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In mammalians and yeast, the splicing factor U2AF65/Mud2p functions in precursor messenger RNA (pre-mRNA) processing. Arabidopsis AtU2AF65b encodes a putative U2AF65 but its specific functions in plants are unknown. This paper examines the function of AtU2AF65b as a negative regulator of flowering time in Arabidopsis. We investigated the expression and function of AtU2AF65b in abscisic acid (ABA)-regulated flowering as well as the transcript abundance and pre-mRNA splicing of flowering-related genes in the knock-out mutants of AtU2AF65b. The atu2af65b mutants show early-flowering phenotype under both long-day and short-day conditions. The transcript accumulation of the flowering repressor gene FLOWERING LOCUS C (FLC) is reduced in the shoot apex of atu2af65b, due to both increased intron retention and reduced transcription activation. Reduced transcription of FLC results, at least partially, from the abnormal splicing and reduced transcript abundance of ABSCISIC ACID-INSENSITIVE 5 (ABI5), which encodes an activator of FLC in ABA-regulated flowering signaling. Additionally, the expression of AtU2AF65b is promoted by ABA. Transition to flowering and splicing of FLC and ABI5 in the atu2af65b mutants are compromised during ABA-induced flowering. ABA-responsive AtU2AF65b functions in the pre-mRNA splicing of FLC and ABI5 in shoot apex, whereby AtU2AF65b is involved in ABA-mediated flowering transition in Arabidopsis.

Copper‐based antimicrobial compounds are widely and historically used to control plant diseases, such as late blight caused by Phytophthora infestans, which seriously affects the yield and quality of potato. We previously identified that copper ion (Cu2+) acts as an extremely sensitive elicitor to induce ethylene (ET)‐dependent immunity in Arabidopsis. Here, we found that Cu2+ induces the defence response to P. infestans in potato. Cu2+ suppresses the transcription of the abscisic acid (ABA) biosynthetic genes StABA1 and StNCED1, resulting in decreased ABA content. Treatment with ABA or inhibitor fluridone made potato more susceptible or resistance to late blight, respectively. In addition, potato with knockdown of StABA1 or StNCED1 showed greater resistance to late blight, suggesting that ABA negatively regulates potato resistance to P. infestans. Cu2+ also promotes the rapid biosynthesis of ET. Potato plants treated with 1‐aminocyclopropane‐1‐carboxylate showed enhanced resistance to late blight. Repressed expression of StEIN2 or StEIN3 resulted in enhanced transcription of StABA1 and StNCED1, accumulation of ABA and susceptibility to P. infestans. Consistently, StEIN3 directly binds to the promoter regions of StABA1 and StNCED1. Overall, we concluded that Cu2+ triggers the defence response to potato late blight by activating ET biosynthesis to inhibit the biosynthesis of ABA. Cu2+‐mediated late blight resistance activates ET signalling, subsequently suppressing ABA biosynthesis. This recalls two tips when using copper‐based antimicrobial compounds: water in advance; avoid strong sunshine and drought.

This paper investigates the impacts of migration characteristics on rural migrant households’ farmland use arrangements in China. The results reveal that trailing migration, duration of migration and the proportion of co-migrants have a significant effect on the probability of rural migrant households’ farmland abandonment. Commercial employment migration has a negative impact on the abandonment of farmland by migrant families. Migrant households are most likely to choose farmland abandonment in the western and middle regions of China and in small farmland areas. In the eastern region, and first tier and second tier Chinese cities, migrant households are more inclined to choose farmland transfer. Household earnings increase, which induces households to gradually give up the cultivation of farmland or to transfer farmland, constituting a mechanism in Chinese households’ farmland use arrangements. Notably, the consolidation of arable land should be the focus in areas of low economic development. Furthermore, an effective mechanism for the transfer of farmland should be established.

HighlightsGraphene-like 2D V2O5 nanosheets rich in oxygen vacancies are designed as multi-functional catalysts to fabricate MgH2-H-V2O5 composites.Hydrogen release starts from 185 °C and capacity retention is as high as 99% after 100 cycles at 275 °C.The composites present rapid kinetics and impressive hydrogen absorption capability at near room temperature.The oxygen vacancies could directly enhance kinetics of MgH2 while indirectly exciting “hydrogen pump” effect of VH2/V.MgH2 is a promising high-capacity solid-state hydrogen storage material, while its application is greatly hindered by the high desorption temperature and sluggish kinetics. Herein, intertwined 2D oxygen vacancy-rich V2O5 nanosheets (H-V2O5) are specifically designed and used as catalysts to improve the hydrogen storage properties of MgH2. The as-prepared MgH2-H-V2O5 composites exhibit low desorption temperatures (Tonset = 185 °C) with a hydrogen capacity of 6.54 wt%, fast kinetics (Ea = 84.55 ± 1.37 kJ mol−1 H2 for desorption), and long cycling stability. Impressively, hydrogen absorption can be achieved at a temperature as low as 30 °C with a capacity of 2.38 wt% within 60 min. Moreover, the composites maintain a capacity retention rate of ~ 99% after 100 cycles at 275 °C. Experimental studies and theoretical calculations demonstrate that the in-situ formed VH2/V catalysts, unique 2D structure of H-V2O5 nanosheets, and abundant oxygen vacancies positively contribute to the improved hydrogen sorption properties. Notably, the existence of oxygen vacancies plays a double role, which could not only directly accelerate the hydrogen ab/de-sorption rate of MgH2, but also indirectly affect the activity of the catalytic phase VH2/V, thereby further boosting the hydrogen storage performance of MgH2. This work highlights an oxygen vacancy excited “hydrogen pump” effect of VH2/V on the hydrogen sorption of Mg/MgH2. The strategy developed here may pave a new way toward the development of oxygen vacancy-rich transition metal oxides catalyzed hydride systems.

