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'Performance and Cosmopolitics' is a ground-breaking study of cross-cultural theatre in the Australasian region. Focusing on a range of theatrical events and practices in avant-garde, mainstream and community contexts, the text explores the cultural, political and ethical dimensions of Australia's engagement with Asia.

Cellular adaptation to stress is essential to ensure organismal survival. NRF2/NFE2L2 is a key determinant of xenobiotic stress responses, and loss of negative regulation by the KEAP1-CUL3 proteasome system is implicated in several chemo- and radiation-resistant cancers. Advantageously using C. elegans alongside human cell culture models, we establish a new WDR23-DDB1-CUL4 regulatory axis for NRF2 activity that operates independently of the canonical KEAP1-CUL3 system. WDR23 binds the DIDLID sequence within the Neh2 domain of NRF2 to regulate its stability; this regulation is not dependent on the KEAP1-binding DLG or ETGE motifs. The C-terminal domain of WDR23 is highly conserved and involved in regulation of NRF2 by the DDB1-CUL4 complex. The addition of WDR23 increases cellular sensitivity to cytotoxic chemotherapeutic drugs and suppresses NRF2 in KEAP1-negative cancer cell lines. Together, our results identify WDR23 as an alternative regulator of NRF2 proteostasis and uncover a cellular pathway that regulates NRF2 activity and capacity for cytoprotection independently of KEAP1.

Complex and tall buildings have been constructed in many cities recently. Fire safety should be a major concern of building designers, engineers, and governments. Previous fire experience has made us understand the importance of acquiring fire-ground information to facilitate firefighting operations, evacuation processes, rescues, etc. Recently, the rapid advancement in Information Technology, Data Analytics, and other detection and monitoring systems has provided the basis for fire safety researchers to re-think fire safety strategies in the built environment. Amongst all fire safety studies, evacuation in tall buildings, including elevator evacuations, has attracted much attention. IoT-aided building fire evacuation is a new concept of the building evacuation mode, which improves the building evacuation process by making decisions of escape based on the real-time fire-ground information, such as the fire environment and occupant situations. Focusing on IoT applications in building fire evacuation, this paper explores the advantages and insufficiencies of current smart building fire evacuation systems. A conceptual design of an IoT-aided building fire evacuation control system is described. The system is introduced in the sequence of information needs, information sources and data transmission, and potential services and applications. Finally, new insights into promising 5G technologies for future building fire evacuations are discussed.

With the aging society, the evacuation efficiency of older people during emergencies gain increasing attention from the scholars. This study investigates the influence of the residents’ distribution strategy and the desired speed of the older people on evacuation efficiency in the nursing home. Two resident distribution strategies (zoned and random) and four desired speeds (0.6-1.2 m/s at the interval of 0.2 m/s) are considered. Using an enhanced agent-based model capable of intelligently selecting evacuation routes and avoiding collisions, evacuation simulations are conducted in a real-world complex nursing home setting. The trajectories and the evacuation time are obtained and the results demonstrate that increasing desired speed significantly improves evacuation efficiency. While different from pre-conceived results, the zoned distribution strategy does not positively affect evacuation efficiency.

Mechanisms that coordinate different metabolic pathways, such as glucose and lipid, have been recognized. However, a potential interaction between amino acid and lipid metabolism remains largely elusive. Here we show that during starvation of Caenorhabditis elegans , proline catabolism is coupled with lipid metabolism by SKN-1. Mutation of alh-6 , a conserved proline catabolic enzyme, accelerates fat mobilization, enhances the expression of genes involved in fatty acid oxidation and reduces survival in response to fasting. This metabolic coordination is mediated by the activation of the transcription factor SKN-1/Nrf2, possibly due to the accumulation of the alh-6 substrate P5C, and also requires the transcriptional co-regulator MDT-15. Constitutive activation of SKN-1 induces a similar transcriptional response, which protects animals from fat accumulation when fed a high carbohydrate diet. In human cells, an orthologous alh-6 enzyme, ALDH4A1, is also linked to the activity of Nrf2, the human orthologue of SKN-1, and regulates the expression of lipid metabolic genes. Our findings identify a link between proline catabolism and lipid metabolism, and uncover a physiological role for SKN-1 in metabolism. The coordinated metabolism of cellular nutrients is important to maintain energy homeostasis, particularly if nutrients are scarce. Here, the authors report that the sensor protein SKN-1/Nrf2 links catabolism of the amino acid proline with lipid metabolism in C. elegans and in cultured human cells.

It is known that organizations can gain a competitive advantage only by managing effectively for today, while simultaneously creating innovation for tomorrow, and sustainability is one of the innovative strategies in major architecture, engineering, and construction (AEC) organizations. Innovation is vital to AEC organizations’ growth, yet most do not have a comprehensive measurement of innovation performance. Similar to the balanced scorecard approach, key indicators should be identified for the measuring of innovation performance to facilitate management. This article presents a study by using a triangulation approach that integrates systematic literature reviews and two-step consultations with experienced senior professionals to compile a set of key indicators for innovation performance measures for the AEC Industry.

