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A DNA-prime/human adenovirus serotype 5 (HuAd5) boost vaccine encoding Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP) and Pf apical membrane antigen-1 (PfAMA1), elicited protection in 4/15 (27%) of subjects against controlled human malaria infection (CHMI) that was statistically associated with CD8+ T cell responses. Subjects with high level pre-existing immunity to HuAd5 were not protected, suggesting an adverse effect on vaccine efficacy (VE). We replaced HuAd5 with chimpanzee adenovirus 63 (ChAd63), and repeated the study, assessing both the two-antigen (CSP, AMA1 = CA) vaccine, and a novel three-antigen (CSP, AMA1, ME-TRAP = CAT) vaccine that included a third pre-erythrocytic stage antigen [malaria multiple epitopes (ME) fused to the Pf thrombospondin-related adhesive protein (TRAP)] to potentially enhance protection. This was an open label, randomized Phase 1 trial, assessing safety, tolerability, and VE against CHMI in healthy, malaria naïve adults. Forty subjects (20 each group) were to receive three monthly CA or CAT DNA priming immunizations, followed by corresponding ChAd63 boost four months later. Four weeks after the boost, immunized subjects and 12 infectivity controls underwent CHMI by mosquito bite using the Pf3D7 strain. VE was assessed by determining the differences in time to parasitemia as detected by thick blood smears up to 28-days post CHMI and utilizing the log rank test, and by calculating the risk ratio of each treatment group and subtracting from 1, with significance calculated by the Cochran-Mantel-Haenszel method. In both groups, systemic adverse events (AEs) were significantly higher after the ChAd63 boost than DNA immunizations. Eleven of 12 infectivity controls developed parasitemia (mean 11.7 days). In the CA group, 15 of 16 (93.8%) immunized subjects developed parasitemia (mean 12.0 days). In the CAT group, 11 of 16 (63.8%) immunized subjects developed parasitemia (mean 13.0 days), indicating significant protection by log rank test compared to infectivity controls (p = 0.0406) and the CA group (p = 0.0229). VE (1 minus the risk ratio) in the CAT group was 25% compared to -2% in the CA group. The CA and CAT vaccines induced robust humoral (ELISA antibodies against CSP, AMA1 and TRAP, and IFA responses against sporozoites and Pf3D7 blood stages), and cellular responses (IFN-[gamma] FluoroSpot responses to CSP, AMA1 and TRAP) that were not associated with protection. This study demonstrated that the ChAd63 CAT vaccine exhibited significant protective efficacy, and confirmed protection was afforded by adding a third antigen (T) to a two-antigen (CA) formulation to achieve increased VE. Although the ChAd63-CAT vaccine was associated with increased frequencies of systemic AEs compared to the CA vaccine and, historically, compared to the HuAd5 vectored malaria vaccine encoding CSP and AMA1, they were transient and associated with increased vector dosing.

Preschoolers naturally learn and develop within their environments and communities. Itinerant early childhood special education (ECSE) services within community-based settings such as homes, childcare locations, and private preschool programs are used in some areas to provide inclusive services. Key collaborators to this model include families, ECSE professionals, and early childhood education (ECE) staff (Division for Early Childhood [DEC] & National Association for the Education of Young Children [NAEYC], 2009). The purpose of this study was to explore and describe the experiences and perspectives of adult collaborators in a single case of a Wisconsin district implementing itinerant ECSE services in community-based settings. Using a phenomenological case study design, built on a framework of the bioecological systems theory (Bronfenbrenner, 1976, 1994; Bronfenbrenner & Morris, 2006) paired with access, participation, and supports as components of inclusion (DEC & NAEYC, 2009), a holistic description of the program was obtained to further understanding of this service model.Data collection for this project included interviews, observations, researcher journaling, and material data (Creswell & Poth, 2018). There were 11 participants comprised of family participants, community-based early childhood staff, and district staff, and observations were conducted in six different settings. Data were collected,ivanalyzed, and coded into themes over several months using a constant comparative method.Outcomes revealed eleven overarching themes addressing the research questions. Some subthemes were consistently present among collaborator groups, while others emerged from one or two roles. Themes included Meet Them Where They Are, Adult Relationships, Logistics, Service Implementation, Child Needs and Individualization, Peer Community, Adult Preparedness, Staffing Factors, Varying Methods and Expectations, Safety and Wellbeing, and Program Awareness and Understanding.The present study offered evidence that itinerant community-based services had value for collaborators, while challenges also existed. Through the complex interworking of people, systems, and settings, the program aimed to individualize supports for child access and participation. Findings indicated the model could foster child development, belonging, and adult partnerships. A strong value for meeting preschoolers and families where they are was present. Relationships, trust, and collaboration were central to the program, while personalities, attitudes, skills, experience, and environmental considerations could impact team success.

