Explore the vast range of titles available.

Amid escalating compound shocks that threaten global agricultural sustainability, this study establishes a multidimensional framework to systematically evaluate the spatiotemporal evolution and underlying mechanisms of agricultural economic resilience across 31 provinces in China from 2010 to 2022. The results indicate a consistent improvement in provincial resilience levels (ranging from 0.1 to 0.4), accompanied by a distinct clustering pattern in central China, whereas the western regions remain persistently vulnerable. Spatial autocorrelation analysis reveals a dynamic “hotspot–coldspot” configuration, with interregional disparities serving as the main source of overall inequality. Econometric analysis identifies agricultural mechanization, rural economic revitalization, educational progress, and targeted fiscal support as interacting factors that collectively enhance agricultural resilience. These findings offer empirically grounded, context-specific policy implications for building shock-resistant agricultural systems capable of maintaining long-term food security, thereby contributing to the broader discourse on agricultural resilience amid environmental and economic uncertainty.

Diabetic kidney disease (DKD) stands as the predominant cause of chronic kidney disease (CKD) on a global scale, with its incidence witnessing a consistent annual rise, thereby imposing a substantial burden on public health. The pathogenesis of DKD is primarily rooted in metabolic disorders and inflammation. Recent years have seen a surge in studies highlighting the regulatory impact of energy metabolism on innate immunity, forging a significant area of research interest. Within this context, fibroblast growth factor 21 (FGF21), recognized as an energy metabolism regulator, assumes a pivotal role. Beyond its role in maintaining glucose and lipid metabolism homeostasis, FGF21 exerts regulatory influence on innate immunity, concurrently inhibiting inflammation and fibrosis. Serving as a nexus between energy metabolism and innate immunity, FGF21 has evolved into a therapeutic target for diabetes, nonalcoholic steatohepatitis, and cardiovascular diseases. While the relationship between FGF21 and DKD has garnered increased attention in recent studies, a comprehensive exploration of this association has yet to be systematically addressed. This paper seeks to fill this gap by summarizing the mechanisms through which FGF21 operates in DKD, encompassing facets of energy metabolism and innate immunity. Additionally, we aim to assess the diagnostic and prognostic value of FGF21 in DKD and explore its potential role as a treatment modality for the condition.

Iron deficiency is highly prevalent in patients with heart failure (HF) complicated by chronic kidney disease (CKD), yet the efficacy of intravenous (IV) iron therapy remains unclear. We performed a meta-analysis of randomized controlled trials (RCTs) retrieved from Embase, PubMed, and the Cochrane Library from inception to January 1, 2026. A total of 8 RCTs involving 7009 participants were included. Clinical outcomes were assessed by generating forest plots using the random-effects model and pooling relative risks (RRs) or mean differences (MDs). IV iron therapy showed a significantly reduced incidence of first heart failure hospitalization or cardiovascular death (RR = 0.79, 95% CI: 0.72–0.86, P  < 0.001), heart failure hospitalization or cardiovascular death (RR = 0.85, 95% CI: 0.75–0.98, P  = 0.02) in HF-CKD patients as compared with the control group, with significant improvements in relevant biomarkers. Subgroup analyses revealed no effect modification by CKD status. Anemia status modified the treatment effect on all-cause mortality ( P  = 0.04). Anemic patients exhibited a trend toward clinical benefit (RR = 0.84, 95% CI: 0.70–1.01, P  = 0.06), while no such trend was observed in non-anemic patients (RR = 1.28, 95% CI: 0.90–1.81, P  = 0.16). Further large-sample, long-term trials are needed to identify the optimal patient population and clarify the long-term safety of this therapy.

The important task of community construction in China in the new era is to establish a scientific and effective community mental health service model, which plays an important role in improving the psychological quality of community residents and having a happy and beautiful life. On the basis of analyzing the current supply and demand situation of mental health services for community residents in D city and investigating the mental health status of community residents, countermeasures and suggestions for improving the construction of community mental health service system are proposed.

At present, the side effects of hormonal and immunosuppressant therapy for intermediate-to-high risk primary membranous nephropathy (PMN) are relatively large, and the remission rate is limited, so more safe and effective regimens are needed. This study is a clinical prospective case series study. 31 patients were finally included. The intervention was cyclophosphamide (CTX) combined with \"Shuli Fenxiao formula(SLFX formula)\", and the patients were treated for 24 weeks. The observation nodes were baseline, 2 weeks、12weeks and 24weeks after treatment. At 12 weeks of treatment, 38.7% of patients achieved partial response. At 24 weeks of treatment, 61.3% of patients achieved partial response and 24.5% achieved complete response. All Anti-phosholipase A2 Receptor Antibody (Anti-PLA2R) seropositive patients achieved immune remission. 24-hour urine total protein quantification (24hUTP) decreased from a median of 6.1 (IQR, 4.6-8.4) g/d to 2.7 (IQR, 0.6-8.7) g/d (P<0.001). Serum albumin (ALB) increased from 27.2 ± 6.4 g/L to 31.9 ± 8.0 (P<0.05). Within 24 weeks of follow-up after discharge, no patients relapsed. During the treatment follow-up period, 6 adverse events occurred in 31 patients, 1 patient developed heart failure during the treatment period, which was not considered to be clearly associated with treatment regimen or nephrotic syndrome (NS), 3 patients were infected, and 2 patients had liver impairment. The results suggest that the combination of CTX and SLFX formula dramatically decreased Anti-PLA2R titers and 24hUTP levels, increased ALB in short term. The combination was safe and had few adverse effects. It has the potential to be used as a potential option for the clinical treatment of intermediate-to-high risk PMN patients, particularly for elderly patients with contraindications to corticosteroid use or those with refractory disease. http://itmctr.ccebtcm.org.cn/, identifier ITMCTR2025000355.

