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"Li, Yiping"
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The rise of tourism in China : social and cultural change
\"This book offers a comprehensive understanding of China's tourism development from 1992 onwards, focusing on the social-cultural change that accompanied the rise of tourism. It examines both the economic benefits and sociocultural impacts of tourism and argues that a delicate balance between these is needed to achieve sustainable tourism\"-- Provided by publisher.
Book
Have Housing Prices Affected Residents’ Level of Social Integration?
In recent decades, most cities in China have experienced a large number of population movements, and the local integration of mobile populations has become a new challenge, not only in relation to their own quality of life, but also in relation to the development potential of the cities. While urban housing prices have soared, real estate has gradually become the main economic industry in China, and high housing prices have brought enormous housing pressure to this group. This paper analyzes the negative impact of house prices on social integration by combining labor market discrimination theory.
Journal Article
Regional patterns and trends of compound hot extremes in mainland China: a new objective approach
Compound hot extremes (CHEs) are receiving increasing attention due to their significant impacts on human health, ecosystems, and society compared to individual hot days or nights. While previous studies have focused on the characteristics of CHEs at individual points or stations, assessments of features for regional CHEs (RCHEs), which have a specific impact area and duration, are still lacking. This study aimed to investigate the climatic characteristics of RCHEs in mainland China by applying an objective identification technique for regional extreme events based on a compound index. The results show that 379 RCHEs were identified during 1961–2020, most of the events had a duration of 5–11 d and a maximum impacted area of approximately 460 10 4 km 2 . Long-duration RCHEs were found to have vigorous extreme intensity and large maximum impacted area. The middle and lower reaches of the Yangtze River were most susceptible to RCHEs, while the Yellow River Valley had the most robust positive trend of frequency for RCHEs, suggesting a significant risk of compound temperature disasters in this region. Furthermore, RCHEs in mainland China showed significant increasing trends in several aspects, such as annual frequency, integrated index, and single indices (e.g. duration, accumulated intensity, accumulated impacted area, and extreme intensity). These upward trends were accompanied by evident interdecadal variations, with low values before 1992 and high values after 1992. This study provides valuable insights into understanding and monitoring CHEs in China from the perspective of regional extremes.
Journal Article
A single-dose circular RNA vaccine prevents Zika virus infection without enhancing dengue severity in mice
Antibody-dependent enhancement (ADE) is a potential concern for the development of Zika virus (ZIKV) vaccines. Cross-reactive but poorly neutralizing antibodies, usually targeting viral pre-membrane or envelope (E) proteins, can potentially enhance dengue virus (DENV) infection. Although E domain III (EDIII) contains ZIKV-specific epitopes, its immunogenicity is poor. Here, we show that dimeric EDIII, fused to human IgG1 Fc fragment (EDIII-Fc) and encoded by circular RNA (circRNA), induces better germinal center reactions and higher neutralizing antibodies compared to circRNAs encoding monomeric or trimeric EDIII. Two doses of circRNAs encoding EDIII-Fc and ZIKV nonstructural protein NS1, another protective antigen, prevent lethal ZIKV infection in neonates born to immunized C57BL/6 mice and in interferon-α/β receptor knockout adult C57BL/6 mice. Importantly, a single-dose optimized circRNA vaccine with improved antigen expression confers potent and durable protection without inducing obvious DENV ADE in mice, laying the groundwork for developing flavivirus vaccines based on circRNAs encoding EDIII-Fc and NS1.
Neutralizing antibodies binding the domain III of Zika virus envelope protein (EDIII) are desired in vaccine development. Here, the authors express dimeric EDIII fused to human IgG1 Fc fragment from circular RNA, and show immunogenicity and protection in mice.
Journal Article
Epidemiological features of and changes in incidence of infectious diseases in China in the first decade after the SARS outbreak: an observational trend study
The model of infectious disease prevention and control changed significantly in China after the outbreak in 2003 of severe acute respiratory syndrome (SARS), but trends and epidemiological features of infectious diseases are rarely studied. In this study, we aimed to assess specific incidence and mortality trends of 45 notifiable infectious diseases from 2004 to 2013 in China and to investigate the overall effectiveness of current prevention and control strategies.
