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Recent years have witnessed a surge in studies that examine the education and health consequences of parental migration on children. Most studies focus on the short-term consequences and there is an urgent need to study the long-term consequences. Capitalizing on a unique survey in China, we aim to study the lasting educational and health consequences of parental migration on children. We measure respondents' experiences of being left behind during different stages of life, namely prior to elementary school, during elementary school, and during middle school. Among people who have experienced being left behind, we further classify the experience into several categories such as left behind with grandparents and left behind with others. We estimate a variety of regression models taking into account respondents' different living arrangements when growing up. We find that being left behind with grandparents during the elementary school stage compromises educational attainment. Individuals who were left behind with others during primary school were more likely to have poor self-rated and mental health at the time of the survey. The long-term educational and health consequences of parental migration raise new concerns for today's left-behind children. We show that parental migration, especially during elementary school years, is likely to have long term consequences for children's educational and health outcomes.

Taking an origin-destination linked approach, we compare remittance behaviors of Fuzhou-US and Mingxi-Europe migrants. We find that different mechanisms predict propensity to remit and the amount of remittances. Altruistic remittance is more consistent with the remitting propensities of migrants from the poorer Mingxi region but is also reflected in the remittance amount of migrants from Fuzhou, where there is higher economic disparity and where people who fail to consume lavishly are socially sanctioned. When emigration is risky, circuitous, and expensive, we find, migration cost drives the remittance amount. In Fuzhou, where cultural practice is developed to confer honor on public project donors, more households are motivated to contribute to public infrastructure. These results provide economic, political, and cultural contexts for remittance theories, identify contexts that promote community development, and help reconcile debates derived from single case studies in various settings.

During the last three decades, China has experienced the largest migration in human history. China's great migration has had transformative social, economic, and demographic consequences for China and the world. In this review, first I provide background on China's household registration system ( hukou ), which has been in existence since the late 1950s and continues to affect the life chances of Chinese people. Then I focus on the great migration by discussing research that has examined its causes, migration trends, the adaptation assimilation of migrants in urban China, the well-being of migrant children, and migration's impact on rural China. Finally, I identify key areas for future research and argue that China's great migration holds major promise to contribute to the literature on migration studies.

Patients with Philadelphia chromosome‐like acute lymphoblastic leukaemia (Ph‐like ALL) often face a grim prognosis, with PDGFRB gene fusions being commonly detected in this subgroup. Our study has unveiled a newfound fusion gene, TERF2::PDGFRB, and we have found that patients carrying this fusion gene exhibit sensitivity to dasatinib. Ba/F3 cells harbouring the TERF2::PDGFRB fusion display IL‐3‐independent cell proliferation through activation of the p‐PDGFRB and p‐STAT5 signalling pathways. These cells exhibit reduced apoptosis and demonstrate sensitivity to imatinib in vitro. When transfused into mice, Ba/F3 cells with the TERF2::PDGFRB fusion gene induce tumorigenesis and a shortened lifespan in cell‐derived graft models, but this outcome can be improved with imatinib treatment. In summary, we have identified the novel TERF2::PDGFRB fusion gene, which exhibits oncogenic potential both in vitro and in vivo, making it a potential therapeutic target for tyrosine kinase inhibitors (TKIs).

China’s monumental volume of labor migration has led to a rise in the migrant children population in urban China. In this study, we examine school choices for migrant children (ages 6–12) using data from a nationally representative survey. We focus on two important decisions related to migrant children’s education: whether parents enroll their children in public schools versus special migrant schools and if they pay fees for children’s enrollment in local public schools. We find that the majority of migrant children are enrolled in local public schools but a non-negligible proportion of migrant children is enrolled in special migrant schools. Despite official government policy that prohibits public schools from charging enrollment fees, about 20% of migrant children’s parents paid fees in 2012. We also reveal that migrant children whose parents possess more local social capital are able to navigate through the public school system. A significant regional difference emerges from our analysis: compared to other parts of China, migrant children in Eastern China are less likely to be enrolled in public schools and their parents are more likely to pay for children’s education in public schools. These findings present new evidence that migrant children continue to face significant obstacles in access to public education, which is not consistent with  Chinese government’s plan to promote a people-centered urbanization.

