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Developing a single-phase self-rectifying memristor with the continuously tunable feature is structurally desirable and functionally adaptive to dynamic environmental stimuli variations, which is the pursuit of further smart memristors and neuromorphic computing. Herein, we report a van der Waals ferroelectric CuInP 2 S 6 as a single memristor with superior continuous modulation of current and self-rectifying to different bias stimuli (sweeping speed, direction, amplitude, etc.) and external mechanical load. The synergetic contribution of controllable Cu + ions migration and interfacial Schottky barrier is proposed to dynamically control the current flow and device performance. These outstanding sensitive features make this material possible for being superior candidate for future smart memristors with bidirectional operation mode and strong recognition to input faults and variations. Developing a single-phase self-rectifying memristor is desirable and functionally adaptive to dynamic environmental stimuli variations. Here, the authors report a single phase CuInP 2 S 6 based memristor with continuously tunable current rectifying.

Respiratory infections are a major public health concern caused by pathogens that colonize and invade the respiratory mucosal surface. Nasal vaccines have the advantage of providing protection at the primary site of pathogen infection, as they induce higher levels of mucosal secretory IgA antibodies and antigen-specific T and B cell responses. Adjuvants are crucial components of vaccine formulation that enhance the immunogenicity of the antigen to confer long-term and effective protection. Saponins, natural glycosides derived from plants, shown potential as vaccine adjuvants, as they can activate the mammalian immune system. Several licensed human vaccines containing saponins-based adjuvants administrated through intramuscular injection have demonstrated good efficacy and safety. Increasing evidence suggests that saponins can also be used as adjuvants for nasal vaccines, owing to their safety profile and potential to augment immune response. In this review, we will discuss the structure-activity-relationship of saponins, their important role in nasal vaccines, and future prospects for improving their efficacy and application in nasal vaccine for respiratory infection.

The Jump Point Search (JPS) algorithm ignores the possibility of any-angle walking, so the paths found by the JPS algorithm under the discrete grid map still have a gap with the real paths. To address the above problems, this paper improves the path optimization strategy of the JPS algorithm by combining the viewable angle of the Angle-Propagation Theta* (AP Theta*) algorithm, and it proposes the AP-JPS algorithm based on an any-angle pathfinding strategy. First, based on the JPS algorithm, this paper proposes a vision triangle judgment method to optimize the generated path by selecting the successor search point. Secondly, the idea of the node viewable angle in the AP Theta* algorithm is introduced to modify the line of sight (LOS) reachability detection between two nodes. Finally, the paths are optimized using a seventh-order polynomial based on minimum snap, so that the AP-JPS algorithm generates paths that better match the actual robot motion. The feasibility and effectiveness of this method are proved by simulation experiments and comparison with other algorithms. The results show that the path planning algorithm in this paper obtains paths with good smoothness in environments with different obstacle densities and different map sizes. In the algorithm comparison experiments, it can be seen that the AP-JPS algorithm reduces the path by 1.61–4.68% and the total turning angle of the path by 58.71–84.67% compared with the JPS algorithm. The AP-JPS algorithm reduces the computing time by 98.59–99.22% compared with the AP-Theta* algorithm.

Background Neocinnamomum plants are considered a promising feedstock for biodiesel in China, due to the richness in long-chain fatty acids (LCFAs) found in their seeds. However, the mitochondrial genome (mitogenome) of this genus has not yet been systematically described, and the exploration of species relationships within this genus using mitogenome sequences is also an uncharted territory. This has hindered our understanding of mitogenome diversity and the evolutionary relationships within Neocinnamomum . Results In this study, a total of 24 individuals representing seven distinct taxa from the genus Neocinnamomum were subjected to Illumina sequencing, and the species N. delavayi was sequenced using Oxford Nanopore sequencing technology. We successfully assembled the mitogenome of N. delavayi , which is 778,066 bp in size and exhibits a single circular structure. The analysis identified 659 dispersed repeats, 211 simple sequence repeats (SSRs), and 30 tandem repeats within the mitogenome. Additionally, 37 homologous fragments, totaling 9929 bp, were found between the mitogenome and the plastid genome (plastome). The codons of 41 protein-coding genes (PCGs) had a preference for ending in A/T, and the codon usage bias of the majority of these genes was influenced by natural selection pressures. Comparative genomic analysis revealed low collinearity and significant gene rearrangements between species. Phylogenetic analysis resulted in the classification of Neocinnamomum into six distinct clades, contradicting previous findings which based on complete plastomes and nuclear ribosomal cistron (nrDNA). In the PCGs of 24 individuals, 86 mutation events were identified, which included three indels and 83 SNPs. Notably, the ccmC gene underwent positive selection in pairwise comparisons of three species pairs. Furthermore, 748 RNA editing sites were predicted within the PCGs of the N. delavayi mitogenome. Conclusions This study enriches our knowledge of the mitogenomes in the family Lauraceae, and provides valuable data and a foundation for genomic evolution research, genetic resource conservation, and molecular breeding in Neocinnamomum .