China is a big agricultural country, as well as a big country in the production, supply and consumption of agricultural products. With the increasing demand for agricultural products, the effective supply of agricultural products logistics needs to be improved. or thinks it is necessary to explore the rapid development of agricultural product logistics and Internet of things technology in China, so as to achieve the goal of maximizing the profit of agricultural product logistics. In this regard, based on the Internet of things technology, this paper discusses the problems and shortcomings of agricultural products logistics cold chain supply, and puts forward optimization suggestions, to provide theoretical reference for the improvement of effective supply mode, so as to promote the development of cold chain, and promote the development of China’s agricultural products logistics supply.

We assessed the expression of M3 receptor in non-small cell lung cancer (NSCLC) and determined its relationship with clinicopathological features and its impact on patient outcome. Specimens from 192 patients with NSCLC were investigated by immunohistochemistry for M3 receptor and Ki67 expression. Correlation between the expression of M3 receptor and Ki67 and various clinicopathological features of NSCLC patients was analyzed. We found that M3 receptor expression was gradually elevated from normal to metaplasia/dysplasia tissues to cancer tissues. Furthermore, there was a similar trend for Ki67 expression. Statistical analysis revealed that M3 receptor expression in tumor cells were correlated significantly with stage ( P  < 0.0001), histology type ( P  = 0.0003), Ki67 expression ( P  < 0.0001), tumor size ( P  < 0.0001), lymph node status ( P  < 0.0001), LVS invasion ( P  = 0.0002), and histology grade ( P  < 0.0001). Patients with M3 receptor high expression showed far lower disease-free survival (DFS) and overall survival (OS) rates than those with M3 receptor low expression. Multivariate Cox regression analysis demonstrated that high M3 receptor expression was an independent prognostic factor for both DFS and OS. High M3 receptor expression correlates with poor survival in NSCLC patients. M3 receptor expression may be related with tumor progression in NSCLC, indicating that M3 receptor may be a novel antineoplastic target in the future.

In the distributed security control for air-sea heterogeneous multiagent systems (HMASs) with cooperative-antagonistic interactions, data security and transient-steady state performance of the system are two key problems. To ensure data security, an intermittent privacy preservation (IPP) mechanism is proposed for the first time. A novel setting time initial mask function and a novel intermittent mask function are constructed. Users can implement intermittent preservation for the system according to actual requirements, which solves the irreversibility problem after conventional mask disappears and balances control accuracy and system security. To ensure transient-steady state performance, a novel error transformation function (ETF) is proposed and integrated into the predefined-time prescribed performance control strategy. Compared to conventional hyperbolic tangent type ETFs, the proposed ETF can improve the convergence accuracy of errors under the same conditions. Furthermore, a unified model of the air-sea HMASs is established, which improves the model accuracy compared with the simplified model. Finally, the proposed IPP security control strategy is applied to the air-sea delivery mission to verify its feasibility and effectiveness.

In this paper, a command filter-based adaptive fuzzy predefined-time event-triggered tracking control problem is investigated for uncertain nonlinear systems with time-varying full-state constraints. By designing a sliding mode differentiator, the inherent computational complexity problem within the predefined-time backstepping framework is solved. Different from the existing command filter-based finite-time and fixed-time control strategies that the convergence time of the filtering error is adjusted through the system initial value or numerous parameters, a novel command filtering error compensation method is presented, which tunes one control parameter to make the filtering error converge in the predefined time, thereby reducing the complexity of design and analysis of processing the filtering error. Then, an improved event-triggered mechanism (ETM) that builds upon the switching threshold strategy, in which an inverse cotangent function is designed to replace the residual term of the ETM, is proposed to gradually release the controller’s dependence on the residual term with increasing time. Furthermore, a tan-type nonlinear mapping technique is applied to tackle the time-varying full-state constraints problem. By the predefined-time stability theory, all signals in the uncertain nonlinear systems exhibit predefined-time stability. Finally, the feasibility of the proposed algorithm is substantiated through two simulation results.

Ovarian function declines significantly as females enter middle-age, but the mechanisms underlying this decline remain unclear. Here, we utilize whole-organ imaging to observe a notable decrease in ovarian blood vessel (oBV) density and angiogenesis intensity of middle-aged mice. This leads to a diminished blood supply to the ovaries, resulting in inadequate development and maturation of ovarian follicles. Utilizing genetic-modified mouse models, we demonstrate that granulosa cell secreted VEGFA governs ovarian angiogenesis, but the physiological decline in oBV is not attributed to VEGFA insufficiency. Instead, through single-cell sequencing, we identify the aging of the ovarian vascular endothelium as the primary factor contributing to oBV decline. Consequently, the administration of salidroside, a natural compound that is functional to reverse oBV aging and promote ovarian angiogenesis, significantly enhances ovarian blood supply and improve fertility in older females. Our findings highlight that enhancing oBV function is a promising strategy to boost fertility in females. This study identifies ovarian vascular decline as a key physiological driver of fertility loss in middle-aged female mice and demonstrates that restoring vascular function with Salidroside might be a promising approach to improve fertility in aged females.