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In the digital economy era, the significance of data assets has increasingly become evident, particularly against the backdrop of the rapid development of Generative Artificial Intelligence. This paper constructed a data asset valuation model based on Generative AI, aimed at dynamically assessing the commercial value of data assets. The model integrates data feature extraction, value generation algorithms, and market adaptability evaluations to address the shortcomings of traditional valuation methods in dynamic market environments. The validity and applicability of the model were verified through an empirical analysis of data from Chinese A-share listed companies from 2015 to 2023. The results indicated that the integrated model exhibited a significant advantage over individual models in accuracy and stability, especially in data-intensive industries such as information technology and financial services. This research provided new perspectives and methodologies for enterprises in digital transformation and data asset management, thereby promoting the sustainable development of the data economy.

This study explores the mechanisms through which the street built environment (BE) influences mobile physical activity (MPA) using multi-source data and explainable machine learning methods. The research combines Geographically Weighted Regression (GWR) and Random Forest (RF) models to reveal the complex spatial heterogeneity between BE factors and MPA, and enhances the interpretability of results through the SHAP model, providing theoretical support for future targeted urban planning and MPA interventions. The study finds that the “density” dimension of BE plays a crucial role in MPA, particularly population density and building density. Additionally, accessibility and safety also significantly influence MPA, while design factors such as greening rates, water landscapes, and building façade design promote MPA. The study emphasizes that the influence of BE factors on MPA is nonlinear, with significant interaction effects between different variables, indicating that improving a single variable alone cannot fully explain changes in MPA. This research provides a new theoretical perspective for understanding the impact of BE factors on MPA and offers empirical evidence for precise interventions. In areas with low MPA participation, improving street design, enhancing traffic safety, and increasing green and water-friendly spaces can significantly promote residents’ MPA, thereby improving public health.

Abstract This study continuously monitored the concentrations of five heavy metals (Cu, Zn, Pb, Cr, and Cd) in the surface water of the famous crater lake in Southern China based on a once a week sampling frequency of four locations from June 2018 to May 2019. The concentrations of these heavy metals and their seasonal variations were discussed by correlating with the lake’s water temperature, pH, and rainfall. The results showed that the weekly Cu, Zn, Pb, Cr, and Cd concentrations ranged from 0.31 to 1.10 µg/L, 0.10 to 2.03 µg/L, 0.01 to 0.50 µg/L, 0.39 to 2.71 µg/L, and 0.00 to 0.86 µg/L, respectively. The mean annual metal concentrations of lake water were in decreasing order of Cr > Zn > Cu > Pb > Cd and within the permissible levels of national water quality guidelines. There was no significant seasonal variation in the heavy metal concentration between the wet and dry seasons. However, except for Cr, the other metals’ mean concentrations were slightly higher in the wet season than the dry season, likely due to rainfall-related inputs. Based on correlation analysis, water temperature and pH may have influenced the concentrations of Zn and Cu, respectively, while the concentration of both metals was not affected by rainfall and showed high fluctuations throughout the sampling period, suggesting airborne related dust source inputs. Conversely, Pb concentration was influenced mainly by rainfall and temperature and is likely rain-related source inputs. Meanwhile, the negative correlation between the Cr concentration and pH value of lake water suggests that Cr is mainly derived from sediments. In contrast, the Cd concentration is not related to these factors as its content is generally a reflection of background value. Finally, the characteristics of these five heavy metals in this closed hydrological system of the Huguang Maar Lake suggest that atmospheric deposition and weathering-related inputs are important in evaluating heavy metal concentration levels in a close lake system for sustainable protection of its ecosystem.

Background Otitis media with effusion (OME) is a common disease in ear, nose, and throat clinics characterized by aural fullness and hearing loss and mainly caused by eustachian tube dysfunction (ETD). Tympanostomy tube insertion (TTI) is a conventional surgical treatment option that can alleviate symptoms but does not provide a definitive cure, and it is prone to recurrence. Balloon dilation eustachian tuboplasty (BDET) has become a novel procedure for the treatment of ETD, demonstrating significant potential in addressing the aforementioned limitations. However, it is not widely available in the clinic and few high-quality randomized clinical trials was conducted to investigate its long-term efficacy and security in OME. Therefore, the purpose of this study is to verify the efficacy of BDET combined with TTI for patients with OME and its prospects for providing a definitive cure. Methods and analysis This is a prospective, parallel-group, single-blind, randomized controlled prospective trial. Totally 124 patients with OME will be randomized into either group A or B. Group A will receive conventional therapy (TTI) while group B will use BDET therapy in addition to TTI. Outcome assessments will take place at baseline and at the 3rd, 6th, 12th, and 24th months after surgery. The primary outcome is eustachian tube function, which will be measured by the eustachian tube dysfunction questionnaire (ETDQ-7) and eustachian tube score (ETS). The secondary outcomes include middle ear function, hearing situation, and quality of life, which will be measured by acoustic impedance measurement, pure-tone audiometry, and Chinese-version Chronic Ear Survey (CCES). The main analysis of change in the outcomes will use mixed-model with repeated measures (MMRM) analyses of variance (ANOVAs). Discussion This is the first prospective trial in Chinese populations that aims to validate the long-term efficacy and safety of BDET-combined TTI therapy in patients with OME. This parallel-group, single-blind, randomized controlled trial may provide an opportunity to decrease the recurrence rate of OME and explore a definitive cure for patients with OME. This trial’s rigorous design enhances the reliability of the findings, ensuring a robust answer to the research question. In the future, the research team will further expand upon the clinical evidence and applications of the BDET combined therapy. Trial registration Chinese Clinical Trial Registry ChiCTR2400079632. Registered on 8 January 2024, https://www.chictr.org.cn/bin/project/edit?pid=214452 .

