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\"Recent events suggest liberal capitalism harbours two dangerous seeds of self-destruction; growing inequality and a tendency for markets to spiral out of control. This book advocates the restoration to an earlier state of another sub-system of liberal capitalism, some of the features of which lie at the heart of liberal capitalisms malaise\"--Provided by publisher.

BackgroundPeople-centred initiatives to create and retain local wealth, such as Community Wealth Building (CWB), have potential to stimulate regional economic regeneration that addresses economic inequalities by increasing the economic inclusion of more disadvantaged groups. Preston, a relatively deprived city in England, has implemented a CWB programme that has been associated with improvements in local wages and well-being. We estimated the effect of Preston’s CWB programme on employment and examined differential effects by disability status and other equality dimensions.MethodsWe conducted a difference-in-differences analysis combined with entropy balancing to estimate the effect of the introduction of the CWB programme in Preston on local employment rates, using individual-level data from the Annual Population Survey collected between 2011 and 2019. We performed subgroup analysis to investigate whether the effect on employment was modified by disability, ethnic group, sex or education level.ResultsWe analysed survey responses from 95 476 individuals. The introduction of the CWB programme was associated with an increase in the employment rate of 4% (95% CI 2.4% to 5.7%) among people living in Preston, compared with what would have been expected in the absence of the programme. The effect on employment was greater among people with disabilities, minority ethnic groups, men and people with lower levels of education.ConclusionsOur findings indicate that CWB can have a positive impact on employment over a relatively short period of time, which disproportionately benefits people with disabilities and other disadvantaged groups. This evidence can be used to inform the development, implementation and evaluation of CWB strategies in other places. Preston’s CWB programme may represent a strategy to achieve more equitable economic growth and reduce health inequalities.

\"In 'The Woman's Place is in the Boardroom' the authors put the business case for more women on company boards. In the next book they explained how to acheive it. Here the authors discuss the role women directors can play in the reform of corporate governance systems following recent financial, crises in leadership, governance and the economy\"-- Provided by publisher.

A comprehensive guide to technical analysis for both the novice and the professional Technical analysis is a vital tool for any trader, asset manager, or investor who wants to earn top returns. Successful Stock Signals for Traders and Portfolio Managers lets you combine technical analysis and fundamental analysis using existing technical signals to improve your investing performance. Author Tom Lloyd Sr. explains all the technical indicators you need to know, including moving averages, relative strength, support and resistance, sell and buy signals, candlesticks, point and figure charts, Fibonacci levels, Bollinger Bands, and both classic and new indicators. Merging these technical indicators with fundamental analysis will keep you in a portfolio of outperforming stocks, sharpen your fundamental buy discipline, and put your sell discipline on autopilot. * Includes case studies applying technical analysis to current trending and hotly debated stocks like Facebook, LinkedIn, and Netflix * Offers thorough and straightforward guidance on technical analysis for both professional and individual investors * Covers the vital indicators in the public domain that investors need to know Whether you're an individual investor who wants to beat the indexes, a trader looking for high-risk, high-return positions, or a portfolio manager who wants to take a fundamental approach, this an ideal guide to technical analysis and indicators.

There is growing evidence that in many neurodegenerative disorders, cell-to-cell transmission of a pathological, misfolded protein, such as misfolding of α-synuclein (α-syn) in Parkinson's disease (PD), may be a vehicle for the spreading of pathology throughout the brain. This misfolded protein, or seed, further induces misfolding of native proteins within the cell. Pathological misfolded proteins may exist in diverse conformations with distinct cellular and biochemical properties. We investigate whether microbiota-derived metabolites may help attenuate the misfolding of α-syn and thereby promote resilience against PD phenotypes. We identified six biologically available gut microbiota-derived compounds (GMP10, GMP11, GMP26, GMP28, GMP39, and GMP44) for investigation. Using independent in vitro protein aggregation assays (e.g., photo-induced cross-linking of unmodified proteins assay, thioflavin-T, fluorescence assay, and electron microscopy), we demonstrated that three of the compounds (GMP26, GMP44, GMP28), potently inhibit aggregations of monomeric α-syn (or monomeric β-amyloid peptides) into neurotoxic protein aggregates, in vitro. Based on evidence linking the c9orf72 gene with expansions of GGGGCC hexanucleotide repeats and PD, as well as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), we continue to test the neuroprotective ability of our compounds in vivo using a Drosophila model with overexpression of GGGGCC hexanucleotide repeats. Overexpression of 30 GGGGCC repeats in the Drosophila eye causes age-dependent photoreceptor neurodegeneration. We treated Drosophila by mixing individual test compounds into the food. We found all six compounds significantly suppressed eye degeneration at 10 µM, with compounds GMP26 and GMP11 almost completely suppressing the eye phenotype. The comparative efficacy of the six compounds are GMP26 = GMP11 > GMP39 > GMP10 > GMP44 > GMP28. Outcomes from our studies link gut microbiota with mechanisms underlying PD and suggest the feasibility of developing GMP26 as a means to simultaneously target both α-syn misfolding and C9orf72 expansion to increase the likelihood of therapeutic efficacy in PD, ALS, FTD patients with C9orf72 expansion.

