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To address the measurement instability of reflective ultrasonic anemometers in complex wind fields, this study systematically investigates the mechanisms by which shadow effects caused by transducers and reflector support pillars affect measurement accuracy under varying wind speeds and directions. By integrating particle image velocimetry (PIV) experiments with computational fluid dynamics (CFD) simulations, 1:1 and 1:2 scale models are employed to reveal the flow field characteristics and error mechanisms. The results indicate that at a wind direction of 0°, wall-following vortices and turbulent wakes generated by transducer structures cause systematic wind speed deviations along the measurement paths. At a 45° wind direction, flow disturbances around the support pillars become the dominant source of shadow effects. The 1:1 scale model exhibits insufficient decay of large-scale, low-frequency turbulent energy, resulting in the accumulation of turbulent kinetic energy and significant wind speed errors at 0°. In contrast, the 1:2 scale model enables efficient energy transfer through high-frequency, small-scale vortices, enhances vortex intensity uniformity, and achieves improved spatial homogeneity in cross-wind measurement errors. These findings provide an important theoretical foundation for improving the high-precision measurement performance of reflective ultrasonic anemometers in complex wind environments.

We investigate the spin- and valley-dependent transport properties of electrons in silicene modulated by metallic gates, which can produce a potential barrier to affect the electron transport. The numerical results show that in such a silicene nanostructure the large spin polarization and valley polarization can be obtained, and they are strongly dependent on the height and width of the potential barrier. Therefore, the required degree of spin polarization and valley polarization can be realized through changing the height and/or width of the potential barrier. This valuable discovery well reveals the spin- and valley-dependent electron transport mechanism in such a silicene and is helpful for designing new kinds of spintronic and valleytronic devices modulated by metallic gates.

Objectives Early predictors of progression in structural joint damage in RA are lacking. We evaluated if early MRI measures of inflammation & erosion at baseline (BL), 12 & 24wks could predict subsequent progression in structural damage as measured by standard x-ray at 1 & 2 yrs of follow-up among 256 pts from GO-BEFORE, a large randomized trial of golimumab+MTX vs MTX alone in RA pts who were MTX-naïve. Methods Methods & results of the original trial have been published1. MRIs (contrast-enhanced; 1.5T) of the wrist & the 2nd-5th metacarpophalangeal joints of the dominant hand at BL & wks12, 24, 52, & 104 were obtained. MRIs were scored by 2 independent, blinded readers using the RA MRI Scoring (RAMRIS) system. X-rays (hands, wrists, forefeet at BL, wk 52, & 104) were scored by 2 other, blinded readers using the van der Heijde-Sharp (vdHS) system. X-ray progression was defined as a change in vdHS score > 0.5 as it was in the original trial. MRI synovitis & bone edema scores were evaluated as continuous variables (per unit difference or change). Change in RAMRIS bone erosion scores was highly skewed, & was therefore dichotomized at >0.5. Multivariable logistic regression was used to determine if BL & early measures of change in component RAMRIS scores predicted x-ray progression independent of clinical disease activity [DAS28(CRP)], change in DAS28(CRP), age, sex, BL vdHS score, & treatment group. Results Higher BL synovitis scores & less improvement in synovitis over the first 24 wks of follow-up were both significantly & independently associated with a greater risk of x-ray progression at 1- & 2 yrs (Table). Higher BL bone edema & less improvement in bone edema were independently associated with a greater risk of x-ray progression at 1yr, & tended to be associated with progression at 2yrs. An increase in RAMRIS bone erosion score >0.5 at wk 24 significantly predicted x-ray progression at 1- & 2 yrs. BL & wk12 changes in MRI scores all significantly predicted x-ray progression at wk52 (all p<0.05), & tended to be associated with x-ray progression at wk 104 (p= 0.004-0.2). Conclusions Early MRI measures at 12 & 24 wks independently predict x-ray changes at 1 & 2 yrs of follow-up. These data support the use of MRI in clinical trials for early identification of pts with (OR who will develop) structural joint damage progression during follow-up. This has implications for clinical trial design. References Østergaard M, Emery P, Conaghan PG, et al. Arthritis Rheum2011; 63(12): 3712-3722. Disclosure of Interest J. Baker Grant/research support from: Janssen R&D, LLC, M. Østergaard Grant/research support from: Janssen R&D, LLC, P. Emery Grant/research support from: Janssen R&D, LLC, E. Hsia Employee of: Janssen R&D, LLC, J. D. Lu Employee of: Janssen R&D, LLC, D. Baker Employee of: Janssen R&D, LLC, P. G. Conaghan Grant/research support from: Janssen R&D, LLC

