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Purpose The purpose of this paper is to reveal the knowledge evolution process, research hotspots and future trends in the accessible tourism research literature from 2008 to 2020. Design/methodology/approach A total of 213 articles on accessible tourism were selected from the core collection database of Web of Science (WoS) and analyzed using CiteSpace. Findings Over the 13-year period between 2008 and 2020, an increasing number of studies have been published concerning accessible tourism, but the overall base is still small. The research content mainly includes six modules. Among institutions, the University of Technology Sydney has published the largest number of papers. Cooperation among countries involves the USA, the United Kingdom, Australia, Portugal and China. Tourism Management is the leading journal for disseminating research on accessible tourism. Definition of “Accessible tourism” and the different scope of this phenomenon are re-discussed. In recent years, “experience” and “participation” have become the “new favorites” in accessible tourism research, which could reveal insights into future research directions. Research limitations/implications The sampling frame was defined in terms of the WoS database and even though this is an important database for global academic information, in the big data era, the authors may have to integrate information from multiple sources to comprehensively reveal and understand knowledge maps. Second, because of the operational constraints of the CiteSpace software, the authors only selected outputs published in peer-reviewed journals, excluding other published works, such as books and conference papers. Finally, because of the language restrictions of the authors, this research is limited to journals published in the English language. Practical implications Practically, the results of this study made a conclusion of accessible tourism research so that the researchers can easily know what has currently been done and what future research can do. Tourism managers can also understand the demands and the constraints of tourism for the people who have barriers to travel. They can supply more specific products for the accessible tourism and further promote the construction of barrier-free travel environments. Originality/value This paper unifies the literature on senior tourism and people with disabilities tourism, and uses CiteSpace to construct data and network visualizations, including a burst and dynamic analysis for the period covered by the sample. Furthermore, this paper proposed a more diversified accessible tourism. 无障碍旅游：文献计量学研究综述 (2008-2020) 目的 此篇论文目的是通过对2008年到2020年间无障碍旅游研究文献进行科学计量和可视化分析, 展示该领域的知识演变进程、研究热点和未来趋势。 设计/方法/途径 从Web of Science核心合集数据库中经过多次筛选, 挑选出213篇文章, 并利用CiteSpace进行分析。 发现 13年来无障碍旅游的研究文献数量总体呈上升趋势, 但总体基数仍然不大, 研究内容主要包含六个模块。机构中悉尼科技大学的发文量最多。国家间的合作以美国、英国、澳大利亚、葡萄牙和中国为基础。主要发行期刊是Tourism Management。本文还对无障碍旅游的定义和内涵重新进行了思考和讨论。近年来“体验”和“参与”成为了无障碍旅游研究中的“新宠”, 揭示出未来的研究方向。 独创性 此篇论文将老年旅游和残障旅游统一起来, 并利用CiteSpace做出清晰的数据和网络展示, 包含了过去13年的突发性和动态性分析。并且, 本文提出了更为广泛和多元的无障碍旅游。 关键词 无障碍旅游; 残障旅游; 老年旅游; 文献综述; CiteSpace 文章类型： 研究综述 Turismo accesible: una revisión bibliométrica (2008–2020) Objetivo El objetivo de este trabajo es revelar el proceso evolutivo del conocimiento, los puntos críticos de la investigación y las futuras tendencias de la literatura de investigación del turismo accesible del 2008 a 2020. Diseño/metodología/enfoque De la base de datos central de la red científica, se seleccionaron 213 artículos sobre turismo accesible y se analizaron utilizando citespace. Resultados En los 13 años transcurridos entre 2008 y 2020 se han realizado cada vez más publicaciones relacionadas con el turismo accesible, pero la base general sigue siendo pequeña. Las investigaciones incluyen principalmente seis módulos. Entre los institutos, la Universidad Tecnológica de Sídney a publicado el mayor número de investigaciones. La cooperación entre los países incluye a los Estados Unidos, Reino Unido, Australia, Portugal y China. La “Tourism Management” es la principal revista de investigación sobre el turismo accesible. Este artículo rediscute la definición de “turismo accesible” y el diferente alcance de este fenómeno. En los últimos años, la “experiencia” y la “participación” se han convertido en el “nuevo favorito” de las investigaciones sobre el turismo accesible, lo que podría revelar perspectivas con relación a la dirección de futuras investigaciones. Originalidad/valor Esta investigación combina la literatura relacionada con el turismo adulto mayor y personas con discapacidad, utiliza citespace para construir los datos y la visualización de la red, incluyendo un análisis dinámico y de ráfagas para el período cubierto por la muestra. Además, este documento propone un turismo accesible más diversificado. Palabras clave Turismo accesible, Personas con discapacidad, Adulto mayor, Bibliometría, CiteSpace Tipo de trabajo RevisiÓn de la literatura