2007 was a big year for accidental pregnancies carried to term in the movies. Comedic films Knocked Up, Juno, and Waitress all hinged on this particular event. But is accidental pregnancy a laughing matter? The following professional project explores that quandary utilizing the works of feminist theorists Susan Bordo and Mary Russo, critical analysis, and my own authority of experience. Each is an enjoyable film, but each has a very specific message about to whom the pregnant body belongs and how it can be utilized for agency—not all of those messages are feminist ideals.

Existing literature suggests that influenza C typically causes mild respiratory tract disease. However, clinical and epidemiological data are limited. Four outpatient clinics and 3 hospitals submitted clinical data and respiratory specimens through a surveillance network for acute respiratory infection (ARI) from May 2013 through December 2016. Specimens were tested using multitarget nucleic acid amplification for 19-22 respiratory pathogens, including influenza C. Influenza C virus was detected among 59 of 10 202 (0.58%) hospitalized severe ARI cases and 11 of 2282 (0.48%) outpatients. Most detections occurred from December to March, 73% during the 2014-2015 season. Influenza C detections occurred among patients of all ages, with rates being similar between inpatients and outpatients. The highest rate of detection occurred among children aged 6-24 months (1.2%). Among hospitalized cases, 7 required intensive care. Medical comorbidities were reported in 58% of hospitalized cases and all who required intensive care. At least 1 other respiratory pathogen was detected in 40 (66%) cases, most commonly rhinovirus/enterovirus (25%) and respiratory syncytial virus (20%). The hemagglutinin-esterase-fusion gene was sequenced in 37 specimens, and both C/Kanagawa and C/Sao Paulo lineages were detected in inpatients and outpatients. We found seasonal circulation of influenza C with year-to-year variability. Detection was most frequent among young children but occurred in all ages. Some cases that were positive for influenza C, particularly those with comorbid conditions, had severe disease, suggesting a need for further study of the role of influenza C virus in the pathogenesis of respiratory disease.

Date Presented 4/8/2016 This study evaluated the effectiveness of a one-to-one fatigue management course on participants with chronic health conditions. Participants (N = 49) showed significant improvements in fatigue, self-efficacy, and quality of life at posttest. These beneficial effects were maintained at follow-up. Primary Author and Speaker: Ashley Mogush Additional Author and Speaker: Virgil Mathiowetz Contributing Author: Katy Lindstrom

Date Presented 4/8/2016 This study evaluated the effectiveness of a one-to-one fatigue management course on participants with chronic health conditions. Participants (N = 49) showed significant improvements in fatigue, self-efficacy, and quality of life at posttest. These beneficial effects were maintained at follow-up. Primary Author and Speaker: Ashley Mogush Additional Author and Speaker: Virgil Matiowetz Contributing Author: Katy Lindstrom

Lamb–Shaffer syndrome (LAMSHF) is a neurodevelopmental disorder described in just over two dozen patients with heterozygous genetic alterations involving SOX5, a gene encoding a transcription factor regulating cell fate and differentiation in neurogenesis and other discrete developmental processes. The genetic alterations described so far are mainly microdeletions. The present study was aimed at increasing our understanding of LAMSHF, its clinical and genetic spectrum, and the pathophysiological mechanisms involved. Clinical and genetic data were collected through GeneMatcher and clinical or genetic networks for 41 novel patients harboring various types ofSOX5 alterations. Functional consequences of selected substitutions were investigated. Microdeletions and truncating variants occurred throughout SOX5. In contrast, most missense variants clustered in the pivotal SOX-specific high-mobility-group domain. The latter variants prevented SOX5 from binding DNA and promoting transactivation in vitro, whereas missense variants located outside the high-mobility-group domain did not. Clinical manifestations and severity varied among patients. No clear genotype–phenotype correlations were found, except that missense variants outside the high-mobility-group domain were generally better tolerated. This study extends the clinical and genetic spectrum associated with LAMSHF and consolidates evidence that SOX5 haploinsufficiency leads to variable degrees of intellectual disability, language delay, and other clinical features.

We present our first results for a sample of southern high-amplitude delta Scuti stars (HADS), based on a spectrophotometric survey started in 2003. For CY Aqr and AD CMi, we found very stable light and radial velocity curves; we confirmed the double-mode nature of ZZ Mic, BQ Ind and RY Lep. Finally, we detected gamma-velocity changes in RS Gru and RY Lep