HighlightsA comprehensive discussion of the recent advances in the nanostructure engineering of Mg-based hydrogen storage materials is presented.The fundamental theories of hydrogen storage in nanostructured Mg-based hydrogen storage materials and their practical applications are reviewed.The challenges and recommendations of current nanostructured hydrogen storage materials are pointed out.With the depletion of fossil fuels and global warming, there is an urgent demand to seek green, low-cost, and high-efficiency energy resources. Hydrogen has been considered as a potential candidate to replace fossil fuels, due to its high gravimetric energy density (142 MJ kg−1), high abundance (H2O), and environmental-friendliness. However, due to its low volume density, effective and safe hydrogen storage techniques are now becoming the bottleneck for the \"hydrogen economy\". Under such a circumstance, Mg-based hydrogen storage materials garnered tremendous interests due to their high hydrogen storage capacity (~ 7.6 wt% for MgH2), low cost, and excellent reversibility. However, the high thermodynamic stability (ΔH =  − 74.7 kJ mol−1 H2) and sluggish kinetics result in a relatively high desorption temperature (> 300 °C), which severely restricts widespread applications of MgH2. Nano-structuring has been proven to be an effective strategy that can simultaneously enhance the ab/de-sorption thermodynamic and kinetic properties of MgH2, possibly meeting the demand for rapid hydrogen desorption, economic viability, and effective thermal management in practical applications. Herein, the fundamental theories, recent advances, and practical applications of the nanostructured Mg-based hydrogen storage materials are discussed. The synthetic strategies are classified into four categories: free-standing nano-sized Mg/MgH2 through electrochemical/vapor-transport/ultrasonic methods, nanostructured Mg-based composites via mechanical milling methods, construction of core-shell nano-structured Mg-based composites by chemical reduction approaches, and multi-dimensional nano-sized Mg-based heterostructure by nanoconfinement strategy. Through applying these strategies, near room temperature ab/de-sorption (< 100 °C) with considerable high capacity (> 6 wt%) has been achieved in nano Mg/MgH2 systems. Some perspectives on the future research and development of nanostructured hydrogen storage materials are also provided.

Hepatocellular carcinoma (HCC), particularly when accompanied by microvascular invasion (MVI), has a markedly high risk of recurrence after liver resection. Adjuvant immunotherapy is considered a promising avenue. This multicenter, open-label, randomized, controlled, phase 2 trial was conducted at six hospitals in China to assess the efficacy and safety of adjuvant sintilimab, a programmed cell death protein 1 inhibitor, in these patients. Eligible patients with HCC with MVI were randomized (1:1) into the sintilimab or active surveillance group. The sintilimab group received intravenous injections every 3 weeks for a total of eight cycles. The primary endpoint was recurrence-free survival (RFS) in the intention-to-treat population. Key secondary endpoints included overall survival (OS) and safety. From September 1, 2020, to April 23, 2022, a total of 198 eligible patients were randomly allocated to receive adjuvant sintilimab ( n  = 99) or undergo active surveillance ( n  = 99). After a median follow-up of 23.3 months, the trial met the prespecified endpoints. Sintilimab significantly prolonged RFS compared to active surveillance (median RFS, 27.7 versus 15.5 months; hazard ratio 0.534, 95% confidence interval 0.360–0.792; P  = 0.002). Further follow-up is needed to confirm the difference in OS. In the sintilimab group, 12.4% of patients experienced grade 3 or 4 treatment-related adverse events, the most common of which were elevated alanine aminotransferase levels (5.2%) and anemia (4.1%). These findings support the potential of immune checkpoint inhibitors as effective adjuvant therapy for these high-risk patients. Chinese Clinical Trial Registry identifier: ChiCTR2000037655 . Results from a multicenter, randomized phase 2 trial in China show that adjuvant anti-PD-1 therapy in patients with resected hepatocellular carcinoma with microvascular invasion leads to prolonged recurrence-free survival compared to active surveillance.