Incidence and mortality data for 45 notifiable infectious diseases were extracted from a WChinese public health science data centre from 2004 to 2013, which covers 31 provinces in mainland China. We estimated the annual percentage change in incidence of each infectious disease using joinpoint regression.
Between January, 2004, and December, 2013, 54 984 661 cases of 45 infectious diseases were reported (average yearly incidence 417·98 per 100 000). The infectious diseases with the highest yearly incidence were hand, foot, and mouth disease (114·48 per 100 000), hepatitis B (81·57 per 100 000), and tuberculosis (80·33 per 100 000). 132 681 deaths were reported among the 54 984 661 cases (average yearly mortality 1·01 deaths per 100 000; average case fatality 2·4 per 1000). Overall yearly incidence of infectious disease was higher among males than females and was highest among children younger than 10 years. Overall yearly mortality was higher among males than females older than 20 years and highest among individuals older than 80 years. Average yearly incidence rose from 300·54 per 100 000 in 2004 to 483·63 per 100 000 in 2013 (annual percentage change 5·9%); hydatid disease (echinococcosis), hepatitis C, and syphilis showed the fastest growth. The overall increasing trend changed after 2009, and the annual percentage change in incidence of infectious disease in 2009–13 (2·3%) was significantly lower than in 2004–08 (6·2%).
Although the overall incidence of infectious diseases was increasing from 2004, the rate levelled off after 2009. Effective prevention and control strategies are needed for diseases with the highest incidence—including hand, foot, and mouth disease, hepatitis B, and tuberculosis—and those with the fastest rates of increase (including hydatid disease, hepatitis C, and syphilis).
Chinese Ministry of Science and Technology, National Natural Science Foundation (China).
Journal Article
Single-cell CAS-seq reveals a class of short PIWI-interacting RNAs in human oocytes
Small RNAs have important functions. However, small RNAs in primate oocytes remain unexplored. Herein, we develop CAS-seq, a single-cell small RNA sequencing method, and profile the small RNAs in human oocytes and embryos. We discover a class of ~20-nt small RNAs that are predominantly expressed in human and monkey oocytes, but not in mouse oocytes. They are specifically associated with HIWI3 (PIWIL3), whereas significantly shorter than the commonly known PIWI-interacting RNAs (piRNAs), designated as oocyte short piRNAs (os-piRNAs). Notably, the os-piRNAs in human oocytes lack 2’-O-methylation at the 3’ end, a hallmark of the classic piRNAs. In addition, the os-piRNAs have a strong 1U/10 A bias and are enriched on the antisense strands of recently evolved transposable elements (TEs), indicating the potential function of silencing TEs by cleavage. Therefore, our study has identified an oocyte-specific piRNA family with distinct features and provides valuable resources for studying small RNAs in primate oocytes.
PIWI-interacting RNAs (piRNAs) are ~25–33 nt small RNAs expressed in animal germ cells. Here, the authors develop a single-cell small RNA sequencing method and report that a class of ~20-nt piRNAs lacking 3′ end 2′-O-methylation are associated with PIWIL3 protein and predominantly expressed in human and monkey oocytes.
Journal Article
An Analysis of Deep Learning Models in SSVEP-Based BCI: A Survey
The brain–computer interface (BCI), which provides a new way for humans to directly communicate with robots without the involvement of the peripheral nervous system, has recently attracted much attention. Among all the BCI paradigms, BCIs based on steady-state visual evoked potentials (SSVEPs) have the highest information transfer rate (ITR) and the shortest training time. Meanwhile, deep learning has provided an effective and feasible solution for solving complex classification problems in many fields, and many researchers have started to apply deep learning to classify SSVEP signals. However, the designs of deep learning models vary drastically. There are many hyper-parameters that influence the performance of the model in an unpredictable way. This study surveyed 31 deep learning models (2011–2023) that were used to classify SSVEP signals and analyzed their design aspects including model input, model structure, performance measure, etc. Most of the studies that were surveyed in this paper were published in 2021 and 2022. This survey is an up-to-date design guide for researchers who are interested in using deep learning models to classify SSVEP signals.
