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"Liu, Shu"
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Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19
Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein of SARS-CoV-2, which plays a key role in the receptor recognition and cell membrane fusion process, is composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain that recognizes and binds to the host receptor angiotensin-converting enzyme 2, while the S2 subunit mediates viral cell membrane fusion by forming a six-helical bundle via the two-heptad repeat domain. In this review, we highlight recent research advance in the structure, function and development of antivirus drugs targeting the S protein.
Journal Article
Fabricating polyoxometalates-stabilized single-atom site catalysts in confined space with enhanced activity for alkynes diboration
Effecting the synergistic function of single metal atom sites and their supports is of great importance to achieve high-performance catalysts. Herein, we successfully fabricate polyoxometalates (POMs)-stabilized atomically dispersed platinum sites by employing three-dimensional metal-organic frameworks (MOFs) as the finite spatial skeleton to govern the accessible quantity, spatial dispersion, and mobility of metal precursors around each POM unit. The isolated single platinum atoms (Pt
1
) are steadily anchored in the square-planar sites on the surface of monodispersed Keggin-type phosphomolybdic acid (PMo) in the cavities of various MOFs, including MIL-101, HKUST-1, and ZIF-67. In contrast, either the absence of POMs or MOFs yielded only platinum nanoparticles. Pt
1
-PMo@MIL-101 are seven times more active than the corresponding nanoparticles in the diboration of phenylacetylene, which can be attributed to the synergistic effect of the preconcentration of organic reaction substrates by porous MOFs skeleton and the decreased desorption energy of products on isolated Pt atom sites.
It is of great significance to exert the synergistic effect between single atom and support. Here, the authors prepare polyoxometalates-stabilized single-atom site catalysts in confined space with enhanced activity for alkynes diboration.
Journal Article
الكرز أثمر على شجر الرمان : رواية
كان الجو جميلا، فبعد هطول الأمطار، تحول لون القمح إلى اللون الأخضر، وسيطرت على الجو رائحة العشب الأخضر. هذه الرائحة حلوة بعض الشيء ومريرة بعض الشيء، دافئة قليلا وباردة قليلا، كم يُفرح هذا الجوّ القلب وينعش الذهن ! في ذلك الحين، كان قلب \"فان خوا\" يشعر بالراحة والطمأنينية. وفي المساء أثناء موعد عقد الاجتماع شعرت أن رؤوس الحيوانات المفترسة التي تعلو جانبي سقف المسرح جميلة المنظر، وضوء القمر أيضاً ساحر للغاية يشبه ثغر فتاة جميلة تضحك. لذا ابتسمت، إلا أن ضحكتها لم تكن ظاهرة على وجهها، بل كانت مختفية داخل قلبها.
Virus-induced phytohormone dynamics and their effects on plant–insect interactions
Attacks on plants by both viruses and their vectors is common in nature. Yet the dynamics of the plant–virus–vector tripartite system, in particular the effects of viral infection on plant–insect interactions, have only begun to emerge in the last decade. Viruses can modulate the interactions between insect vectors and plants via the jasmonate, salicylic acid and ethylene phytohormone pathways, resulting in changes in fitness and viral transmission capacity of their insect vectors. Virus infection of plants may also modulate other phytohormones, such as auxin, gibberellins, cytokinins, brassinosteroids and abscisic acid, with yet undefined consequences on plant–insect interactions. Moreover, virus infection in plants may incur changes to other plant traits, such as nutrition and secondary metabolites, that potentially contribute to virus-associated, phytohormone-mediated manipulation of plant–insect interactions. In this article, we review the research progress, discuss issues related to the complexity and variability of the viral modulation of plant interactions with insect vectors, and suggest future directions of research in this field.
Journal Article
The Chinese Society of Clinical Oncology (CSCO): clinical guidelines for the diagnosis and treatment of gastric cancer
China is one of the countries with the highest incidence of gastric cancer. There are differences in epidemiological characteristics, clinicopathological features, tumor biological characteristics, treatment patterns, and drug selection between gastric cancer patients from the Eastern and Western countries. Non-Chinese guidelines cannot specifically reflect the diagnosis and treatment characteristics for the Chinese gastric cancer patients. The Chinese Society of Clinical Oncology (CSCO) arranged for a panel of senior experts specializing in all sub-specialties of gastric cancer to compile, discuss, and revise the guidelines on the diagnosis and treatment of gastric cancer based on the findings of evidence-based medicine in China and abroad. By referring to the opinions of industry experts, taking into account of regional differences, giving full consideration to the accessibility of diagnosis and treatment resources, these experts have conducted experts’ consensus judgement on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes. This guideline uses tables and is complemented by explanatory and descriptive notes covering the diagnosis, comprehensive treatment, and follow-up visits for gastric cancer.
