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Engineering trustworthy software systems : 4th International School, SETSS 2018, Chongqing, China, April 7-12, 2018, Tutorial Lectures
This volume contains lectures on leading-edge research in methods and tools for use in computer system engineering; at the 4th International School on Engineering Trustworthy Software Systems, SETSS 2018, held in April 2018 at Southwest University in Chongqing, China. The five chapters in this volume provide an overview of research in the frontier of theories, methods, and tools for software modelling, design, and verification. The topics covered in these chapter include Software Verification with Whiley, Learning Büchi Automata and Its Applications, Security in IoT Applications, Programming in Z3, and The Impact of Alan Turing: Formal Methods and Beyond. The volume provides a useful resource for postgraduate students, resarchers, academics, and engineers in industry, who are interested in theory, methods, and tools for the development of trustworthy software.
Book
Singular angular magnetoresistance in a magnetic nodal semimetal
Transport coefficients of correlated electron systems are often useful for mapping hidden phases with distinct symmetries. Here we report a transport signature of spontaneous symmetry breaking in the magnetic Weyl semimetal cerium-aluminum-germanium (CeAlGe) system in the form of singular angular magnetoresistance (SAMR). This angular response exceeding 1000% per radian is confined along the high-symmetry axes with a full width at half maximum reaching less than 1° and is tunable via isoelectronic partial substitution of silicon for germanium. The SAMR phenomena is explained theoretically as a consequence of controllable high-resistance domain walls, arising from the breaking of magnetic point group symmetry strongly coupled to a nearly nodal electronic structure. This study indicates ingredients for engineering magnetic materials with high angular sensitivity by lattice and site symmetries.
Journal Article
Targeting metabolic dysregulation for fibrosis therapy
Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and there are currently no therapies that can prevent or reverse fibrosis. Metabolic alterations are increasingly recognized as an important pathogenic process that underlies fibrosis across many organ types. As a result, metabolically targeted therapies could become important strategies for fibrosis reduction. Indeed, some of the pathways targeted by antifibrotic drugs in development — such as the activation of transforming growth factor-β and the deposition of extracellular matrix — have metabolic implications. This Review summarizes the evidence to date and describes novel opportunities for the discovery and development of drugs for metabolic reprogramming, their associated challenges, and their utility in reducing fibrosis. Fibrotic therapies are potentially relevant to numerous common diseases such as cirrhosis, non-alcoholic steatohepatitis, chronic renal disease, heart failure, diabetes, idiopathic pulmonary fibrosis, and scleroderma.
Journal Article
Microring resonator-assisted Fourier transform spectrometer with enhanced resolution and large bandwidth in single chip solution
Single chip integrated spectrometers are critical to bring chemical and biological sensing, spectroscopy, and spectral imaging into robust, compact and cost-effective devices. Existing on-chip spectrometer approaches fail to realize both high resolution and broad band. Here we demonstrate a microring resonator-assisted Fourier-transform (RAFT) spectrometer, which is realized using a tunable Mach-Zehnder interferometer (MZI) cascaded with a tunable microring resonator (MRR) to enhance the resolution, integrated with a photodetector onto a single chip. The MRR boosts the resolution to 0.47 nm, far beyond the Rayleigh criterion of the tunable MZI-based Fourier-transform spectrometer. A single channel achieves large bandwidth of ~ 90 nm with low power consumption (35 mW for MRR and 1.8 W for MZI) at the expense of degraded signal-to-noise ratio due to time-multiplexing. Integrating a RAFT element array is envisaged to dramatically extend the bandwidth for spectral analytical applications such as chemical and biological sensing, spectroscopy, image spectrometry, etc.
Here, the authors demonstrate a microring resonator-assisted Fourier-transform spectrometer, which is realized using a thermally tunable photonic Mach-Zehnder interferometer cascaded with a tunable microring resonator to enhance the resolution, all integrated with a photodetector onto a single chip.
