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Research on carbon disclosure (CD) and corporate value (CV) has expanded rapidly in response to global climate concerns, yet the field remains conceptually scattered and lacks an integrated overview of its development. To address this issue, this study reviews 143 peer-reviewed articles published between 2012 and 2025 and uses CiteSpace to examine publication patterns, collaborative structures, knowledge bases, and thematic movements within the carbon disclosure and corporate value literature. The analysis shows a clear rise in academic interest, with early work centred on regulatory and governance aspects of disclosure, followed by a gradual shift toward value-related outcomes involving financial, social, and environmental performance. Co-citation networks highlight several influential foundations in sustainability accounting and corporate governance, but also reveal persistent gaps between carbon disclosure and corporate value research streams. Keyword evolution further illustrates growing attention to financial performance, investor reactions, and carbon-risk assessment, suggesting that carbon disclosure is increasingly embedded in corporate valuation practices. By combining bibliometric mapping with insights from the triple bottom line and stakeholder perspectives, this study clarifies the intellectual structure of the field and identifies opportunities for more integrated and data-driven research. The review also offers practical guidance for scholars and policymakers seeking to understand or strengthen the link between disclosure practices and corporate value creation.

A floating offshore wind turbine (FOWT) normally suffers from complex external load conditions. It is vital to accurately estimate these loads and the subsequent structural motion and deformation responses for the safety design of the FOWT throughout its service lifetime. To this end, a coupled computational fluid dynamics (CFD) and finite element analysis (FEA) approach is proposed, which is named the CFD–FEA coupled approach. For the CFD approach, the volume of fluid (VOF), the dynamic fluid–body interaction (DFBI), and overset with sliding meshes are used to capture the interface of the air and the water and to calculate wind/wave loads and the motion response of the FOWT. For the FEA approach, the explicit nonlinear dynamic finite element method is employed to evaluate structural deformation. The one-way coupling scheme is used to transfer the data from the CFD approach to the FEA approach. Using the NREL 5 MW FOWT with a catenary mooring system as the research object, a series of full-scale simulations with various wind speeds, wave heights, and wave directions are implemented. The simulation results provide a good insight into the effect of aero-hydrodynamics and fluid hydrodynamics loads on both the motion and deformation responses of the FOWT, which would contribute to improving its design.

The unprecedented coronavirus disease 2019 (COVID-19) pandemic has caused millions of infections worldwide and represents a significant challenge facing modern health care systems. This study was conducted to investigate the impact of lockdown measures in a tertiary Children's Hospital in southwest China, which might be used to predict long-term effects related to health-seeking behavior of parents/caregivers. This study included newborns enrolled over a span of 86 weeks between January 4, 2019, and August 27, 2020. We designated two time periods for analysis purposes: a stable pre-COVID period(55 weeks between January 4, 2019, and January 23, 2020) and a COVID-impacted period (31 weeks between January 24, 2020, and August 27, 2020). An interrupted time-series analysis was employed to compare changes and trends in hospital admissions and disease spectra before and after the period of nonpharmaceutical interventions (NPIs). Furthermore, this study was conducted to evaluate whether the health-seeking behavior of parents/caregivers was influenced by pandemic factors. Overall, 16,640 infants were admitted to the neonatology department during the pre-COVID period (n = 12,082) and the COVID-impacted period (n = 4,558). The per week neonatal admissions consistently decreased following the first days of NPIs (January 24, 2020). The average weekly admission rates of 220/week pre-COVID period and 147/week COVID-impacted period. There was an evident decrease in the volume of admissions for all disease spectra after the intervention, whereas the decrease of patients complaining about pathological jaundice-related conditions was statistically significant (p<0.05). In the COVID-impacted period, the percentage of patients who suffered from respiratory system diseases, neonatal encephalopathy, and infectious diseases decreased, while the percentage of pathological jaundice-related conditions and gastrointestinal system diseases increased. The neonatal mortality rates (NMRs) increased by 8.7% during the COVID-impacted period compared with the pre-COVID period. In summary, there was a significant decline in neonatal admissions in a tertiary care hospital during the COVID-19 Pandemic and the associated NPIs. Additionally, this situation had a remarkable impact on disease spectra and health-seeking behavior of parents/caregivers. We, therefore, advise continuing follow-ups and monitoring the main health indicators in vulnerable populations affected by this Pandemic over time.

