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The present study focused on an environmental scandal that occurred in Italy, the Land of Fires toxic waste scandal, which caused consumer concerns related to the safety of food produced in the affected region, as well as massive market reduction in products associated with the polluted area. Based on a representative sample of Italian households (N = 1134), this study applied an extended Theory of Planned Behavior (TPB) model to analyze consumer purchases of regional food products after this environmental hazard. In addition to attitudes, subjective norms and perceived behavioral control, the model included risk perception, trust, and actual purchases. Using a structural equation model, our results provided support to the hypothesis that consumer perceptions of risk negatively impacted their purchase behaviors and suggested that increasing Italians’ trust in government information could reduce their perceived risk and, consequently, increase their intention to purchase regional food.

The function of lysosomes relies on the ability of the lysosomal membrane to fuse with several target membranes in the cell. It is known that in lysosomal storage disorders (LSDs), lysosomal accumulation of several types of substrates is associated with lysosomal dysfunction and impairment of endocytic membrane traffic. By analysing cells from two severe neurodegenerative LSDs, we observed that cholesterol abnormally accumulates in the endolysosomal membrane of LSD cells, thereby reducing the ability of lysosomes to efficiently fuse with endocytic and autophagic vesicles. Furthermore, we discovered that soluble N‐ethylmaleimide‐sensitive factor attachment protein (SNAP) receptors (SNAREs), which are key components of the cellular membrane fusion machinery are aberrantly sequestered in cholesterol‐enriched regions of LSD endolysosomal membranes. This abnormal spatial organization locks SNAREs in complexes and impairs their sorting and recycling. Importantly, reducing membrane cholesterol levels in LSD cells restores normal SNARE function and efficient lysosomal fusion. Our results support a model by which cholesterol abnormalities determine lysosomal dysfunction and endocytic traffic jam in LSDs by impairing the membrane fusion machinery, thus suggesting new therapeutic targets for the treatment of these disorders. Lysosomal storage disorders involve lysosomal dysfunction and defective endocytic membrane trafficking. However, the underlying mechanism(s) remain largely unclear. In this study, Andrea Ballabio et al. reveal that cholesterol accumulates in the endolysosomal system of LSD cells and interferes with the activity of the lysosomal SNARE membrane fusion machinery

Among foods with credence attributes, food with “natural” components have received in the last years particular attention by consumers. This study applies the BDM incentive compatible mechanism to explore young (18–35 years old) consumers’ interest and willingness to pay for chewing gums having the natural attribute. Our analysis shows that over 68% of consumers are interested in the natural attribute and are willing to pay a price premium. We also find that consumers’ higher age and interest in the environment have significant impacts on consumers’ preferences for the natural attribute.

The adoption of circular bioeconomy (CBE) strategies in forest-wood supply chains is a possible avenue for the future of this sector. However, the uptake of CBE models may face several barriers in the coming years, particularly in disadvantaged forest areas lacking appropriate resources and a suitable business environment to start radical innovation pathways. Based on interviews with 29 representatives (business actors and other key informants) of the forest-food sector of the Salerno province (Italy), the current study investigated the main strengths, weaknesses, opportunities, and threats (SWOT) involved in the transition of disadvantaged forest areas into a circular bioeconomy. Respondents also contributed to identifying the most suitable strategies in order to foster the CBE transition in the territory at hand. The paper offers an outlook for the potentialities of CBE in disadvantaged forest areas for policy actors, willing to bridge the gap between CBE agendas and territorial development challenges. The role of policy actors is particularly crucial, in order to patronize investments, stimulate improved know-how and cooperation, and fix policy inconsistencies related to biomass valorization.

Background: Levodopa ( L -Dopa), representing the therapeutic gold standard for the treatment of Parkinson disease (PD), is associated with side effects like L -Dopa induced dyskinesia (LID). Although several non-genetic and genetic factors have been investigated for association with LID risk, contrasting results were reported and its genetic basis remain largely unexplored. Methods: In an Italian PD cohort (N = 460), we first performed stepwise multivariable Cox Proportional Hazard regressions modeling LID risk as a function of gender, PD familiarity, clinical subtype, weight, age-at-onset (AAO) and years-of-disease (YOD), L -Dopa dosage, severity scores, and scales assessing motor (UPDRS-III), cognitive (MoCA), and non-motor symptoms (NMS). Then we enriched the resulting model testing two variants—rs356219 and D4S3481—increasing the expression of the SNCA gene, previously suggested as a potential mechanism of LID onset. To account for more complex (non-linear) relations of these variables with LID risk, we built a survival random forest (SRF) algorithm including all the covariates mentioned above. Results: Among tested variables (N = 460 case-complete, 211 LID events; total follow-up 31,361 person-months, median 61 months), disease duration showed significant association ( p < 0.005), with 6 (3–8)% decrease of LID risk per additional YOD. Other nominally significant associations were observed for gender—with women showing a 39 (5–82)% higher risk of LID—and AAO, with 2 (0.3–3)% decrease of risk for each year increase of PD onset. The SRF algorithm confirmed YOD as the most prominent feature influencing LID risk, with a variable importance of about 8% in the model. In genetic models, no statistically significant effects on incident LID risk was observed. Conclusions: This evidence supports a protective effect of late PD onset and gender (men) against LID risk and suggests a new independent protective factor, YOD. Moreover, it underlines the importance of personalized therapeutic protocols for PD patients in the future.

