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"Lin, Yin"
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Analgesia and anesthesia using the pericapsular nerve group block in hip surgery and hip fracture: a scoping review
IntroductionPericapsular nerve group (PENG) block is a novel regional analgesia technique to reduce pain after hip surgery and hip fractures. This review was conducted to summarize current literature.MethodsA scoping review was carried out using the Joanna Briggs Institute framework. All articles describing the use of PENG block as a regional analgesia and/or anesthesia technique for hip pain were considered eligible for inclusion. Ovid Medline, Embase, CINAHL, PubMed and Google Scholar were searched. Adult and pediatric studies were included. Excluded were articles not available in English language, not available in full-text, related to non-orthopedic indications such as soft tissue surgery, and pelvic or femoral shaft fractures.ResultsDatabase searches identified 345 articles, 20 of which could be included in the current review, with a combined patient number of 74. Included articles comprised case reports and case series only, describing 1 to 10 patients. In all studies, PENG block was described to provide sufficient analgesia or anesthesia. Transient motor side effects occurred only when the local anesthetic was deposited in an unintended location (n=2).ConclusionsCurrent evidence of using PENG block for hip surgery or hip pain is limited to case reports and case series only. PENG block is a promising regional analgesia technique as an alternative to other regional nerve blocks such as femoral nerve block or iliac fascia nerve block. Observational and experimental studies are required to determine the effectiveness, efficacy and safety of the PENG block.
Journal Article
Danshen Improves Survival of Patients With Breast Cancer and Dihydroisotanshinone I Induces Ferroptosis and Apoptosis of Breast Cancer Cells
Danshen (salvia miltiorrhiza Bunge) is widely used in traditional Chinese medicine. However, it is definite clinical effort and mechanism on breast cancer is unclear. In our study, we used the real-world database to investigate in vivo protective effort of danshen in the breast cancer patients through using population-based data from the Taiwan National Health Insurance Research Database (NHIRD). In vitro , human breast cancer cells (MCF-7 cells and MDA-MB-231 cells) were used to investigate the effect and the underlying mechanism through XTT assay, flow cytometry, glutathione peroxidase (GPX) activity assay, GSH (reduced glutathione)/GSSG (oxidized glutathione), malondialdehyde (MDA), and western blot analysis. The in vivo effect was investigated through a xenograft nude mouse model. We found that dihydroisotanshinone I (DT), a pure compound present in danshen, can inhibit the growth of breast carcinoma cells, including MCF-7 cells and MDA-MB-231 cells. Moreover, DT induced apoptosis and ferroptosis in these breast cancer cells. DT also repressed the protein expression of GPX4 (Glutathione peroxidase 4). For in vivo study, DT treatment also significantly inhibited the final tumor volume without adverse effects in a xenograft nude mouse model. In conclusion, danshen has protective efforts in breast cancer patients, which could be attributed to DT through inducing apoptosis and ferroptosis of breast cancer cells.
Journal Article
تعرف على 5000 عام من تاريخ الصين : نحو قراءة ميسرة لتاريخ الصين
يضم الكتاب قصص من تاريخ الصين القديم ذلك البلد الذي يعد من أقدم حضارات العالم التي يعود تاريخها إلى ما قبل خمسة آلاف عام حيث يجمع الكتاب بين المعرفة والمتعة والإبداع ويحتوي على نصوص من معارف تاريخية وجزءا خاصا بالثقافة يعمل على توسيع الأفق المعرفي للقراء ويعتمد الكتاب في طرح أفكاره بطريقة قص الحكايات كأسلوب لسرد الأحداث التاريخية كما يحتوي على مجموعة هائلة من الصور مما يزيد من شغف القارئ.
BOOK
Simple non-fused electron acceptors for efficient and stable organic solar cells
The flexibility in structural design of organic semiconductors endows organic solar cells (OSCs) not only great function-tunabilities, but also high potential toward practical application. In this work, simple non-fused-ring electron acceptors are developed through two-step synthesis from single aromatic units for constructing efficient OSCs. With the assistance of non-covalent interactions, these rotatable non-fused acceptors (in solution) allow transiting into planar and stackable conformation in condensed solid, promoting acceptors not only feasible solution-processability, but also excellent film characteristics. As results, decent power conversion efficiencies of 10.27% and 13.97% can be achieved in single and tandem OSCs consisting of simple solution-cast blends, in which the fully unfused acceptors exhibit exceptionally low synthetic complexity index. In addition, the unfused acceptor and its based OSCs exhibit promising stabilities under continuous illumination. Overall, this work reveals valuable insights on the structural design of simple and effective electron acceptors with great practical perspectives.
Non-fullerene electron acceptors have pushed the efficiency of organic solar cells up to 15% but they all contain fused rings and are inconvenient to synthetic access. Here Yu et al. develop fully unfused acceptors featuring non-covalent intramolecular interactions, high efficiencies and high stability.
