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Emerging evidences demonstrate that circular RNAs (circRNAs) are abnormally expressed in tumors and could serve as prognostic markers for cancers. However, the expression patterns and clinical implications of circRNAs in non-small cell lung cancer (NSCLC) remain obscure. In this study, we profiled circRNA expressions in 10 pairs of lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) after ribosomal RNA-depletion and RNase R digestion to enrich circRNAs. Combining five circRNA computational programs, we found that LUAD and LUSC not only share common expression patterns, but also exhibit distinct circRNA expression signatures. Moreover, the Receiver Operating Characteristic (ROC) curve analysis indicated that hsa_circ_0077837 and hsa_circ_0001821 could serve as potential biomarkers for both LUAD and LUSC, while hsa_circ_0001073 and hsa_circ_0001495 could be diagnostic/subtyping marker for LUAD and LUSC, respectively. Therefore, our findings highlight the important diagnostic potential of circRNAs in NSCLC.

Background Circular RNAs (circRNAs) are differentially expressed between normal and cancerous tissues, contributing to tumor initiation and progression. However, comprehensive landscape of dysregulated circRNAs across cancer types remains unclear. Methods In this study, we conducted Ribo-Zero transcriptome sequencing on tumor tissues and their adjacent normal samples including glioblastoma, esophageal squamous cell carcinoma, lung adenocarcinoma, thyroid cancer, colorectal cancer, gastric cancer and hepatocellular carcinoma. CIRCexplorer2 was employed to identify circRNAs and dysregulated circRNAs and genes were determined by DESeq2 package. The expression of hsa_circ_0072309 (circLIFR) was measured by reverse transcription and quantitative real-time PCR, and its effect on cell migration was examined by Transwell and wound healing assays. The role of circLIFR in tumor metastasis was evaluated via mouse models of tail-vein injection and spleen injection for lung and liver metastasis, respectively. Results Distinct circRNA expression signatures were identified among seven types of solid tumors, and the dysregulated circRNAs exhibited cancer-specific expression or shared common expression signatures across cancers. Bioinformatics analyses indicated that aberrant expression of host genes and/or RNA-binding proteins contributed to circRNA dysregulation in cancer. Finally, circLIFR was experimentally validated to be downregulated in six solid tumors and to significantly inhibit cell migration in vitro and tumor metastasis in vivo. Conclusions Our results provide a comprehensive landscape of differentially expressed circRNAs in solid tumors and highlight that circRNAs are extensively involved in cancer pathogenesis.

The penis is a vital organ of perception that transmits perceived signals to ejaculation-related centers. The penis consists of the glans penis and penile shaft, which differ considerably in both histology and innervation. This paper aims to investigate whether the glans penis or the penile shaft is the main source of sensory signals from the penis and whether penile hypersensitivity affects the whole organ or only part of it. The thresholds, latencies, and amplitudes of somatosensory evoked potentials (SSEPs) were recorded in 290 individuals with primary premature ejaculation using the glans penis and penile shaft as the sensory areas. The thresholds, latencies, and amplitudes of SSEPs from the glans penis and penile shaft in patients were significantly different (all P < 0.0001). The latency of the glans penis or penile shaft was shorter than average (indicating hypersensitivity) in 141 (48.6%) cases, of which 50 (35.5%) cases were sensitive in both the glans penis and penile shaft, 14 (9.9%) cases were sensitive in the glans penis only, and 77 (54.6%) cases were sensitive in the penile shaft only (P < 0.0001). There are statistical differences in the signals perceived through the glans penis and the penile shaft. Penile hypersensitivity does not necessarily mean that the whole penis is hypersensitive. We classify penile hypersensitivity into three categories, namely, glans penis, penile shaft, and whole-penis hypersensitivity, and we propose the new concept of penile hypersensitive zone.

