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Born in fire. Raised by monsters. Destined to smash! On an alien planet shattered by war, no one is stronger than Skaar -- the savage Son of Hulk! But as a warlord and a princess spread chaos through the wastelands, will Skaar save the puny survivors -- or eat them? Skaar seeks the mysterious Old Power, but can even he stop the coming of the Silver Surfer-and Galactus the Devourer? The soothsayers sing: One day, monsters will clash -- the boy will confront the man who abandoned him. When the Son of Hulk seeks vengeance on his father, will Earth be turned into Planet Skaar?

Bruton’s tyrosine kinase (BTK) is crucial for FcεRI-mediated mast cell activation and essential for autoantibody production by B cells in chronic spontaneous urticaria (CSU). Fenebrutinib, an orally administered, potent, highly selective, reversible BTK inhibitor, may be effective in CSU. This double-blind, placebo-controlled, phase 2 trial (EudraCT ID 2016-004624-35 ) randomized 93 adults with antihistamine-refractory CSU to 50 mg daily, 150 mg daily and 200 mg twice daily of fenebrutinib or placebo for 8 weeks. The primary end point was change from baseline in urticaria activity score over 7 d (UAS7) at week 8. Secondary end points were the change from baseline in UAS7 at week 4 and the proportion of patients well-controlled (UAS7 ≤ 6) at week 8. Fenebrutinib efficacy in patients with type IIb autoimmunity and effects on IgG-anti-FcεRI were exploratory end points. Safety was also evaluated. The primary end point was met, with dose-dependent improvements in UAS7 at week 8 occurring at 200 mg twice daily and 150 mg daily, but not at 50 mg daily of fenebrutinib versus placebo. Asymptomatic, reversible grade 2 and 3 liver transaminase elevations occurred in the fenebrutinib 150 mg daily and 200 mg twice daily groups (2 patients each). Fenebrutinib diminished disease activity in patients with antihistamine-refractory CSU, including more patients with refractory type IIb autoimmunity. These results support the potential use of BTK inhibition in antihistamine-refractory CSU. Fenebrutinib, an oral Bruton’s tyrosine kinase inhibitor, reduces disease activity in patients with chronic spontaneous urticaria refractory to antihistamines, suggesting that this treatment type could be an alternative to standard of care anti-IgE therapy.

Relatively blue light extends beyond a spiral disk from a radius of ∼5 kpc out to ∼14 kpc from the center of NGC 1275. Analyses of its spectrum and broadband colors reveal a population of young stars having subsolar metallicities superposed on a dominant population of old stars having supersolar metallicities. The young stars have a characteristic age of ∼160 Myr and may span ages of a few hundred Myr, similar to that of stars comprising the central spiral disk, and a total mass of about one-third that of this disk for a combined stellar mass (at birth) of ∼4 × 109 M⊙. A multitude of arc-like features embedded in the extended blue light have brightnesses comparable to the somewhat older (∼500 Myr) super star clusters (SSCs) projected against the central spiral disk. The SSCs have a relatively shallow mass function, suggesting that the tidal disruption of an initially larger population that we estimate could have had an initial total mass (far) exceeding ∼1 × 109 M⊙ gave rise to the extended blue light—the arc-like features corresponding to stellar streams tracing disrupted star clusters—and perhaps also the central spiral disk. We speculate that, beginning about 500 Myr ago, an enhanced episode of active galactic nucleus activity in NGC 1275, leaving still visible X-ray bubbles, induced a vigorous cooling of the intracluster medium to fuel the formation of numerous star clusters: many were tidally disrupted to leave bluish light at the inner region of this galaxy, with the survivors being the SSCs projected against the central spiral disk.

