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In order to study the development of overburden fractures and the distribution characteristics of the “three zones” in extra-thick coal seams, a rota-table physical similarity simulation test platform was used to analyze the deformation and failure characteristics of overburden during the mining of extra-thick coal seams. The displacement patterns of key layers were measured under different excavation distances. A statistical analysis of the overburden fracture distribution was conducted, revealing the evolution characteristics of fracture development in the overburden with increasing advancing distance. Stress changes in key layers during excavation were also recorded and analyzed. By combining the study of the influence of overburden fracture development on gas migration, the mechanism of elliptical paraboloid-shaped fracture zones formed by mining-induced overburden fractures in extra-thick inclined coal seams was identified. A method for arranging directional high-level long boreholes based on fracture development characteristics was proposed. In field practice, the average pure gas drainage volume increased from 3.40 m 3 /min to 5.70 m 3 /min, showing a significant improvement in drainage efficiency.

This paper presents an attention-enhanced deep reinforcement learning control system for thermal-visual collaborative optimization in multi-sensory art installations. The proposed system integrates three key innovations: (1) an attention-based DDPG algorithm with dynamic modality weighting (α = 0.6–0.8 for thermal, 0.6–0.7 for visual features), (2) adaptive sensor fusion combining Kalman and particle filtering with 8 ± 2 ms processing latency, and (3) hierarchical four-layer architecture achieving 65% control accuracy improvement and 40% response time reduction compared to traditional approaches. The system architecture incorporates a hierarchical four-layer design with perception, fusion, decision-making, and execution components. The core innovation lies in an attention-based deep reinforcement learning algorithm that dynamically processes multi-modal sensory inputs and optimizes thermal-visual coordination through continuous learning. The algorithm employs spatiotemporal alignment mechanisms, adaptive feature weighting, and collaborative optimization strategies to achieve superior control performance. Experimental validation demonstrates quantified improvements over conventional methods: control accuracy improved from 0.247 ± 0.067 RMSE (PID baseline) to 0.085 ± 0.012 RMSE (proposed method), representing 65% improvement; response times reduced from 78 ± 22 ms (fuzzy control) to 45 ± 8 ms (proposed method), achieving 40% improvement; energy efficiency increased from baseline consumption to 23% reduction through intelligent coordination. Real-world deployment results confirm practical effectiveness with measured user satisfaction scores of 4.1 ± 0.7 on a 5-point scale and system availability of 98.5% over 186-hour continuous operation periods. The proposed system enables more sophisticated multi-sensory experiences while maintaining artistic integrity and provides a foundation for advanced digital art technologies.

Association of frailty with adverse clinical outcomes has been reported in Western countries, but data from the Asian population are scarce. This study aimed to evaluate the epidemiology of frailty among community-dwelling middle-aged and elderly population and to explore its association with musculoskeletal health in Taiwan. I-Lan Longitudinal Aging Study (ILAS) data were retrieved for this study. Frailty was defined by the Fried's criteria; a comparison of demographic characteristics, physical performance, and body composition, including skeletal muscle mass and bone mineral density (BMD), as well as recent falls, history of hip fractures and the functional status of subjects with different frailty statuses were accomplished. Overall, the data of 1,839 participants (mean age: 63.9±9.3 years, male 47.5%) were obtained for analysis. The prevalence of pre-frailty was 42.3% in men and 38.8% in women, whereas the prevalence of frailty was 6.9% and 6.7% in men and women, respectively. Frailty was significantly associated with older age, the male gender, larger waist circumference, lower skeletal muscle index, lower hip BMD, poorer physical function, poorer nutritional status, and poorer cognitive function. Also, frailty was significantly associated with osteoporosis (OR: 7.73, 95% CI: 5.01-11.90, p<0.001), history of hip fractures (OR: 8.66, 95% CI: 2.47-30.40, p = 0.001), and recent falls (O.R: 2.53, 95% CI: 1.35-4.76, p = 0.004). Frailty and pre-frailty, in Taiwan, was closely associated with recent falls, history of hip fractures and osteoporosis among community-dwelling people 50 years of age and older. Furthermore, frailty intervention programs should take an integrated approach towards strengthening both and muscle mass, as well as prevention of falls.