ترصد موسوعة \"تاريخ التبادلات الأدبية الصينية العربية\" مسيرة التبادلات الثقافية والأدبية منذ القدم بين الحضارتين الصينية والعربية، والترجمات الصينية الأولى للأدب العربي، كما تسلط الضوء على الأدب الصيني في الدول العربية، ورحلة التبادلات بين الأدباء العرب والصينيين والأحداث التاريخية التي واكبت محطات حركة التبادلات الأدبية بين الجانبين. كما ترصد التاريخ الطويل للأمة العربية في التواصل التجاري والثقافي والأدبي مع الصين، حيث عرفت الصين العرب منذ القرن الثاني قبل الميلاد مع رحلة المبعوث الصيني تشانغ تشيان إلى الغرب في عصر الإمبراطور هان وو دي، ثم عبر طريق الحرير البري القديم وطريق الحرير البحري \"طريق التوابل\" اللذين شهدا تدفقا للتجار العرب على الصين لتنتعش التبادلات الثقافية والأدبية إلى جانب التجارية بين الجانبين يوما بعد يوم.

Araliaceae species produce various classes of triterpene and triterpenoid saponins, such as the oleanane-type triterpenoids in Aralia species and dammarane-type saponins in Panax , valued for their medicinal properties. The lack of genome sequences of Panax relatives has hindered mechanistic insight into the divergence of triterpene saponins in Araliaceae. Here, we report a chromosome-level genome of Aralia elata with a total length of 1.05 Gb. The loss of 12 exons in the dammarenediol synthase (DDS)-encoding gene in A . elata after divergence from Panax might have caused the lack of dammarane-type saponin production, and a complementation assay shows that overexpression of the PgDDS gene from Panax ginseng in callus of A. elata recovers the accumulation of dammarane-type saponins. Tandem duplication events of triterpene biosynthetic genes are common in the A. elata genome, especially for AeCYP72As , AeCSLMs , and AeUGT73s , which function as tailoring enzymes of oleanane-type saponins and aralosides. More than 13 aralosides are de novo synthesized in Saccharomyces cerevisiae by overexpression of these genes in combination. This study sheds light on the diversity of saponins biosynthetic pathway in Araliaceae and will facilitate heterologous bioproduction of aralosides. Unlike Panax species, which can produce dammarane-type saponins, Aralia elata can only synthesize oleananetype saponins. Here, the authors reveal that the loss of the dammaranediol synthase-encoding gene and tandem duplication of triterpene biosynthetic genes drive structural divergences of saponins between the two genera.

The rapid development of electric vehicle (EV) technology and the consequent charging demand have brought challenges to the stable operation of distribution networks (DNs). The problem of the collaborative optimization of the charging scheduling of EVs and voltage control of the DN is intractable because the uncertainties of both EVs and the DN need to be considered. In this paper, we propose a deep reinforcement learning (DRL) approach to coordinate EV charging scheduling and distribution network voltage control. The DRL-based strategy contains two layers, the upper layer aims to reduce the operating costs of power generation of distributed generators and power consumption of EVs, and the lower layer controls the Volt/Var devices to maintain the voltage stability of the distribution network. We model the coordinate EV charging scheduling and voltage control problem in the distribution network as a Markov decision process (MDP). The model considers uncertainties of charging process caused by the charging behavior of EV users, as well as the uncertainty of uncontrollable load, system dynamic electricity price and renewable energy generation. Since the model has a dynamic state space and mixed action outputs, a framework of deep deterministic policy gradient (DDPG) is adopted to train the two-layer agent and the policy network is designed to output discrete and continuous control actions. Simulation and numerical results on the IEEE-33 bus test system demonstrate the effectiveness of the proposed method in collaborative EV charging scheduling and distribution network voltage stabilization.

