Explore the vast range of titles available.

To investigate the targeting effect of toluidine blue-dextran-40 (TB-Dex-40) on the head and neck lymphatic system. Thirty healthy adult New Zealand white rabbits were randomly divided into two groups: the experimental group (TB-Dex-40 group, n = 15) and the control group (TB group, n = 15). In the experimental group, 1.0% TB-Dex-40 (0.14 mOsm/L) was submucosally injected at the lingual margin (1 cm from the tip of the tongue), while in the control group, 1.0% toluidine blue (32.60 mOsm/L) was administered under the same conditions. The time required for the dye to reach and stain the sentinel lymph node (SLN) was recorded, and the diffusion range of the dyes in the tongue was measured. SLN samples were collected at 30 min and 2 h post-injection for histopathological examination. SLN staining persistence was observed at 1 day, 2 days, and 4 weeks post-injection. Routine blood and biochemical tests were conducted before and 2 weeks after the experiment to evaluate systemic safety. Additionally, in two separate rabbits, the two dyes were injected into the common carotid artery to observe their effects on cervical lymph nodes, submandibular glands, and tongue tissue. A sucrose preference test was performed during animal rearing to assess potential neurotoxicity induced by the dyes. In the experimental group, it took (21.67 ± 0.19) seconds for the dye to reach the SLN and stain lymphatic vessels, which was significantly longer than that in the control group [(3.22 ± 0.34) seconds] ( P  < 0.01). The SLN stained in the experimental group remained clearly visible even after 4 weeks, whereas the SLN stained in the control group had completely faded by 2 days. The diffusion range of the dye in the tongue was significantly smaller in the experimental group [(10.53 ± 1.09) mm] compared with the control group [(20.04 ± 1.06) mm] ( P  < 0.01). No abnormalities were detected in the blood parameters of the experimental animals. Neither group exhibited neurological abnormalities. After injection via the common carotid artery, significant staining was observed in the lymph nodes of the TB group but not in the TB-Dex-40 group. TB-Dex-40 demonstrates superior targeting capabilities within the lymphatic system and holds substantial potential for clinical translation. Clinical relevance: TB-Dex-40 exhibits specificity for lymphatic vessels and serves as an effective tracer with significant clinical potential. Its molecular structure provides a robust theoretical foundation for the development of future imaging agents.

In this study, we aimed to evaluate the possible function of miR-130a in atherosclerosis (AS), protection against AS, and its molecular biological mechanism. Apoe-/- mice were fed a high-fat diet as the AS mice model. Human umbilical vein endothelial cells (HUVECs) were used as in vitro model. Serum samples or cells were used to measure the expression of inflammation. Serum samples or cells were used to determine MiRNA expression profiles using the edgeR tool from Bioconductor. Western Blot analysis was used to assess protein expressions of proliferator-activated receptor γ (PPARγ) and nuclear factor (NF)-κB. MiRNA-130a expression was up-regulated in atherosclerotic mice. In addition, over-expression of miRNA-130a promoted inflammation factors [tumor necrosis factor (TNF)-α and interleukin (IL)-1β, IL-6, and IL-8] in the in vitro model of AS. However, down-regulation of miRNA-130a reduced inflammation (suppressed TNF-α, IL-1β, IL-6 and IL-8) in the in vitro model. Furthermore, over-expression of miRNA-130a could also suppress the protein expression of PPARγ and induce NF-κB protein expression in the in vitro model. However, suppression of miRNA-130a induced the protein expression of PPARγ and suppressed NF-κB protein expression in the in vitro model of AS. Activation of PPARγ reduced the pro-inflammatory effects of miRNA-130a on the AS-induced in vitro model. These results strongly support that miRNA-130a suppression can protect against atherosclerosis through inhibiting inflammation by regulating the PPARγ/ NF-κB expression.

