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Textile-based wearable electronics have attracted intensive research interest due to their excellent flexibility and breathability inherent in the unique three-dimensional porous structures. However, one of the challenges lies in achieving highly conductive patterns with high precision and robustness without sacrificing the wearing comfort. Herein, we developed a universal and robust in-textile photolithography strategy for precise and uniform metal patterning on porous textile architectures. The as-fabricated metal patterns realized a high precision of sub-100 µm with desirable mechanical stability, washability, and permeability. Moreover, such controllable coating permeated inside the textile scaffold contributes to the significant performance enhancement of miniaturized devices and electronics integration through both sides of the textiles. As a proof-of-concept, a fully integrated in-textiles system for multiplexed sweat sensing was demonstrated. The proposed method opens up new possibilities for constructing multifunctional textile-based flexible electronics with reliable performance and wearing comfort. It is challenging to achieve simultaneous robustness, permeability and high electrical performance when patterning textile electronics. Here, the authors report an in-textile photolithography method for precise metal patterns while maintaining the 3D porous structure for wearable textile electronics.

Our study aims to evaluate the risk of drug-induced hypertrophic rhinitis and analyze its epidemiological characteristics utilizing real-world data. We employed reporting odds ratios (ROR) to assess the disproportionality in reports of drug-induced hypertrophic rhinitis between January 2004 and September 2024. Single-factor, LASSO, and multi-factor regression analyses were conducted to investigate drugs associated with hypertrophic rhinitis. The Bonferroni correction was implemented to conduct multiple comparisons. 250 drugs were linked to hypertrophic rhinitis, with 85 drugs (case number > 100) identified as independent risk factors for drug-induced hypertrophic rhinitis. Those drugs’ indications were classified as Allergic disease (19/85), Multi-indication (13/85), Cardiovascular disease (12/85), Rheumatoid disease (6/85), Autoimmune disease (6/85), Respiratory disease (5/85), Cancer (4/85), Metabolic disease (4/85), Contrast agent (3/85), Erectile dysfunction (3/85), Infection (3/85), Disease of the nervous system (2/85), Urologic Disease (2/85) Esophageal disease (1/85), Hereditary disorder (1/85), and Ophthalmic disease (1/85). Multiple medications have possible risks of drug-induced hypertrophic rhinitis. Further research is needed to clarify causality and guide clinical decision-making.

While the biogeophysical effects of deforestation on average and extreme temperatures are broadly documented, how deforestation influences temperature variability remains largely unknown. To fill this knowledge gap, we investigate the biogeophysical effects of idealized deforestation on daily temperature variability at the global scale based on multiple earth system models and in situ observations. Here, we show that deforestation can intensify daily temperature variability (by up to 20%) in the northern extratropics, particularly in winter, leading to more frequent rapid extreme warming and cooling events. The higher temperature variability can be attributed to the enhanced near-surface horizontal temperature advection and simultaneously is partly offset by the lower variability in surface sensible heat flux. We also show responses of daily temperature variability to historical deforestation and future potential afforestation. This study reveals the overlooked effects of deforestation or afforestation on temperature variability and has implications for large-scale afforestation in northern extratropic countries. A new study finds that deforestation in the northern extratropics can enhance horizontal temperature advection through biogeophysical processes, leading to higher local daily temperature variability, particularly in winter.

HighlightsA confined thermal expansion strategy to fabricate liquid metal (LM)-based monoliths with continuous LM network at ultra-low content.The results show a strong integration advantage of LM-based monoliths in density, mechanical strength, electromagnetic interference shielding effectiveness, and near field shielding effectiveness, as well as multi-functions such as magnetic actuation.Liquid metal (LM) has become an emerging material paradigm in the electromagnetic interference shielding field owing to its excellent electrical conductivity. However, the processing of lightweight bulk LM composites with finite package without leakage is still a great challenge, due to high surface tension and pump-out issues of LM. Here, a novel confined thermal expansion strategy based on expandable microsphere (EM) is proposed to develop a new class of LM-based monoliths with 3D continuous conductive network. The EM/LM monolith (EM/LMm) presents outstanding performance of lightweight like metallic aerogel (0.104 g cm−1), high strength (3.43 MPa), super elasticity (90% strain), as well as excellent tailor ability and recyclability, rely on its unique gas-filled closed-cellular structure and refined LM network. Moreover, the assembled highly conducting EM/LMm exhibits a recorded shielding effectiveness (98.7 dB) over a broad frequency range of 8.2–40 GHz among reported LM-based composites at an ultra-low content of LM, and demonstrates excellent electromagnetic sealing capacity in practical electronics. The ternary EM/LM/Ni monoliths fabricated by the same approach could be promising universal design principles for multifunctional LM composites, and applicable in magnetic responsive actuator.

