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"Lin, Tao"
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Taipei : a novel
Following Paul from New York, where he comically navigates Manhattan's art and literary scenes, to Taipei, Taiwan, where he confronts his family's roots, we see one relationship fail, while another is born on the internet and blooms into an unexpected wedding in Las Vegas. Along the way --whether on all night drives up the East Coast, shoplifting excursions in the South, book readings on the West Coast, or ill advised grocery runs in Ohio --movies are made with laptop cameras, massive amounts of drugs are ingested, and two young lovers come to learn what it means to share themselves completely. The result is a suspenseful meditation on memory, love, and what it means to be alive, young, and on the fringe in America, or anywhere else for that matter.
Book
Whether and how tourism industry upgrading promotes employee social upgrading? Insights from China
In response to the decent work agenda in the United Nations Sustainable Development Goal 2030, an increasing body of studies has focused on social upgrading in developing countries. Numerous studies have explored whether and how economic upgrading promotes social upgrading in various industries and regions. However, few studies have examined the employee social upgrading resulting from the upgrading in the tourism industry. Moreover, most existing studies have adopted a qualitative approach, with limited quantitative research exploring the economic-social upgrading relationships. Using data from a survey conducted in China in 2024, this study examines whether and how tourism industry upgrading promotes social upgrading among related employees, as well as the role of governance environment in this relationship, employing a structural equation modeling (SEM) approach. The modeling results highlight the significance of tourism industry upgrading in promoting social upgrading of tourism industry employees. Additionally, the local governance environment is found to significantly moderate the relationship between tourism industry upgrading and employee social upgrading. This study contributes to the literature on economic and social upgrading by providing empirical evidence from the tourism sector and emphasizing the importance of governance in facilitating social improvements.
Journal Article
Ferroptosis: past, present and future
Ferroptosis is a new type of cell death that was discovered in recent years and is usually accompanied by a large amount of iron accumulation and lipid peroxidation during the cell death process; the occurrence of ferroptosis is iron-dependent. Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury, and blood diseases. How to intervene in the occurrence and development of related diseases by regulating cell ferroptosis has become a hotspot and focus of etiological research and treatment, but the functional changes and specific molecular mechanisms of ferroptosis still need to be further explored. This paper systematically summarizes the latest progress in ferroptosis research, with a focus on providing references for further understanding of its pathogenesis and for proposing new targets for the treatment of related diseases.
Journal Article
Editorial: New techniques in microbiome research - volume II: Host-microbiome interactions using ‘meta-omics’ techniques
Probiotic and prebiotic interventions, as well as fecal microbiota transplantation (FMT), are being investigated for their potential to restore healthy microbiome composition and mitigate disease progression. Research also highlights the gut-lung axis, showing that gut microbial imbalances can impact respiratory infections, suggesting a systemic role of the microbiome in maintaining immune homeostasis (Acevedo-Román et al., 2024). [...]sputum microbiota is associated with an severe and critically ill influenza patients (Gu et al., 2023), In addition, evidence indicates that the gut microbiota can alter SARS-CoV-2 virus load and COVID-19 severity (Zuo et al., 2020). Single-cell analysis and spatial resolution of the gut microbiome The authors reviewed innovative microbial single cell sequencing techniques, highlighting their broad applications in addressing critical questions regarding microbiome composition and spatial heterogeneity. Patients with Parkinson’s disease (PD) often exhibit gut microbiota dysbiosis (Jia et al.). [...]the gut microbiome and its associated metabolic pathways appear to play a significant role in the long-term development of depression (Li et al.).
