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Against the backdrop of the booming digital economy, innovation has emerged as the core driving force for enterprise development, with employees’ innovative capabilities serving as a key competitive advantage for innovative enterprises. Adopting grounded theory as the methodological framework, we obtain multi-source data to investigate the factors influencing employees’ innovative capabilities and their underlying mechanisms. Furthermore, we develop a theoretical model elucidating the formation mechanism of employees’ innovative capabilities in human–machine collaboration contexts, identifying four core dimensions—innovation drivers, human–AI collaboration patterns, knowledge conversion pathways, and technological breakthroughs—that dominantly shape these capabilities. Thus, we reveal that the formation of innovative capabilities constitutes a dynamic interplay of technology empowerment, cognitive restructuring, and collaborative reinforcement and demonstrate its spiral progression characterized by “triggering, collaboration, and iteration”. This research not only contributes to academic discourse but also offers actionable theoretical and practical insights for innovative enterprises to enhance employees’ innovative capabilities, thereby fostering sustainable development in global competition.

Osteoarthritis (OA), known as one of the most common types of aseptic inflammation of the musculoskeletal system, is characterized by chronic pain and whole-joint lesions. With cellular and molecular changes including senescence, inflammatory alterations, and subsequent cartilage defects, OA eventually leads to a series of adverse outcomes such as pain and disability. CRISPR-Cas-related technology has been proposed and explored as a gene therapy, offering potential gene-editing tools that are in the spotlight. Considering the genetic and multigene regulatory mechanisms of OA, we systematically review current studies on CRISPR-Cas technology for improving OA in terms of senescence, inflammation, and cartilage damage and summarize various strategies for delivering CRISPR products, hoping to provide a new perspective for the treatment of OA by taking advantage of CRISPR technology.

Fostering niche leaders to achieve technological breakthroughs has become a national strategic priority in emerging markets in order to overcome technology blockades and drive technological progress. Previous research indicates that achieving breakthrough innovation, particularly for firms with resource constraints, is a multifaceted phenomenon occurring across various levels. Based on the technology–organization–environment (TOE) framework, this paper aims to examine the influence of technological, organizational, and environmental factors on the breakthrough innovation of niche leaders in emerging markets from a configurational perspective. Using dynamic qualitative comparative analysis (QCA), we analyzed panel data from 87 Chinese niche leaders (2018–2023) through inter-group, intra-group, and pooled comparisons to uncover distinct configurational pathways to breakthrough innovation. Our findings reveal three effective pathways: an R&D-driven innovation pathway, a digital transformation-driven innovation pathway, and a comprehensive support innovation pathway. Additionally, we identified two configurational pathways leading to the absence of high-breakthrough innovation: the conservative management configuration, and the digital island configuration. Our results underscore the essential role of government subsidies, the complementary impact of digital transformation and R&D, and the restrictive effect of rigid governance structures. Furthermore, these pathways demonstrate significant regional variations and temporal evolution, highlighting the context-dependent nature of breakthrough innovation in emerging economies.

The Ficus erecta complex, characterized by its morphological diversity and frequent interspecific overlap, shares pollinating fig wasps among several species. This attribute, coupled with its intricate phylogenetic relationships, establishes it as an exemplary model for studying speciation and evolutionary patterns. Extensive researches involving RADseq (Restriction-site associated DNA sequencing), complete chloroplast genome data, and flow cytometry methods were conducted, focusing on phylogenomic analysis, genetic structure, and ploidy detection within the complex. Significantly, the findings exposed a pronounced nuclear-cytoplasmic conflict. This evidence, together with genetic structure analysis, confirmed that hybridization within the complex is a frequent occurrence. The ploidy detection revealed widespread polyploidy, with certain species exhibiting multiple ploidy levels, including 2×, 3×, and 4×. Of particular note, only five species ( F. abelii , F. erecta , F. formosana , F. tannoensis and F. vaccinioides ) in the complex were proved to be monophyletic. Species such as F. gasparriniana , F. pandurata , and F. stenophylla were found to encompass multiple phylogenetically distinct lineages. This discovery, along with morphological comparisons, suggests a significant underestimation of species diversity within the complex. This study also identified F. tannoensis as an allopolyploid species originating from F. vaccinioide and F. erecta . Considering the integration of morphological, molecular systematics, and cytological evidences, it is proposed that the scope of the F. erecta complex should be expanded to the entire subsect. Frutescentiae . This would redefine the complex as a continuously evolving group comprising at least 33 taxa, characterized by blurred species boundaries, frequent hybridization and polyploidization, and ambiguous genetic differentiation.

Fig–wasp coevolution has been extensively studied as a fascinating case of extreme plant–insect codiversification, yet little is known about how fig trees reproduce without pollinating fig wasps. This study provides direct evidence that fig trees sustain their populations by producing polyploid and polyembryonic seeds through apomixis without fig wasp pollination. We report herein that the seeds of unpollinated Ficus gasparriniana are derived from adventitious embryos formed in the nucellar tissues and show sporophytic apomixis. Apomixis is an important reproductive mode of F. gasparriniana, which has diverse pedigree sources. Flow cytometry combined with chromosome counting and short tandem repeat typing results showed that apomixis in F. gasparriniana was closely related to polyploidy, suggesting that sexual reproduction occurred at the diploid level and apomixis occurred at the polyploid level. Thus, other polyploid Ficus species may also exhibit apomictic reproduction. This study provides essential data for advancing research on apomixis in Ficus and its role in the coevolution of fig–wasp mutualism. Development of apomictic adventitious embry o in Ficus gasparriniana. Apomixis is a key reproductive strategy for F. gasparriniana, especially when pollination by fig wasps is limited. In the absence of pollination, F. gasparriniana produces seeds through adventitious embryos formed within the nucellar tissue, which is accompanied by polyploidization. The number of seeds produced by apomixis is sufficient to meet the reproductive needs of F. gasparriniana. This study provides the first case for understanding apomictic reproduction in Ficus.

