Explore the vast range of titles available.

Fecal microbiota transplantation has been primarily investigated as a therapeutic tool for a number of gut disorders. Optimistic results from clinical studies on Clostridium difficile infection, inflammatory bowel disease and irritable bowel syndrome have stimulated the expansion of possible indications in which FMT might represent a game changing approach. Microbial dysbiosis was shown in a number of non-gastrointestinal disorders. Moreover, FMT was proven to be effective in therapy of numerous animal models of disease. However, only a proportion of these disorders have been addressed in clinical studies using FMT. These include obesity, non-alcoholic fatty liver disease, cardiovascular inflammation and neurological disorders such as autism, depression and Parkinson's disease. Results from preclinical and clinical studies also outlined possible molecular mechanisms that contribute to alleviation of the disease. These range from increasing the circulating levels of microbial metabolites (trimethylamine N-oxide, lipopolysaccharide, short chain fatty acids) to stimulation of the enteric nervous system. Several methodological shortcomings are still to be addressed; however, positive results of the clinical studies indicate that further investigation of FMT as a therapeutic tool for non-gastrointestinal disorders can be expected in upcoming years.

Circulating extracellular DNA (ecDNA) is known to worsen the outcome of many diseases. ecDNA released from neutrophils during infection or inflammation is present in the form of neutrophil extracellular traps (NETs). It has been shown that higher ecDNA concentration occurs in a number of inflammatory diseases including inflammatory bowel disease (IBD). Enzymes such as peptidyl arginine deiminases (PADs) are crucial for NET formation. We sought to describe the dynamics of ecDNA concentrations and fragmentation, along with NETosis during a mouse model of chemically induced colitis. Plasma ecDNA concentration was highest on day seven of dextran sulfate sodium (DSS) intake and the increase was time-dependent. This increase correlated with the percentage of cells undergoing NETosis and other markers of disease activity. Relative proportion of nuclear ecDNA increased towards more severe colitis; however, absolute amount decreased. In colon explant medium, the highest concentration of ecDNA was on day three of DSS consumption. Early administration of PAD4 inhibitors did not alleviate disease activity, but lowered the ecDNA concentration. These results uncover the biological characteristics of ecDNA in IBD and support the role of ecDNA in intestinal inflammation. The therapeutic intervention aimed at NETs and/or nuclear ecDNA has yet to be fully investigated.

Background: The role of cell-free DNA (cfDNA) in the pathogenesis of inflammatory bowel disease (IBD) has been recently suggested. The aim of this study was to analyze circulating cfDNA and deoxyribonuclease (DNase) activity in IBD patients in clinical remission. Materials and Methods: Plasma and serum were obtained from 72 patients with Crohn's disease and 28 patients with ulcerative colitis. Total cfDNA, nuclear DNA (ncDNA), mitochondrial DNA (mtDNA) and DNase activity were measured. Results: IBD patients showed higher levels of both ncDNA and mtDNA compared to healthy controls. Concentration of ncDNA was higher in males compared to females, including patients and healthy controls. However, unlike males higher amount of ncDNA was found in female IBD patients compared to healthy controls. DNase activity was significantly lower in male IBD patients compared with healthy controls. In addition, there was a negative correlation between DNase activity and ncDNA levels in male IBD patients. Conclusions: Herein we present increased amount of circulating ncDNA and mtDNA in IBD patients in clinical remission. Thus, unlike total cfDNA, circulating ncDNA and mtDNA might not represent the optimal biomarkers of disease activity. This is also the first report on sex difference in circulating ncDNA levels, possibly associated with lower DNase activity in males.

Resveratrol is a natural polyphenol studied for its possible protective properties in inflammatory bowel diseases. Moreover, it has been shown to interact with estrogen receptors. In the present study, we aimed to investigate possible diverse effects of resveratrol on female and male mice in DSS-induced colitis. Thirty-seven C57BL/6 mice (21 female and 16 male) were divided into three groups for each sex. The first group received pure water (CTRL). The other two groups received 1.5% dextran sulfate sodium (DSS) to induce colitis from which one group was treated with resveratrol (DSS + RSV). Intake of 1.5% DSS caused weight loss in all DSS groups compared to control mice. Weight loss, stool consistency, and discomfort did not show any protective effect of resveratrol in males and showed even adverse effects in females. In females, the activity of myeloperoxidase was lower compared to that in males. However, colon length and spleen weight showed no sex differences, which can indicate the induction of only mild colitis in mice. Resveratrol did not have any effect on TNF-alpha levels. Taken together, these results for the first time propose possible diverse effects of resveratrol in DSS-induced colitis model depending on the sex of the animal. However, this conclusion must be confirmed by further analyses.

Recent studies show that the salivary microbiome in subjects with obesity differ from those without obesity, but the mechanism of interaction between the salivary microbiome composition and body weight is unclear. Herein we investigate this relation by analyzing saliva samples from 35 adult patients with obesity undergoing bariatric surgery. Our aim was to describe salivary microbiome changes during body weight loss on an individual-specific level, and to elucidate the effect of bariatric surgery on the salivary microbiome which has not been studied before. Analysis of samples collected before and 1 day after surgery, as well as 3 and 12 months after surgery, showed that the salivary microbiome changed in all study participants, but these changes were heterogeneous. In the majority of participants proportions of Gemella species , Granulicatella elegans, Porphyromonas pasteri, Prevotella nanceiensis and Streptococcus oralis decreased, while Veillonella species , Megasphaera micronuciformis and Prevotella saliva increased. Nevertheless, we found participants deviating from this general trend which suggests that a variety of individual-specific factors influence the salivary microbiome composition more effectively than the body weight dynamics alone. The observed microbiome alternations could be related to dietary changes. Therefore, further studies should focus on association with altered taste preferences and potential oral health consequences.