Galactic-scale outflows of molecular gas from star-forming galaxies constitute the most direct evidence for the regulation of star formation. In the early Universe (z > 4), such outflows have recently been inferred from gravitationally lensed dusty star-forming galaxies (DSFGs) based on ubiquitous detections of OH absorption extending to more blueshifted velocities than [C ii] or CO emission in spatially integrated spectra. Because these lines are redshifted to submillimeter wavelengths, such measurements require careful corrections for atmospheric absorption lines, and a proper accounting of sometimes large variations in measurement uncertainties over these lines. Taking these factors into consideration, we reanalyze OH and [C ii] data taken with the Atacama Large Millimeter/submillimeter Array for five sources where such data are available, of which four were categorised as exhibiting outflows. Based on their spatially integrated spectra alone, we find statistically significant (≥3σ) OH absorption more blueshifted than [C ii] emission in only one source. By contrast, searching channel maps for signals diluted below the detection threshold in spatially integrated spectra, we find evidence for a separate kinematic component in OH absorption in all five sources in the form of (i) more blueshifted OH absorption than [C ii] emission and/or (ii) a component in OH absorption exhibiting a different spatio-kinematic pattern than in [C ii] emission, the latter presumably tracing gas in a rotating disk. Providing a more complete and accurate assessment of molecular outflows in gravitationally lensed DSFGs, we suggest methods to assess the precision of corrections for atmospheric absorption better and to measure the source continuum in future observations more accurately.

Fuzzy dark matter (FDM), a scalar particle coupled to the gravitational field without self-interaction, whose mass range is m ∼ 10−24–10−20 eV, is one of the promising alternative dark matter candidates to cold dark matter. The quantum interference pattern, which is a unique structure of FDM, can be seen in halos in cosmological FDM simulations. In this paper, we first provide an analytic model of the subgalactic matter power spectrum originating from quantum clumps in FDM halos, in which the density distribution of the FDM is expressed by a superposition of quantum clumps whose size corresponds to the de Broglie wavelength of the FDM. These clumps are assumed to be distributed randomly, such that the ensemble average density follows a halo profile such as the Navarro–Frenk–White profile. We then compare the convergence power spectrum projected along the line of sight around the Einstein radius, which is converted from the subgalactic matter power spectrum, to that measured in the strong lens system SDSS J0252 + 0039. While we find that the current observation provides no useful constraint on the FDM mass, we show that future deep, high spatial resolution observations of strong lens systems can tightly constrain FDM with a mass around 10−22 eV.

We set the stage for reassessing how star formation, emission-line nebulae, and active galactic nuclei (AGNs) in brightest cluster galaxies (BCGs) depend on the thermodynamics of the intracluster medium (ICM). Our work is based on the 25 clusters observed in the CLASH program for which the aforementioned attributes in their BCGs can be well scrutinized, as has the thermodynamics of their ICM. Nine of these BCGs display complex UV morphologies tracing recent star formation, whereas the remaining 16 are characterized by a relatively compact central UV enhancement. Here, we show definitively that three of the latter BCGs also display star formation, whereas the diffuse UV of the remaining 13 is entirely consistent with old low-mass stars. The overall results support the previously established dependence of star formation and nebulae in BCGs on an “excess core entropy,” K 0, for the ICM: all 11 clusters with K 0 ≤ 24 keV cm2 (but only one of 14 clusters with K 0 ≥ 42 keV cm2) host star-forming BCGs that almost if not always possess nebulae. Instead of an entropy floor, we show that K 0 reflects the degree to which the radial entropy profile decreases inward within ∼100 kpc rather than (except perhaps at large K 0) actually flattening: clusters with lower ICM entropies and hence shorter cooling times at their cores preferentially host BCGs displaying star formation, nebulae, and more radio-luminous AGNs. Nearly all BCGs possess detectable AGNs, however, indicating multiple pathways for fuelling their AGNs.

Abstract Background Low-wage dormitory-dwelling migrant workers in Singapore were disproportionately affected by coronavirus disease 2019 (COVID-19) infection. This was attributed to communal living in high-density and unhygienic dormitory settings and a lack of inclusive protection systems. However, little is known about the roles of social and geospatial networks in COVID-19 transmission. The study examined the networks of non-work–related activities among migrant workers to inform the development of lockdown exit strategies and future pandemic preparedness. Methods A population-based survey was conducted with 509 migrant workers across the nation, and it assessed dormitory attributes, social ties, physical and mental health status, COVID-19-related variables and mobility patterns using a grid-based network questionnaire. Mobility paths from dormitories were presented based on purposes of visit. Two-mode social networks examined the structures and positions of networks between workers and visit areas with individual attributes. Results COVID-19 risk exposure was associated with the density of dormitory, social ties and visit areas. The migrant worker hub in the city centre was the most frequently visited for essential services of grocery shopping and remittance, followed by south central areas mainly for social gathering. The hub was positioned as the core with the highest degree of centrality with a cluster of workers exposed to COVID-19. Conclusions Social and geospatial networks of migrant workers should be considered in the implementation of lockdown exit strategies while addressing the improvement of living conditions and monitoring systems. Essential services, like remittance and grocery shopping at affordable prices, need to be provided near to dormitories to minimize excess gatherings.

