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Restoring cardiac function after myocardial infarction remains a major challenge, as current pharmacological and interventional therapies primarily mitigate symptoms and slow disease progression without addressing the irreversible loss of functional myocardium. Although a diverse range of biologically active agents has been developed to modulate inflammation, angiogenesis, fibrosis, and cardiomyocyte survival, their therapeutic impact is frequently limited by delivery strategies that fail to match the dynamic and heterogeneous nature of post-infarction healing. Advances in biomaterials, nanotechnology, and device engineering have enabled drug delivery systems capable of spatiotemporally programmed therapeutic engagement. By responding to injury-associated cues, recreating key features of the myocardial microenvironment, and incorporating programmable release architectures, these systems coordinate localization, release kinetics, and duration of action with distinct phases and regions of cardiac repair. When combined with appropriate delivery interfaces, including nanocarriers, injectable depots, structured platforms, and biologically derived vehicles, spatiotemporal drug delivery transforms therapy from passive administration into an active determinant of biological outcome. This Review synthesizes recent mechanistic and engineering advances to frame spatiotemporal precision as a unifying principle for cardiac drug delivery. Aligning therapeutic action with the intrinsic biology of myocardial healing provides a rational pathway toward more effective, durable, and biologically informed strategies for cardiac repair and, where biology permits, regeneration. Spatiotemporal strategies transform cardiac therapy approaches Ischemic heart disease results in the permanent loss of cardiomyocytes after myocardial infarction, leading to heart failure. Current treatments focus on symptom relief rather than tissue restoration, hindered by ineffective delivery to the injured myocardium. This Review explores drug delivery strategies for cardiac repair, emphasizing the importance of aligning therapeutic presence with the dynamic biological demands of post-infarction healing. The authors discuss smart biomaterials that interact with injury-associated microenvironments, enabling context-dependent therapeutic control. They highlight significant findings, such as the use of stimuli-responsive biomaterials that leverage injury-associated signals to regulate therapeutic activation. These advancements are crucial as they offer a framework for more precise and personalized cardiac therapy. Future directions include integrating biosensor systems for real-time release and developing scalable, cell-free vesicle-based therapies, potentially accelerating clinical translation and improving patient outcomes. This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.

Rapid improvements in the precision of mobile technologies now make it possible for advertisers to go beyond real-time static location and contextual information on consumers. In this paper we propose a novel “trajectory-based” targeting strategy for mobile recommendation that leverages detailed information on consumers’ physical-movement trajectories using fine-grained behavioral information from different mobility dimensions. To analyze the effectiveness of this new strategy, we designed a large-scale randomized field experiment in a large shopping mall that involved 83,370 unique user responses for a 14-day period in June 2014. We found that trajectory-based mobile targeting can, as compared with other baselines, lead to higher redemption probability, faster redemption behavior, and higher transaction amounts. It can also facilitate higher revenues for the focal store as well as the overall shopping mall. Moreover, the effect of trajectory-based targeting comes not only from improvements in the efficiency of customers’ current shopping processes but also from its ability to nudge customers toward changing their future shopping patterns and, thereby, generate additional revenues. Finally, we found significant heterogeneity in the impact of trajectory-based targeting. It is especially effective in influencing high-income consumers. Interestingly, however, it becomes less effective in boosting the revenues of the shopping mall during the weekends and for those shoppers who like to explore across products categories. Our overall findings suggest that highly targeted mobile promotions can have the inadvertent impact of reducing impulse-purchasing behavior by customers who are in an exploratory shopping stage. On a broader note, our work can be viewed as a first step toward the study of large-scale, fine-grained digital traces of individual physical behavior and how they can be used to predict—and market according to—individuals’ anticipated future behavior. This paper was accepted by Anandhi Bharadwaj, information systems.

Non-small cell lung cancer (NSCLC) represents the most common pathological type of lung cancer, and the combination of neoadjuvant immunotherapy with chemotherapy has emerged as the first-line treatment for NSCLC. Nevertheless, the efficacy of this therapeutic approach remains variable. The present study aims to examine the impact of chemoimmunotherapy in NSCLC patients, with a view to identifying key molecules, critical cell subpopulations, communication patterns and spatial distributions that potentially correlate with therapeutic sensitivity. A total of 16 lung cancer tissue samples were collected from a cohort of 12 NSCLC patients and subjected to single-cell RNA and spatial transcriptome sequencing. Our data demonstrated that the distribution of CD4 + Treg T cells and mCAFs indicated an immunosuppressive tumor microenvironment, while the accumulation of CD4 + Th17 T cells and iCAFs could act as a positive marker for the sensitivity to chemoimmunotherapy. Furthermore, a significant high level of SELENOP-macrophages was observed in tissues from positive responders, and a strong co-localization between SELENOP-macrophages and antigen-presenting cancer associated fibroblasts (CAFs) in the tumor boundaries was identified, indicating the cooperative roles of these two cell types in response to combined therapy. Moreover, SELENOP-macrophages were observed to be accumulated in tertiary lymphoid structures, which further suggested its critical role in recruiting lymphocytes. Furthermore, analysis of cell–cell communication, based on spatial transcriptomics, suggests that the interactions between SELENOP-macrophages, apCAFs, CD4 + and CD8 + T cells were significantly enhanced in responders. In addition, SELENOP-macrophages recruited CD4 + Naïve, Helper and CD8 + Naïve T cells through pathways such as the cholesterol, interleukin, chemokine and HLA when responding to combined therapy. The present study further unveils the dynamic spatial and transcriptional changes in the tumor microenvironment of non-small cell lung cancer in response to combination therapy. Graphical Abstract

