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Bladder cancer (BCa) presents a significant clinical challenge, with a pressing need for biomarkers to predict prognosis and guide immunotherapy. Aly/REF export factor (ALYREF) is a key regulator in various cancers, but its role in bladder cancer (BCa) remains unclear. This study aimed to investigate the clinical significance of ALYREF and its association with immunotherapy response and metastatic potential in BCa. We integrated pan-cancer bioinformatic analyses with clinical validation using RT-qPCR, immunohistochemistry, and Western blot on patient samples. We assessed ALYREF’s correlation with clinicopathological features, survival, and response to immune checkpoint inhibitors (ICIs). Circulating tumor cell (CTC) counts were analyzed to link ALYREF to metastatic potential. Functional roles in migration and invasion were validated in vitro using the T24 cell line. ALYREF was significantly upregulated in BCa tissues, correlating with higher tumor grade and poorer overall survival. Paradoxically, high ALYREF expression was also associated with a better response to ICI therapy. Furthermore, elevated ALYREF levels in tumors corresponded to increased CTC counts. In vitro experiments confirmed that ALYREF promotes BCa cell migration and invasion. ALYREF is a dual-role biomarker in BCa. Its overexpression signifies aggressive tumor biology and metastatic risk yet also predicts a favorable response to immunotherapy. ALYREF holds promise for refining patient stratification and personalizing BCa treatment.

Nitric oxide (NO), a pivotal signalling molecule, plays multifaceted roles in physiological and pathological processes, including cardiovascular and immune functions, neurotransmission and cancer progression. Nevertheless, measuring NO in vivo is challenging due to its transient nature and the complexity of the biological environment. Here we describe NO-responsive magnetic probes made of crosslinked superparamagnetic iron oxide nanoparticles tethered to a NO-sensitive cleavable linker for highly sensitive and selective NO magnetic resonance imaging in vivo. These probes enable the detection of NO at concentrations as low as 0.147 μM, allowing for the imaging and quantification of NO in mouse tumour models, studying its effects on tumour progression and immunity and assessing the response of tumour-associated macrophages to cancer immunotherapeutic agents. Additionally, they facilitate concurrent anatomical and molecular imaging of organs, helping to identify pathological alterations in the liver. Overall, these probes represent promising non-invasive tools for investigating the dose-dependent conflicting role of NO in physiological and pathophysiological processes. Iron oxide nanoparticles containing a nitric oxide-responsive cleavable linker allow in vivo magnetic resonance imaging and the quantification of nitric oxide with high sensitivity and selectivity in mice.

Defining the degree of risk of maritime transport nodes is an important basis for studying the security status of maritime transport passages. However, some important straits or canals are key nodes in the maritime transport passage, and their system security conditions are affected by the interaction of uncertainty risk factors. This study addresses the issue of the security status of transport nodes from the perspective of the characteristics of influencing factors. With a focus on catastrophes and the mutual coupling characteristics of the factors that influence the security of maritime transport nodes, a model based on principal component analysis (PCA) and catastrophe theory (CT) is constructed, and the coupled risk degree of the key nodes in Chinese maritime transportation is empirically analysed. The results show that the Taiwan Strait has the lowest risk degree and that the Windward Strait has the highest risk degree among the key nodes in Chinese maritime transport. From the perspective of the security status of these key nodes, most nodes are currently in a stable and safe state.

The microstructure of continuously hot-dip galvanizing Zn-Mg coating was investigated in order to obtain the mechanism of the effects of Mg on the corrosion resistance. In this paper, the vertical section of the Zn-0.20 wt % Al-Mg ternary phase diagram near the Al-low corner was calculated. The results indicates that the phase composition of the Zn-0.20 wt % Al-Mg ternary phase diagram near the Al-low corner is the same as Zn-Mg binary phase diagram, suggesting Al in the Zn-Mg (ZM) coatings mainly concentrates on the interfacial layer between the coating and steel substrate. The microstructure of continuously hot-dip galvanizing ZM coatings with 0.20 wt % Al containing 1.0–3.0 wt % Mg was investigated using tunneling electron microscopy (TEM). The morphology of Zn in the coating changes from bulk to strip and finally to mesh-like, and the MgZn2 changes from rod-like to mesh-like with the Mg content increasing. Al in the ZM coatings mainly segregates at the Fe2Al5 inhibition layer and the Mg added to the Zn bath makes this inhibition layer thinner and uneven. Compared to GI coating, the time of the first red rust appears increases by more than two-fold and expansion rate of red rust reduces by more than four-fold in terms of salt spray experiment. The ZM coating containing 2.0 wt % Mg has the best corrosion resistance. The enhanced corrosion resistance of ZM coatings mainly depends on different corrosion products.

Lectin receptor-like kinases (LecRKs) are a class of membrane proteins found in higher plants. They play important roles in defense against of pathogens, perception of insect feeding, and stress tolerance. LecRK-VII.1 (AT4G04960) is one member of the LecRK family, which contains a conserved lectin domain and a kinase domain. In this study, the lecrk - VII.1 mutants ( lecrk - VII.1 - 1 and lecrk - VII.1 - 2 ) showed increased seed germination rates and primary root length compared to ecotype Columbia-0 (Col-0) when treated with different concentrations of NaCl and methyl jasmonate (MeJA). To further confirm the possible role of LecRK-VII.1 in salt and jasmonic acid (JA) responses, we performed a comparative proteomic analysis of Arabidopsis Col-0 and lecrk - VII.1 - 1 mutant seedlings. In total, 312 proteins were differentially expressed of which 75 were related to stress responses including salt stress and JA response. Among them, decreased expressions of lipoxygenase (LOX) and annexin were confirmed by RT-PCR analyses. Activity of LOX was accordingly reduced in lecrk - VII.1 mutants. These results provide some valuable data to understand the role of LecRK-VII.1 in the response to salt stress and MeJA. Graphical Abstract In order to understand the role of LecRK-VII.1 in the response to salt stress and MeJA, we studied the phenotypes and expression patterns between the lecrk-VII.1 mutants and wild type. Comparative proteomic analysis of differentially expressed proteins of the lecrk-VII.1 mutants and wild type in Arabidopsis was performed.