The first deep field images from the James Webb Space Telescope (JWST) of the galaxy cluster SMACS J0723.3-7327 reveal a wealth of new lensed images at uncharted infrared wavelengths, with unprecedented depth and resolution. Here we securely identify 14 new sets of multiply imaged galaxies totaling 42 images, adding to the five sets of bright and multiply imaged galaxies already known from Hubble Space Telescope data. We find examples of arcs crossing critical curves, allowing detailed community follow-up, such as JWST spectroscopy for precise redshift determinations, and measurements of the chemical abundances and of the detailed internal gas dynamics of very distant, young galaxies. One such arc contains a pair of compact knots that are magnified by a factor of hundreds, and features a microlensed transient. We also detect an Einstein cross candidate only visible thanks to JWST’s superb resolution. Our parametric lens model is available through the following link (https://www.dropbox.com/sh/gwup2lvks0jsqe5/AAC2RRSKce0aX-lIFCc9vhBXa?dl=0) and will be regularly updated using additional spectroscopic redshifts. The model is constrained by 16 of these sets of multiply imaged galaxies, three of which have spectroscopic redshifts, and reproduces the multiple images to better than an rms of 0.″5, allowing for accurate magnification estimates of high-redshift galaxies. The intracluster light extends beyond the cluster members, exhibiting large-scale features that suggest a significant past dynamical disturbance. This work represents a first taste of the enhanced power JWST will have for lensing-related science.

Ultrashort electron bunches are useful for applications like ultrafast imaging, coherent radiation production, and the design of compact electron accelerators. Currently, however, the shortest achievable bunches, at attosecond time scales, have only been realized in the single- or very few-electron regimes, limited by Coulomb repulsion and electron energy spread. Using ab initio simulations and complementary theoretical analysis, we show that highly-charged bunches are achievable by subjecting relativistic (few MeV-scale) electrons to a superposition of terahertz and optical pulses. We provide two detailed examples that use realistic electron bunches and laser pulse parameters which are within the reach of current compact set-ups: one with bunches of >240 electrons contained within 20 as durations and 15 m radii, and one with final electron bunches of 1 fC contained within sub-400 as durations and 8 m radii. Our results reveal a route to achieve such extreme combinations of high charge and attosecond pulse durations with existing technology.

Background Plant-based diets offer more beneficial microbes and can modulate gut microbiomes to improve human health. We evaluated the effects of the plant-based OsomeFood Clean Label meal range (‘AWE’ diet), on the human gut microbiome. Methods Over 21 days, ten healthy participants consumed OsomeFood meals for five consecutive weekday lunches and dinners and resumed their regular diets for other days/meals. On follow-up days, participants completed questionnaires to record satiety, energy and health, and provided stool samples. To document microbiome variations and identify associations, species and functional pathway annotations were analyzed by shotgun sequencing. Shannon diversity and regular diet calorie intake subsets were also assessed. Results Overweight participants gained more species and functional pathway diversity than normal BMI participants. Nineteen disease-associated species were suppressed in moderate-responders without gaining diversity, and in strong-responders with diversity gains along with health-associated species. All participants reported improved short-chain fatty acids production, insulin and γ-aminobutyric acid signaling. Moreover, fullness correlated positively with Bacteroides eggerthii ; energetic status with B. uniformis , B. longum , Phascolarctobacterium succinatutens , and Eubacterium eligens ; healthy status with Faecalibacterium prausnitzii , Prevotella CAG 5226 , Roseburia hominis , and Roseburia sp. CAG 182 ; and overall response with E. eligens  and Corprococcus eutactus . Fiber consumption was negatively associated with pathogenic species. Conclusion Although the AWE diet was consumed for only five days a week, all participants, especially overweight ones, experienced improved fullness, health status, energy and overall responses. The AWE diet benefits all individuals, especially those of higher BMI or low-fiber consumption.