Background Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease characterized by idiopathic acute tubulointerstitial nephritis and uveitis. To date, there are no standard therapeutic protocols. The renal damage may be clinically severe and persistent, and the uveitis tends to recur or progress to a chronic state, posing significant treatment challenges. We present a pediatric case of refractory TINU syndrome successfully treated with adalimumab, which provide a reference for its management. Case presentation A 7-year-old boy initially presented with mild proteinuria and acute kidney injury, accompanied by a reduced estimated glomerular filtration rate (eGFR) of 57.5 mL/min/1.73 m². A kidney biopsy revealed acute tubulointerstitial nephritis. He was treated with oral prednisolone, with partial improvement of kidney function. Three months after the first symptoms, bilateral anterior uveitis developed, establishing the diagnosis of TINU syndrome. Treatment initially involved systemic glucocorticoids combined with mycophenolate mofetil, but the uveitis persisted with recurrent episodes refractory to treatment. The patient received a 10-month course of adalimumab, a monoclonal antibody targeting Tumor necrosis factor-α (TNF-α). There was a significant resolution of ocular inflammation and normalization of kidney function, with a restored eGFR of 101.05 mL/min/1.73 m². Throughout the 1.25-year follow-up, no adverse events (including infections) occurred, and no recurrence was observed. Conclusions Adalimumab can effectively control inflammatory responses and reduce recurrence in pediatric TINU syndrome, with a favorable safety profile, thereby providing a novel and promising biologic alternative for steroid-resistant or refractory cases. It is recommended to focus on ocular lesions in patients with tubulointerstitial injuries to avoid missing the diagnosis of TINU syndrome.

Herein, a new series of 2-chloro-N-(5-(2-oxoindolin-3-yl)-4H-pyrazol-3-yl) acetamide derivatives containing 1,3,4-thiadiazole (10a - i) and 4H-1,2,4-triazol-4-amine (11a - r) moiety was designed, synthesised as novel anticancer agents. The antiproliferative activity values indicated that compound 10 b stood as the most potent derivative with IC 50 values of 12.0 nM and 10 nM against A549 and K562 cells, respectively. Mechanism investigation and docking studies of 10 b indicated that it possessed good apoptosis characteristic and dose-dependent growth arrest of A549 and K562 cells, blocked cell cycle into G2/M phase. Interestingly, 10 b suppressed the growth of A549 and K562 cells via modulation of EGFR and p53-MDM2 mediated pathway.

Background This study aimed to assess the impact of the pandemic of the coronavirus disease 2019 (COVID-19) on neonatology residency training in a tertiary children’s hospital in Chongqing, located in southwest China. Specifically, the study encompassed the effects on residents’ education, lived experiences, well-being, and the quality of neonatal care delivered. As higher educational institutions adapt to the post-COVID-19 era after the pandemic disruption, it is imperative that educational designers/academics learn from their experiences and challenges in curriculum design and delivery, ensuring quality and relevance in education. Methods This study employed a mixed-methods approach to investigate the influence of the COVID-19 pandemic on neonatology residency training at a tertiary children’s hospital in Chongqing. The first phase surveyed residents’ perceptions and experiences of their clinical education and well-being during the crisis. The second phase compared the quality of neonatal care between the pre-pandemic and pandemic periods. Results The survey of 123 neonatology residents examines the effects of COVID-19 on their learning, training, and mental health. The survey showed that most residents adapted well to the situation. Still, some faced challenges in their clinical education and experiences, such as reduced clinical exposure and opportunities to see rare diseases and conditions. A retrospective analysis of clinical data revealed that 7,151 neonates were admitted to the neonatology department during the study period. There was a 27.6% decrease in neonatal admissions during COVID-19, with more premature births and transfers. Residents conducted fewer clinical procedures but managed more complex cases. During COVID, hospital stays and costs were higher, but antibiotic use was lower. Although the case-mix index (CMI) score increased during the pandemic (1.25 vs. 1.18, p  < 0.05), there was no significant difference in the rates of readmission within 7 days or poor prognosis. Conclusions Despite reduced clinical exposure, the quality of neonatal care was maintained through innovative training methods that enhanced comprehensive residency programs. The study suggested that neonatology residency education remained effective and resilient during the crisis. Exceptional health professional education is vital to train qualified physicians and enhance healthcare systems for future challenges.

The emerging floating vertical axis wind turbines (VAWTs) are regarded as a preferred solution to overcome the challenges faced by the traditional horizontal type in open-sea environments. Numerous numerical models have been advanced for assessing this novel object. However, current fully coupled models predominantly rely on simplified theories, assuming a linear fluid load and a one-dimensional slender beam structure. Despite computational fluid dynamic and finite element (CFD-FEA) coupling being qualified for high precision, this technology remains limited to the fixed VAWT field. To predict the load and structural response accurately and comprehensively, this study aims to extend CFD-FEA technology to floating VAWTs. First, an aero-hydro-moor-elastic fully coupled model is developed, and this model is validated by comparing it with several model experiments. Subsequently, a full-scale floating straight-bladed VAWT is simulated with the geometry and numerical models introduced. Furthermore, load and structural responses in a typical case are analyzed in both time and frequency domains. Finally, the sensitivity analysis of each structure part in floating VAWTs to environmental parameters is conducted and discussed. The discovery highlights the intricate nature of tower structural response, which incorporates 2-node, 3-node, wind frequency, and wave frequency components. Distinct from blades or floating foundations, which are primarily influenced by a single environmental parameter, the tower response is significantly amplified by the combined effects of wind and waves.