Under the revised substitution regulations in soccer, this study aims to analyze the performance characteristics of substitution events in Chinese Football Association Super League (CSL) matches and explore the relationship between soccer substitution networks and team performance over the season. Using non-goalkeeper substitution events (n=2125) from the 2023 CSL season as the research sample, the study conducted substitution network modeling and clustering to investigate the relationship between network characteristics and team performance, as well as the performance traits of different types of substitution events. Results showed that professional soccer teams with higher substitution network density demonstrated better performance in goal difference and goals conceded. Out-degree centralization positively influenced goal difference, goals scored, and team ranking, while higher In-degree centralization correlated with fewer goals conceded. Additionally, players with more balanced on-field participation were substituted most frequently. Offensive players with strong attacking abilities were substituted in earlier, while wide players were the most frequently substituted out. Players with a high frequency of high-risk passes were substituted out later. Therefore, a substitution strategy centered around some soccer players contributes to better seasonal performance. Substitutions out of players are more focused on physical condition, with high-performing teams tending to substitute out similar types of players at different times. Substitutions in, on the other hand, emphasize the compatibility of player abilities. Under the “five substitutions” rule, greater attention is given to the running distance and maximum sprint speed of soccer substitute players.

The structural and photophysical characteristics of MAPbBr 3 single crystals prepared using the inverse temperature crystallization method are evaluated using temperature-dependent X-ray diffraction (XRD) and optical spectroscopy. Contrary to previous research reports on perovskite materials, we study phase transitions in crystal lattice structures accompanied with changes in optical properties expand throughout a wide temperature range of 300–1.5 K. The XRD studies reveal several phase transitions occurred at ~210 K, ~145 K, and ~80 K, respectively. The coexistence of two different crystallographic phases was observed at a temperature below 145 K. The emission peaks in the PL spectra are all asymmetric in line shape with weak and broad shoulders near the absorption edges, which are attributed to the Br atom vacancy on the surface of the crystals. The time-resolved PL measurements reveal the effect of the desorption/adsorption of gas molecules on the crystal surface on the PL lifetimes. Raman spectroscopy results indicate the strong interplays between cations and different halide atoms. Lastly, no diamagnetic shift or split in emission peaks can be observed in the magneto-PL spectra even at an applied magnetic field up to 5 T and at a temperature as low as 1.5 K.

Considering the notable influence of traditional Confucian culture on China’s housing market, this study introduces an innovative index to quantify the magnitude of the real estate bubble within China, employing a familial generational iterative model. Utilizing rent-buy policy as a conceptual framework, our research constructs a difference-in-differences model to investigate the impact of macroeconomic policies on the housing bubble phenomenon. Empirical observations from 2022 reveal pronounced bubble dynamics in first and second-tier cities, while housing prices in third and fourth-tier cities, alongside select fifth-tier cities, exhibit a declining trend. On a national scale, apart from minor affordability observed during 2005–2007, no significant affordability was identified in other years, with the housing price bubble index demonstrating a downward trajectory from 2020 to 2022. Furthermore, the implementation of the rent-buy policy that equality the rights of renter and owner has directly influenced the housing market, notably mitigating the overall escalation of housing prices. Additional analysis indicates that the rent-and-buy policy has been more successful in curbing price hikes in newly constructed and smaller-sized housing units compared to second-hand and larger-scale properties.

Severe fever with thrombocytopenia syndrome virus (SFTSV), an etiological agent causing febrile human disease was identified as an emerging tick-borne bunyavirus. The clinical disease characteristics and case fatality rates of SFTSV may vary across distinct regions and among different variant genotypes. From 2018 to 2022, we surveyed and recruited 202 severe fever with thrombocytopenia syndrome (SFTS) patients in Hubei Province, a high-incidence area of the epidemic, and conducted timely and systematic research on the disease characteristics, SFTSV diversity, and the correlation between virus genome variation and clinical diseases. Our study identified at least 6 genotypes of SFTSV prevalent in Hubei Province based on the analysis of the S, M, and L genome sequences of 88 virus strains. Strikingly, the dominant genotype of SFTSV was found to change during the years, indicating a dynamic shift in viral genetic diversity in the region. Phylogenetic analysis revealed the genetic exchange of Hubei SFTSV strains was relatively frequent, including 3 reassortment strains and 8 recombination strains. Despite the limited sample size, SFTSV C1 genotype may be associated with higher mortality compared to the other four genotypes, and the serum amyloid A (SAA) level, an inflammatory biomarker, was significantly elevated in these patients. Overall, our data summarize the disease characteristics of SFTSV in Hubei Province, highlight the profound changes in viral genetic diversity, and indicate the need for in-depth monitoring and exploration of the relationship between viral mutations and disease severity.