Journal Article
Exploring Purchase Intention in Online Influencer Marketing Campaigns Through an Integrated Model
Social media offer a digital space for people to connect with online influencers, such as bloggers, YouTubers, and Instagram celebrities. This study aims to investigate the factors affecting consumers’ purchase intention in social media-based influencer marketing context, while simultaneously revealing the underlying mechanisms through an integrated model. An online survey with 335 participants who have followed social media influencers (SMIs) was conducted to empirically test our proposed model. PLS-SEM was employed to analyze the measurement and structural models. The findings indicate that SMIs, when perceived as credible sources exhibiting high levels of expertise, trustworthiness, and homophily, stimulate consumers’ fear of missing out (FOMO) and establish parasocial relationships with these influencers, which in turn enhance purchase intention. Furthermore, when consumers perceived a high level of serendipity, the relationship between FOMO and purchase intention will be strengthened. This study extends the perspective of source credibility and parasocial relationships in the context of influencer marketing by incorporating the impact of smart recommendation algorithms and the emotional anxiety experienced by consumers. It offers a novel approach to analyze why consumers are motivated to purchase products endorsed by SMIs.
Journal Article
Metabolomic Identification of Exosome-Derived Biomarkers for Schizophrenia: A Large Multicenter Study
Abstract
Exosomes have been suggested as promising targets for the diagnosis and treatment of neurological diseases, including schizophrenia (SCZ), but the potential role of exosome-derived metabolites in these diseases was rarely studied. Using ultra-performance liquid chromatography-tandem mass spectrometry, we performed the first metabolomic study of serum-derived exosomes from patients with SCZ. Our sample comprised 385 patients and 332 healthy controls recruited from 3 clinical centers and 4 independent cohorts. We identified 25 perturbed metabolites in patients that can be used to classify samples from patients and control participants with 95.7% accuracy (95% CI: 92.6%–98.9%) in the training samples (78 patients and 66 controls). These metabolites also showed good to excellent performance in differentiating between patients and controls in the 3 test sets of participants, with accuracies 91.0% (95% CI: 85.7%–96.3%; 107 patients and 62 controls), 82.7% (95% CI: 77.6%–87.9%; 104 patients and 142 controls), and 99.0% (95% CI: 97.7%–100%; 96 patients and 62 controls), respectively. Bioinformatic analysis suggested that these metabolites were enriched in pathways implicated in SCZ, such as glycerophospholipid metabolism. Taken together, our findings support a role for exosomal metabolite dysregulation in the pathophysiology of SCZ and indicate a strong potential for exosome-derived metabolites to inform the diagnosis of SCZ.
Journal Article
The effects of older Chinese adults’ online behaviors on their health habits and health status
Objective
This study aimed to assess the effects of older Chinese adults’ online behaviors (including recent access to the Internet and duration of Internet use) on their current health habits and health status. Health status comprised self-rated physical and mental health.
Methods
Interviewees aged over 60 years who participated consecutively in the 2010, 2014, 2018, and 2020 China Family Panel Studies were selected. Ordinary least squares and ordered logit regression analyses were used to analyze the associations between older adults’ online behaviors and their health habits and status. Propensity score matching analysis was employed to mitigate selection bias. Structural equation modeling was conducted to test the robustness of the findings and to explore whether the associations between recent and continued Internet use and their health were mediated by older adults’ prioritization of online entertainment, learning, communication, and lifestyle-related activities.
Results
The results showed that Internet access among older adults was positively associated with health habits, increased self-rated health levels, and improved physical and mental health. Continuous Internet use among older adults may be a predictor of better mental health. While prioritization of online life style could improve physical health, prioritization of online communication might be prejudicial to acquiring health habits.
Conclusion
Internet access may support healthy aging by encouraging older adults to adopt healthier lifestyles. However, the varied effects of different types of online behavior underscore the importance of designing targeted digital interventions rather than blanket promotion of technology adoption.
Journal Article