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In this paper, a variety of 2D materials on the surface plasmon resonance sensor based on Al–Ni bimetallic layer are compared. Simulation results indicate that lateral position shift, which is calculated according to the real and imaginary parts of the refractive index of material, can be used as an effective parameter to optimize the sensitivity. By using the parameters for optimizing the SPR structures, the results show that the multiple layer models of Al(40 nm)–Ni(22 nm)–black phosphorus (BP)(1 L) and Al(40 nm)–Ni(22 nm)–blue phosphorus (BlueP)/WS2(1 L) exhibit average angular sensitivities of 507.0 °/RIU and 466 °/RIU in the refractive index range of 1.330–1.335, and maximum sensitivity of 542 °/RIU and 489 °/RIU at the refractive index of 1.333, respectively. We expect more applications can be explored based on the highly sensitive SPR sensor in different fields of optical sensing.

HighlightsHigh performance Al nanostructures/ZnO quantum dots heterostructure photodetectors with a controllable geometry of the Al nanostructures are demonstrated.Light utilization of the photoactive layers is significantly boosted with the Al nanostructures.The light confinement effect is inherently determined by the geometries of the Al nanostructures.Light confinement induced by spontaneous near-surface resonance is inherently determined by the location and geometry of metallic nanostructures (NSs), offering a facile and effective approach to break through the limitation of the light-mater interaction within the photoactive layers. Here, we demonstrate high-performance Al NS/ZnO quantum dots (Al/ZnO) heterostructure UV photodetectors with controllable morphologies of the self-assembled Al NSs. The Al/ZnO heterostructures exhibit a superior light utilization than the ZnO/Al heterostructures, and a strong morphological dependence of the Al NSs on the optical properties of the heterostructures. The inter-diffusion of Al atoms into ZnO matrixes is of a great benefit for the carrier transportation. Consequently, the optimal photocurrent of the Al/ZnO heterostructure photodetectors is significantly increased by 275 times to ~ 1.065 mA compared to that of the pristine ZnO device, and an outstanding photoresponsivity of 11.98 A W−1 is correspondingly achieved under 6.9 mW cm−2 UV light illumination at 10 V bias. In addition, a relatively fast response is similarly witnessed with the Al/ZnO devices, paving a path to fabricate the high-performance UV photodetectors for applications.

The accurate monitoring of flow velocity is crucial in applications such as blood microcirculation and microfluidic systems. However, the high sensitivity of current hot wire flowmeters is often achieved at the expense of increasing the initial temperature, which imposes significant limitations when measuring blood or other temperature sensitive fluids. In this study, a fiber sensor probe with a plano-concave cavity, fabricated from a PbS quantum dots (QDs)-doped photoresist, is proposed for the sensitive flow velocity detection of microfluidics. In the proposed hot wire-based micro-flowmeter, the excitation laser (980 nm) is efficiently absorbed and converted into thermal energy, while minimally affecting the high-quality interference of the cavity at the C-band. The experimental results show that only a 3 °C increase in temperature is required for flow velocity monitoring, with a sensitivity of 7.7 pm/(mm/s) achieved within a linear response range of 3.82 mm/s to 16.72 mm/s. Additionally, an intensity interrogation scheme is introduced for the hot wire-based fiber sensor probe. This low initial temperature requirement makes the proposed sensor suitable for microfluidics, demonstrating promising potential for use in microcirculation measurement and drug delivery systems.