Saliva can be used as an alternative diagnostic fluid enabling easy and non-invasive disease monitoring. Urea and creatinine can be measured in saliva and both were shown to be increased in renal failure. However, the dynamics of these markers during the development of kidney diseases is unknown. We aimed to describe the dynamics of salivary urea and creatinine in various animal models of acute kidney injury (AKI) and chronic kidney disease (CKD) and in patients with different stages AKI or CKD. Ninety Wistar rats underwent bilateral nephrectomy (BNX), ischemia–reperfusion injury (IRI) or glycerol-induced kidney injury to model AKI. CKD was modelled using 5/6 nephrectomy. In the clinical part 57 children aged 12.6 ± 4.9 years with AKI (n = 11) or CKD (n = 46) and 29 healthy controls (aged 10.2 ± 3.7 years) were enrolled. Saliva and blood samples were collected in both, animal experiments and the human study. In animal models of AKI, plasma urea and creatinine were higher than in controls. An increase of salivary urea and creatinine (twofold) was observed in BNX and IRI, but only after 12 h and 24 h, respectively. In glycerol nephropathy and 5/6 nephrectomy, salivary urea increased (by 100% and by 50%), while salivary creatinine did not change during the observation period. Salivary urea and creatinine were significantly higher in all patients compared to controls (threefold) and in both, AKI and CKD they were associated with the severity of renal failure. Plasma and salivary concentrations correlated only in children with renal failure (R = 0.72 for urea; R = 0.93 for creatinine), but not in controls (R = -0.007 for urea; R = 0.02 for creatinine). Our study indicates that during the development of renal impairment saliva could be used for non-invasive monitoring in higher stages of AKI or CKD, rather than for screening of early stages of kidney diseases.

The Hungarian society and the Hungarian state are constantly increasing their solar capacity. More and more solar power plants are being put into operation. The largest of these has a 100 MW peak capacity. Such power plants do not require constant maintenance. However, in the case of low productivity, a conditional assessment is required. The reason for production loss can also be manufacturing, installation, and operational errors. A flying drone was used for finding failures by thermographic scouting. Furthermore, electroluminescent (EL) and flash tests give a comprehensive view of the real state of the modules in a mobile laboratory. We had the opportunity to summarize these test results of more than a thousand modules operating in a solar power plant. The report on the power plant shows that a significant part of the modules became unusable in a short time. After four years, 10% of the 260 Wp modules suffered a performance reduction of more than 10%.

A jelenlegi villamosenergia-ellátási rendszer hátránya az, hogy a termelés és nagy távolságra való szállítás következtében kedvezőtlen a rendszer hatásfoka, továbbá teljes áramkimaradás miatt a rendszer sebezhető. Az intelligens hálózatok célja, hogy orvosolja a jelenlegi hálózat jelentős gyengeségeit és lehetőséget teremtsen a szolgáltatásban résztvevőknek, hogy folyamatos információ legyen a hálózati elemekről, valamint a hálózat állapotáról és a működéséről. A Microgrid hálózatok rendelkeznek kommunikációs hálózattal, valamint vezérlőrendszerrel is, amely lehetővé teszi a rendszer szabályozását. Az intelligens Microgrid hálózatok struktúráját úgy tervezik meg, illetve alakítják ki, hogy csatlakoztatható, valamint leválasztható legyen a közüzemi villamos hálózatról, ezáltal az intelligens vezérlő rendszer lehetőséget biztosít arra, hogy a villamosenergia termelése és annak felhasználása optimalizálva legyen.

Renewable energy sources, especially solar systems, have become increasingly important energy sources in recent times. Connecting large PV systems to utility networks can cause a number of operational problems for distribution networks. The extent of these problems depends directly on the percentage of PV penetration and the geographical location of the installation. Possible problems caused by PV systems: over-voltage, output power fluctuation, harmonic distortion, frequency fluctuation Harmonic distortion is a serious energy quality problem which can occur in photovoltaic systems due to the use of power inverters that convert direct current to alternating current. The resulting harmonics can cause parallel and series resonances, transformer overheating, and protection device malfunctions, which can reduce the reliability of power supply systems.

In solar systems, faults in the module and inverter occur in proportion to increased operating time. The identification of fault types and their effects is important information not only for manufacturers but also for investors, solar operators and researchers. Monitoring and diagnosing the condition of photovoltaic (PV) systems is becoming essential to maximize electric power generation, increase the reliability and lifetime of PV power plants. Any faults in the PV modules cause negative economic and safety impacts, reducing the performance of the system and making unwanted electric connections that can be dangerous for the user. In this paper have been classified all possible faults that happen in the PV system, and is presented to detect common PV array faults, such as open-circuit fault, line-to-line fault, ground fault, shading condition, degradation fault and bypass diode fault. In this studies examines the equivalent circuits of PV arrays with different topological configurations and fault conditions to evaluate the effects of these faults on the performance of a solar system, taking into account the influence of temperature and solar radiation. This work presents the validation of a simulated solar network by measuring the output curves of a low-power photovoltaic array system under real outdoor conditions. This method can be useful in future solar systems.