Journal Article
Diagnostic utility of GDF15 in neurodegenerative diseases: A systematic review and meta‐analysis
Introduction GDF15 may be a potential biomarker for neurodegenerative diseases. In this analysis, we aimed to quantitative analysis the levels of GDF15 in patients with neurological diseases and in health control, and then to determine its potential diagnostic utility. Methods Two researchers separately conducted a systematic search of the relevant studies up to January 2021 in Embase, PubMed, and Web of Science. Effect sizes were estimated to use the standardized mean difference (SMD) with 95% confidence interval (CI). Sensitivity and specificity were calculated by the summary receiver operating characteristics curve (SROC) method. The sensitivity analysis was performed by the “one‐in/one‐out” approach. Considering the considerable heterogeneity among studies, random‐effects model was used for the meta‐analysis investigation. Results A total of eight articles were included in this meta‐analysis and systematic review. The pooled results of the random effect model indicated GDF15 levels were significantly higher in patients with neurodegenerative disease than healthy people (SMD = 0.92, 95% CI: 0.44–1.40, Z = 3.75, p < 0.001). Sensitivity and specificity of biomarker of GDF15 were 0.90 (95% CI: 0.75–0.97), 0.77 (95% CI: 0.67–0.65), and AUC = 0.87 (95% CI: 0.84–0.90), respectively. Conclusions GDF15 levels were higher in patients with neurodegenerative disease than healthy people. And serum levels of GDF15 were a better marker for diagnostic utility of neurodegenerative disease. Our results found that GDF15 levels were higher in patient with neurodegenerative disease than that in the healthy people. And serum levels of GDF15 were a better marker for diagnostic utility of neurodegenerative diseases.
Journal Article
Editorial: New techniques in microbiome research
The application of cutting-edge technologies, such as in vivo monoclonization and functional assays in specific pathogen free (SPF) and germ-free (GF) mouse models, in vitro co-cultures of the anaerobic microbiome and aerobic host tissues, and ‘meta-omics’-related research (such as metagenomics, transcriptomics, metabolomics, proteomics, and spatial resolution) have provided major insights into the complexity of relationships between the host and microbiome as well as the mechanisms of the functional roles of the microbiota and individual bacteria on host health and disease. High throughput genome-wide mutagenesis, such as transposon mutagenesis, Signature Tagged Mutagenesis (STM), transposon insertion sequencing (Tn-seq), molecular and microbiome Koch’s postulates, and more will be utilized to study the host-microbiome interactions and functional analysis of the microbiome (Figure 1). The authors compared relative microbiome profiling to microbial cell counting using flow cytometry, flow cytometry combined with the microbial composition of intact cells, and molecular-based quantification using qPCR targeting the 16S rRNA gene. New technologies might help to understand the causative role of gut microbes in neurodegeneration. [...]this paper reviews the recent advances in the study of the microbiota-gut-brain axis in the field of neurodegenerative disorders to identify specific microbial signaling pathways and characterize advanced engineered tools to study the interactions between human cells and gut bacteria.
Journal Article
Multidimensional mechanisms and therapies underlying gastroesophageal reflux disease: focus on immunity, signaling pathways, and the microbiota-gut-brain axis
Gastroesophageal reflux disease (GERD) has a high incidence rate and a complex pathogenesis that is not yet fully understood. This review aims to provide a comprehensive exploration of the mechanisms underlying GERD, emphasizing the interplay between immune responses, signaling pathways, and the microbiota-gut-brain axis. Specifically, it highlights the contributions of immune cells (e.g., T-lymphocytes, dendritic cells, mast cells), pro-inflammatory cytokines, and key signaling pathways, including nuclear factor (NF)-κB, mitogen-activated protein kinase (MAPK), and phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), in driving esophageal inflammation and barrier dysfunction. Furthermore, the review examines the bidirectional interactions between psychological stress, gut microbiota dysbiosis, and GERD pathophysiology via the gut-brain axis. In bridging these mechanisms to potential therapeutic strategies, this review evaluates both established pharmacological treatments, such as proton pump inhibitors (PPIs) and immunotherapy, and emerging approaches, including herbal formulations and neuromodulation techniques. By synthesizing current evidence, the review identifies critical knowledge gaps, particularly in understanding the cross-talk between immune pathways and therapeutic targets. These findings underscore the need for mechanism-driven research to facilitate the development of personalized treatment strategies and address unresolved challenges in GERD management.
