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Presents essays responding to a question about what scientific term or concept ought to be more widely known, written by such authors as Jared Diamond, Richard Thaler, Richard Dawkins, Lisa Randall, Steven Pinker, and Carlo Roveri.

Abstract Observing negative and positive valence virtual stimuli can influence the onlookers’ subjective and brain reactivity. However, the relationship between vicarious experiences, observer’s perspective-taking, and cerebral activity remains underexplored. To address this gap, we asked 24 healthy participants to passively observe pleasant, painful, and neutral stimuli delivered to a virtual hand seen from a first-person (1PP) or third-person perspective (3PP) while undergoing time and time–frequency EEG recording. Participants reported a stronger sense of ownership over the virtual hand seen from a 1PP, rated pain and touch valence appropriately, and more intense than the neutral ones. Distinct EEG patterns emerged across early (N2, early posterior negativity, EPN), late (late positive potential, LPP) event-related potentials, and EEG power. The N2 and EPN components showed greater amplitudes for pain and pleasure than neutral stimuli, particularly in 1PP. The LPP component exhibited lower amplitudes for pleasure than pain and neutral stimuli. Furthermore, theta-band power increased, and alpha power decreased for pain and pleasure stimuli viewed from a 1PP vs. 3PP perspective. In the ultra-late time window, we observed decreased theta, alpha, and beta-band power specifically associated with pleasure stimuli. Our study provides novel evidence that perspective-taking modulates the temporal dynamics of vicarious pain and pleasure.

Right ventricular failure (RVF) after left ventricular assist device (LVAD) implant is associated with increasing morbidity and mortality. The aim of this study was to identify the best predictors of RVF post LVAD-implant among biochemical, haemodynamic and echocardiographic parameters. From 2009 to 2019, 38 patients who underwent LVAD implantation at our centre were prospectively enrolled. Preoperative clinical, laboratory, echocardiographic and haemodynamic parameters were reported. Overall, eight patients (21%) developed RVF over time, which revealed to be strongly related to overall mortality. Pulmonary artery pulsatility index (PAPi) resulted to be the most significant right heart catheterization index in discriminating RVF vs no RVF patients [(1.32 ± 0.26 vs. 3.95 ± 3.39 respectively) p = 0.0036]. Regarding transthoracic echocardiography, RVF was associated with reduced free wall right ventricular longitudinal strain (fw-RVLS) (− 7.9 ± 1.29 vs. − 16.14 ± 5.83) (p < 0.009), which was superior to other echocardiographic determinants of RVF. Among laboratory values, N-terminal pro-brain natriuretic peptide (NT-proBNP) was strongly increased in RVF patients [(10,496.13 pg/ml ± 5272.96 pg/ml vs. 2865, 5 pg/ml ± 2595.61 pg/ml) p = 0.006]. PAPi, NT-proBNP and fwRVLS were the best pre-operative predictors of RVF, a post-LVAD implant complication which was confirmed to have a great impact on survival. In particular, fwRVLS has been proven to be the strongest independent predictor.

This paper explores multi-instrument space-borne observations in order to validate physical concepts of Lithosphere-Atmosphere-Ionosphere Coupling (LAIC) in relation to a selection of major seismic events. In this study we apply some validated techniques to observations in order to identify atmospheric and ionospheric precursors associated with some of recent most destructive earthquakes: M8.6 of March 28, 2005 and M8.5 of Sept. 12, 2007 in Sumatra, and M7.9 of May 12, 2008 in Wenchuan, China. New investigations are also presented concerning these three earthquakes and for the M7.2 of March 2008 in the Xinjiang-Xizang border region, China (the Yutian earthquake). It concerns the ionospheric density, the Global Ionospheric Maps (GIM) of the Total Electron Content (TEC), the Thermal Infra-Red (TIR) anomalies, and the Outgoing Longwave Radiation (OLR) data. It is shown that all these anomalies are identified as short-term precursors, which can be explained by the LAIC concept proposed in [S. Pulinets, D. Ouzounov, J. Asian Earth Sci. 41 , 371 (2011)].