Maintaining a healthy cellular environment requires the constant control of proteostasis. E3 ubiquitin ligase complexes facilitate the post-translational addition of ubiquitin, which based on the quantity and specific lysine linkages, results in different outcomes. Our studies reveal the CUL4-DDB1 substrate receptor, WDR23, as both a positive and a negative regulator in cellular stress responses. These opposing roles are mediated by two distinct isoforms: WDR-23A in the cytoplasm and WDR-23B in the nucleus. C. elegans expressing only WDR-23A display activation of SKN-1 and enhanced survival to oxidative stress, whereas animals with restricted WDR-23B expression do not. Additionally, we identify GEN-1, a Holliday junction resolvase, as an evolutionarily conserved WDR-23 substrate and find that the nuclear and cytoplasmic isoforms of WDR-23 differentially affect double-strand break repair. Our results suggest that through differential ubiquitination, nuclear WDR-23B inhibits the activity of substrates, most likely by promoting protein turnover, while cytoplasmic WDR-23A performs a proteasome-independent role. Together, our results establish a cooperative role between two spatially distinct isoforms of WDR-23 in ensuring proper regulation of WDR-23 substrates.

In recent years, environmentally-friendly, sustainable, and compact development has become increasingly popular with governments. An extensive body of literature has focused on the influence on housing prices from an economic perspective. Although residential urban planning from the perspective of individual needs must be considered, little attention has been paid to residents’ demands in high-density and compact urban areas. In this study, we selected Hong Kong as the case and adopted a reliability interval method to rank residential attitude metrics, which indicated residents’ neighborhood needs in densely populated cities. The influences of location attributes on residents’ demands and residential value were compared. A hedonic price model was used to estimate the impacts of the attributes on housing prices. The results showed that both access to metro stations and median household income had important influences on residents’ preferences and housing prices. However, access to the central business district contributed largely to housing prices but not to residents’ attitudes. These findings support urban planners and policy makers during sustainable residential planning and policy formation by understanding residents’ needs in compact urban areas, help them to optimize the match between housing attributes and residents’ expectations, and balance the relationship between residents’ needs and economic interest.

IntroductionThe global COVID-19 vaccine rollout has been impacted by socioeconomic disparities and vaccine hesitancy, but few studies examine reasons for changed attitudes. In Lao People’s Democratic Republic (Lao PDR), a nationwide government-led initiative was developed in response to COVID-19, focused on community health ownership and trust in primary healthcare. The intervention team including health and governance sectors conducted capacity-building workshops with local staff and community representatives and visited villages for vaccination outreach. This study investigates the impact of this intervention on COVID-19 vaccine acceptance in rural communities.MethodsConducted in Xiengkhuang province, Lao PDR, from December 2022 to February 2023, the study employed a sequential mixed-methods research design. Data on vaccinated individuals from 25 villages were collected from 11 primary healthcare units; pre-post analysis was applied. Qualitative data, gathered through interviews and focus group discussions with villagers, village authorities, health staff and local government (n=102) in six villages, underwent inductive thematic analysis.ResultsFirst-dose vaccine uptake after the intervention increased significantly (6.9 times). Qualitative analysis identified key reasons for vaccination hesitancy: (1) mistrust due to rumours and past experiences; (2) poor communication and inconsistent messaging and (3) challenges in access for priority groups. Influencing factors during the intervention included (1) effective local-context communication; (2) leveraging existing community structures and influential individuals in a multisectoral approach and (3) increased community motivation through improved satisfaction, ownership and relationships.ConclusionThis study highlights the impact and methods of building trust with unreached populations in health interventions, emphasising locally led solutions. Successful reversal of vaccine hesitancy was achieved by addressing root causes and fostering ownership at community and local government levels through a ‘positive approach’. This diverges from conventional supplemental immunisation activities and holds potential for systematically building trust between unreached populations and health systems. Further research could explore the impacts of routine vaccination for sustained improvements in health equity.

Community engagement and local governance are important components of health interventions aiming to empower local populations. Yet, there is limited evidence on how to effectively engage with communities and codevelop interventions, especially in Southeast Asian contexts. Despite rapid progress, the Lao People’s Democratic Republic (Lao PDR) still has high maternal and child mortality, with essential service coverage showing significant disparities across socioeconomic strata. Long-standing challenges in community health were exacerbated by the COVID-19 pandemic and reinforced by poor trust between users and health providers. However, the pandemic also provided an opportunity to develop approaches for enhanced community engagement and local governance capacity to tackle health inequities. The Community Network Engagement for Essential Healthcare and COVID-19 Responses through Trust (CONNECT) Initiative, developed by the Lao PDR government, WHO and partners, has resulted in initial positive outcomes in community health such as increased vaccination uptake, facility births and trust in health providers. This case study describes the iterative, adaptive process by which the CONNECT Initiative was developed, and how the core components, key stakeholders, theory of change and evaluation framework evolved from grounded observations and hypotheses. Lessons learnt include (1) awareness of entry points and existing structures to strengthen local governance for health through mutually beneficial intersectoral collaboration; (2) building relationships and trust with an adaptive, grounds-up approach for sustainability and scalability. As a model which can be adapted to other settings, this case study provides evidence on how to engage with communities, strengthen local governance and codevelop interventions towards greater health equity.