This study adopts the revised gravity model to construct the spatial association network of trade in RECP countries and reveals its characteristics through a social network analysis method. The results are as follows: the spatial correlation of trade among RECP countries presents a complex, multithreaded network structure; the spatial correlation network of trade among RECP countries appears to fluctuate, indicating that their correlations, although influenced by the national environment, are still moving in the direction of regional integration; the degree centrality of China, Australia, and Korea is higher in terms of intermediary centrality and proximity centrality. This indicates that these countries are not only at the core of the network and have many associated relationships with other countries but also all are located at the center of the trade spatial association network; and the analysis results of the block model show that the trade spatial association network of RECP countries can be divided into four sections: net spillover, net benefit, broker, and two-way spillover. The spillover effect between the two sections has obvious gradient transmission characteristics.

Quantum teleportation of single-photon qubits from a ground observatory to a satellite in low-Earth orbit via an uplink channel is achieved with a fidelity that is well above the classical limit. Quantum security in orbit The laws of quantum physics give rise to protocols for ultra-secure cryptography and quantum communications. However, to be useful in a global network, these protocols will have to function with satellites. Extending existing protocols to such long distances poses a tremendous experimental challenge. Researchers led by Jian-Wei Pan present a pair of papers in this issue that take steps toward a global quantum network, using the low-Earth-orbit satellite Micius. They demonstrate satellite-to-ground quantum key distribution, an integral part of quantum cryptosystems, at kilohertz rates over 1,200 kilometres, and report quantum teleportation of a single-photon qubit over 1,400 kilometres. Quantum teleportation is the transfer of the exact state of a quantum object from one place to another, without physical travelling of the object itself, and is a central process in many quantum communication protocols. These two experiments suggest that Micius could become the first component in a global quantum internet. An arbitrary unknown quantum state cannot be measured precisely or replicated perfectly 1 . However, quantum teleportation enables unknown quantum states to be transferred reliably from one object to another over long distances 2 , without physical travelling of the object itself. Long-distance teleportation is a fundamental element of protocols such as large-scale quantum networks 3 , 4 and distributed quantum computation 5 , 6 . But the distances over which transmission was achieved in previous teleportation experiments, which used optical fibres and terrestrial free-space channels 7 , 8 , 9 , 10 , 11 , 12 , were limited to about 100 kilometres, owing to the photon loss of these channels. To realize a global-scale ‘quantum internet’ 13 the range of quantum teleportation needs to be greatly extended. A promising way of doing so involves using satellite platforms and space-based links, which can connect two remote points on Earth with greatly reduced channel loss because most of the propagation path of the photons is in empty space. Here we report quantum teleportation of independent single-photon qubits from a ground observatory to a low-Earth-orbit satellite, through an uplink channel, over distances of up to 1,400 kilometres. To optimize the efficiency of the link and to counter the atmospheric turbulence in the uplink, we use a compact ultra-bright source of entangled photons, a narrow beam divergence and high-bandwidth and high-accuracy acquiring, pointing and tracking. We demonstrate successful quantum teleportation of six input states in mutually unbiased bases with an average fidelity of 0.80 ± 0.01, well above the optimal state-estimation fidelity on a single copy of a qubit (the classical limit) 14 . Our demonstration of a ground-to-satellite uplink for reliable and ultra-long-distance quantum teleportation is an essential step towards a global-scale quantum internet.