Objective:To determine whether vascular function assessed by low-flow-mediated constriction (L-FMC), a novel non-invasive method, complements the information obtained with “traditional” flow-mediated dilatation (FMD).Design and patients:In protocol 1, 12 healthy young volunteers underwent FMD and L-FMC measurements at rest and immediately after isometric exercise of the same hand. In protocol 2, 24 patients with coronary artery disease, 24 with congestive heart failure, 24 hypertensive patients and 64 healthy volunteers were enrolled to undergo L-FMC and FMD measurements.Results:In protocol 1, exercise was associated with mean (SD) increases in radial artery blood flow, diameter and L-FMC (from −5.1 (1.5)% to −7.8 (3.4)%, p<0.05), while FMD was significantly blunted (from 6.0 (2.4)% to 3.0 (3.2)%, p<0.05). In protocol 2, both FMD and L-FMC were blunted in the patient groups. Receiver operating curve analysis showed that, as compared with FMD alone, the combination of L-FMC and FMD significantly improved the sensitivity and specificity in detecting patients diagnosed with cardiovascular disease (p<0.05).Conclusion:In the first protocol, FMD and L-FMC were shown to be reciprocally regulated. A blunted FMD may, in certain cases, be an expression of increased resting vascular activation and not only of impaired endothelial function. In the second protocol, a statistical approach showed that implementation of L-FMC provides a better characterisation than FMD of vascular function in cardiovascular disease. Vascular (endothelial) function is a complex phenomenon which requires a multifaceted approach; it is suggested that a combination of L-FMC and FMD will provide additive and complementary information to “traditional” FMD measurements.

Purpose We analyzed outcomes of doxorubicin-cyclophosphamide (AC) followed by weekly paclitaxel as neoadjuvant chemotherapy (NAC) for breast cancer (BC), in an everyday practice with long-term follow-up of patients. Methods All patients ( n  = 200) who received the AC-paclitaxel combination as NAC for BC at the Soroka University Medical Center from 2003 to 2012 were included in this retrospective cohort study. AC was administered on an every 3-week schedule (standard dose) until May, 2007 ( n  = 99); and subsequently every 2-week dose dense (dd) ( n  = 101). Clinical pathologic features, treatment course, and outcome information were recorded. Complete pathologic response (pCR) was analyzed according to BC subtype, dose regimen, and stage. Results Median age was 49 years; 55.5% and 44.5% of patients were clinically stage 2 and 3, respectively. Standard dose patients had more T3 tumors. Subtypes were human epidermal growth factor receptor-2 (HER2)-positive 32.5% (of whom 82% received trastuzumab), hormone receptor-positive/HER2-negative 53%, and triple negative 14.5%. Breast-conserving surgery (BCS) was performed in 48.5% of patients; only 9.5% were deemed suitable for BCS prior to NAC. Toxicity was acceptable. The overall pCR rate was 26.0% and was significantly higher in the dd group and HER2-positive patients. With a median follow-up of 9.51 years median event-free survival (EFS) and overall survival (OS) are 10.85 years and 12.61 years, respectively. Patients achieving pCR had significantly longer EFS and OS. Conclusion NAC for BC with AC-paclitaxel can be safely administered in the “real-world’ setting with high efficacy. Current efforts are aimed at increasing rates of pCR and identifying patients who may benefit from additional therapy or conversely, de-escalated treatment.

Dissimilar lap joints were produced by friction stir welding (FSW) out of Ti6Al4V titanium alloy and AA2024 aluminum alloy sheets. The joints, welded with varying tool rotation and feed rate, were studied by analyzing the maximum shear strength, Vickers microhardness and optical observations. A dedicated numerical model, able to take into account the presence of the two different alloys, was used to highlight the effects of the process parameters on temperature distribution, strain distribution, and material flow. The combined analysis of experimental measurements and numerical predictions allowed explaining the effects of tool rotation and feed rate on the material flow. It was found that tool rotation had a larger impact on the joint effectiveness with respect to feed rate. A competition between material mixing and heat input occurs with increasing tool rotation, resulting in higher joint strength when lower values of tool rotation are used.

