Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
7,011
result(s) for
"Lin, Gang"
Sort by:
China's long quest for democracy : a historical institutional perspective
\"Conceptualizing China as a country with rapid economic transformation and little political progress has led to a normative misjudgment that economic reform should occur before significant democratization. This book compares several historical junctures during China's long journey towards democracy to observe the constraints of pre-chosen ideological and institutional patterns on political elites in advancing legal and electoral reforms. Confucian legacies of moralism, elitism, and state centralism, in addition to revolutionary guardianship and populism remain embedded in Chinese practice in rule by law, grassroots autonomy, and intra-party democracy. However, China's hope for democratic development is encouraged by urban and educational development, generational change and growing individualism. This book explores the feasible paths toward democracy in China, challenging methodological wisdom in employing quantitative changes in socioeconomic structure to predict change in the political system\"-- Provided by publisher.
Book
Microbial proteasomes as drug targets
Proteasomes are compartmentalized, ATP-dependent, N-terminal nucleophile hydrolases that play essentials roles in intracellular protein turnover. They are present in all 3 kingdoms. Pharmacological inhibition of proteasomes is detrimental to cell viability. Proteasome inhibitor rugs revolutionize the treatment of multiple myeloma. Proteasomes in pathogenic microbes such as Mycobacterium tuberculosis (Mtb), Plasmodium falciparum (Pf), and other parasites and worms have been validated as therapeutic targets. Starting with Mtb proteasome, efforts in developing inhibitors selective for microbial proteasomes have made great progress lately. In this review, we describe the strategies and pharmacophores that have been used in developing proteasome inhibitors with potency and selectivity that spare human proteasomes and highlight the development of clinical proteasome inhibitor candidates for treatment of leishmaniasis and Chagas disease. Finally, we discuss the future challenges and therapeutical potentials of the microbial proteasome inhibitors.
Journal Article
The evolutionary origin and domestication history of goldfish (Carassius auratus)
Goldfish have been subjected to over 1,000 y of intensive domestication and selective breeding. In this report, we describe a highquality goldfish genome (2n = 100), anchoring 95.75% of contigs into 50 pseudochromosomes. Comparative genomics enabled us to disentangle the two subgenomes that resulted from an ancient hybridization event. Resequencing 185 representative goldfish variants and 16 wild crucian carp revealed the origin of goldfish and identified genomic regions that have been shaped by selective sweeps linked to its domestication. Our comprehensive collection of goldfish varieties enabled us to associate genetic variations with a number of well-known anatomical features, including features that distinguish traditional goldfish clades. Additionally, we identified a tyrosine-protein kinase receptor as a candidate causal gene for the first well-known case of Mendelian inheritance in goldfish—the transparent mutant. The goldfish genome and diversity data offer unique resources to make goldfish a promising model for functional genomics, as well as domestication.
Journal Article
A Review on the Overall Optimization of Production–Living–Ecological Space: Theoretical Basis and Conceptual Framework
The 18th National Congress of the Communist Party of China put forward the optimization of territorial space development patterns as the primary measure of ecological civilization construction, and put forward the goal of “promoting intensive and efficient production space, livable and moderate living space, and beautiful (picturesque scenery) ecological space”. Through literature research and summing induction, this paper combs the research progress of the overall optimization of “Production–Living–Ecological” space (PLES) systematically. It is found that the existing work mainly focuses on the overall optimization of PLES from the perspectives of land-use quality, land-use suitability evaluation, resource and environmental carrying capacity, and comparative advantages. However, due to the lack of understanding of the scientific connotation of PLES, and the imperfect construction of quantitative identification methods and classification system, there are many problems in the technical approaches of the overall optimization of PLES, which remain to be clarified. In the future, the technological approach to the overall optimization of PLES should be guided by the vision of building a beautiful China, with the theory of a human–Earth coupling system as the core, and systematically build a theoretical system and technical framework to identify and optimize territorial space.
Journal Article
Locoregional therapy combined with targeted therapy and immunotherapy for hepatocellular carcinoma with portal vein tumor thrombosis: a systematic review and meta-analysis
Hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) represents a challenging clinical scenario with poor prognosis. This study aimed to evaluate the efficacy and safety of combining locoregional therapy with targeted therapy and immunotherapy (triple therapy) in unresectable HCC with PVTT. We conducted a Bayesian network meta-analysis of ten studies involving 1,241 HCC-PVTT patients, comparing triple therapy with targeted therapy plus immunotherapy in terms of overall survival (OS), progression-free survival (PFS), tumor response, and treatment-related adverse events. The results demonstrated that triple therapy significantly improved OS and PFS compared to targeted therapy plus immunotherapy alone. For OS, hepatic arterial infusion chemotherapy (HAIC)-based combination showed the greatest benefit (HR 0.48, 95% CI 0.32–0.74), followed by radiotherapy-based (HR 0.53, 95% CI 0.30–0.91) and transarterial chemoembolization-based combinations (HR 0.65, 95% CI 0.45–0.94). For PFS, radiotherapy-based triple therapy demonstrated the most pronounced benefit (HR 0.43, 95% CI 0.30–0.63), followed by HAIC-based combination (HR 0.49, 95% CI 0.34–0.72). While the addition of locoregional therapies increased the incidence of grade 3–4 adverse events (73.5% vs. 39.4%,
p
< 0.001), the safety profile remained clinically manageable. In conclusion, triple combination therapies represent a promising approach for unresectable HCC with PVTT that requires validation through large-scale randomized controlled trials to establish optimal treatment regimens.
