Explore the vast range of titles available.

This article uses Taiwan as an example to examine how families manage work and care when the government and workplace provide limited support. Many Taiwanese households employ live-in migrant care workers to negotiate care responsibilities and adults’ paid jobs. Based on interviews with employers of live-in migrant care workers and workers, the findings demonstrate that daughters-in-law and occasionally daughters and sons become employers of live-in migrant care workers because of the limitation of public care services and lack of support they receive in seeking to combine paid work and family care responsibility. Even after employing migrant workers, women retain greater care responsibility in daily practices than their husbands. Hiring live-in migrant care workers also imposes risks to all parties involved in the processes of organising, coordinating, and providing care due to the uncertainty of care quality and the nature of care work.

The myriad studies of migrant care workers adopt a rights perspective to address their liminal status and experience of exploitation. However, this perspective may fail to recognise the complexities of care and caring. Through describing the lived experiences of migrant live-in care workers and care recipients, this study illustrates the dynamics of care work and care relationships. It presents the complex dimensions of care work embedded in the intersections of labour, love, empathy, reciprocity, power and interdependency. A feminist ethics of care can be an alternative perspective in order to improve the well-being and interests of migrant care workers and care recipients.

Myostatin is a secreted protein that normally functions as a negative regulator of muscle growth. Agents capable of blocking the myostatin signaling pathway could have important applications for treating human muscle degenerative diseases as well as for enhancing livestock production. Here we describe a potent myostatin inhibitor, a soluble form of the activin type MB receptor (ACVR2B), which can cause dramatic increases in muscle mass (up to 60% in 2 weeks) when injected into wild-type mice. Furthermore, we show that the effect of the soluble receptor is attenuated but not eliminated in Mstn-/-mice, suggesting that at least one other ligand in addition to myostatin normally functions to limit muscle growth. Finally, we provide genetic evidence that these ligands signal through both activin type II receptors, ACVR2 and ACVR2B, to regulate muscle growth in vivo.

Addition of livestock manures and plant residues is a feasible practice to largely mitigate soil-degradative trends by the soil-dwelling fungi. However, long-term impacts of these fertilization regimes on the fungal community are poorly documented in tea (Camellia sinensis (L.) Kuntze) plantations in subtropical areas. In this study, MiSeq sequencing approach was used to estimate the diversity and composition of fungal communities in soils treated with 10 yr of non-fertilization control (CK), chemical fertilizers only (CF), and integrated use of chicken manure and legume straw with chemical fertilizers (IF), respectively. We found that different fertilization treatments produced little effect on the richness and diversity of soil fungi compared to those of the controls. In addition, Ascomycota, Basidiomycota, Zygomycota, Glomeromycota, and Chytridiomycota were the five most abundant phyla in soils under different fertilization treatments. Moreover, IF resulted in the prevalence of the genera Fusarium, unclassified Microascaceae, and unclassified Ascomycota, which accounted for 30.04%, 18.77%, and 6.92% of the total fungi, respectively. Additionally, the relative abundance of the phylum Ascomycota was positively correlated with pH, total N (TN), soil organic C (SOC), soil moisture (SM) and silt (SI) contents; however, these soil physicochemical properties were negatively correlated with the relative abundance of the phylum Basidiomycota. Together, these results suggest that the changes of the fungal community structure at the genus and phylum level under IF treatment could be the result of their responses to variations of soil pH, SM, TN, SOC, and SI contents.

According to the characteristics of highway network for sustainable development and make clear the purpose and content of evaluation. On the basis of that this paper from network capacity, network traffic environmental carrying capacity, social benefit continuity and management system and policy this four aspects to set up the evaluation index system for the degree of highway network sustainable development, and illustrate the quantitative method of the attribute value of quantitative and qualitative indicators. This paper put forward the comprehensive evaluation method which is based on the Fuzzy AHP. Finally take the trunk road network of Zhang Jiakou city for instance to study.

In this paper, the recent studies of laboratory astrophysics with strong magnetic fields in China have been reviewed. On the Shenguang-II laser facility of the National Laboratory on High-Power Lasers and Physics, a laser-driven strong magnetic field up to 200 T has been achieved. The experiment was performed to model the interaction of solar wind with dayside magnetosphere. Also the low beta plasma magnetic reconnection (MR) has been studied. Theoretically, the model has been developed to deal with the atomic structures and processes in strong magnetic field. Also the study of shock wave generation in the magnetized counter-streaming plasmas is introduced.

Addition of livestock manures and plant residues is a feasible practice to largely mitigate soil-degradative trends by the soil-dwelling fungi. However, long-term impacts of these fertilization regimes on the fungal community are poorly documented in tea ( Camellia sinensis (L.) Kuntze) plantations in subtropical areas. In this study, MiSeq sequencing approach was used to estimate the diversity and composition of fungal communities in soils treated with 10 yr of non-fertilization control (CK), chemical fertilizers only (CF), and integrated use of chicken manure and legume straw with chemical fertilizers (IF), respectively. We found that different fertilization treatments produced little effect on the richness and diversity of soil fungi compared to those of the controls. In addition, Ascomycota, Basidiomycota, Zygomycota, Glomeromycota, and Chytridiomycota were the five most abundant phyla in soils under different fertilization treatments. Moreover, IF resulted in the prevalence of the genera Fusarium , unclassified Microascaceae, and unclassified Ascomycota, which accounted for 30.04%, 18.77%, and 6.92% of the total fungi, respectively. Additionally, the relative abundance of the phylum Ascomycota was positively correlated with pH, total N (TN), soil organic C (SOC), soil moisture (SM) and silt (SI) contents; however, these soil physicochemical properties were negatively correlated with the relative abundance of the phylum Basidiomycota. Together, these results suggest that the changes of the fungal community structure at the genus and phylum level under IF treatment could be the result of their responses to variations of soil pH, SM, TN, SOC, and SI contents.