Next-generation advanced high/pulsed power capacitors rely heavily on dielectric ceramics with high energy storage performance. However, thus far, the huge challenge of realizing ultrahigh recoverable energy storage density ( W rec ) accompanied by ultrahigh efficiency ( η ) still existed and has become a key bottleneck restricting the development of dielectric materials in cutting-edge energy storage applications. Here, we propose a high-entropy strategy to design “local polymorphic distortion” including rhombohedral-orthorhombic-tetragonal-cubic multiphase nanoclusters and random oxygen octahedral tilt, resulting in ultrasmall polar nanoregions, an enhanced breakdown electric field, and delayed polarization saturation. A giant W rec ~10.06 J cm −3 is realized in lead-free relaxor ferroelectrics, especially with an ultrahigh η ~90.8%, showing breakthrough progress in the comprehensive energy storage performance for lead-free bulk ceramics. This work opens up an effective avenue to design dielectric materials with ultrahigh comprehensive energy storage performance to meet the demanding requirements of advanced energy storage applications. Dielectric ceramics are widely used in advanced high/pulsed power capacitors. Here, the authors propose a high-entropy strategy to design “local polymorphic distortion” in lead-free ceramics, achieving high energy storage performance.

In recent years, cancer immunotherapy based on immune checkpoint inhibitors (ICIs) has achieved considerable success in the clinic. However, ICIs are significantly limited by the fact that only one third of patients with most types of cancer respond to these agents. The induction of cell death mechanisms other than apoptosis has gradually emerged as a new cancer treatment strategy because most tumors harbor innate resistance to apoptosis. However, to date, the possibility of combining these two modalities has not been discussed systematically. Recently, a few studies revealed crosstalk between distinct cell death mechanisms and antitumor immunity. The induction of pyroptosis, ferroptosis, and necroptosis combined with ICIs showed synergistically enhanced antitumor activity, even in ICI-resistant tumors. Immunotherapy-activated CD8+ T cells are traditionally believed to induce tumor cell death via the following two main pathways: (i) perforin-granzyme and (ii) Fas-FasL. However, recent studies identified a new mechanism by which CD8+ T cells suppress tumor growth by inducing ferroptosis and pyroptosis, which provoked a review of the relationship between tumor cell death mechanisms and immune system activation. Hence, in this review, we summarize knowledge of the reciprocal interaction between antitumor immunity and distinct cell death mechanisms, particularly necroptosis, ferroptosis, and pyroptosis, which are the three potentially novel mechanisms of immunogenic cell death. Because most evidence is derived from studies using animal and cell models, we also reviewed related bioinformatics data available for human tissues in public databases, which partially confirmed the presence of interactions between tumor cell death and the activation of antitumor immunity.

Background Few studies have made longitudinal comparisons between frailty phenotype (FP) and frailty index (FI) changes. We aimed to investigate frailty status changes defined by FP and FI concurrently, and to compare the associated factors and incident disability among different combination of FI and FP trajectory groups. Methods Data on respondents aged over 50 who completed the 1999, 2003 and 2007 Taiwan Longitudinal Study on Aging (TLSA) surveys ( n  = 2807) were excerpted. Changes of FI, FP and major time-dependent variables were constructed by group-based trajectory modeling. Logistic regression was used to investigate the associated factors and relationships with incident disability among different frailty trajectories. Results We identified four FP trajectories – stably robust, worsened frailty, improved frailty, and stably frail and three FI trajectories – stable FI, moderate increase FI and rapid increase FI. Lower self-rated health, mobility impairment, and depressed mood were associated with unfavorable FP and FI changes (all p  < 0.001). Regardless of FP trajectory groups, the moderate and rapid increase FI group had significantly more comorbidities than the stable FI group, and more visual, hearing, oral intake impairment, more difficulty in meeting living expenses, and poorer cognitive function in ≥65-year-olds (all p  < 0.05). In addition, the worsened frailty, improved frailty, and stably frail groups had ORs for incident disability of 10.5, 3.0, and 13.4, respectively, compared with the stably robust group (all p  < 0.01); the moderate and rapid increase FI groups had 8.4-fold and 77.5-fold higher risk than the stable FI group (both p  < 0.001). When combining FI and FP trajectories, risk increased with FI trajectory steepness, independent of FP change (all p  < 0.01 in rapid increase FI vs stable FI). Conclusions Four FP trajectories (stably robust, worsened frailty, improved frailty, and stably frail) and three FI trajectories (stable FI, moderate increase FI and rapid increase FI) were identified. Lower self-rated health, mobility impairment, and depressed mood were associated with both unfavorable FP and FI trajectories. Nevertheless, even for individuals in stably robust or improved frailty FP groups, moderate or rapid increase in FI, either due to comorbidities, sensory impairment, cognitive deficits, or financial challenges, may still increase the risk of incident disability.