Background This study aims to assess the effectiveness of neutrophil/lymphocyte ratio (NLR) and C-reactive protein (CRP) in diagnosing cholecystolithiasis with cholecystitis in elderly patients. Additionally, the study seeks to determine the predictive value of preoperative NLR in determining the severity of the condition in this population. Methods This study is a retrospective cohort study, including 160 elderly patients with cholecystolithiasis with cholecystitis (45 cases of simple cholecystitis, 58 cases of suppurative cholecystitis, 57 cases of gangrenous cholecystitis) and 60 cases of normal gallbladder histology. The study collected clinical data of the patients detected the preoperative CRP content, neutrophil, and lymphocyte levels through blood routine tests, and calculated the NLR value. The diagnostic value of NLR and CRP was determined by using the Receiver Operating Characteristic Curve (ROC), and the optimal value of preoperative NLR related to the severity of elderly patients with cholecystolithiasis with cholecystitis was identified. Results This study found that for elderly patients with cholecystolithiasis with cholecystitis, preoperative NLR and CRP levels can be used to distinguish the condition. The critical value for NLR was found to be 2.995 (95% CI, 0.9465–0.9853; P  < 0.001) with an area under the ROC curve of 0.9659, while the critical value for CRP was 13.05 (95% CI, 0.9284–0.9830; P  < 0.001) with an area under the ROC curve of 0.9557. Both NLR and CRP were found to have equivalent diagnostic abilities. Additionally, the study found that there were significant differences in neutrophil and lymphocyte levels in elderly patients with different severity levels, with NLR increasing as severity increased ( P  < 0.001). The study identified cut-off values for preoperative NLR that could distinguish Simple cholecystitis and Purulent cholecystitis, as well as Purulent cholecystitis and Gangrenous cholecystitis in elderly patients with cholecystolithiasis, with respective AUCs of 0.8441 (95% CI: 0.7642–0.9239; P  < 0.001) and 0.7886(95% CI: 0.7050–0.8721, P  < 0.001), sensitivities of 91.38% and 87.72%, and specificities of 73.33% and 63.79%. Conclusions Preoperative NLR and CRP values can serve as indicators to detect cholecystolithiasis with cholecystitis in elderly patients. Additionally, NLR has been recognized as a potential tool to differentiate the severity of cholecystolithiasis with cholecystitis in the elderly population.

Phase boundary provides a fertile ground for exploring emergent phenomena and understanding order parameters couplings in condensed-matter physics. In Pb(Zr 1-x Ti x )O 3 , there are two types of composition-dependent phase boundary with both technological and scientific importance, i.e. morphotropic phase boundary (MPB) separating polar regimes into different symmetry and ferroelectric/antiferroelectric (FE/AFE) phase boundary dividing polar and antipolar dipole configurations. In contrast with extensive studies on MPB, FE/AFE phase boundary is far less explored. Here, we apply atomic-scale imaging and Rietveld refinement to directly demonstrate the intermediate phase at FE/AFE phase boundary exhibits a rare multipolar Pb-cations ordering, i.e. coexistence of antipolar or polar displacement, which manifests itself in both periodically gradient lattice spacing and anomalous initial hysteresis loop. In-situ electron/neutron diffraction reveals that the same parent intermediate phase can transform into either FE or AFE state depending on suppression of antipolar or polar displacement, coupling with the evolution of long-/short-range oxygen octahedra tilts. First-principle calculations further show that the transition between AFE and FE phase can occur in a low-energy pathway via the intermediate phase. These findings enrich the structural understanding of FE/AFE phase boundary in perovskite oxides. Ferroelectric/antiferroelectric phase boundary is both technologically and scientifically important. Here, the authors reveal the structure of intermediate phase involved in classical Pb(Zr 1-x Ti x )O 3 .

Fine particulate matter (PM 2.5 ) has become a significant issue of ecological environment. However, few studies have explored the vertical distribution of PM 2.5 in cities. The objectives of this paper are to reveal the vertical distribution regular pattern of PM 2.5 over urban underlying surfaces near the ground with a hexacopter-type unmanned aerial vehicle (UAV) in winter. Results showed that the maximum vertical gradient of PM 2.5 near the ground was typically the greatest in the morning as the stable atmospheric conditions. Moreover, regression model illustrated that relative humidity had the greatest impact on the vertical profile of PM 2.5 compared to air temperature and altitude as hygroscopic of PM 2.5 aerosols. Curve model shown that vertical profile of PM 2.5 over the surfaces of water and green space first increased slowly and then declined, besides, the highest concentration inflection of PM 2.5 above the water body (23.7 m) is higher than the green space (14.3 m). Thus, suggesting residents living vertical of 10–30 m from the ground around large water bodies and green spaces should not open windows for ventilation in the morning. Therefore, this study provides insights into the vertical distributions of PM 2.5 over different underlying surfaces and should be of reference value to urban planners for designing urban spaces to optimize atmosphere environment to provide a healthy living environment.