How many species there are in the world remains a fundamental scientific question, serving as a critical reference for formulating and implementing effective biodiversity conservation strategies. The accelerating global biodiversity crisis has propelled scientific interest in understanding spatial-temporal patterns of new species discovery, particularly as these findings inform urgent conservation priorities. Digitalization of plant specimens provides important information on the discovery process of new species and clarifies the general situation of the core distributions in China over the last century. However, the new species discovery process of plants has not been the focus of much attention in Asia. The study analyzes digitized herbarium specimen data to investigate new species discoveries, specimen collection gaps, and collection preferences in China over the past century. First, we collected the herbarium type specimens data. Then we analyzed sampling biases of functional traits (life form, floral colors, fruit colors and types) in specimens collection and summarize distributional patterns in new species discovery. We answered the question of what plant species are more likely to be found and explored the distribution areas of new species discoveries over the last century. Our results reveal that there are more new plant species been found in herbaceous plants (90.8%) than woody (9.2%) plants, and new species with bright flowers and fruits, and the smaller height are easier to be discovered. There is also an observable inter-annual and seasonal variation in the discovery of new species, with peak collections occurring four year periods, and summer (June-August) witnessing the highest number of new species discoveries. The southern regions of China offer easier access to new species, and higher numbers of new species have been identified in the regions with the richness of plant diversity. The number of specimens collected by individuals (58%) surpasses those collected by teams (42%). More attention should also be paid to species with different plant functional traits (herbs, species with bright flowers and fruits) and the potential distribution of vacant regions. This study provides scientific reference and direction for the accelerating discovery of more new species in the future, and also contribute to the future conservation of biodiversity.

In the past 11 years, there has been a surge in studies exploring the regulatory effect of Traditional Chinese Medicine (TCM) on ferroptosis. However, a significant gap persists in comprehensive scientometric analysis and scientific mapping research, especially in tracking the evolution, primary contributors, and emerging research focal points. This study aims to comprehensively update the advancements in targeting ferroptosis with various TCMs during the previous 11 years. The data, covering the period from 1 January 2012, to 30 November 2023, were retrieved from the Web of Science database. For in-depth scientometric and visualized analyses, a series of advanced analytical instruments were employed. The findings highlight China’s predominant role, accounting for 71.99% of total publications and significantly shaping research in this domain. Noteworthy productivity was observed at various institutions, including Guangzhou University of Chinese Medicine, Chengdu University of Traditional Chinese Medicine, and Zhejiang University. Thomas Efferth emerged as the foremost author within this field, while Frontiers in Pharmacology boasted the highest publication count. This study pinpointed hepatocellular carcinoma, chemical and drug-induced liver injury, mitochondrial diseases, acute kidney injury, and liver failure as the most critical disorders addressed in this research realm. The research offers a comprehensive bibliometric evaluation, enhancing our understanding of the present status of TCM therapy in managing ferroptosis-related diseases. Consequently, it aids both seasoned researchers and newcomers by accelerating access to vital information and fostering innovative concept extraction within this specialized field.

Osteoarthritis (OA) is a degenerative disease linked to aging and obesity. The global aging population has led to an increasing number of OA patients, imposing a significant economic burden on society. Traditional drugs treatment methods often fail to achieve satisfactory outcomes. With the rapid advancement of nanomaterial delivery systems, numerous studies have focused on utilizing nanomaterials as carriers to achieve efficient OA treatment by effectively loading and delivering bioactive ingredients (e.g., drugs, nucleic acids) tailored to the unique pathological conditions, such as the weakly acidic microenvironment of synovial fluid in OA patients. This review highlights the latest advancements in the use of pH-responsive nanoparticles for OA treatment, emphasizing the principle of targeted drug delivery leveraging the acidic microenvironment of inflamed joints. It further discusses the composition, synthesis, response mechanism, target selection, application, and recent research findings of nanoparticles, while also addressing the challenges and future directions in this promising field.

Due to the development of manufacturing and launch technologies for satellites, there are now more and more satellite networks. Hence, cooperative reconnaissance is possible to implement among satellite networks, aerial vehicles and ground stations. In this paper, we study the method of geolocation and tracking by time difference of arrival (TDOA) measurements based on space–air–ground integrated (SAGI) network. We first analyze the Cramer Rao lower bound (CRLB) for the source localization accuracy in different coordinate systems. Then, we compare the effects of different system errors, such as clock synchronization error, position bias of the observers, elevation bias of the target and non-horizontal velocity of the target. Further, we also develop a maximum likelihood (ML) estimator for target position and velocity. Finally, the theoretical performance of the proposed estimator is validated via computer simulations.

Ficus benjamina , the weeping fig, is one of the most widely distributed and cultivated figs, with important ecological functions and landscape value. However, the lack of a reference genome has hindered molecular and functional research on this well-known fig-tree. Here we present a chromosome-scale genome assembly and annotation for F. benjamina , based on a combination of Illumina short-reads, PacBio subreads, and Hi-C sequencing data. The genome consists of 13 pseudochromosomes that contain 362.73 Mb of assembled sequences, with a contig N50 length of 25.76 Mb and a complete BUSCO score of 98.10%. In total, 28,840 protein-coding genes were identified, of which 96.22% were functionally annotated. Our study provides the first chromosome-level genome of F. benjamina , providing an important resource for exploring the genetic basis of its ecological and horticultural characters.