Explore the vast range of titles available.

This study showed an association of loss-of-function mutations in ANGPTL4 with low triglyceride levels and protection against coronary artery disease. Inhibition of Angptl4 in mice and monkeys with a monoclonal antibody reduced triglyceride levels. The level of serum triglycerides is, in part, heritable, and elevated levels are associated with a risk of ischemic cardiovascular disease. 1 – 3 Mendelian randomization studies of genetically determined triglyceride levels have suggested that this association is causal. 4 Two lines of genetic evidence have further established a causal role for serum triglycerides in the risk of cardiovascular disease. First, inactivating mutations in the gene encoding apolipoprotein C3 ( APOC3 ), a component of remnant particles, were reported to be associated with decreased serum triglyceride levels, a decreased burden of subclinical atherosclerosis, and a reduced risk of ischemic cardiovascular disease, which suggests . . .

The university is an important pillar in sustainable development; however, COVID-19 imposed new dynamics that called for rethinking university praxis to achieve this mission, and although the systematization of good practices is a powerful mechanism for understanding educational success, this perspective of positive change has been little developed. Hence, the present study aimed to identify positive cores of faculty in their successful post-COVID-19 performance. A qualitative methodological approach was deployed, with the Netnography method, complemented with elements of positive psychology, appreciative inquiry, and management of formative potentialities. The online community consisted of 1238 university teachers from 10 Latin American countries, who participated for two months in an appreciative interview as an asynchronous journey of constructive proposals, for the active co-construction of post-COVID-19 success factors. The findings reveal multiple affirmative topics grouped into nine positive cores, identifying two target categories: digital transformation and technological innovation, as well as the processes directly associated with their dynamization. Finally, the epistemic implications of the findings in theory and practice, and their relevance in the creation of a formative agenda of positive change for Latin American Higher Education, are presented.

Adaptive performance is of central interest for today's organizations, insofar as employees increasingly need to be able to adjust their behaviors to dynamic, changing work situations. The aims of this study were to develop a Spanish adaptation of Charbonnier-Voirin and Roussel's (2012) scale for measuring adaptive performance, and to examine whether the dimensions of adaptive performance moderate the relationship between person-organization fit (PO fit) and organizational citizenship behaviors (OCBs). We hypothesized that the relationship between PO fit and OCBs would be stronger in individuals with a higher level of adaptive performance. The sample comprised 678 employees (65% women) in the public sector in the Basque Country. They ranged from 21 to 63 years old (M = 44.63; SD = 7.66). The Spanish version of the scale has good psychometric properties. Furthermore, the Interpersonal Adaptability dimension of adaptive performance moderates the relationship between PO fit and OCBs directed both at the organization and at individuals, following the expected direction. The relationship between PO fit and OCBs directed at individuals was also moderated by the Reactivity in the Face of Emergencies dimension. We discuss the practical implications of these results in the field of personnel selection.

We propose a distributed rewiring model which starts with a planar graph embedded into the Euclidean space and then behaves as a distributed system, where each node is provided with a set of dynamic links. The proposed rewiring evolves through cycles, where nodes explore the network to identify possible shortcuts and rewire their dynamic links. The rewiring decisions are subject to Euclidean and geodesic distance constrains. The emerging networks were assessed through topological and robustness analyses. We found that the networks display a variety of characteristics observed in complex networks encompassing phenomena such as preferential attachment, the distinctive traits of small-world networks, the presence of community structures, and robustness against degradation process. We consider that our proposal can be applied in the design of those self-managed systems in which there is a limitation on communication resources that can be represented by the Euclidean distance and, however, the components themselves can deploy strategies to optimize the transport of information and develop tolerance before contingencies.

We describe “Doppio”, a ROMS-based (Regional Ocean Modeling System) model of the Mid-Atlantic Bight and Gulf of Maine regions of the northwestern North Atlantic developed in anticipation of future applications to biogeochemical cycling, ecosystems, estuarine downscaling, and near-real-time forecasting. This free-running regional model is introduced with circulation simulations covering 2007–2017. The ROMS configuration choices for the model are detailed, and the forcing and boundary data choices are described and explained. A comprehensive observational data set is compiled for skill assessment from satellites and in situ observations from regional associations of the U.S. Integrated Ocean Observing Systems, including moorings, autonomous gliders, profiling floats, surface-current-measuring coastal radar, and fishing fleet sensors. Doppio's performance is evaluated with respect to these observations by representation of subregional temperature and salinity error statistics, as well as velocity and sea level coherence spectra. Model circulation for the Mid-Atlantic Bight and Gulf of Maine is visualized alongside the mean dynamic topography to convey the model's capabilities.