The purpose of this study is to examine the effects of environmental education on students’ attitudes about the environment in Chinese higher education. The findings showed that students’ environmental attitudes can be greatly enhanced by college-level ecology and environmental education. One of the most major factors influencing students’ environmental attitudes in the context of college environmental education is subjective norms, and curriculum education also has a big impact on this. It is possible that Chinese college students today lack the self-efficacy necessary to safeguard the environment since perceived behavioral control has less of an impact on college students’ environmental attitudes than subjective norms and curricular education. This highlights the need of promoting environmental practices and improving college students’ self-perceive and capacity for environmental protection. The study also showed that factors including gender, location, educational level, and economic status of the family had no impact on college students’ environmental attitudes. The results of this study can be used to examine the factors influencing the environmental views of Chinese college students and to teach educators how to raise college students’ awareness of the environment through curricular modifications, classroom instruction, and perceived behavioral control.

The urgent need for sustainable energy conversion technologies has propelled the development of efficient and cost-effective electrocatalysts for water splitting. In this study, we synthesize carbon-coated NiCoO 2 /NiCo@C composites through the calcination of CoNi Prussian Blue Analogues nanocubes, aiming to enhance the electrocatalytic performance for both oxygen evolution reaction (OER) and hydrogen evolution reaction (HER). Our findings demonstrate that the NiCoO 2 /NiCo@C composites exhibit outstanding catalytic activity, achieving low overpotentials of 329 mV for OER and 61.9 mV for HER at a current density of 10 mA cm −2 , with robust stability under prolonged operational conditions. The enhanced activity is attributed to the large interface area and high density of exposed active sites facilitated by the unique heterojunction structure of NiCoO 2 /NiCo particles embedded in carbon frameworks and nanotubes. This architecture not only prevents the agglomeration of metal nanoparticles but also promotes efficient electron and proton transfer, significantly boosting electrochemical performance. This study introduces a promising approach for designing high-performance, cost-effective electrocatalysts, paving the way for their application in industrial water electrolysis.

The dehydration process is widely recognized as a significant phenomenon in nature. Hydrogels, which are important functional materials with high water content and crosslinked networks, encounter the issue of dehydration in their practical applications. Here, we report the distinctive anisotropic dehydration modality of dynamic hydrogels, which is fundamentally different from the more commonly observed isotropic dehydration of covalent hydrogels. Xerogels derived from dynamic hydrogel dehydration will fully cover a curved substrate surface and exhibit hollow structures with internal knots, in contrast to the bulk xerogels produced by covalent hydrogel dehydration. Depending on the competing cohesion of polymer chains and the adhesion at the hydrogel-substrate interface, the previously overlooked reorganization of polymer networks within dynamic hydrogels, triggered by dehydration-induced stress, has been discovered to regulate such macroscopic structural reconstruction for dynamic hydrogel dehydration. With the attached hydrogel-substrate interface, the surface microstructures of substrates can also be engraved onto xerogels with high resolution and on a large scale. This work will greatly enhance our understanding of the soft matter dehydration process and broaden the applications of dehydration technologies using water-containing materials. Hydrogels have attracted much attention due to their intrinsic viscoelastic properties, porous structures, and processability but dehydration of hydrogels often limits the application of these materials. Here, the authors report the distinctive anisotropic dehydration modality of dynamic hydrogels, which is fundamentally different from the more commonly observed isotropic dehydration of covalent hydrogels.

Closed-loop chemical recycling provides a solution to the end-of-use problem of synthetic polymers. However, it remains a major challenge to design dynamic bonds, capable of effective bonding and reversible cleaving, for preparing chemically recyclable cross-linked polymers. Herein, we report a dynamic maleic acid tertiary amide bond based upon reversible amidation reaction between maleic anhydrides and secondary amines. This dynamic bond allows for the construction of polymer networks with tailorable and robust mechanical properties, covering strong elastomers with a tensile strength of 22.3 MPa and rigid plastics with a yield strength of 38.3 MPa. Impressively, these robust polymeric materials can be completely depolymerized in an acidic aqueous solution at ambient temperature, leading to efficient monomer recovery with >94% separation yields. Meanwhile, the recovered monomers can be used to remanufacture cross-linked polymeric materials without losing their original mechanical performance. This work unveils a general approach to design polymer networks with tunable mechanical performance and closed-loop recyclability, which will open a new avenue for sustainable polymeric materials. Closed-loop chemical recycling provides a solution to the end-of-use problem of synthetic polymers but the design of dynamic bonds for preparing chemically recyclable cross-linked polymers remains challenging. Here, the authors report a dynamic reversible amidation reaction between maleic anhydrides and secondary amines.