Background Subarachnoid hemorrhage (SAH) is a subtype of hemorrhagic stroke characterized by high mortality and low rates of full recovery. This study aimed to investigate the epidemiological characteristics of SAH between 1990 and 2021. Methods Data on SAH incidence, mortality, and disability-adjusted life-years (DALYs) from 1990 to 2021 were obtained from the Global Burden of Disease Study (GBD) 2021. Estimated annual percentage changes (EAPCs) were calculated to evaluate changes in the age-standardized rate (ASR) of incidence and mortality, as well as trends in SAH burden. The relationship between disease burden and sociodemographic index (SDI) was also analyzed. Results In 2021, the incidence of SAH was found to be 37.09% higher than that in 1990; however, the age-standardized incidence rates (ASIRs) showed a decreased [EAPC: -1.52; 95% uncertainty interval (UI) -1.66 to -1.37]. Furthermore, both the number and rates of deaths and DALYs decreased over time. It was observed that females had lower rates compared to males. Among all regions, the high-income Asia Pacific region exhibited the highest ASIR (14.09/100,000; 95% UI 12.30/100,000 − 16.39/100,000) in 2021, with an EPAC for ASIR < 0 indicating decreasing trend over time for SAH ASIR. Oceania recorded the highest age-standardized mortality rates (ASMRs) and age-standardized DALYs rates among all regions in 2021 at values of respectively 8.61 (95% UI 6.03 − 11.95) and 285.62 (95% UI 209.42 − 379.65). The burden associated with SAH primarily affected individuals aged between 50 − 69 years old. Metabolic risks particularly elevated systolic blood pressure were identified as the main risk factors contributing towards increased disease burden associated with SAH when compared against environmental or occupational behavioral risks evaluated within the GBD framework. Conclusions The burden of SAH varies by gender, age group, and geographical region. Although the ASRs have shown a decline over time, the burden of SAH remains significant, especially in regions with middle and low-middle SDI levels. High systolic blood pressure stands out as a key risk factor for SAH. More specific supportive measures are necessary to alleviate the global burden of SAH.

Aim： Berberine （BBR）, an isoquinoline-derived alkaloid isolated from Rhizoma coptidis, exerts cardioprotective effects. Because endoplasmic reticulum （ER） stress plays a pivotal role in myocardial ischemia/reperfusion （MI/R）-induced apoptosis, it was interesting to examine whether the protective effects of BBR resulted from modulating ER stress levels during MI/R injury, and to define the signaling mechanisms in this process. Methods： Male rats were treated with BBR （200 mg.k-1.d-1, ig） for 2 weeks, and then subjected to MI/R surgery. Cardiac dimensions and function were assessed using echocardiography. Myocardial infarct size and apoptosis was examined. Total serum LDH levels and CK activities, superoxide production, MDA levels and the antioxidant SOD activities in heart tissue were determined. An in vitro study was performed on cultured rat embryonic myocardium-derived cells H9C2 exposed to simulated ischemia/reperfusion （SIR）. The expression of apoptotic, ER stress-related and signaling proteins were assessed using Western blot analyses.Results： Pretreatment with BBR significantly reduced MI/R-induced myocardial infarct size, improved cardiac function, and suppressed myocardial apoptosis and oxidative damage. Furthermore, pretreatment with BBR suppressed MI/R-induced ER stress, evidenced by down-regulating the phosphorylation levels of myocardial PERK and elF2a and the expression of ATF4 and CHOP in heart tissues. Pretreatment with BBR also activated the JAK2/STAT3 signaling pathway in heart tissues, and co-treatment with AG490, a specific JAK2/STAT3 inhibitor, blocked not only the protective effects of BBR, but also the inhibition of BBR on MI/R-induced ER stress. In H9C2 cells, treatment with BBR （50 pmol/L） markedly reduced SIR-induced cell apoptosis, oxidative stress and ER stress, which were abolished by transfection with JAK2 siRNA. Conclusion： BBR ameliorates MI/R injury in rats by activating the AK2/STAT3 signaling pathway and attenuating ER stress-induced apoptosis.