Journal Article
Masses of positive- and negative-parity hadron ground-states, including those with heavy quarks
A symmetry-preserving treatment of a vector × vector contact interaction is used to compute spectra of ground-state JP=0±,1±(fg¯) mesons, their partner diquark correlations, and JP=1/2±,3/2± (fgh) baryons, where f,g,h∈{u,d,s,c,b}. Results for the leptonic decay constants of all mesons are also obtained, including scalar and pseudovector states involving heavy quarks. The spectrum of baryons produced by this chiefly algebraic approach reproduces the 64 masses known empirically or computed using lattice-regularised quantum chromodynamics with an accuracy of 1.4(1.2)%. It also has the richness of states typical of constituent-quark models and predicts many baryon states that have not yet been observed. The study indicates that dynamical, nonpointlike diquark correlations play an important role in all baryons; and, typically, the lightest allowed diquark is the most important component of a baryon’s Faddeev amplitude.
Journal Article
The MADS29 Transcription Factor Regulates the Degradation of the Nucellus and the Nucellar Projection during Rice Seed Development
The MADS box transcription factors are critical regulators of rice (Oryza sativa) reproductive development. Here, we here report the functional characterization of a rice MADS box family member, MADS29, which is preferentially expressed in the nucellus and the nucellar projection. Suppressed expression of MADS29 resulted in abnormal seed development; the seeds were shrunken, displayed a low grain-filling rate and suppressed starch biosynthesis, and contained abnormal starch granules. Detailed analysis indicated that the abnormal seed development is due to defective programmed cell death (PCD) of the nucellus and nucellar projection, which was confirmed by a TUNEL assay and transcriptome analysis. Further studies showed that expression of MADS29 is induced by auxin and MADS29 protein binds directly to the putative promoter regions of genes that encode a Cys protease and nucleotide binding site-Leu-rich repeat proteins, thereby stimulating the PCD. This study identifies MADS29 as a key regulator of early rice seed development by regulating the PCD of maternal tissues. It provides informative clues to elucidate the regulatory mechanism of maternal tissue degradation after fertilization and to facilitate the studies of endosperm development and seed filling.
Journal Article
ECG Recurrence Plot-Based Arrhythmia Classification Using Two-Dimensional Deep Residual CNN Features
In this paper, an effective electrocardiogram (ECG) recurrence plot (RP)-based arrhythmia classification algorithm that can be implemented in portable devices is presented. Public databases from PhysioNet were used to conduct this study including the MIT-BIH Atrial Fibrillation Database, the MIT-BIH Arrhythmia Database, the MIT-BIH Malignant Ventricular Ectopy Database, and the Creighton University Ventricular Tachyarrhythmia Database. ECG time series were segmented and converted using an RP, and two-dimensional images were used as inputs to the CNN classifiers. In this study, two-stage classification is proposed to improve the accuracy. The ResNet-18 architecture was applied to detect ventricular fibrillation (VF) and noise during the first stage, whereas normal, atrial fibrillation, premature atrial contraction, and premature ventricular contractions were detected using ResNet-50 in the second stage. The method was evaluated using 5-fold cross-validation which improved the results when compared to previous studies, achieving first and second stage average accuracies of 97.21% and 98.36%, sensitivities of 96.49% and 97.92%, positive predictive values of 95.54% and 98.20%, and F1-scores of 95.96% and 98.05%, respectively. Furthermore, a 5-fold improvement in the memory requirement was achieved when compared with a previous study, making this classifier feasible for use in resource-constricted environments such as portable devices. Even though the method is successful, first stage training requires combining four different arrhythmia types into one label (other), which generates more data for the other category than for VF and noise, thus creating a data imbalance that affects the first stage performance.
Journal Article
Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis
Amyloid fibrils derived from antibody light chains are key pathogenic agents in systemic AL amyloidosis. They can be deposited in multiple organs but cardiac amyloid is the major risk factor of mortality. Here we report the structure of a λ1 AL amyloid fibril from an explanted human heart at a resolution of 3.3 Å which we determined using cryo-electron microscopy. The fibril core consists of a 91-residue segment presenting an all-beta fold with ten mutagenic changes compared to the germ line. The conformation differs substantially from natively folded light chains: a rotational switch around the intramolecular disulphide bond being the crucial structural rearrangement underlying fibril formation. Our structure provides insight into the mechanism of protein misfolding and the role of patient-specific mutations in pathogenicity.
Systemic AL amyloidosis is caused by misfolding of immunoglobulin light chains and is one of the most frequently occurring forms of systemic amyloidosis. Here the authors present the 3.3 Å cryo-EM structure of a λ1 AL amyloid fibril that was isolated from an explanted human heart.
Journal Article