In the last few years, Robust Satellite data analysis Techniques (RST) have been proposed and successfully applied for monitoring major natural and environmental risks. Among the various fields of application, RST analysis has been used as a suitable tool for satellite TIR surveys in seismically active regions, devoted to detect and monitor thermal anomalies possibly related to earthquake occurrence. In this work, RST has been applied, for the first time, to thermal infrared observations collected by MODIS (Moderate Resolution Imaging Spectroradiometer) – the sensor onboard EOS (Earth Observing System) satellites – in the case of Abruzzo (Italy) earthquake occurred on 6 April 2009 (ML~5.8). First achievements, shown in this work, seem to confirm the sensitivity of the proposed approach in detecting perturbations of the Earth s emission thermal field few days before the event. The reliability of such results, based on the analysis of 10 years of MODIS observations, seems to be supported by the results achieved analyzing the same area in similar observation conditions but in seismically unperturbed periods (no earthquakes with ML≥5) that will be also presented.

Space-time fluctuations of Earth's emitted Thermal Infrared (TIR) radiation have been observed from satellite months to weeks before earthquakes occurrence. The general RST approach has been proposed in order to discriminate normal (i.e. related to the change of natural factor and/or observation conditions) TIR signal fluctuations from anomalous signal transient possibly associated to earthquake occurrence. In this work RST approach is applied to the Abruzzo 6 April 2009 event (ML=5.8) by using for the first time MSG-SEVIRI (Meteosat Second Generation -Spinning Enhanced Visible and Infrared Imager) thermal infrared observations. A validation/confutation analysis has been performed in order to verify the presence/absence of anomalous space-time TIR transients in the presence/absence of significant seismic activity. March–April 2009 has been analyzed for validation purposes. Relatively unperturbed periods (no earthquakes with ML≥5) have been taken for confutation. A specific TIR anomalies space-time persistence analysis as well as a cloud coverage distribution test have been introduced in order to eliminate artifacts and outliers both in the validation and confutation phases. Preliminary results show clear differences in TIR anomalies occurrence during the periods used for validation and confutation purposes. Quite clear TIR anomalies appear also to mark main tectonic lines related to the preparatory phases of others, low magnitude (ML~4) earthquakes, occurred in the area.

In patients with severe mitral regurgitation (MR) referred for cardiac surgery, left atrial (LA) remodeling and enlargement are accompanied by mechanical stress, mediated cellular hypertrophy, and interstitial fibrosis that finally lead to LA failure. Speckle tracking echocardiography is a novel non–Doppler-based method that allows an objective quantification of LA myocardial deformation, becoming useful for LA functional analysis. We conducted a study to evaluate the relation between the traditional and novel atrial indexes and the extent of ultrastructural alterations, obtained from patients with severe MR who were undergoing surgical correction of the valvular disease. The study population included 46 patients with severe MR, referred to our echocardiographic laboratory for a diagnostic examination before cardiac surgery. The global peak atrial longitudinal strain (PALS) was measured in all subjects by averaging all atrial segments. LA tissue samples were obtained from all patients. Masson's trichrome staining was performed to assess the extent of the fibrosis. The LA endocardial thickness was measured. A close negative correlation between the global PALS and grade of LA myocardial fibrosis was found (r = −0.82, p <0.0001), with poorer correlations for the LA indexed volume (r = 0.51, p = 0.01), LA ejection fraction (r = 0.61, p = 0.005), and E/E′ ratio (0.14, p = NS). Of these indexes, global PALS showed the best diagnostic accuracy to detect LA fibrosis (area under the curve 0.89), and it appears to be a strong and independent predictor of LA fibrosis. Furthermore, we also demonstrated an inverse correlation between the global PALS and LA endocardial thickness (r = −0.66, p = 0.0001). In conclusion, in patients with severe MR referred for cardiac surgery, impairment of LA longitudinal deformation, as assessed by the global PALS, correlated strongly with the extent of LA fibrosis and remodeling.