The super-large floating bodies are often designed as multimodule structures linked by connectors, and the load and strength evaluation of the connector structure becomes an essential work in the design procedure of these floating bodies. In this paper, the hydrodynamic experimental model of a double floating body with a hinged connecter is designed first, and a hinged connector is adopted for connecting the double module floating bodies. A test is conducted for load calibration. Then, the experiments are carried out in the towing tank under different wave conditions. The load characteristics of the hinged connector are measured in the experiment. The numerical simulations for the load of the hinged connector are conducted based on the commercial platform ANSYS. The time history of the vertical, lateral and longitudinal loads for the hinged connector are illustrated. Finally, the comparison and analysis between the experimental results and numerical results is presented, and the conclusions are drawn, which indicate that the numerical method is effective to predict the load characteristics of a hinged connector. Above all, the methods and conclusions of this study are used to provide reference and guidance for the structural design of hinged connectors for floating bodies.

IntroductionMyopia is the most common visual disorder in school-aged children and adolescents worldwide. This study aimed to explore the ocular biometric characteristics of children aged 6–14 years from the Wenzhou optometry center and to determine the relationship between spherical equivalent refraction (SER) and macular pigment optical density (MPOD).Subjects and methodsParticipants underwent a full-scale ophthalmic examination anteriorly and posteriorly. Relevant parameters were documented, such as axial length (AL), anterior chamber depth (ACD), SER and lens thickness (LT), corneal curvature radius (CCR), and MPOD. Lens power (LP) was calculated using Bennett’s formula. Shapiro–Wilk tests and histograms were used to check the normality of the distribution of refractive and ocular biometric parameters. Scatter diagrams were adopted to analyze the relationships between refraction and parameters of ocular biometry. Multiple linear regression models were employed to fit the associated factors of AL, AL/CCR, and LP.ResultsA total of 902 mild hyperopia to mild myopia (+3.00 D ≤ SE ≤ −3.00 D) children aged 6–14 years were included. The mean age of participants was 10.03 ± 2.47 years, and the prevalence of mild hyperopia, emmetropia, and myopia was 5.65, 27.05, and 67.30%, respectively. The prevalence of mild myopia increased from 30.53% at 6 years of age to 93.62% at 14 years of age. Overall, AL, ACD, and AL/CCR increased, but LP declined from 6 to 14 years of age, whereas CCR and MPOD remained stable. An increase of 1 mm in AL was associated with −0.69 D of myopic change. A unit increase in AL/CCR was associated with −7.87 D in SER. As for the SER variance, AL explained 30.5% and AL/CCR explained 51.1%, whereas AL/CCR and LP accounted for 59.2%.DiscussionIn this work, we have studied the distributions of ocular biometric characteristics of mild hyperopia to mild myopia children from the perspective of an optometry center rather than a sampling survey. In addition, we found that children from the optometry center had a slower progression toward myopia than those from previous sampling surveys, which was an informative finding for future myopia prevention. In addition, we have made a correlation analysis between the macular pigment optical density and spherical equivalent refraction. Though, no correlation was found.

Prophylaxis of brain injury in newborns has been a main concern since the first neonatal neuronal intensive care unit (NNICU) was established in the world in 2008. The aim of this study was to outline and evaluate the unit’s development by analyzing the demographics of the patients, the services delivered, the short-term outcomes before and after the establishment of NNICU. During the two investigation periods, 384 newborns were diagnosed or suspected as “neonatal encephalopathy”, among which 185 patients admitted to NNICU between 2011.03.01 and 2012.09.30 before the establishment of NNICU were enrolled in the pre-NNICU group, another 199 neonates hospitalized during 2018.03.01 to 2019.09.30 were included in the post-NNICU group. Patients in the post-NNICU group were more likely to have seizures ( P = 0.001), incomplete or absent primitive reflexes ( P = 0.002), therapeutic hypothermia ( P <0.001) and liquid control ( P <0.001) in acute phase. Meanwhile, amplitude-integrated electro encephalogram (aEEG) monitoring ( P <0.001) and cranial ultrasound ( P <0.001) were more often used in NNICU. Both of the follow-up rate in brain MRI and the assessment of neurodevelopment at 3 months were higher in the post-NNICU group ( P <0.001). In conclusion, the NNICU focused on the neonatal neurocritical care for the babies susceptible to NE with the guidance of evidence-based medicine, the establishment of NNICU is gradually improving and standardizing the neuroprotective therapy and clinical follow-up to improve neurodevelopmental prognosis of the NE patients in CHCMU.