Background There is growing evidence that in many neurodegenerative disorders, cell‐to‐cell transmission of a pathological, misfolded protein, such as misfolding of α‐synuclein (α‐syn) in Parkinson’s disease (PD), may be a vehicle for the spreading of pathology throughout the brain. This misfolded protein, or seed, further induces misfolding of native proteins within the cell. Pathological misfolded proteins may exist in diverse conformations with distinct cellular and biochemical properties. We investigate whether microbiota‐derived metabolites may help attenuate the misfolding of α‐syn and thereby promote resilience against PD phenotypes. We identified six biologically available gut microbiota‐derived compounds (GMP10, GMP11, GMP26, GMP28, GMP39, and GMP44) for investigation. Method Using independent in vitro protein aggregation assays (e.g., photo‐induced cross‐linking of unmodified proteins assay, thioflavin‐T, fluorescence assay, and electron microscopy), we demonstrated that three of the compounds (GMP26, GMP44, GMP28), potently inhibit aggregations of monomeric α‐syn (or monomeric β‐amyloid peptides) into neurotoxic protein aggregates, in vitro. Result Based on evidence linking the c9orf72 gene with expansions of GGGGCC hexanucleotide repeats and PD, as well as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), we continue to test the neuroprotective ability of our compounds in vivo using a Drosophila model with overexpression of GGGGCC hexanucleotide repeats. Overexpression of 30 GGGGCC repeats in the Drosophila eye causes age‐dependent photoreceptor neurodegeneration. We treated Drosophila by mixing individual test compounds into the food. We found all six compounds significantly suppressed eye degeneration at 10 µM, with compounds GMP26 and GMP11 almost completely suppressing the eye phenotype. The comparative efficacy of the six compounds are GMP26 = GMP11 > GMP39 > GMP10 > GMP44 > GMP28. Conclusion Outcomes from our studies link gut microbiota with mechanisms underlying PD and suggest the feasibility of developing GMP26 as a means to simultaneously target both α‐syn misfolding and C9orf72 expansion to increase the likelihood of therapeutic efficacy in PD, ALS, FTD patients with C9orf72 expansion.

Category: Ankle, Midfoot/Forefoot, Opioid Use Research Introduction/Purpose: Within the United States, opioid abuse has become a national crisis. Twenty-nine percent of patients prescribed opioids misuse them with nearly 12% developing addiction. One previous study has shown that patients undergoing foot/ankle surgery were left with extra narcotic pain medications following surgery, many of whom would have preferred to dispose of them. Our purpose was to evaluate factors in foot and ankle surgery that are associated with increased risk of prolonged post-operative opioid pain medication usage and identify the risk of various post-operative complications that may be associated with pre-operative opioid usage. We hypothesize that pre-operative opioid use will place patients at an increased risk of post-operative usage. Methods: The MarketScan commercial claims and encounters database, including approximately 39 million patients per year, was searched to identify patients who underwent foot/ankle surgery based on CPT code from 2005-2014. Preoperative comorbidities including DSM-V mental health disorders, chronic pain, chronic regional pain syndrome (CRPS), obesity, tobacco use, medications and diabetes were queried and documented. Patients who utilized opioids at least one month up to 3 months prior to surgery were identified. This timeframe was chosen to exclude patients who had been prescribed post-operative narcotic medications up to 1 months pre-operatively. We utilized odds ratios (OR), 95% Confidence Intervals (CI), and regression analysis to determine factors that are associated with prolonged post-operative opioid use at 3 time intervals. Results: 112,893 patients underwent foot/ankle surgery. 11,523 (10.2%) patients utilized opioids 1-3months pre-operatively. Of those, 5,732 (5.0%) utilized opioids post-operatively at 6 weeks, 4,364 (3.8%) at 3 months, 3,475 (3.08%) at 6 months and 2,579 (2.2%) at 1 year. Pre-operative opioid use was associated with increased post-operative use (6-12weeks: OR 7.24, 95% CI 6.92- 7.58; 3-6months: OR 11.03, 95% CI 10.45-11.63; 6-12months: OR 14.1, 95% CI 13.3-15.1; >12months: OR 14.74, 95% CI 13.68-15.88). Tobacco use, chronic pain, DSM-V diagnosis and non-opioid analgesia yielded increased risk of post-operative opioid usage. Diagnosis of CRPS, obesity or diabetes did not have an increased risk. Pre-operative opioid use was associated with an increased risk of readmission, DVT, pulmonary embolism, I&D of surgical site, myocardial infarction, UTI and post-operative bleeding (Table 1). Conclusion: Our study found a number of factors that are associated with prolonged post-operative opioid usage which included pre-operative opioid use 1-3months before surgery, tobacco use, chronic pain, DSM-V diagnoses and pre-operative use of certain non-opioid medications. We also found patients with pre-operative opioid exposure to be at an increased risk of a number of significant post-operative complications, including an increased risk of readmission at 30 and 90 days. This data provides orthopaedic surgeons a number of variables to consider when determining post-operative analgesia strategies, and provides health systems, providers and payers information on complications associated with pre-operative opioid utilization.