Journal Article
Orbital stability analysis and photometric characterization of the second Earth Trojan asteroid 2020 XL5
Trojan asteroids are small bodies orbiting around the
L
4
or
L
5
Lagrangian points of a Sun-planet system. Due to their peculiar orbits, they provide key constraints to the Solar System evolution models. Despite numerous dedicated observational efforts in the last decade, asteroid 2010 TK
7
has been the only known Earth Trojan thus far. Here we confirm that the recently discovered 2020 XL
5
is the second transient Earth Trojan known. To study its orbit, we used archival data from 2012 to 2019 and observed the object in 2021 from three ground-based observatories. Our study of its orbital stability shows that 2020 XL
5
will remain in
L
4
for at least 4 000 years. With a photometric analysis we estimate its absolute magnitude to be
H
r
=
18.5
8
−
0.15
+
0.16
, and color indices suggestive of a C-complex taxonomy. Assuming an albedo of 0.06 ± 0.03, we obtain a diameter of 1.18 ± 0.08 km, larger than the first known Earth Trojan asteroid.
Although Trojan asteroids have been known for decades in other Solar System planets, only one Earth Trojan asteroid was detected. Here, the authors show that recently discovered 2020 XL
5
is the second transient Earth Trojan asteroid.
Journal Article
Role of innate and adaptive immune mechanisms in cardiac injury and repair
Key Points
Cardiac injury can lead to cardiomyocyte death, intense inflammation, scar formation and, over time, adverse cardiac remodelling.
Following injury, cardiac inflammation is triggered by the release of conserved endogenous molecules and the production of pro-inflammatory cytokines and chemokines that lead to cellular infiltration.
Early activation of mast cells leads to neutrophil recruitment, a robust inflammatory response and tissue damage.
Recruited monocytes and resident macrophages modulate both tissue injury and tissue healing.
Macrophage origin may dictate function in the heart. Primitive embryonically derived macrophages mediate cardiac tissue repair, whereas bone marrow-derived monocytes contribute to inflammation following cardiac injury.
Lymphocytes and macrophages are involved in the complex transition from initial cardiac tissue inflammation to wound healing.
This Review describes the immune responses that occur in the heart, explaining how different innate and adaptive immune cell populations can have beneficial or detrimental roles during cardiac tissue injury. In particular, the authors focus on the unique macrophage subsets that are found in the heart and their roles in regenerating damaged cardiac tissue.
Despite the advances that have been made in developing new therapeutics, cardiovascular disease remains the leading cause of worldwide mortality. Therefore, understanding the mechanisms underlying cardiovascular tissue injury and repair is of prime importance. Following cardiac tissue injury, the immune system has an important and complex role in driving both the acute inflammatory response and the regenerative response. This Review summarizes the role of the immune system in cardiovascular disease — focusing on the idea that the immune system evolved to promote tissue homeostasis following injury and/or infection, and that the inherent cost of this evolutionary development is unwanted inflammatory damage.
Journal Article
Quantifying atmospheric nitrogen deposition through a nationwide monitoring network across China
A Nationwide Nitrogen Deposition Monitoring Network (NNDMN) containing 43 monitoring sites was established in China to measure gaseous NH3, NO2, and HNO3 and particulate NH4+ and NO3− in air and/or precipitation from 2010 to 2014. Wet/bulk deposition fluxes of Nr species were collected by precipitation gauge method and measured by continuous-flow analyzer; dry deposition fluxes were estimated using airborne concentration measurements and inferential models. Our observations reveal large spatial variations of atmospheric Nr concentrations and dry and wet/bulk Nr deposition. On a national basis, the annual average concentrations (1.3–47.0 μg N m−3) and dry plus wet/bulk deposition fluxes (2.9–83.3 kg N ha−1 yr−1) of inorganic Nr species are ranked by land use as urban > rural > background sites and by regions as north China > southeast China > southwest China > northeast China > northwest China > Tibetan Plateau, reflecting the impact of anthropogenic Nr emission. Average dry and wet/bulk N deposition fluxes were 20.6 ± 11.2 (mean ± standard deviation) and 19.3 ± 9.2 kg N ha−1 yr−1 across China, with reduced N deposition dominating both dry and wet/bulk deposition. Our results suggest atmospheric dry N deposition is equally important to wet/bulk N deposition at the national scale. Therefore, both deposition forms should be included when considering the impacts of N deposition on environment and ecosystem health.