Supramolecular self-assembly offers a powerful strategy to produce high-performance, stimuli-responsive nanomaterials. However, lack of molecular understanding of stimulated responses frequently hampers our ability to rationally design nanomaterials with sharp responses. Here we elucidated the molecular pathway of pH-triggered supramolecular self-assembly of a series of ultra-pH sensitive (UPS) block copolymers. Hydrophobic micellization drove divergent proton distribution in either highly protonated unimer or neutral micelle states along the majority of the titration coordinate unlike conventional small molecular or polymeric bases. This all-or-nothing two-state solution is a hallmark of positive cooperativity. Integrated modelling and experimental validation yielded a Hill coefficient of 51 in pH cooperativity for a representative UPS block copolymer, by far the largest reported in the literature. These data suggest hydrophobic micellization and resulting positive cooperativity offer a versatile strategy to convert responsive nanomaterials into binary on/off switchable systems for chemical and biological sensing, as demonstrated in an additional anion sensing model. Understanding stimuli responsiveness on a molecular level can help with the rational design of nanomaterials with sharp responses. Here, Gao and co-workers have shown the molecular pathway of the supramolecular self-assembly of a series of ultra-pH sensitive block copolymers.

Dual-porosity structures of fine-grained soils can noticeably affect their ability to retain water. This work jointly employs axis translation technique, filter paper method, and vapor equilibrium technique to study the soil–water retention curve (SWRC) over a wide suction range of Nanyang expansive soil characterized by double porosity. Mercury intrusion porosimetry tests are carried out to investigate the correlations between the aforementioned water-retention response and underlying pore structure characteristics. The test data show that dual-porosity distribution leads to bimodal SWRC. The change in void ratio mainly affects the median size of the inter-aggregate pores and consequently the portion of SWRC at low suction range. Based on these experimental observations, this work presents an SWRC equation for fine-grained soils with dual-porosity structures. Attracting water through capillary and adsorptive processes is explicitly distinguished. The capillary water is described by a relation that includes the characteristics of both inter- and intra-aggregate pore size distributions as parameters for representing bimodal characteristics. The adsorbed water is modeled by a relation that considers capillary condensation within intra-aggregate pores and allows for the decoupling between adsorptive water-retention mechanism and void ratio change. The latter feature is the foundation for the model to include the void ratio effect on SWRC in a way consistent with how it affects the pore structures of soils. By simulating test data in this work and in the literature, the proposed model is shown to be capable of representing the water-retention behavior of fine-grained soils with dual-porosity structures under different void ratios. To include the aforementioned key factors that influence the SWRC of fine-grained soils, seven parameters are required in the proposed model. This feature can reduce the practical applicability of the model. Future directions to enhance this aspect are discussed.

The impact of chirality on immune response has attracted great interest in cancer vaccine research recently. However, the study of chiral synthetic polypeptide hydrogels as cancer vaccines as well as of the impact of biomaterials themselves for antitumor immunotherapy has rarely been reported. Here, we show the key role of residue chirality of polypeptide hydrogels in antitumor immunity and local immune microenvironment regulation. Compared to poly(γ-ethyl-L-glutamate)-based hydrogels (L-Gel), poly(γ-ethyl-D-glutamate)-based hydrogels (D-Gel) induces enhanced level of immune cell infiltration. However, D-Gel causes higher levels of suppressive markers on antigen-presenting cells and even induces stronger T cell exhaustion than L-Gel. Finally, D-Gel establishes a local chronic inflammatory and immunosuppressive microenvironment and shows insufficient anti-tumor effects. Conversely, the milder host immune responses induced by L-Gel leads to more effective tumor inhibition. This study provides insights on the role of residue chirality in the regulation of local immune microenvironment and affecting antitumor immune response. The impact of chemical chirality on immune response attracts attention in cancer vaccine design recently. Here this group reports the chirality of poly(γ-ethyl-D-glutamate)-based hydrogel exhibiting higher levels of suppression on antigen-presenting cells and inducing stronger T cell exhaustion than L-Gel eventually leading to insufficient anti-tumor efficacy.

