Kong, Mainland China, Taiwan, Singapore, Japan, Malaysia, Macau, Thailand, The Philippines, India, Indonesia, Korea, Australia & New Zealand. This book selects the best projects from the excellent entries for the 20th Asia Pacific Interior Design Awards (APIDA). They fall into chapters, including food space, hotel space, leisure and entertainment space, living space, installation and exhibition space, public space, work space, shopping space and students' projects. This collection shows the readers the wisdom and design ideas of the designers in Asia-pacific region and unveil the design hotspots which belong to the Asia-pacific region.
Book
Current understanding of the interplays between host hormones and plant viral infections
Phytohormones mediate plant development and responses to stresses caused by biotic agents or abiotic factors. The functions of phytohormones in responses to viral infection have been intensively studied, and the emerging picture of complex mechanisms provides insights into the roles that phytohormones play in defense regulation as a whole. These hormone signaling pathways are not simple linear or isolated cascades, but exhibit crosstalk with each other. Here, we summarized the current understanding of recent advances for the classical defense hormones salicylic acid (SA), jasmonic acid (JA), and ethylene (ET) and also the roles of abscisic acid (ABA), auxin, gibberellic acid (GA), cytokinins (CKs), and brassinosteroids (BRs) in modulating plant–virus interactions.
Journal Article
Zhu Guangqian and Benedetto Croce on aesthetic thought : with a translation of the Wenyi xinlixue (The psychology of art and literature)
\"In Zhu Guangqian and Benedetto Croce on Aesthetic Thought, Mario Sabattini analyses Croce's influence on the aesthetic thought of Zhu Guangqian. Zhu Guangqian is one of the most representative figures of contemporary Chinese aesthetics. Since the '30s, he had an active role in China both on the literary and philosophical scenes, and, through his writings, he exerted an important influence in the moulding of numerous generations of intellectuals. Some of his works have been widely read, and they still provoke considerable interest in China, on the mainland as well as in Taiwan and Hong Kong. The volume also presents a revised translation of Zhu Guangqian's Wenyi xinlixue (Psychology of Art and Literature)\"-- Provided by publisher.
Book
Emerging applications of zeolites in catalysis, separation and host–guest assembly
Zeolites are a family of microporous crystalline materials, which, since the 1940s, have had an indispensable role in the chemical industry as catalysts, adsorbents and ion exchangers. Advances in synthetic methodologies and characterization techniques have enabled the fabrication of new zeolitic materials, with emerging applications in diverse areas. By tuning their porous architectures, framework compositions and crystal morphologies, coupled with the incorporation of exotic active species, zeolites and zeolite-based materials have exhibited unprecedentedly high performance in many challenging processes. In this Review, we focus on the high-efficiency catalytic production of industrially important hydrocarbons and oxygenates using non-petrochemical feedstocks, energy-efficient separations of hydrocarbon mixtures that are difficult using conventional methods and materials, and host–guest assemblies that exhibit physical properties unprecedented to either the zeolite hosts or free guest species. Finally, we provide our perspectives on future directions for the development of zeolitic materials to meet the ever-growing demands from diverse fields.
New zeolitic materials have shown high performance in emerging applications across diverse areas. This Review focuses on the advances in zeolite applications, including the catalytic production of hydrocarbons and oxygenates from non-petrochemical feedstocks, the efficient separation of hydrocarbon mixtures that are otherwise challenging, and host–guest assemblies with unprecedented physical properties.
Journal Article