Journal Article
Modern Software Development for JUNO offline software
The Jiangmen Underground Neutrino Observatory (JUNO), under construction in South China, primarily aims to determine the neutrino mass hierarchy and to precise measure the neutrino oscillation parameters. The data-taking is expected to start in 2024 and the detector plans to run for more than 20 years. The development of the JUNO offline software (JUNOSW) started in 2012, and it is quite challenging to maintain the JUNOSW for such a long time. In the last ten years, tools such as Subversion, Trac, and CMT had been adopted for software development. However, new stringent requirements came out, such as how to reduce the building time for the whole project, how to deploy offline algorithms to an online environment, and how to improve the code quality with code review and continuous integration. To meet the further requirements of software development, modern development tools are evaluated for JUNOSW, such as Git, GitLab, CMake, Docker, and Kubernetes. This contribution will present the software development system based on these modern tools for JUNOSW and the functionalities achieved: CMake macros are developed to simplify the build instructions for users; CMake generator expressions are used to control the build flags for the online and offline environments; a tool named git-junoenv is developed to help users partially checkout and build the software; a script is used to build and deploy the software on the CVMFS server; a Docker image with CVMFS client installed is created for continuous integration; a GitLab agent is set up to manage GitLab runners in Kubernetes with all the configurations in a GitLab repository.
Journal Article
Ion pair sites for efficient electrochemical extraction of uranium in real nuclear wastewater
Electrochemical uranium extraction from nuclear wastewater represents an emerging strategy for recycling uranium resources. However, in nuclear fuel production which generates the majority of uranium-containing nuclear wastewater, fluoride ion (F
−
) co-exists with uranyl (UO
2
2+
), resulting in the complex species of UO
2
F
x
and thus decreasing extraction efficiency. Herein, we construct Ti
δ+
-PO
4
3−
ion pair extraction sites in Ti(OH)PO
4
for efficient electrochemical uranium extraction in wastewater from nuclear fuel production. These sites selectively bind with UO
2
F
x
through the combined Ti-F and multiple O-U-O bonds. In the uranium extraction, the uranium species undergo a crystalline transition from U
3
O
7
to K
3
UO
2
F
5
. In real nuclear wastewater, the uranium is electrochemically extracted with a high efficiency of 99.6% and finally purified as uranium oxide powder, corresponding to an extraction capacity of 6829 mg g
−1
without saturation. This work paves an efficient way for electrochemical uranium recycling in real wastewater of nuclear production.
Electrochemical uranium extraction from real nuclear wastewater is appealing but challenging. Herein, Lin et al develop a strategy of ion pair site for enhanced binding of dominant uranium fluoride species in real wastewater, achieving efficient recycling of uranium as powder product.
Journal Article
Influencing factors of early neurological deterioration in COVID-19 -associated acute ischemic stroke
Coronavirus Disease-2019 (COVID-19) contributes to dysfunction and increased mortality in patients with acute ischemic stroke (AIS). However, whether COVID-19 causes early neurological deterioration (END) in patients with AIS and its underlying influencing factors are currently unclear.To ascertain the autonomous risk factors associated with END in stroke cases related to COVID-19. This is a retrospective observational study of data collected from November 2022 to February 2023 from patients with AIS complicated with COVID-19. The patients were divided into non-END and END groups, and their demographic characteristics, laboratory and imaging data were analyzed to investigate the risk factors for END in AIS patients complicated with COVID-19. A total of 83 patients were enrolled in this study, and divided in to END (
n
= 22) and non-END (
n
= 61) groups. We found that patients with high baseline the National Institutes of Health Stroke Scale (NIHSS) score (
P
= 0.044), preexisting diabetes (
P
< 0.01), stroke (
P
< 0.01) and abnormal electrocardiogram (
P
< 0.01) were prone to END. Compared to patients with non-END, the serum high-sensitivity C-reactive proteinhs(hs-CRP,
P
< 0.01), the high-sensitivity cardiac troponin (hs-CTN,
P
< 0.01), the prothrombin time (PT,
P
< 0.01), and the D-Dimer(DD,
P
< 0.01) were obviously increased in patients with EDN. Furthermore, multivariate Logistic regression analysis identified preexisting diabetes, stroke, high baseline NIHSS score, abnormal electrocardiogram, prolonged PT value, increased hs-CRP and elevated DD as independent risk factors for ENG in COVID-19-associated AIS. Patients with preexisting diabetes, stroke, high baseline NIHSS score, abnormal electrocardiogram, prolonged serum PT value, significantly increased hs-CRP and DD are prone to END in COVID-19-associated AIS.
Journal Article