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Digital Design using QuarkXPress 4 gives you the ability to fully understand QuarkXPress, while developing a knowledge of the rules of design and how computers can exploit them. Students with non-visual backgrounds can rapidly improve, producing worthy examples of pages that integrate text and image. Knowledge gives you choices. The authors approach the subject of teaching QuarkXPress from all the necessary directions. Learning software enables you to lay out a page but not to design one. So this does not take the reader through a series of steps reproducing designed pages - that teaches you nothing. Instead, the authors provide an objective understanding of what makes your designs work.

George Daley and colleagues show that Lin28 and Lin28B promote cellular transformation by repressing let-7 family members, leading to derepression of let-7 targets. They also find that LIN28 and LIN28B are overexpressed in ∼15% of primary human tumors and cancer cell lines and that their expression is associated with aggressive disease and poor prognosis across multiple tumor types. Multiple members of the let-7 family of miRNAs are often repressed in human cancers 1 , 2 , thereby promoting oncogenesis by derepressing targets such as HMGA2, K-Ras and c-Myc 3 , 4 . However, the mechanism by which let-7 miRNAs are coordinately repressed is unclear. The RNA-binding proteins LIN28 and LIN28B block let-7 precursors from being processed to mature miRNAs 5 , 6 , 7 , 8 , suggesting that their overexpression might promote malignancy through repression of let-7. Here we show that LIN28 and LIN28B are overexpressed in primary human tumors and human cancer cell lines (overall frequency ∼15%), and that overexpression is linked to repression of let-7 family miRNAs and derepression of let-7 targets. LIN28 and LIN28b facilitate cellular transformation in vitro , and overexpression is associated with advanced disease across multiple tumor types. Our work provides a mechanism for the coordinate repression of let-7 miRNAs observed in a subset of human cancers, and associates activation of LIN28 and LIN28B with poor clinical prognosis.