The nature of packet loss of wireless links at 2.4G band was analyzed and a wireless link quality prediction algorithm for wireless sensor networks was proposed. In the proposal, RSSI (Received Signal Strength Indicator) and LQI (Link Quality Indicator) were utilized to produce a couple of metrics of wireless link quality, named 8m and delta respectively, and their distributions were studied. By using SAX (Symbol Aggregation approximately) method, the LQIs were mapped into different symbols, and summarized the preceding symbols of link quality deterioration in collection of patterns. Then the distance of a sample to patterns was used to determine the probability the link deterioration, so that the link quality of the next period was predicted. The proposed method is simple, so it is easy to implement in wireless sensor network. Finally, the experiment using practical link data showed that the proposed method can predict more than 80 percent of the link deteriorations. Index Terms-Wireless Sensor Network; Link Quality Prediction; Pattern Match; Symbolic Aggregate Approximation

The Mujicun Cu （Mo） ore deposit at Laiyuan, Hebei Province, is a currently proven large-sized Cu （Mo） polymetallic ore deposit and it is located in the second-ordered fault depression basin of the ditachment belt on the hanging-wall on the western side at the juncture of the Laiyuan dumbell-shaped complex in the northern part of the Fuping mantle-branch structure. Metallogenesis is controlled by diorite porphyrite in intrusive relation with the fault depression basin and other relevant fault structure systems and intenstive wall-rock alteration zones. This study, in conjunction with the most recent exploration data, analyzed the geological background of metallogenesis of this deposit, summaried the geological characteristics of typical ore deposits, determined the alteration zonation of the deposit, investigated regional metallogenesis and the genesis of typical ore deposits, discussed the regional ore-forming and ore-controlling structures, and generalized the regional ore-controlling model and metallogenic model of the deposit. It is considered that the Mujicun porphry Cu （Mo） deposit, the Tieling, Futuyu, Xiaoligou and other skarn-type Fe-Cu deposits and the He’ergou hydrothermal-type Pb-Zn-Ag deposit jointly constitute a three-in-one polymetallic orefield, with the characteristics of typical metallogenic series.

According to EGTS proposal, an adaptive channel hopping algorithm that can be used in wireless mesh sensor networks was is designed in this paper. The nodes select proper channels independently and use them to communicate with their neighbors. Once a pair of nodes find their current channel has been deteriorated, they abandoned the current channel and enable the reserved channel, so that the reliability of the network is improved. The algorithm is compatible with the primitives and the frame structure of EGTS and makes use of multi-channels efficiently. The data structure and the procedure of the mechanism were described in detail and the feasibility and the efficiency was given by analysis and experiment. Finally, it is concluded that the algorithm is practicable when the density of network is less than 8 and the topology is relatively static.

The Mujicun Cu (Mo) ore deposit at Laiyuan, Hebei Province, is a currently proven large-sized Cu (Mo) polymetallic ore deposit and it is located in the second-ordered fault depression basin of the ditachment belt on the hanging-wall on the western side at the juncture of the Laiyuan dumbell-shaped complex in the northern part of the Fuping mantle-branch structure. Metallogenesis is controlled by diorite porphyrite in intrusive relation with the fault depression basin and other relevant fault structure systems and intenstive wall-rock alteration zones. This study, in conjunction with the most recent exploration data, analyzed the geological background of metallogenesis of this deposit, summaried the geological characteristics of typical ore deposits, determined the alteration zonation of the deposit, investigated regional metallogenesis and the genesis of typical ore deposits, discussed the regional ore-forming and ore-controlling structures, and generalized the regional ore-controlling model and metallogenic model of the deposit. It is considered that the Mujicun porphry Cu (Mo) deposit, the Tieling, Futuyu, Xiaoligou and other skarn-type Fe-Cu deposits and the He’ergou hydrothermal-type Pb-Zn-Ag deposit jointly constitute a three-in-one polymetallic orefield, with the characteristics of typical metallogenic series.

P618.41; The Mujicun Cu (Mo) ore deposit at Laiyuan,Hebei Province,is a currently proven large-sized Cu (Mo) polymetallic ore deposit and it is located in the second-ordered fault depression basin of the ditachment belt on the hanging-wall on the western side at the juncture of the Laiyuan dumbell-shaped complex in the northern part of the Fuping mantle-branch structure.Metallogenesis is controlled by diorite porphyrite in intrusive relation with the fault depression basin and other relevant fault structure systems and intenstive wall-rock alteration zones.This study,in conjunction with the most recent exploration data,analyzed the geological background of metallogenesis of this deposit,summaried the geological characteristics of typical ore deposits,determined the alteration zonation of the deposit,investigated regional metallogenesis and the genesis of typical ore deposits,discussed the regional ore-forming and ore-controlling structures,and generalized the regional ore-controlling model and metallogenic model of the deposit.It is considered that the Mujicun porphry Cu (Mo) deposit,the Tieling,Futuyu,Xiaoligou and other skarn-type Fe-Cu deposits and the He'ergou hydrothermal-type Pb-Zn-Ag deposit jointly constitute a three-in-one polymetallic orefield,with the characteristics of typical metallogenic series.