Ciprofol (HSK3486 injectable emulsion) is a 2.6-disubstituted phenol derivative that acts similarly to propofol with a fast onset, quick, and stable recovery. Moreover, remimazolam is a new benzodiazepine with a faster onset and recovery than midazolam, and more stable hemodynamics than propofol. We found no relevant literature that directly compared these two drugs. The primary objective of this study was to compare the recovery of HSK3486 with that of remimazolam during successful general anesthesia. This prospective, randomized, double-blind study included 93 patients who had undergone fundus surgery. The patients were divided into three groups: HSK3486 (H group), remimazolam-saline group), and remimazolam-flumazenil (RF group). The primary outcome was the time from drug withdrawal to eye opening, and the secondary outcome was the time from drug withdrawal to laryngeal mask removal, the time for Aldrete modified score ≥ 9, intraoperative hemodynamic changes, post-operative adverse events (nausea, vomiting, pain, delirium, re-sedation), and the Quality of Recovery-15 score before surgery and at 1, 7, and 14 days post-operatively. The RF group showed the shortest eye-opening time: 3.8 (2.8) min vs 13.3 (5.2) min for the H group, < 0.001; and 11.5 (5.5) min for the group, < 0.001. And laryngeal mask removal time was 5.2 (3.1) min for the RF group vs 14.1 (5.2) min for the H group, < 0.001; and 12.4 (5.5) min for the group, < 0.001. There were no significant differences in other post-operative outcomes. The incorporation of flumazenil with remimazolam for total intravenous anesthesia provided rapid and reliable recovery of consciousness, although there were no significant visible differences between HSK3486 and Remimazolam-saline.

As various fields and industries have progressed, the use of drones has grown tremendously. The problem of path planning for drones flying at low altitude in urban as well as mountainous areas will be crucial for drones performing search-and-rescue missions. In this paper, we propose a convergent approach to ensure autonomous collision-free path planning for drones in the presence of both static obstacles and dynamic threats. Firstly, this paper extends the jump point search algorithm (JPS) in three dimensions for the drone to generate collision-free paths based on static environments. Next, a parent node transfer law is proposed and used to implement the JPS algorithm for any-angle path planning, which further shortens the planning path of the drones. Furthermore, the optimized paths are smoothed by seventh-order polynomial interpolation based on minimum snap to ensure the continuity at the path nodes. Finally, this paper improves the artificial potential field (APF) method by a virtual gravitational field and 3D Bresenham’s line algorithm to achieve the autonomous obstacle avoidance of drones in a dynamic-threat conflict environment. In this paper, the performance of this convergent approach is verified by simulation experiments. The simulation results show that the proposed approach can effectively solve the path planning and autonomous-obstacle-avoidance problems of drones in low-altitude flight missions.

Two ruthenium(II) complexes, Λ-[Ru(phen)(2)(p-HPIP)](2+) and Δ-[Ru(phen)(2)(p-HPIP)](2+), were synthesized and characterized via proton nuclear magnetic resonance spectroscopy, electrospray ionization-mass spectrometry, and circular dichroism spectroscopy. This study aims to clarify the anticancer effect of metal complexes as novel and potent telomerase inhibitors and cellular nucleus target drug. First, the chiral selectivity of the compounds and their ability to stabilize quadruplex DNA were studied via absorption and emission analyses, circular dichroism spectroscopy, fluorescence-resonance energy transfer melting assay, electrophoretic mobility shift assay, and polymerase chain reaction stop assay. The two chiral compounds selectively induced and stabilized the G-quadruplex of telomeric DNA with or without metal cations. These results provide new insights into the development of chiral anticancer agents for G-quadruplex DNA targeting. Telomerase repeat amplification protocol reveals the higher inhibitory activity of Λ-[Ru(phen)(2)(p-HPIP)](2+) against telomerase, suggesting that Λ-[Ru(phen)(2)(p-HPIP)](2+) may be a potential telomerase inhibitor for cancer chemotherapy. MTT assay results show that these chiral complexes have significant antitumor activities in HepG2 cells. More interestingly, cellular uptake and laser-scanning confocal microscopic studies reveal the efficient uptake of Λ-[Ru(phen)(2)(p-HPIP)](2+) by HepG2 cells. This complex then enters the cytoplasm and tends to accumulate in the nucleus. This nuclear penetration of the ruthenium complexes and their subsequent accumulation are associated with the chirality of the isomers as well as with the subtle environment of the ruthenium complexes. Therefore, the nucleus can be the cellular target of chiral ruthenium complexes for anticancer therapy.