A flexible drilling tool is a special drilling tool for ultrashort-radius radial horizontal wells. This tool is composed of many parts and has the characteristics of a multibody system. In this paper, a numerical method for the dynamic analysis of flexible drilling tools is proposed. The flexible drill tool is discretized into spatial beam elements, while the multilayer contact of the flexible drilling tool is represented by the multilayer dynamic gap element, and the dynamic model of the multibody system for the flexible drilling tool’s multilayer contact is established, considering the interaction force between the drill bit and the rock. The nonlinear dynamic equation is solved using the Newmark method and Newton–Raphson method. An analysis of the dynamic behavior of a flexible drilling tool is conducted. The results indicate that the flexible drilling tool experiences vortex formation due to the interaction between the flexible drilling pipe and the guide pipe, leading to increased friction and wear. This situation hinders safe drilling operations with flexible drilling tools. The collision force of the flexible drilling tool near the bottom of the hole is more severe than that of the other tool types, which may lead to failure of the connection.

HighlightsA transparent, conductive, and flexible metal mesh film has been developed by a low-cost, uniform self-forming crackle template and electroplating strategy.The Cu mesh films show an ultra-low sheet resistance (0.18 Ω □−1), high transmittance (85.8%@550 nm), high figure of merit (> 13,000), excellent stretchability and mechanical stability.The metal mesh film can be used as a flexible heater and electromagnetic interference shielding film (40.4 dB at 2.5 μm).Despite the growing demand for transparent conductive films in smart and wearable electronics for electromagnetic interference (EMI) shielding, achieving a flexible EMI shielding film, while maintaining a high transmittance remains a significant challenge. Herein, a flexible, transparent, and conductive copper (Cu) metal mesh film for EMI shielding is fabricated by self-forming crackle template method and electroplating technique. The Cu mesh film shows an ultra-low sheet resistance (0.18 Ω □−1), high transmittance (85.8%@550 nm), and ultra-high figure of merit (> 13,000). It also has satisfactory stretchability and mechanical stability, with a resistance increases of only 1.3% after 1,000 bending cycles. As a stretchable heater (ε > 30%), the saturation temperature of the film can reach over 110 °C within 60 s at 1.00 V applied voltage. Moreover, the metal mesh film exhibits outstanding average EMI shielding effectiveness of 40.4 dB in the X-band at the thickness of 2.5 μm. As a demonstration, it is used as a transparent window for shielding the wireless communication electromagnetic waves. Therefore, the flexible and transparent conductive Cu mesh film proposed in this work provides a promising candidate for the next-generation EMI shielding applications.

To address the issues of poor harvesting efficiency, unsatisfactory cutting performance, and high energy consumption in current golden needle mushroom harvesting machinery, this study designed a novel rotary cutter-type root cutting device featuring a slitting cutting angle cutter. The device utilizes a clamping mechanism on a feed turntable to secure the mushrooms, with root cutting achieved through synchronized rotation of the rotary cutter and the turntable. The study commenced with a theoretical analysis of the device’s trajectory displacement model and cutting process, determining the structural form and parameter ranges for key components. Utilizing EDEM discrete element software, simulation optimization tests were conducted using cutting force and unit area power consumption as evaluation metrics. Experiments investigated the effects of rotary cutter geometry and operational parameters, ultimately identifying the optimal cutter parameter combination: a sliding cutting angle of 26°, a cutting edge angle of 15°, and a thickness of 2 mm. The best operational parameters were determined to be a cutting speed of 1400 r/min, a turntable feed speed of 6 r/min, and a cutting height of 20 mm An test platform was constructed to validate the simulation results. The findings demonstrated that the new slitting angle cutter reduced cutting force by 39.4% and unit area power consumption by 24.5%. Additionally, the design significantly improved cutting flatness, ensuring that the device’s performance and efficiency met the design requirements. This study provides an effective solution to key technical challenges in the mechanized harvesting of golden needle mushrooms.