Journal Article
Identification of Putative Olfactory Genes from the Oriental Fruit Moth Grapholita molesta via an Antennal Transcriptome Analysis
The oriental fruit moth, Grapholita molesta, is an extremely important oligophagous pest species of stone and pome fruits throughout the world. As a host-switching species, adult moths, especially females, depend on olfactory cues to a large extent in locating host plants, finding mates, and selecting oviposition sites. The identification of olfactory genes can facilitate investigation on mechanisms for chemical communications.
We generated transcriptome of female antennae of G.molesta using the next-generation sequencing technique, and assembled transcripts from RNA-seq reads using Trinity, SOAPdenovo-trans and Abyss-trans assemblers. We identified 124 putative olfactory genes. Among the identified olfactory genes, 118 were novel to this species, including 28 transcripts encoding for odorant binding proteins, 17 chemosensory proteins, 48 odorant receptors, four gustatory receptors, 24 ionotropic receptors, two sensory neuron membrane proteins, and one odor degrading enzyme. The identified genes were further confirmed through semi-quantitative reverse transcription PCR for transcripts coding for 26 OBPs and 17 CSPs. OBP transcripts showed an obvious antenna bias, whereas CSP transcripts were detected in different tissues.
Antennal transcriptome data derived from the oriental fruit moth constituted an abundant molecular resource for the identification of genes potentially involved in the olfaction process of the species. This study provides a foundation for future research on the molecules involved in olfactory recognition of this insect pest, and in particular, the feasibility of using semiochemicals to control this pest.
Journal Article
MicroRNA-15b Targets VEGF and Inhibits Angiogenesis in Proliferative Diabetic Retinopathy
Abstract
Background
Vascular endothelial growth factor (VEGF)-induced angiogenesis is a critical compensatory response to microvascular rarefaction in the diabetic retina that contributes to proliferative diabetic retinopathy (PDR). In this study, we sought to determine the role of specific micro ribonucleic acids (RNAs) (miRs) associated with VEGF in patients with PDR pathology.
Methods
RNA sequencing was employed to detect differentially circulating miR associated with VEGF in patients with diabetes mellitus (DM), nonproliferative diabetic retinopathy (NPDR) and PDR. Quantitative real-time polymerase chain reaction was performed to measure the concentration of miR-15b in the serum of patients with DM (n = 115), NPDR (n = 47), or PDR (n = 76). The effects of miR-15b on DR and regulation of VEGF and endothelial cell function were also characterized.
Results
We demonstrated that circulating miR-15b was directly associated with VEGF compared with other miRs in patients with PDR. We found a significant inverse relationship between low levels of miR-15b and high levels of VEGF in patients with PDR when compared with the DM or NPDR groups. We found that miR-15b regulates the expression of VEGF by targeting the 3'-untranslated regions to inhibit its transcription. Similarly, overexpression of miR-15b suppressed vascular abnormalities in vivo in diabetic GK rats, inhibiting endothelial tube formation and VEGF expression.
Conclusion
Circulating miR-15b is associated with PDR and may be targeted to regulate VEGF expression and angiogenesis.
Journal Article
Side-Scan Sonar Image Generation Under Zero and Few Samples for Underwater Target Detection
The acquisition of side-scan sonar (SSS) images is complex, expensive, and time-consuming, making it difficult and sometimes impossible to obtain rich image data. Therefore, we propose a novel image generation algorithm to solve the problem of insufficient training datasets for SSS-based target detection. For zero-sample detection, we proposed a two-step style transfer approach. The ray tracing method was first used to obtain an optically rendered image of the target. Subsequently, UA-CycleGAN, which combines U-net, soft attention, and HSV loss, was proposed for generating high-quality SSS images. A one-stage image-generation approach was proposed for few-sample detection. The proposed ADA-StyleGAN3 incorporates an adaptive discriminator augmentation strategy into StyleGAN3 to solve the overfitting problem of the generative adversarial network caused by insufficient training data. ADA-StyleGAN3 generated high-quality and diverse SSS images. In simulation experiments, the proposed image-generation algorithm was evaluated subjectively and objectively. We also compared the proposed algorithm with other classical methods to demonstrate its advantages. In addition, we applied the generated images to a downstream target detection task, and the detection results further demonstrated the effectiveness of the image generation algorithm. Finally, the generalizability of the proposed algorithm was verified using a public dataset.
Journal Article