Ulcer Ointment (UO), a topical agent derived from traditional Chinese medicine, has been widely used for skin ulcers. This review evaluates its effectiveness and safety. We systematically searched eight databases for randomized controlled trials (RCTs) focusing on UO for skin ulcers. Pooled mean difference (MD) and relative risks (RR) with 95% confidence intervals (CI) were calculated. Fourteen RCTs involving 978 participants with diabetic foot ulcers, venous leg ulcers, acutely infected ulcers, and pressure ulcers were included. Overall study quality was low. Compared with no intervention, UO was associated with a higher healing rate (RR = 2.24, 95% CI: 1.42-3.52, 2 RCTs, n = 140), reduced ulcer area, shorter healing time, lower pain scores, and elevated vascular endothelial growth factor (VEGF) levels. UO were more efficacious than standard topical drugs in healing rate (RR = 1.87, 95% CI: 1.49-2.34, 8 RCTs, n = 462), percentage reduction in ulcer area (RR = 17.82%, 95% CI: 12.63-23.00, 3 RCTs, n = 179), ulcer area (RR = -1.66 cm , 95% CI: -1.98 to -1.35, 3 RCTs, n = 157), healing time, clinical effective rate (RR = 1.21, 95% CI: 1.10-1.32, 9 RCTs, n = 491), TCM symptom complex scores, pain scores, and VEGF levels. Although these differences are statistically significant, the clinical reliability of these benefits remain uncertain. No severe adverse events were reported in the UO group. Based on the currently available low-quality evidence, UO has shown preliminary indications of potential benefits in ulcer healing, improvement of TCM symptoms, pain alleviation, and elevation of VEGF levels. However, the exact efficacy of UO for skin ulcers requires further validation through high-quality double-blind RCTs.

Objective The aim of this study was to evaluate the clinical effectiveness and reliability of an improved maxillary sinus floor elevation technique combined with immediate implant placement in patients with insufficient residual bone height in the posterior maxilla. Methods A total of 64 edentulous patients with inadequate posterior maxillary bone height were enrolled. Among these patients, 34 underwent the improved maxillary sinus floor elevation technique with simultaneous implant placement, whereas 30 underwent the conventional bone chisel technique under the same surgical protocol. Radiological and clinical assessments were performed to comprehensively evaluate the effectiveness of the improved technique and to compare its osteogenic outcomes with those of the conventional method. Results The mean immediate increase in vertical bone height was significantly greater in the improved technique group (6.016 ± 1.312 mm) than in the bone chisel group (2.797 ± 0.898 mm; P  < 0.001). Significant differences were also observed between the two groups in terms of apical bone coverage along the implant axis immediately postoperatively and at the 6–10 month follow-up ( P  < 0.001). Similarly, peri-implant bone coverage significantly increased in the improved technique group at both time points ( P  < 0.001). No significant differences were found in the short-term implant success or survival rates between the two groups. Notably, no intraoperative maxillary sinus membrane perforations occurred in the improved technique group, and postoperative complications were limited to mild swelling and pain at the surgical site. Conclusion The improved maxillary sinus floor elevation technique yields favourable clinical outcomes in patients with severely resorbed posterior maxillae, particularly when the residual bone height is smaller than 5 mm. This technique constitutes a viable alternative to lateral window sinus augmentation for such cases.

To investigate the effects of Bletilla striata polysaccharides (BSPs) on the proliferation and migration of human gingival fibroblasts (HGFs) on titanium surfaces and clarify the regulatory role of the PI3K/AKT signaling pathway. Primary HGFs were isolated from healthy gingival tissues and subjected to hematoxylin‒eosin (HE) staining and immunofluorescence (purity ≥ 95%). HGFs were cocultured with titanium sheets and divided into control, BSP (800 µg/mL, optimal concentration), and BSP + wortmannin (WM, PI3K inhibitor) groups. Cell proliferation was evaluated by a CCK-8 assay, live/dead staining, and quantitative real-time PCR (qRT‒PCR) for Ki67 and PCNA mRNA expression. Cell migration was detected by scratch wound healing and Transwell assays. ELISA was used to measure the secretion of fibronectin (FN) and type I collagen (COLI) in the culture medium. Scanning electron microscopy (SEM) was used to observe the cell morphology on the titanium surfaces. HE staining and immunofluorescence confirmed the successful isolation and identification of HGFs. BSPs significantly promoted HGF proliferation, as evidenced by increased CCK-8 absorbance, a higher live cell ratio, an increased proportion of Ki67/PCNA double-positive cells, and increased mRNA and protein expression levels of Ki67 and PCNA (P < 0.01). Scratch and Transwell assays revealed that BSPs enhanced HGF migratory capacity, accompanied by increased secretion of FN and COLI (P < 0.01). SEM revealed that BSPs improved cell spreading and surface coverage on titanium. Mechanistically, BSPs activated the PI3K/AKT pathway, and WM cotreatment abolished both the pathway activation and the proproliferative and promigratory effects of BSPs. BSPs promote the proliferation and migration of HGFs on titanium surfaces by activating the PI3K/AKT signaling pathway, which is associated with the upregulation of Ki67 and PCNA expression and increased FN and COLI secretion. This study provides experimental evidence for the potential application of BSPs as bioactive agents in peri-implant soft tissue regeneration, but these findings require further in vivo validation.