Percutaneous endoscopic lumbar discectomy (PELD) presents a challenging learning curve, and the correlation between surgeon experience and clinical outcomes remains contentious. This retrospective study aimed to compare the outcomes of PELD performed by a single surgeon at beginner and experienced stages. Propensity score matching selected 150 patients (75 per group) with a minimum 3-year follow-up. Clinical and radiological outcomes, perioperative complications, and adverse events were assessed. Baseline characteristics, pain improvement, patient satisfaction, and radiological outcomes did not differ between the groups. However, operation time was longer in the beginner group than in the experienced group (57.5 min [IQR, 50.0–70.0] versus 50.0 min [IQR, 45.0–55.0], p < 0.001). The beginner group had higher perioperative complication rates (eight patients [10.7%] versus one patient [1.3%], with a hazard ratio of 8.836 [95% CI, 1.077–72.514], p = 0.034) and lower 3-year survival without adverse events (19 patients [25.3%] in the beginner group and 10 patients [13.3%] in the experienced group, p = 0.045). Our findings indicate that the clinical outcomes were more favorable in patients operated on at the experienced stage compared to those treated at the beginner stage.

A prevailing idea in the organizational context is that men and women differ in personality traits and leadership styles. Few studies, however, have examined gender differences in managerial behavior. The aim of the present study was to explore the presence of such differences in a sample of public sector employees (N = 678), focusing on personality and two key human resources constructs, namely organizational citizenship behaviors (OCBs) and adaptive performance. We also compared gender differences among managers with those observed among employees without managerial responsibilities. Finally, we examined whether the attributes that distinguish managers from non-managers are the same for men and women. Mean comparison strategies and the Cohen’s d effect size index were used. The results suggest that male and female public managers have similar leadership profiles in terms of personality, OCBs and adaptive performance. In addition, and despite small gender differences in this respect, it appears that communal traits, such as Creativity or interpersonal OCBs, are becoming increasingly relevant to managerial positions in the public sector, which implies complementarity in the gender roles linked with the behaviors associated with leadership and access to management positions. Our results support both the gender-invariant role demands and the changing leadership roles perspectives and may have implications for selection and promotion policies in public sector organizations.

Objective One of the primary tools in the assessment of individual‐level patient outcomes is Jacobson and Truax, (1991’s) Reliable Change Index (RCI). Recent efforts to optimize the RCI have revolved around three issues: (a) extending the RCI beyond two timepoints, (b) estimating the RCI using scale scores from item response theory or factor analysis and (c) estimation of person‐ and time‐specific standard errors of measurement. Method We present an adaptation of a two‐stage procedure, a measurement error‐corrected multilevel model, as a tool for RCI estimation (with accompanying Statistical Analysis System syntax). Using DASS‐21 data from a community‐based mental health center (N = 379), we illustrate the potential for the model as unifying framework for simultaneously addressing all three limitations in modeling individual‐level RCI estimates. Results Compared to the optimal‐fitting RCI model (moderated nonlinear factor analysis scoring with measurement error correction), an RCI model that uses DASS‐21 total scores produced errors in RCI inferences in 50.8% of patients; this was largely driven by overestimation of the proportion of patients with statistically significant improvement. Conclusion Estimation of the RCI can now be enhanced by the use of latent variables, person‐ and time‐specific measurement errors, and multiple timepoints.

Measuring solar irradiance is key to assessing the conversion efficiency of photovoltaic (PV) modules. Also, PV modules can be used to estimate irradiance through their electrical response to solar radiation using closed-form models (CFMs). This paper presents a prototype design for irradiance estimation based on evaluating three CFMs by implementing a maximum power point tracking (MPPT) system and a surface temperature measurement system. The system employs an incremental conductance (IC)-based control algorithm, which is optimized to eliminate oscillations at the maximum power point (MPP) and ensure efficient MPP tracking. Experimental validation of the implemented circuits is carried out using Arduino Nano, calibrated sensors, and low-cost electronic devices. Tests in real conditions were performed for four days under different irradiance scenarios, using two monocrystalline PV modules: one with 10 years of use and one new one. The accuracy of the CFMs was evaluated using the mean absolute percentage error (MAPE) and root mean squared error indicators, comparing their estimates with measurements from a Davis Instruments pyranometer. The most accurate CFM obtained a MAPE of 4.38% with the 10-year module and 3.26% with the new module. The results show that the proposed methodology provides estimates with an error of less than 5%, which validates its applicability under various climatic conditions, even with old PV modules.

The suitability of the charcoal obtained from woody biomass pyrolysis in a continuous screw reactor at 573, 773, 973, 1173 K temperature profile as fuel and reducing agent in metallurgical applications has been evaluated, in order to reduce the CO2 emissions in these processes. On the one hand, a comparative study between charcoal and commercial reducers has been carried out. On the other hand, different proportions of this charcoal have been added to an industrial coking coal blend and carbonized together in a semi-pilot movable wall oven, to study the influence in the plastic and mechanical properties of the produced biocoke. The charcoal obtained fulfills the requirements to be used as fuel and reducer in non-ferrous processes where no mechanical strength is required, like rotary kilns, in substitution of fossil reducers. Its higher heating value (>32 MJ kg−1) is in the range or over those of fossil coals, with the advantage of not containing polluting elements (S, N) and having less ash. The addition of up to 0.9 wt.% almost does not affect the quality of the biocoke; but the addition of ≥2 wt.% degrades the biocoke mechanical and plastic properties below the demanded requirements. Moreover, biocoke reactivity seems independent of the amount of charcoal added.