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"Lin, Ed"
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Ghost month
\"August is Ghost Month in Taiwan -- a time to pay respects to the dead and avoid unlucky omens. Jing-nan, who runs a food stand in a bustling Taipei night market, isn't superstitious, but this August will haunt him. He learns that his high school sweetheart has been murdered -- found scantily clad near a highway where she was selling betel nuts. \"Betel nut beauties\" are typically women in desperate circumstances, but Julia Huang was high school valedictorian, and the last time Jing-nan spoke to her, she was far away, happily enrolled in NYU's honor program. The facts don't add up. Julia's parents don't think so, either, but the police seem to have closed the case without asking any questions. The Huangs beg Jing-nan to do some investigating, but nothing can prepare him for what he is about to learn, or how it will change his life.\" --P. [4] of cover.
Book
A novel RBD-protein/peptide vaccine elicits broadly neutralizing antibodies and protects mice and macaques against SARS-CoV-2
The development of safe and effective vaccines to respond to COVID-19 pandemic/endemic remains a priority. We developed a novel subunit protein-peptide COVID-19 vaccine candidate (UB-612) composed of: (i) receptor binding domain of SARS-CoV-2 spike protein fused to a modified single-chain human IgG1 Fc; (ii) five synthetic peptides incorporating conserved helper and cytotoxic T lymphocyte (Th/CTL) epitopes derived from SARS-CoV-2 structural proteins (three from S2 subunit, one from membrane and one from nucleocapsid), and one universal Th peptide; (iii) aluminum phosphate as adjuvant. The immunogenicity and protective immunity induced by UB-612 vaccine were evaluated in four animal models: Sprague-Dawley rats, AAV-hACE2 transduced BALB/c mice, rhesus and cynomolgus macaques. UB-612 vaccine induced high levels of neutralizing antibody and T-cell responses, in all animals. The immune sera from vaccinated animals neutralized the SARS-CoV-2 original wild-type strains and multiple variants of concern, including Delta and Omicron. The vaccination significantly reduced viral loads, lung pathology scores, and disease progression after intranasal and intratracheal challenge with SARS-CoV-2 in mice, rhesus and cynomolgus macaques. UB-612 has been tested in primary regimens in Phase 1 and Phase 2 clinical studies and is currently being evaluated in a global pivotal Phase 3 clinical study as a single dose heterologous booster.
Journal Article
A single surgeon’s experience transitioning to robotic-assisted right colectomy with intracorporeal anastomosis
BackgroundDespite substantial evidence demonstrating benefits of minimally invasive surgery, a large percentage of right colectomies are still performed via an open technique. Most laparoscopic right colectomies are completed as a hybrid procedure with extracorporeal anastomosis. As part of a pure minimally invasive procedure, intracorporeal anastomosis (ICA) may confer additional benefits for patients. The robotic platform may shorten the learning curve for minimally invasive right colectomy with ICA.MethodsFrom January 2014 to May 2016, 49 patients underwent robotic-assisted right colectomy by a board-certified colorectal surgeon (S.R). Extracorporeal anastomosis (ECA) was used in the first 20 procedures, whereas ICA was used in all subsequent procedures. Outcomes recorded in a database for retrospective review included operating time (OT), estimated blood loss (EBL), length of stay (LOS), conversion rate, complications, readmissions, and mortality rate.ResultsComparison of average OT, EBL, and LOS between extracorporeal and intracorporeal groups demonstrated no significant differences. For all patients, average OT was 141.6 ± 25.8 (range 86–192) min, average EBL was 59.5 ± 83.3 (range 0–500) mL, and average LOS was 3.4 ± 1.19 (range 1.5–8) days. Four patients required conversion, all of which occurred in the extracorporeal group. There were no conversions after the 18th procedure. The 60-day mortality rate was 0%. There were no anastomotic leaks, ostomies created, or readmissions. As the surgeon gained experience, a statistically significant increase in lymph node sampling was observed in oncologic cases (p = .02).ConclusionsThe robotic platform may help more surgeons safely and efficiently transition to a purely minimally invasive procedure, enabling more patients to reap the benefits of less invasive surgery. Transitioning from ECA to ICA during robotic right colectomy resulted in no significant change in OT or LOS. A lower rate of conversion to open surgery was noted with increased experience.
Journal Article
Climate change impacts on crop yield and quality with CO2 fertilization in China
A regional climate change model (PRECIS) for China, developed by the UK's Hadley Centre, was used to simulate China's climate and to develop climate change scenarios for the country. Results from this project suggest that, depending on the level of future emissions, the average annual temperature increase in China by the end of the twenty-first century may be between 3 and 4 °C. Regional crop models were driven by PRECIS output to predict changes in yields of key Chinese food crops: rice, maize and wheat. Modelling suggests that climate change without carbon dioxide (CO2) fertilization could reduce the rice, maize and wheat yields by up to 37% in the next 20-80 years. Interactions of CO2 with limiting factors, especially water and nitrogen, are increasingly well understood and capable of strongly modulating observed growth responses in crops. More complete reporting of free-air carbon enrichment experiments than was possible in the Intergovernmental Panel on Climate Change's Third Assessment Report confirms that CO2 enrichment under field conditions consistently increases biomass and yields in the range of 5-15%, with CO2 concentration elevated to 550 ppm Levels of CO2 that are elevated to more than 450 ppm will probably cause some deleterious effects in grain quality. It seems likely that the extent of the CO2 fertilization effect will depend upon other factors such as optimum breeding, irrigation and nutrient applications.
Journal Article
Study on the relationship between soil selenium and plant selenium uptake
Various extraction methods have been used to determine selenium (Se) concentrations in soils and plants in the second seleniferous regions of China. Our results show tea Se contents in the study area range from 1.009 to 2.6 mg/kg, which reveal that the tea areas in Ziyang County are in seleniferous regions. The four extraction methods evaluated in this study provide different information concerning soil and plant Se levels. The quality control/quality assurance program for this project indicated there is excellent agreement between total soil Se and extractable Se. For example, phosphate extractable Se results from the field investigation and greenhouse study were found to be highly correlated (R2 > 0.91) by linear regression analyses. Results from rye seedling experiments further show phosphate extractable Se has significant correlations with plant Se uptake and that a 0.1 M solution of KH2PO4 can be used as the extractant of soil available Se. In the acid soil, the Brassica campestris yield could be significantly reduced when the content of Se6+-Se ≥ 0.5 mg/kg, and the influence on the yield was not as obvious when the content of Se6+-Se reached up to 2.0 mg/kg. The uptake by Brassica campestris of Se6+-Se is higher than that of Se4+-Se. The main factors influencing the biological availability of soil Se, in order of their importance are CaCO3, the presence of silt grains, organic matter and the presence of clay grains. pH could affect KH2PO4 extractable Se through CaCO3.
Journal Article