Background As climate warms, the sugars and secondary metabolites in grapes gradually become uncoupled during development, resulting in the phenomenon of overripe fruit becoming more frequent around the world, especially in some arid regions. However, the key metabolic regulations to grape overripening are still poorly understood. To address this, we conducted a multi-omics study on Cabernet Sauvignon overripe berries over two years, analyzing the non-targeted metabolome, transcriptome, and proteome, aiming to provide a theoretical basis for delayed harvest strategies based on grape quality. Results The delayed harvests caused significant changes in berry transcriptome and proteome. Genes and proteins responding to environmental changes were up-regulated, while those related to metabolism were down-regulated, indicating the primary function of berries during the overripening stage shifted away from extensive metabolite synthesis. The key enzyme genes and proteins linked to changes in metabolites like glucose, pyruvate, malate, alanine, γ-aminobutyric acid, and resveratrol, were identified. Conclusions In hot regions, the overripening stage of grape berries may be detrimental to their quality. This study highlights the core molecular changes during grape overripening and offer valuable insights for optimizing grape harvest date.

Metallic nanostructures (NSs) have been widely adapted in various applications and their physical, chemical, optical and catalytic properties are strongly dependent on their surface morphologies. In this work, the morphological and optical evolution of self-assembled Pt nanostructures on c-plane sapphire (0001) is demonstrated by the control of annealing temperature and dwelling duration with the distinct thickness of Pt films. The formation of Pt NSs is led by the surface diffusion, agglomeration and surface and interface energy minimization of Pt thin films, which relies on the growth parameters such as system temperature, film thickness and annealing duration. The Pt layer of 10 nm shows the formation of overlaying NPs below 650°C and isolated Pt nanoparticles above 700°C based on the enhanced surface diffusion and Volmer-Weber growth model whereas larger wiggly nanostructures are formed with 20 nm thick Pt layers based on the coalescence growth model. The morphologies of Pt nanostructures demonstrate a sharp distinction depending on the growth parameters applied. By the control of dwelling duration, the gradual transition from dense Pt nanoparticles to networks-like and large clusters is observed as correlated to the Rayleigh instability and Ostwald ripening. The various Pt NSs show a significant distinction in the reflectance spectra depending on the morphology evolution: i.e. the enhancement in UV-visible and NIR regions and the related optical properties are discussed in conjunction with the Pt NSs morphology and the surface coverage.

A weak interlayer zone (WIZ) is a poor zonal geotechnical system with loose structure, weak mechanical properties, variable thickness, random distribution, and strong extension, that occurs between different rock strata (e.g., tuff and basalt), due to the intense tectonic movement, representing a potential threat to the overall stability of rock masses with WIZs in large underground cavern excavations. Focusing on the excavation-induced hazards in the weak interlayer zone (WIZ) occurring in underground cavern under high geostress, the mechanical response of WIZ under different loading and unloading stress paths has been well investigated and unearthed, by a series of automatic stress path controlled triaxial tests, as well as through scanning electron microscope (SEM) analysis. Results show that the mechanical characteristics of WIZ are closely related to the initial confining pressure and stress paths. Sudden increases in the circumferential strain and strong dilations of WIZ occur from the start of unloading, among which the unloading total strains are most strongly promoted by stress path II (i.e., axial pressure loading and confining pressure unloading), whereas the unloading stress path IV (i.e., axial pressure and confining pressure unloading) has the greatest promotion on enhancing the plastic volumetric dilatation. The deformation modulus and the Poisson’s ratio follow a deterioration law under the unloading process of confining pressure, and it is the unloading stress path II that most influences the damage of elastic parameters. The ultimate bearing strength, the internal friction angle, and the cohesion of WIZ appear extremely obvious degradation in course of unloading, among which the damage effect of stress path IV is the most remarkable. The macroscopic and mesoscopic analyses reveal that the failure mechanism of WIZ under complicated unloading stress paths lays in the accumulation and propagation of axial and circumferential cracks and fractures, as well as pervasive particle breakage, with the intergranular fractures, transcrystalline fractures, and the shear scratches on a meso level. The research could provide an effective basis and good lessons for the mechanical response and failure mechanism of WIZ under unloading stress paths in underground cavern under high geostress.