Reuse of retired aircraft is an intuitive manifestation of the effective combined development of the aviation industry and the circular economy, which involves the conversion of passenger aircraft to cargo and aircraft dismantling. In the new era, it shows the characteristics of intensive development of technology and capital. According to the operation scale of China’s aircraft in recent years, with the improvement of scientific research and technology, the number of aircraft fleets is also growing continuously, and the corresponding number of retired aircraft is also increasing every year, which proves that the development of China’s retired aircraft reuse industry has a very broad prospect. Therefore, on the basis of understanding the current global trend of aircraft life-cycle training and utilization, this paper calculates the FA model based on the potential output value of the retired aircraft recycling industry based on the FA-SD model, analyzes the empirical analysis and prediction of the evaluation model of the retired aircraft recycling potential, and identifies the effective measures for future development.

This study constructs a multi-stage hybrid forecasting model using hog price time series data and its influencing factors to improve prediction accuracy. First, seven benchmark models including Prophet, ARIMA, and LSTM were applied to raw price series, where results demonstrated that deep learning models significantly outperformed traditional methods. Subsequently, STL decomposition decoupled the series into trend, seasonal, and residual components for component-specific modeling, achieving a 22.6% reduction in average MAE compared to raw data modeling. Further integration of Spearman correlation analysis and PCA dimensionality reduction created multidimensional feature sets, revealing substantial accuracy improvements: The BiLSTM model achieved an 83.6% cumulative MAE reduction from 1.65 (raw data) to 0.27 (STL-PCA), while traditional models like Prophet showed an 82.2% MAE decrease after feature engineering optimization. Finally, the Beluga Whale Optimization (BWO)-tuned STL-PCA-BWO-BiLSTM hybrid model delivered optimal performance on test sets (RMSE = 0.22, MAE = 0.16, MAPE = 0.99%, R 2 = 0.98 ), exhibiting 40.7% higher accuracy than unoptimized BiLSTM (MAE = 0.27). The research demonstrates that the synergy of temporal decomposition, feature dimensionality reduction, and intelligent optimization reduces hog price prediction errors by over 80%, with STL-PCA feature engineering contributing 67.4% of the improvement. This work establishes an innovative “decomposition-reconstruction-optimization” framework for agricultural economic time series forecasting.

In this letter, a dilating and embedding scheme for constructing sparse multiple‐input and multiple‐output radar arrays is addressed, which seeks to increase the uniform degrees of freedom (uDOFs) and reduce the mutual coupling effects for a given number of transmitters and receivers (Tx/Rx). According to this scheme, a dilated maximum inter‐element spacing constraint (MISC) array with an embedded thinned coprime array in the collocated MIMO radar for DOA estimation is proposed. Theoretical analysis shows that the proposed array can provide higher uDOFs and is robust in a scenario with heavy levels of mutual coupling. Numerical simulations are conducted to validate its aforementioned advantages in line with the design scheme. In this letter, a dilating and embedding scheme for constructing sparse multiple‐input and multiple‐output (MIMO) radar is addressed, which seeks to increase the uniform degrees of freedom and reduce the mutual coupling effect for a given number of transmitters and receivers (Tx/Rx). According to this principle, a dilated maximum inter‐element spacing constraint array with an embedded thinned coprime array in collocated MIMO radar for DOA estimation is proposed.

A new 2D Chebyshev-Sine map with natural evaluation is proposed and its dynamical behavior is analyzed. To investigate its application in information security, a color image encryption algorithm is designed. One-time initial condition expressed as ordered quaternion is extracted from colored non Gaussian noise before each encryption process. The algorithm can achieve desired effect after two rounds by exclusive or (XOR) operation with avalanche effect. Simulation results demonstrated that the speed is fast, so the algorithm is suitable for image encryption over the Cloud.

Bearded irises are ornamental plants with distinctive floral fragrance grown worldwide. To identify the floral scent profiles, twenty-seven accessions derived from three bearded iris, including Iris. germanica, I. pumila and I. pallida were used to investigate the composition and relative contents of floral scent components by headspace solid-phase microextraction (HS-SPME) and gas chromatography–mass spectrometry (GC-MS). A total of 219 floral scent components were detected in blooming flowers. The scent profile varied significantly among and within the three investigated species. Principal component analysis (PCA) indicated that terpenes, alcohols and esters contributed the most to the floral scent components and 1-caryophyllene, linalool, citronellol, methyl cinnamate, β-cedrene, thujopsene, methyl myristate, linalyl acetate, isosafrole, nerol, geraniol were identified as the major components. In a hierarchical cluster analysis, twenty-seven accessions could be clustered into six different groups, most of which had representative scent components such as linalool, citronellyl acetate, thujopsene, citronellol, methyl cinnamate and 1-caryophyllene. Our findings provide a theoretical reference for floral scent evaluation and breeding of bearded irises.