本研究選取1994年至2009年間，跨越五國共計74家合作銀行，配合混合資料迴歸模型，試圖探討盈餘管理與市場競爭對合作銀行風險承擔之關聯性。實證發現合作銀行高階經理人若進行盈餘管理會提高銀行的破產風險。而且合作銀行的市占率越高，合作銀行將更加穩定。我們還發現盈餘管理與市場競爭對合作銀行風險存在負向關係，表示處於較低競爭市場之合作銀行，高階經理人越不會進行盈餘管理。原因在於處於較低競爭市場之合作銀行，已經有排擠掉其他商業銀行市場空間的傾向，因此高階經理人無須再進行盈餘管理來掩蓋相關資訊。

Detecting and using bursty patterns to analyze text streams has been one of the fundamental approaches in many temporal text mining applications. So far, most existing studies have focused on developing methods to detect bursty features based purely on term frequency changes. Few have taken the semantic contexts of bursty features into consideration, and as a result the detected bursty features may not always be interesting and can be hard to interpret. In this article, we propose to model the contexts of bursty features using a language modeling approach. We propose two methods to estimate the context language models based on sentence-level context and document-level context.We then propose a novel topic diversity-based metric using the context models to find newsworthy bursty features. We also propose to use the context models to automatically assign meaningful tags to bursty features. Using a large corpus of news articles, we quantitatively show that the proposed context language models for bursty features can effectively help rank bursty features based on their newsworthiness and to assign meaningful tags to annotate bursty features. We also use two example text mining applications to qualitatively demonstrate the usefulness of bursty feature ranking and tagging.

The study examines the relationship between earnings management, competition and risk by using a panel data of 74 cooperative banks for 5 countries during the 1994-2009 periods. The results show that earnings management has a negative effect on risk, indicating that bank managers' manipulation of earnings will raise the probability of bank failures. Competition has a positive effect on risk, showing that a higher cooperative bank presence means less space for commercial banks in the loan market (retail market). We also find that earnings management and competition are negatively related, the evidence supports that bank managers will have less incentive tomanipulate earnings if cooperative banks do not face much competition. [PUBLICATION ABSTRACT]

Solution of phosphoric acid was used to bond TiO2, investigating the effect of adhesive proportion, calcination time, calcination temperature in the process of the preparation. The representation of catalyst was characterized by means of X-ray diffraction (XRD), surface detection system (BET) and scanning electron microscopy (SEM). Results showed that when the drying temperature was at 106°C, calcination temperature was at 800°C and a calcination time was 4h, the catalyst carrier TiO2 was in the form of anatase structure with XRD characterization.

Background： The efficacy and safety of telmisartan combined with clopidogrel, leflunomide, or both drugs for immunoglobulin A nephropathy （IgAN） are unclear. This study was designed to evaluate the efficacy and safety of telmisartan combined with clopidogrel, leflunomide, or both drugs for IgAN. Methods： It is a multicenter, prospective, double-dummy randomized controlled trial. Primary IgAN patients were recruited in 13 renal units across Beijing, China, from July 2010 to June 2012. After a 4-week telmisartan （80 mg/d） wash-in, 400 patients continuing on 80 mg/d telmisartan were randomly assigned to additionally receive placebo （Group A）, 50 mg/d clopidogrel （Group B）, 20 mg/d leflunomide （Group C）, or 50 mg/d clopidogrel and 20 mg/d leflunomide （Group D）. The 24-week intervention was completed by 360 patients. The primary endpoint was change in 24-h proteinuria at 24 weeks. A linear mixed-effect model was used to analyze the changes at 4, 12, and 24 weeks. Generalized estimating equations were used to evaluate changes in hematuria grade. This trial was registered at the Chinese Clinical Trial Registry. Results： The effects oftelmisartan combined with leflunomide on changes in proteinuria （0.36 [95% confidence interval （CI） 0.18 0.55] g/d, P 〈 0.001）, in serum uric acid （76.96 [95% CI 57.44-96.49] μmol/L, P 〈 0.001）, in serum creatinine （9.49 [95% CI 6.54-12.44]μmol/L, P 〈 0.001）, and in estimated glomerular filtration rate （-6.72 [95% CI-9.46 to -3.98] ml.min -1. 1.73 m -2, p 〈 0.001） were statistically significant, whereas they were not statistically significant on changes in systolic and diastolic blood pressure and weight （P 〉 0.05）.Telmisartan combined with clopidogrel had no statistical effect on any outcome, and there was no interaction between the interventions. No obvious adverse reactions were observed. Conclusions： Telmisartan combined with leflunomide, not clopidogrel, is safe and effective for decreasing proteinuria in certain IgAN patients.

The microbiologist Jilun Li＇s excellent work on microbial secondary metabolites and biological nitrogen fixation has made significant contributions to agriculture and has created enormous economic and social benefits in China. He has received many honors throughout his career and was elected as an academician of the Chinese Academy of Sciences in 1995.