The current linear system of production and consumption is unsustainable. In the food sector, despite the fact that valuable natural resources are intensively used to produce and distribute food products, little is done to upcycle residues generated along the supply chain. Circular economy strategies are crucial for restructuring the take-make-dispose model through the active participation of all actors of supply chains. However, little is known about consumers’ willingness to participate in circular economy. A structured questionnaire was submitted to a representative sample of Italian households to assess the willingness of consumers to be actively involved in closed loops aiming at reducing food waste. Consumers are involved by returning their organic food waste to retailers in exchange for discounts on the purchase of animal products. The organic food waste returned enters in the production process of animal products. A choice experiment was designed to analyse alternative programs. Two scenarios were presented: one with a traditional technology (composting), and a second one with a radically innovative technology (insects as feed). Preferences and trade-offs, in monetary terms, among attributes were computed. Results depict a comprehensive portrait of the potential participation of consumers to closed loops inspired by the principles of circular economy.

The introduction of biodegradable and compostable packaging has been a significant milestone in reducing conventional plastic use, particularly in sectors that prioritize sustainability like the organic food industry. This study explores the factors influencing the selection of such packaging, with a specific focus on the role of emotions in a representative sample of Italian consumers. Two models, the Theory of Planned Behavior (TPB) and the Rational-Emotional Model (REM), were evaluated and compared. The TPB model confirms that positive attitudes, subjective norms, and perceived behavioral control influence the intention to choose biodegradable and compostable packaging. The REM reveals that environmental concern, cognitive benefits, and emotions significantly impact purchase intentions. The REM explains a greater variance in intention compared to the TPB model, highlighting the importance of combining rational and emotional components. Biodegradable and compostable packaging aligns well with the target consumers of organic food, making it an excellent solution for organic produce. Emotions play a crucial role in shaping consumer intentions and behaviors. Marketing strategies should appeal to consumers’ emotional responses, address cognitive concerns, and highlight the specific benefits of sustainable packaging. This research emphasizes the relevance of bioplastic packaging for organic products and underscores the significance of emotions in influencing consumer behavior.

Purpose Consumer interest and willingness to pay (WTP) for omega-3 enriched water buffalo mozzarella cheese are evaluated through an in-store experimental auction. The purpose of this paper is to estimate individual WTP for enriched mozzarella cheese and related it to self-efficacy beliefs and outcome expectations of omega-3 consumption, following regulatory focus theory. Design/methodology/approach Data were collected in May-June 2015 from a sample of 150 consumers in Southern Italy. A structural equation modelling procedure was implemented. Findings The results show a significant role is played by prevention outcome expectations on consumer behaviour. While promotion outcome expectation constructs proved non-significant, self-identity correlates with prevention outcome expectations. Research limitations/implications There are several limitations that the authors are aware of regarding this study. First of all, since the authors rely on self-reported measures, optimistic bias might have affected participants’ responses (Weinstein, 1980). Second, results may be influenced by the choice of the specific information provided to consumers for the analysis; different claims and different information framings should be tested (LeBoeuf and Shafir, 2003). Practical implications Implications stemming from the results encourage the promotion of omega-3 enriched mozzarella cheese based on stimulating outcome expectations, bearing in mind that individual motivations should be enhanced by self-identity beliefs. Originality/value Although the combined role of self-efficacy and outcome expectations on personal intention to adopt healthy behaviour has already been demonstrated (Keller, 2006; Tudoran et al., 2012), to the best of the knowledge no previous study relates individual behaviour to an intention measured as a WTP for an actual product. In addition, current study has applied a non-hypothetical BDM (from Becker et al., 1964) auction in-store experiment.

In recent decades, there has been a rapid growth in consumer awareness of the influence of corporate activities on the environment, and society at large. Firms operating in the food supply chain have not been exempted: the vulnerability of agrifood businesses towards public opinion incentivizes firms to implement social, environmental and ethical measures in collaboration with the other food supply chain stakeholders. Previous studies in the food sector have shown that corporate social responsibility has positive effects on firm performance, but what is still unclear is whether, and how much, consumers are willing to pay for such an intangible attribute. In tackling this issue, we attempt to offer insights into consumer willingness to pay for corporate social responsibility attributes, identifying the psychological constructs that are likely to influence consumer preferences. Our contingent valuation experiment involving Italian consumers shows that individual values behave as effective determinants of consumer willingness to pay for corporate social responsibility.