Journal Article
hyperfused mitochondrial state achieved at G₁-S regulates cyclin E buildup and entry into S phase
Mitochondria undergo fission-fusion events that render these organelles highly dynamic in cells. We report a relationship between mitochondrial form and cell cycle control at the G₁-S boundary. Mitochondria convert from isolated, fragmented elements into a hyperfused, giant network at G₁-S transition. The network is electrically continuous and has greater ATP output than mitochondria at any other cell cycle stage. Depolarizing mitochondria at early G₁ to prevent these changes causes cell cycle progression into S phase to be blocked. Inducing mitochondrial hyperfusion by acute inhibition of dynamin-related protein-1 (DRP1) causes quiescent cells maintained without growth factors to begin replicating their DNA and coincides with buildup of cyclin E, the cyclin responsible for G₁-to-S phase progression. Prolonged or untimely formation of hyperfused mitochondria, through chronic inhibition of DRP1, causes defects in mitotic chromosome alignment and S-phase entry characteristic of cyclin E overexpression. These findings suggest a hyperfused mitochondrial system with specialized properties at G₁-S is linked to cyclin E buildup for regulation of G₁-to-S progression.
Journal Article
Spatial Conflict of Production–Living–Ecological Space and Sustainable-Development Scenario Simulation in Yangtze River Delta Agglomerations
Production–living–ecological space (PLES) is a recent research hotspot on land planning and regional sustainable development in China. Taking the Yangtze River Delta agglomerations as a case study, this paper establishes a spatial-conflict index to identify the PLES conflicts, and then builds a cellular-automaton (CA) Markov model to simulate the PLES pattern in 2030 and to evaluate the influence on PLES conflicts under two scenarios. Results showed that the ecological space (ES) and the living–productive space (LPS) of the Yangtze River Delta agglomerations showed a descending tendency in 2010–2015, whereas ecological–productive space (EPS) and productive–ecological space (PES) reflected a small increase. EPS and PES had squeezed ES and LPS with urbanization and industrial development in this region. Meanwhile, the spatial conflicts of PLES worsened during the period, with the average of the spatial-conflict index (SCI) shifting from 0.283 to 0.522, and seemed to gain momentum. On the basis of scenario analysis for 2030, it was concluded that the “ecological red line policy”, appropriate restriction of urban expansion, and ecological management of the bank of the Yangtze River are helpful in alleviating PLES conflicts, and contribute to spatial structure and harmonizing. The results of this study are expected to provide valuable implications for spatial planning and sustainable development in the Yangtze River delta agglomerations.
Journal Article
Pressure Dependence of Permeability in Cracked Rocks: Experimental Evidence of Non‐Linear Pore‐Pressure Gradients From Local Measurements
Understanding the coupling between rock permeability, pore pressure, and fluid flow is crucial, as fluids play an important role in the Earth's crustal dynamics. We measured the distribution of fluid pressure during fluid‐flow experiments on two typical crustal lithologies, granite and basalt. Our results demonstrate that the pore‐pressure distribution transitions from a linear to a non‐linear profile as the imposed pore‐pressure gradient is increased (from 2.5 to 60 MPa) across the specimen. This non‐linearity results from the effective pressure dependence of permeability, for which two analytical formulations were considered: an empirical exponential and a new micromechanics‐based model. In both cases, the non‐linearity of pore pressure distribution is predicted. Using a compilation of permeability versus Terzaghi's effective pressure data for granites and basalts, we show that our micromechanics‐based model has the potential to predict the pore pressure distribution over the range of effective pressures expected within the brittle crust. Plain Language Summary Fluids distributions and fluid migrations play an important role in the Earth's crustal dynamics and how fluids migrate through a rock will depend primarily on permeability. However, the permeability of crustal rocks may exhibit important pressure dependence, because cracks and fractures will increasingly close with increasing tectonic pressure. In this experimental study, we show that the couplings between increasing pressure, crack closure, and permeability reduction may result in non‐linear pore pressure distributions on a rock specimen at the laboratory scale, which confirms for the first time pioneering theoretical and experimental works. Two simple analytical expressions of the pressure dependence of permeability predict this non‐linearity. One empirical expression, most commonly used in the literature, takes the form of an exponential. The second one, a new model, based on crack micromechanics, was developed within this work and shown to outperform the exponential formulation at low Terzaghi's effective pressure. Key Points Pore pressure was measured locally in rocks exhibiting pressure‐dependent permeability We observed a transition from linear to nonlinear pore pressure distribution with increasing fluid pressure gradients A new, micromechanics‐based, analytical model was developed for the pressure dependence of permeability in microcracked rocks
Journal Article