TCP gene family are specific transcription factors for plant, and considered to play an important role in development and growth. However, few related studies investigated the TCP gene trait and how it plays a role in growth and development of Orchidaceae. In this study, we obtained 14 TCP genes ( CgTCPs ) from the Spring Orchid Cymbidium goeringii genome. The classification results showed that 14 CgTCPs were mainly divided into two clades as follows: four PCF genes (Class I), nine CIN genes and one CYC gene (Class II). The sequence analysis showed that the TCP proteins of C. goeringii contain four conserved regions (basic Helix-Loop-Helix) in the TCP domain. The exon−intron structure varied in the clade according to a comparative investigation of the gene structure, and some genes had no introns. There are fewer CgTCP homologous gene pairs compared with Dendrobium catenatum and Phalaenopsis equestris , suggesting that the TCP genes in C. goeringii suffered more loss events. The majority of the cis -elements revealed to be enriched in the function of light responsiveness, followed by MeJA and ABA responsiveness, demonstrating their functions in regulating by light and phytohormones. The collinearity study revealed that the TCPs in D. catenatum , P. equestris and C. goeringii almost 1:1. The transcriptomic data and real-time reverse transcription-quantitative PCR (RT−qPCR) expression profiles showed that the flower-specific expression of the TCP class II genes ( CgCIN2 , CgCIN5 and CgCIN6 ) may be related to the regulation of florescence. Altogether, this study provides a comprehensive analysis uncovering the underlying function of TCP genes in Orchidaceae.

Immunocompromised conditions, including cancer, increase the risk of herpes zoster, a vaccine-preventable disease. However, evidence on vaccine uptake among patients with cancer is limited. This study aimed to (1) evaluate trends in herpes zoster vaccination and (2) identify factors associated with vaccination among U.S. older adults with cancer. Data were obtained from the 2008–2023 U.S. National Health Interview Survey. Joinpoint regression analysis was used to assess vaccination trends. A multivariable logistic regression model was used to identify factors associated with herpes zoster vaccination. A total of 14,809 participants with cancer were included, representing approximately 5.6 million U.S. older adults with cancer. From 2008 to 2023, herpes zoster vaccination rates increased significantly among those with cancer (average annual percent change [AAPC] = 13.64; P < 0.01) and without cancer (AAPC = 14.20; P < 0.01), with consistently higher rates in the cancer group (P < 0.01). This upward trend persisted across all age groups for those with cancer. Disparities in vaccination were observed by age, sex, race/ethnicity, region, educational level, health insurance, income, flu vaccination, number of comorbidities, number of cancers, and years since cancer diagnosis. Herpes zoster vaccination rates have surged among U.S. older adults with cancer over the past 16 years. However, significant disparities remain. Targeted interventions and supportive policies are critical to achieving equitable vaccine coverage in this at-risk population. •From 2008 to 2023, there is an increasing trend in herpes zoster vaccination among U.S. adults with cancer aged 50 and over.•The increasing trend was also observed when stratified by age groups.•Disparities across several characteristics exist, highlighting the importance for targeted policies and interventions.

Tea plant ( Camellia sinensis (L.) O. Kuntze) is one of the most important economic crops with multiple mutants. Recently, we found a special tea germplasm that has an aberrant tissue on its branches. To figure out whether this aberrant tissue is associated with floral bud (FB) or dormant bud (DB), we performed tissue section, transcriptome sequencing, and metabolomic analysis of these tissues. Longitudinal sections indicated the aberrant tissue internal structure was more like a special bud (SB), but was similar to that of DB. Transcriptome data analysis showed that the number of heterozygous and homozygous SNPs was significantly different in the aberrant tissue compared with FB and DB. Further, by aligning the unmapped sequences of the aberrant tissue to the Non-Redundant Protein Sequences (NR) database, we observed that 36.13% of unmapped sequences were insect sequences, which suggested that the aberrant tissue might be a variation of dormant bud tissue influenced by the interaction of tea plants and insects or pathogens. Metabolomic analysis showed that the differentially expressed metabolites (DEMs) between the aberrant tissue and DB were significantly enriched in the metabolic pathways of biosynthesis of plant hormones and biosynthesis of phenylpropanoids. Subsequently, we analyzed the differentially expressed genes (DEGs) in the above mentioned two tissues, and the results indicated that photosynthetic capacity in the aberrant tissue was reduced, whereas the ethylene, salicylic acid and jasmonic acid signaling pathways were activated. We speculated that exogenous infection induced programmed cell death (PCD) and increased the lignin content in dormant buds of tea plants, leading to the formation of this aberrant tissue. This study advanced our understanding of the interaction between plants and insects or pathogens, providing important clues about biotic stress factors and key genes that lead to mutations and formation of the aberrant tissue.