HighlightsA MgH2/TiO2 heterostructure with nano MgH2 assembled on oxygen vacancy-rich 2D TiO2 nanosheets was successfully fabricated via a simple solvothermal strategy.The MgH2/TiO2 heterostructure shows rapid desorption kinetics, low dehydrogenation temperature, and excellent cycling stability.In situ HRTEM observations and ex situ XPS analyses reveal that multi-valance of Ti species, presence of abundant oxygen vacancies, formation of catalytic Mg-Ti oxides, and confinement of TiO2 nanosheets, contribute to the high stability and kinetically accelerated hydrogen sorption performances of Mg.MgH2 has attracted intensive interests as one of the most promising hydrogen storage materials. Nevertheless, the high desorption temperature, sluggish kinetics, and rapid capacity decay hamper its commercial application. Herein, 2D TiO2 nanosheets with abundant oxygen vacancies are used to fabricate a flower-like MgH2/TiO2 heterostructure with enhanced hydrogen storage performances. Particularly, the onset hydrogen desorption temperature of the MgH2/TiO2 heterostructure is lowered down to 180 °C (295 °C for blank MgH2). The initial desorption rate of MgH2/TiO2 reaches 2.116 wt% min−1 at 300 °C, 35 times of the blank MgH2 under the same conditions. Moreover, the capacity retention is as high as 98.5% after 100 cycles at 300 °C, remarkably higher than those of the previously reported MgH2-TiO2 composites. Both in situ HRTEM observations and ex situ XPS analyses confirm that the synergistic effects from multi-valance of Ti species, accelerated electron transportation caused by oxygen vacancies, formation of catalytic Mg-Ti oxides, and stabilized MgH2 NPs confined by TiO2 nanosheets contribute to the high stability and kinetically accelerated hydrogen storage performances of the composite. The strategy of using 2D substrates with abundant defects to support nano-sized energy storage materials to build heterostructure is therefore promising for the design of high-performance energy materials.

This paper investigates the impacts of migration characteristics on rural migrant households' farmland use arrangements in China. The results reveal that trailing migration, duration of migration and the proportion of co-migrants have a significant effect on the probability of rural migrant households' farmland abandonment. Commercial employment migration has a negative impact on the abandonment of farmland by migrant families. Migrant households are most likely to choose farmland abandonment in the western and middle regions of China and in small farmland areas. In the eastern region, and first tier and second tier Chinese cities, migrant households are more inclined to choose farmland transfer. Household earnings increase, which induces households to gradually give up the cultivation of farmland or to transfer farmland, constituting a mechanism in Chinese households' farmland use arrangements. Notably, the consolidation of arable land should be the focus in areas of low economic development. Furthermore, an effective mechanism for the transfer of farmland should be established.

Xinjiang is located in the hinterland of the Asia-Europe continent, neighboring Kazakhstan and Kyrgyzstan, and is a bridgehead for China’s eastward connection to the west, and the classification of Central Asian language emotions has become a development focus under the Belt and Road Initiative in Xinjiang. This paper takes the Kazakh versions of CHINA DAILY of Xinjiang News and SILK ROAD of Asia-Europe News as the source of the Central Asian language corpus and constructs an important corpus and online retrieval platform. Under the Transformer architecture, Word2Vec-TF-IDF and BERT models are used to train Central Asian regional language word vectors and construct word vector features, respectively. The word vector features obtained from the language pre-training model are used as inputs to obtain the local features of the Central Asian languages using multi-channel convolutional CNN, and the global features of the Central Asian languages are extracted by combining with the bi-directional GRU model. Then the fusion of local features and global features is carried out through the attention mechanism, and the SoftMax classifier outputs the classification results of sentiment tendency of Central Asian languages. The sentiment classification model designed in this paper achieves better classification results than other models on the Central Asian regional language corpus, and its accuracy can reach 92.78%, 91.45%, 93.54%, and the training time in classifying the sentiment of Central Asian regional languages using the model in this paper is 359.71 s. Using the language model as the basis of the Central Asian regional language sentiment classification can help Xinjiang Belt and Road Initiative implementation process to understand language sentiment changes.

This study examined blood oxygenation changes during a modified Stroop task with colored Chinese words using functional near‐infrared spectroscopy (fNIRS) in patients with poststroke aphasia. The task included three conditions: neutral, congruent, and incongruent. Participants consisted of 15 healthy adults and 15 patients with poststroke aphasia. Compared to healthy adults, aphasic patients showed significantly longer reaction times and reduced accuracy across all conditions, with a more pronounced interference effect in the incongruent condition. fNIRS analysis revealed distinct neurophysiological differences: decreased activation in Broca’s area, increased activation in the ventromedial frontal pole, and atypical recruitment of the left dorsolateral prefrontal cortex (DLPFC) during Stroop interference tasks. These findings highlight the differing neural mechanisms underlying cognitive interference in poststroke aphasia. The integration of fNIRS with the Stroop task enhances our understanding of intentional inhibition deficits and the impact of cognitive interference in aphasic patients. Importantly, these results suggest that deficits in cognitive control and abnormalities in prefrontal regions, such as the frontal pole and DLPFC, may be potential targets for noninvasive neuromodulation to improve cognitive control in poststroke aphasia. The observed atypical activation patterns in these regions underscore their critical role in managing cognitive interference and intentional inhibition. Noninvasive brain modulation techniques may offer promising strategies for modulating these neural mechanisms. This study underscores the need for targeted interventions that address prefrontal dysfunctions and emphasizes the value of visual language tasks in exploring the complex relationship between language deficits and cognitive control in this population.