Journal Article
Metropolitan-scale ion-photon entanglement via a quantum network node with hybrid multiplexing enhancements
Quantum network and quantum repeater are promising ways to scale up a quantum information system. In a functional quantum network, it is required that the distribution rate of heralded remote entanglement should be higher than the decoherence rate of each local node. A promising scheme to accelerate the remote entanglement distribution is through multiplexing enhancement. In this work, we experimentally realize a multiplexed quantum network node based on a chain of
40
Ca
+
ions. We employ a hybrid multiplexing scheme in which maximally 44 time-bin modes are generated and sent through a long fiber to boost the entangling rate. Via this scheme, we can generate heralded ion-photon entanglement with a success rate of 4.28 s
−1
over a 12 km fiber. In addition, a dual-type framework is utilized to protect quantum information from the destructive ion-photon entangling attempts and a memory coherence time of 366 ms is achieved, which has exceeded the entanglement generation time.
Despite recent advances with trappedion-based platforms, achieving quantum networks with link efficiency greater than unity on metropolitan scales is still a challenge. Here, the authors demonstrate a multiplexed quantum network generating heralded entanglement at a rate faster than local decoherence.
Journal Article
Electrospun Nanofibers for Periodontal Treatment: A Recent Progress
Periodontitis is a major threat to oral health, prompting scientists to continuously study new treatment techniques. The nanofibrous membrane prepared via electrospinning has a large specific surface area and high porosity. On the one hand, electrospun nanofibers can improve the absorption capacity of proteins and promote the expression of specific genes. On the other hand, they can improve cell adhesion properties and prevent fibroblasts from passing through the barrier membrane. Therefore, electrospinning has unique advantages in periodontal treatment. At present, many oral nanofibrous membranes with antibacterial, antiinflammatory, and tissue regeneration properties have been prepared for periodontal treatment. First, this paper introduces the electrospinning process. Then, the commonly used polymers of electrospun nanofibrous membranes for treating periodontitis are summarized. Finally, different types of nanofibrous membranes prepared via electrospinning for periodontal treatment are presented, and the future evolution of electrospinning to treat periodontitis is described. Keywords: periodontitis, electrospinning, barrier membrane, antibacterial, anti- inflammatory, tissue regeneration
Journal Article
Comparative Study of TESS Photometry and Radial Velocities on Six Early K-type Contact Binaries with Similar Periods around 0.268 Day
High-precision light curves were extracted from TESScut images. Together with APOGEE and LAMOST medium-resolution spectra, a joint study was made for six early K-type contact binary candidates selected unbiasedly with orbital periods around 0.268 day. It is found that all of them (RV CVn, EK Com, V384 Ser, V1038 Her, EH CVn, and CSS_J125403.7+503945) are W-subtype shallow contact systems, though with different mass ratios (1/q = 0.27–0.62). The effective temperature differences between the binary components are around a few hundred kelvins. The original definitions of the A and W subtypes were compared with the customarily used methods, which rely on the shape or photometric solutions of the light curves. The latter two methods are not always reliable; therefore, the radial velocity analysis is strongly recommended. Through a collection of all available K-type contact binaries with both photometric and spectroscopic measurements, it is found that almost all of them are W-subtype systems, except for a few objects that have nearly identical temperatures for binary components. This W-subtype phenomenon for K-type contact binaries should be further checked with more samples in the future. Finally, the physical parameters of the targets were determined with joint data analysis, and the multiplicity is discussed for these targets. Objects V384 Ser and RV CVn are confirmed to very likely be triple systems from comprehensive analysis, while V1038 Her is a candidate of a triple system based on photometric and spectroscopic solutions.
Journal Article