The physiological interactions between the peripheral and central auditory systems are crucial for auditory information transmission and perception, while reliable models for auditory neural circuits are currently lacking. To address this issue, mouse and human neural pathways are generated by utilizing a carbon nanotube nanofiber system. The super‐aligned pattern of the scaffold renders the axons of the bipolar and multipolar neurons extending in a parallel direction. In addition, the electrical conductivity of the scaffold maintains the electrophysiological activity of the primary mouse auditory neurons. The mouse and human primary neurons from peripheral and central auditory units in the system are then co‐cultured and showed that the two kinds of neurons form synaptic connections. Moreover, neural progenitor cells of the cochlea and auditory cortex are derived from human embryos to generate region‐specific organoids and these organoids are assembled in the nanofiber‐combined 3D system. Using optogenetic stimulation, calcium imaging, and electrophysiological recording, it is revealed that functional synaptic connections are formed between peripheral neurons and central neurons, as evidenced by calcium spiking and postsynaptic currents. The auditory circuit model will enable the study of the auditory neural pathway and advance the search for treatment strategies for disorders of neuronal connectivity in sensorineural hearing loss. The lack of therapeutic avenues for auditory neural pathway disorders is primarily attributed to inadequate research models. This study pioneers a novel auditory circuit model using super‐aligned carbon nanotubes. The peripheral‐central neural organoids with functional synaptic transmission facilitate the exploration of the auditory neural pathway and propel the quest for strategies for neuronal connectivity disorders in sensorineural hearing loss.

The dissolved organic carbon (DOC) in the surface water of Huguangyan Maar Lake was continuously monitored based on once per week sampling frequency of 4 locations from June 2018 to May 2019. The DOC concentrations and its seasonal variation were discussed by correlating with the rainfall, water temperature, and pH of lake water. The results showed that the weekly DOC varied from 8.15 to 32.65 mg/L with an annual average concentration of 17.96 mg/L. There was a significant difference in the average DOC concentrations between the rainy and dry seasons as the monthly average DOC concentration was 21.72 mg/L for the wet season compared to the dry season concentration of 14.21 mg/L. The rainfall shows a significant effect on the DOC concentration of lake water, as DOC concentration was much high during the wet season. There were no significant spatial variations in the average monthly concentration among the four sampling locations except occasional variation during the wet season. The reason for the wet season DOC differences among four sampling locations is likely due to the uneven runoff and underground water inputs and the relatively slow circulation of lake water. Finally, the seasonal fluctuation of DOC concentration in this closed lake water suggests that dissolved soil organic matter inputs through the rainfall related to surface runoff and subsurface infiltration from the surrounding watershed land is important to the primary production and organic matter deposition in the lake sediments.

Objectives To systematically explore the differences in acoustic changes and healing outcomes of tympanic membranes (TMs) with pars flaccida perforation (PFP) and pars tensa perforation (PTP). Methods We created PFPs and PTPs of various sizes in Sprague–Dawley rats, and evaluated TM umbo velocity and hearing function using laser Doppler vibrometry and auditory brainstem response (ABR) measurement before and immediately after perforation. Two weeks later, hearing was reevaluated and TMs were investigated by immunohistochemical staining. Results Small PFPs and PTPs did not significantly affect umbo velocity and hearing function. Large PFPs increased umbo velocity loss at low frequency (1.5 kHz) and elevated ABR thresholds within 1–2 kHz. Large PTP caused significant velocity loss at low frequencies from 1.5 to 3.5 kHz and threshold elevations at full frequencies (1–2 kHz). Two weeks after the perforation, the hearing function of rats with healed PFPs recovered completely. However, high‐frequency hearing loss (16–32 kHz) persisted in rats with healed PTPs. Morphological staining revealed that no increase in the thickness and obvious increase in collagen I level of regenerated par flaccida; regenerated pars tensa exhibited obvious increase in thickness and increased collagen I, while the collagen II regeneration was limited with discontinuous and disordered structure in regenerated pars tensa. Conclusion The hearing loss caused by large PFP limits at low frequencies while large PTP can lead to hearing loss at wide range frequencies. PFP and PTP have different functional outcomes after spontaneous healing, which is determined by the discrepant structure reconstruction and collagen regeneration.