Background Metabolic reprograming and immune escape are two hallmarks of cancer. However, how metabolic disorders drive immune escape in head and neck squamous cell carcinoma (HNSCC) remains unclear. Therefore, the aim of the present study was to investigate the metabolic landscape of HNSCC and its mechanism of driving immune escape. Methods Analysis of paired tumor tissues and adjacent normal tissues from 69 HNSCC patients was performed using liquid/gas chromatography‐mass spectrometry and RNA‐sequencing. The tumor‐promoting function of kynurenine (Kyn) was explored in vitro and in vivo. The downstream target of Kyn was investigated in CD8+ T cells. The regulation of CD8+ T cells was investigated after Siglec‐15 overexpression in vivo. An engineering nanoparticle was established to deliver Siglec‐15 small interfering RNA (siS15), and its association with immunotherapy response were investigated. The association between Siglec‐15 and CD8+ programmed cell death 1 (PD‐1)+ T cells was analyzed in a HNSCC patient cohort. Results A total of 178 metabolites showed significant dysregulation in HNSCC, including carbohydrates, lipids and lipid‐like molecules, and amino acids. Among these, amino acid metabolism was the most significantly altered, especially Kyn, which promoted tumor proliferation and metastasis. In addition, most immune checkpoint molecules were upregulated in Kyn‐high patients based on RNA‐sequencing. Furthermore, tumor‐derived Kyn was transferred into CD8+ T cells and induced T cell functional exhaustion, and blocking Kyn transporters restored its killing activity. Accroding to the results, mechanistically, Kyn transcriptionally regulated the expression of Siglec‐15 via aryl hydrocarbon receptor (AhR), and overexpression of Siglec‐15 promoted immune escape by suppressing T cell infiltration and activation. Targeting AhR in vivo reduced Kyn‐mediated Siglec‐15 expression and promoted intratumoral CD8+ T cell infiltration and killing capacity. Finally, a NH2‐modified mesoporous silica nanoparticle was designed to deliver siS15, which restored CD8+ T cell function status and enhanced anti‐PD‐1 efficacy in tumor‐bearing immunocompetent mice. Clinically, Siglec‐15 was positively correlated with AhR expression and CD8+PD‐1+ T cell infiltration in HNSCC tissues. Conclusions The findings describe the metabolic landscape of HNSCC comprehensively and reveal that the Kyn/Siglec‐15 axis may be a novel potential immunometabolism mechanism, providing a promising therapeutic strategy for cancers.

Four new dimeric sorbicillinoids (1–3 and 5) and a new monomeric sorbicillinoid (4) as well as six known analogs (6–11) were purified from the fungal strain Hypocrea jecorina H8, which was obtained from mangrove sediment, and showed potent inhibitory activity against the tea pathogenic fungus Pestalotiopsis theae (P. theae). The planar structures of 1–5 were assigned by analyses of their UV, IR, HR-ESI-MS, and NMR spectroscopic data. All the compounds were evaluated for growth inhibition of tea pathogenic fungus P. theae. Compounds 5, 6, 8, 9, and 10 exhibited more potent inhibitory activities compared with the positive control hexaconazole with an ED50 of 24.25 ± 1.57 µg/mL. The ED50 values of compounds 5, 6, 8, 9, and 10 were 9.13 ± 1.25, 2.04 ± 1.24, 18.22 ± 1.29, 1.83 ± 1.37, and 4.68 ± 1.44 µg/mL, respectively. Additionally, the effects of these compounds on zebrafish embryo development were also evaluated. Except for compounds 5 and 8, which imparted toxic effects on zebrafish even at 0.625 μM, the other isolated compounds did not exhibit significant toxicity to zebrafish eggs, embryos, or larvae. Taken together, sorbicillinoid derivatives (6, 9, and 10) from H. jecorina H8 displayed low toxicity and high anti-tea pathogenic fungus potential.