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"Locke, Thomas"
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Renegades
\"When twins Sean and Dillon Kirrell use their transit abilities to rescue a kidnap victim, they cross a clandestine group within their government who seeks to control all planets with their transit powers, forcing the brothers to choose sides in what could explode into full-blown war\"-- Provided by publisher.
Book
The immune evasion roles of Staphylococcus aureus protein A and impact on vaccine development
While Staphylococcus aureus ( S. aureus ) bacteria are part of the human commensal flora, opportunistic invasion following breach of the epithelial layers can lead to a wide array of infection syndromes at both local and distant sites. Despite ubiquitous exposure from early infancy, the life-long risk of opportunistic infection is facilitated by a broad repertoire of S. aureus virulence proteins. These proteins play a key role in inhibiting development of a long-term protective immune response by mechanisms ranging from dysregulation of the complement cascade to the disruption of leukocyte migration. In this review we describe the recent progress made in dissecting S. aureus immune evasion, focusing on the role of the superantigen, staphylococcal protein A (SpA). Evasion of the normal human immune response drives the ability of S. aureus to cause infection, often recurrently, and is also thought to be a major hindrance in the development of effective vaccination strategies. Understanding the role of S. aureus virulence protein and determining methods overcoming or subverting these mechanisms could lead to much-needed breakthroughs in vaccine and monoclonal antibody development.
Journal Article
Flash point
\"A scrappy young banker accepts a dare and is thrust into an out-of-sequence world. Laced with corporate intrigue and unexpected romance, this innovative thriller challenges assumptions about the nature of reality\"--Provided by publisher.
Book
Presurgical detection of brain invasion status in meningiomas based on first-order histogram based texture analysis of contrast enhanced imaging
•Prior studies on meningiomas have correlated histologic grading with semantic MRI features like heterogeneity and tumor-brain interface.•Main limitation of semantic analysis is subjective assessment. Radiomics offers a more reproducible method to quantitatively assess lesions.•Studies showed diagnostic utility of MRI texture analysis in meningioma grading. None of these studies evaluated brain invasion status alone.•In this study, we assessed a radiomics based approach on post-contrast T1-WI for characterization of brain invasion status of meningiomas.•Our results indicate that first-order radiomics-derived texture analysis features can detect brain invasion status with good success.
Invasion of brain parenchyma by meningioma can be a critical factor in surgical planning. The aim of this study was to determine the diagnostic utility of first-order texture parameters derived from both whole tumor and single largest slice of T1-contrast enhanced (T1-CE) images in differentiating meningiomas with and without brain invasion based on histopathology demonstration.
T1-CE images of a total of 56 cases of grade II meningiomas with brain invasion (BI) and 52 meningiomas (37 grade I and 15 grade II) with no brain invasion (NBI) were analyzed. Filtration-based first-order histogram derived texture parameters were calculated both for whole tumor volume and largest axial cross-section. Random forest models were constructed both for whole tumor volume and largest axial cross-section individually and were assessed using a 5-fold cross validation with 100 repeats.
In detection of brain invasion, random forest model based on whole tumor segmentation had an AUC of 0.988 (95 % CI 0.976–1.00) with a cross validated value of 0.74 (95 % CI 0.45-0.96). For differentiation of grade I meningiomas from grade II meningiomas with brain invasion, the AUC was 0.999 (95 % CI 0.995–1.00) and 0.81 (95 % CI 0.61-0.99) in the training and validation cohorts, respectively. Similarly, when using only the single largest slice, the cross-validated AUC to distinguish BI versus NBI and BI versus grade I meningiomas was 0.67 (95 % CI 0.47, 0.92 and 0.78 (95 % CI 0.52, 0.95) respectively.
Radiomics based feature analysis applied on routine MRI post-contrast images may be helpful to predict presence of brain invasion in meningioma, possibly with better performance when comparing BI versus grade I meningiomas.
Journal Article
Enclave
\"Four-time Christy award-winner crafts a compelling novel of scientific suspense with complex characters, intrigue, and cover-up in a world where nothing is as it seems.\"-- Provided by publisher.
Book
Recruits
Twin brothers Sean and Dillon discover they have the ability to transfer between worlds and become recruits to the planetary Assembly.
Book
Mycetoma in Timor-Leste and First Report of Nocardiosis
Mycetoma is a neglected tropical disease with an unknown global burden. Although considered endemic to South-east Asia, it has not previously been reported from Timor-Lest. We describe two cases in Timor-Leste, highlighting the challenges surrounding microbiological diagnosis and management shared by many low to middle-income countries. As characteristically described, both patients lived rurally and presented late with marked soft tissue involvement and multiple draining sinuses following a prolonged period of high morbidity. Nocardia brasiliensis, a beadedbranched, modified acid-fast, gram-positive bacilli, was isolated and confirmed by molecular testing in the first case. The causative organism in the second case could not be confirmed due to limited microbiological capabilities. Due to limited local laboratory capabilities, Nocardia spp. infection cannot be routinely confirmed in Timor- Leste. However, the microbiology laboratory is essential for the successful diagnosis and management of Mycetoma. In both cases, medical therapy alone resulted in cure and favorable outcomes, although supply of antibiotic remains an ongoing resource issue.
Journal Article