Building on the growing literature on new immigrant destinations, this paper examines new employment patterns of low-skilled Chinese immigrants in the United States. We identify an important channel of employment in new destinations for the case of Chinese low-skilled immigrants: employment agencies in New York City’s Chinatown. We carried out two surveys of employment agencies during 2010–2011. Our findings suggest that there has been a profound change in settlement patterns of low-skilled immigrants: moving away from traditional Chinatowns in major American cities toward non-gateway destinations and rural areas. These new settlement locations are characterized by a low unemployment rate and low crime rate. Contrary to predictions from ethnic economy and mainstream economic perspectives, Chinese restaurant jobs tend not to be in places with a high concentration of Chinese immigrants, but rather in places with a high proportion of non-Hispanic whites. In addition, the farther the jobs are from New York City, the higher the salary. We discuss the implications of this fundamental change for re-conceptualizing the immigrant labor market and immigrant socioeconomic mobility in American society.

Background Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare malignancy-related respiratory complication, demonstrating rapid progression of pulmonary hypertension (PH) and respiratory failure. Although a number of treatments have been attempted for patients diagnosed with or suspected of having PTTM, successful-treated cases of PTTM were mainly from imatinib therapy, which was a PDGF receptor inhibitor. Anlotinib was a novel tyrosine kinase inhibitor that targets VEGFR, FGFR, PDGFR, and c-kit. Case presentation We reported a patient of PTTM associated with gastric carcinoma, whom were treated with anlotinib, thereby exhibiting significant improvement of PH and respiratory dysfunction. Conclusion Our case provides a new understanding of therapy to PTTM, with implications for defining anlotinib as candidate drug for PTTM. Clinical diagnosis and prompt initiation of anlotinib might be one of the strategies in patients with unstable PTTM.

Block matching based 3D filtering methods have achieved great success in image denoising tasks. However, the manually set filtering operation could not well describe a good model to transform noisy images to clean images. In this paper, we introduce convolutional neural network (CNN) for the 3D filtering step to learn a well fitted model for denoising. With a trainable model, prior knowledge is utilized for better mapping from noisy images to clean images. This block matching and CNN joint model (BMCNN) could denoise images with different sizes and different noise intensity well, especially images with high noise levels. The experimental results demonstrate that among all competing methods, this method achieves the highest peak signal to noise ratio (PSNR) when denoising images with high noise levels ( σ > 40), and the best visual quality when denoising images with all the tested noise levels.

The present study evaluated the effect of epigallocatechin-3-gallate (EGCG), the most abundant catechin in green tea, on irradiation-induced pulmonary fibrosis and elucidated its mechanism of action. A rat model of irradiation-induced pulmonary fibrosis was generated using a 60Co irradiator and a dose of 22 Gy. Rats were intraperitoneally injected with EGCG (25 mg/kg) or dexamethasone (DEX; 5 mg/kg) daily for 30 days. Mortality rates and lung index values were calculated. The severity of fibrosis was evaluated by assaying the hydroxyproline (Hyp) contents of pulmonary and lung tissue sections post-irradiation. Alveolitis and fibrosis scores were obtained from semi-quantitative analyses of hematoxylin and eosin (H&E) and Masson's trichrome lung section staining, respectively. The serum levels of transforming growth factor β1 (TGF-β1), interleukin (IL)-6, IL-10, and tumor necrosis factor-α (TNF-α) were also measured. Surfactant protein-B (SPB) and α-SMA expression patterns were evaluated using immunohistochemistry, and the protein levels of nuclear transcription factor NF-E2-related factor 2 (Nrf-2) and its associated antioxidant enzymes heme oxygenase-1 enzyme (HO-1) and NAD(P)H:quinone oxidoreductase-1 (NQO-1) were examined via western blot analysis. Treatment with EGCG, but not DEX, reduced mortality rates and lung index scores, improved histological changes in the lung, reduced collagen depositions, reduced MDA content, enhanced SOD activity, inhibited (myo)fibroblast proliferation, protected alveolar epithelial type II (AE2) cells, and regulated serum levels of TGF-β1, IL-6, IL-10, and TNF-α. Treatment with EGCG, but not DEX, activated Nrf-2 and its downstream antioxidant enzymes HO-1 and NQO-1. Taken together, these results showed that EGCG treatment significantly inhibits irradiation-induced pulmonary fibrosis. Furthermore, the results suggested promising clinical EGCG therapies to treat this disorder.

This article uses tabulations from the 2000 Population Census of China along with a micro-level data sample from the census to provide a picture of China's floating population: migrants without local household registration (hukou), a status resulting in significant social and economic disadvantages. By 2000, the size of China's floating population had grown to nearly 79 million, if that category is defined as migrants who moved between provinces or counties and resided at their destinations for six months or more. Intracounty floating migration is similarly large, contributing another 66 million to the size of the floating population. The article also discusses the geographic pattern of the floating population and the reasons for moving as reported by migrants. Policy implications are noted.