Seasonal and spatial variations in the macrobenthic community in an intertidal gulfweed field off Naozhou Island were investigated from April 2011 to January 2012. We identified 407 macrobenthic organism species: 64 macroalgae (15.72% of total species); 123 Arthropoda (30.22%); 107 Mollusca (26.29%); 67 Annelida (16.46%); 15 Cnidaria (3.69%); 14 Echinodermata (3.44%); 8 Porifera (1.97%); 4 Chordata (0.98%); 2 Urochorda (0.49%); and 1 each of Echiura, Sipunculida and Angiospermae (0.25%). Arthropods, mollusks, annelids, and macroalgae were four main groups in the benthic organism community and accounted for 88.70% of the total species. In terms of abundance of biomass, there were 15 dominant species, including 8 macroalgal, 5 mollusk and 2 arthropod species. The species diversity indices ranged from 1.21 to 4.42 with an average of 2.80; the annual average of evenness was 0.47. Species richness indices varied from 2.97 to 7.24 (average 4.97); and Simpson dominance indices varied from 0.20 to 0.92 in annual average of 0.75. Macroalgal distribution showed clear vertical zonation and seasonal changes. The number of macroalgal species found in the high tide zone, upper middle tide zone, middle tide zone, lower middle tide zone, low tide zone, and below low tide zone were 1, 8, 10, 16, 22, and 32, respectively. Biomass among the benthic organisms, macroalgae and crustaceans had significant positive correlation ( P <0.05) with the coefficients of 0.802, 0.894, and 0.592, respectively. Macroalgal biomass showed a clearly negative correlation with the concentration of dissolved inorganic nitrogen (DIN) ( R =0.486, P <0.05). During the winter and spring, when macroalgae were growing vigorously, DIN reached the lowest level in seawater and displayed a clear weak correlation between macroalgal growth and the nutrient concentration.

The samples of Anthomedusae were collected from the Guangdong coastal water, China. Three new species of Anthomedusae, i.e. Zhangiella condensum Huang, Zhang et Sun, sp. nov., Hydractinia leizhouensis Huang, Zhang et Yang, sp. nov., and Cladosarsia simplex Huang, Zhang et Ke, sp. nov. are described. All type specimens are deposited in College of Ocean and Earth Sciences, Xiamen University.

Guanine nucleotide‐binding protein gamma 10 (GNG10) is implicated in various biological processes, yet its specific oncogenic role in colorectal cancer (CRC) remains poorly defined. This study aimed to elucidate the expression patterns, biological functions, and underlying mechanisms of GNG10 in CRC progression. We integrated TCGA datasets with tissue microarray immunohistochemistry and multivariate Cox regression models to evaluate the clinical significance of GNG10. Functional impacts on CRC malignant phenotypes and cancer stemness were assessed through gain‐ and loss‐of‐function models in vitro and in vivo. Mechanistic insights were gained via GSEA, Western blotting, and dual rescue strategies employing both pharmacological inhibition (Box5) and genetic depletion (shRHOA). We found that GNG10 was markedly overexpressed in CRC tissues, correlating with advanced pathological stage and poor overall survival. Multivariate analysis indicated that the prognostic value of GNG10 is closely associated with tumour progression. Functionally, GNG10 knockdown inhibited CRC cell proliferation, migration, and stemness while promoting apoptosis. Mechanistically, GNG10 activated the non‐canonical Wnt/RHOA/JNK/NFATc1 signalling axis. Crucially, manipulation of GNG10 did not affect active or total β‐catenin levels, thereby excluding canonical Wnt involvement. Both pharmacological inhibition with Box5 and genetic ablation of RHOA effectively abrogated GNG10‐induced oncogenic phenotypes and the upregulation of cancer stem cell markers (CD44, CD133, OCT4, Nanog, SOX2). In vivo xenograft models confirmed that GNG10 knockdown suppressed tumour growth and decreased the expression of proliferation and stemness markers. Our findings demonstrate that GNG10 promotes CRC progression and stemness via the non‐canonical Wnt signalling pathway. These findings highlight GNG10 as a promising prognostic indicator and a vulnerable target in CRC.