Using an unbiased interrogation of the memory B cell repertoire of convalescent COVID-19 patients, we identified human antibodies that demonstrated robust antiviral activity in vitro and efficacy in vivo against all tested SARS-CoV-2 variants. Here, we describe the pre-clinical characterization of an antibody cocktail, IMM-BCP-01, that consists of three unique, patient-derived recombinant neutralizing antibodies directed at non-overlapping surfaces on the SARS-CoV-2 spike protein. Two antibodies, IMM20184 and IMM20190 directly block spike binding to the ACE2 receptor. Binding of the third antibody, IMM20253, to its unique epitope on the outer surface of RBD, alters the conformation of the spike trimer, promoting release of spike monomers. These antibodies decreased SARS-CoV-2 infection in the lungs of Syrian golden hamsters, and efficacy in vivo efficacy was associated with broad antiviral neutralizing activity against multiple SARS-CoV-2 variants and robust antiviral effector function response, including phagocytosis, ADCC, and complement pathway activation. Our pre-clinical data demonstrate that the three antibody cocktail IMM-BCP-01 shows promising potential for preventing or treating SARS-CoV-2 infection in susceptible individuals. Competing Interest Statement The described approach, antibodies and cocktail composition have been included in patent applications. PAN, JMD, JPD, NBP, JLBS, BCH, NH, CN, AP, MN, HS, JPF, LFL, TS, PS, DHG, MJM and MKR are employees and shareholders of Immunome, Inc. MSD is a consultant for Inbios, Vir Biotechnology, and Carnival Corporation, and on the Scientific Advisory Boards of Moderna and Immunome. MSD has stock equity options from Immunome. The Diamond laboratory has received funding support in sponsored research agreements from Immunome, and unrelated support from Vir Biotechnology, Moderna, and Emergent BioSolutions.

One juvenile and one adult female wolf snake（Colubridae： Lycodon） were sampled at Yixian and Fuxi, Huangshan, Anhui, China in the summer of 2011 and 2012, respectively. The two specimens were identified as Lycodon liuchengchaoi based on external morphology and molecular data. This is a new reptile record in Anhui Province. In our laboratory, four eggs were laid and three neonates were hatched successfully. This is the first record of the laying and incubation of L. liuchengchaoi eggs. The five specimens were deposited at the Museum of Huangshan University（HUM20140001） and Guangdong Entomological Institute（HB-lcfsp12613, HB-lcfsp-ch1~3）.

Background： Attention-deficit hyperactivity disorder （ADHD） is the most common mental and behavioral disorder in school-aged children. This study evaluated the effect of osmotic-release oral system （OROS） methylphenidate （MPH） on cognitive function and academic performance of Chinese school-aged children with ADHD. Methods： This 12-week, prospective, multicenter, open-label, self-controlled study enrolled 153 Chinese school-aged children with ADHD and 41 non-ADHD children. Children with ADHD were treated with once-daily OROS-MPH （18 mg, 36 mg, or 54 mg）. The primary endpoints were Inattention/Overactivity （I/O） with Aggression Conners Behavior Rating Scale （IOWA） and Digit Span Test at week 12 compared with baseline. Secondary endpoints included opposition/defiant （O/D） subscale of IOWA, Clinical Global Impression （CGI）, Coding Test, Stroop Color-word Test, Wisconsin Card Sorting Test （WCST）, academic performance on teacher-rated school examinations, and safety at week 12 compared with baseline. Both non-ADHD and ADHD children received the same frequency of cognitive operational test to avoid the possible bias caused by training. Results： A total of 128 patients were evaluated with cognitive assessments. The OROS-MPH treatment significantly improved IOWA Conners I/O subscale scores at week 12 （3.8 ± 2.3） versus baseline （10.0 ± 2.4; P 〈 0.0001）. Digit Span Test scores improved significantly （P 〈 0.0001 ） with a high remission rate （81.1%） at week 12 versus baseline. A significant （P 〈 0.0001 ） improvement was observed in O/D subscale of IOWA, CGI, Coding Test, Stroop Color-word Test, WCST, and academic performance at week 12 versus baseline. Very few practice-related improvements were noticed in the non-ADHD group at week 12 compared with baseline. No serious adverse events and deaths were reported during the study. Conclusions： The OROS-MPH treatment effectively controlled symptoms of ADHD and significantly improved academic performance and cognitive fimction of Chinese school-aged children with ADHD. The treatment was found to be sate and generally well-tolerated over 12 weeks.