Objectives Safety, efficacy, & radiographic progression in GLM-treated pts from long-term extension of GO-REVEAL is presented. Methods 405 PsA pts (≥3 SJ, ≥3 TJ counts) were rand to SC PBO (Grp1, n=113), GLM50mg (Grp2, n=146), or GLM100mg (Grp3, n=146) q4wks thru wk20. Concomitant MTX at baseline (BL) was allowed but not required. At wk16, pts with <10% improvement in SJ&TJ were eligible for rescue tx. All pts received GLM from wk24 forward. After wk52, pts could change GLM dose based on investigator judgment. The last GLM inj was at wk252; efficacy was assessed at wk256 based on rand grp&completer analyses using ACR response criteria, DAS28-CRP, PASI, HAQ, enthesitis/dactylitis assessments, NAPSI scores, & PsA-modified Sharp/van der Heijde Score (SHS). Safety evaluations included all pts who received at least one GLM dose thru 5yrs. Results Of 405 pts rand, 335 cont’d in the study at wk104, & 279 pts (69%) cont’d GLM thru wk252. 29% of Grp2 pts dose escalated to GLM100mg; 25% of Grp3 pts decreased dose from 100mg to 50mg. BL characteristics of pts who cont’d in the study at wk104 & efficacy at wk256 are provided(Table). ACR&PASI responses were similar in pts tx with or without MTX; changes from BL in SHS scores were minimal&numerically less in pts tx with GLM & MTXvs GLM alone. 88%, & 21% GLM-tx pts experienced AE & SAE, resp. 12% of pts d/c GLM due to AE, & 5% & 4% pts experienced malignancy (incl NMSC),& serious infection, resp. Antibodies to GLM were detected in 6% of pts. Conclusions Pt attrition thru 5yrs of GLM tx was low. GLM tx resulted in long-term maintenance of clinically meaningful responses in arthritic & skin components of PsA, improved physical function, & arrest of radiographic progression. No apparent differences between long-term safety&efficacy of 2 GLM doses administered q4wks were observed, however, interpretation of the data is limited due to tx changes allowed across rand grps. Disclosure of Interest A. Kavanaugh Grant/research support from: Janssen Research and Development, LLC, D. van der Heijde Grant/research support from: Janssen Research and Development, LLC, I. McInnes Grant/research support from: Janssen Research and Development, LLC, P. Mease Grant/research support from: Janssen Research and Development, LLC, G. G. Krueger Grant/research support from: Janssen Research and Development, LLC, D. Gladman Grant/research support from: Janssen Research and Development, LLC, Y. Zhou Employee of: Janssen Research and Development, LLC, J. D. Lu Employee of: Janssen Research and Development, LLC, Z. Xu Employee of: Janssen Research and Development, LLC, L. Noonan Employee of: Janssen Research and Development, LLC, A. Beutler Employee of: Janssen Research and Development, LLC

To enable designers to construct geometric models of MEMS devices in a straightforward environment and get mask and process flow automatically, a 3D MEMS CAD system for surface micromachined devices is proposed based on traditional design software—SolidWorks. With Application Programming Interfaces (APIs) of SolidWorks, component modules and databases of the system are developed with Visual Basic, such as geometric model design module, mask and process flow generation module, process simulation module, 3D feature database and material database. Their development method is discussed in this paper. A practical example shows that surface micromachined devices can be designed efficiently in the system without tedious fabrication process.

In 2000, the American Brachytherapy Society (ABS) published incompletely evaluated guidelines for curative chemoradiation and high–dose rate (HDR) brachytherapy for cervical cancer: our aim was to assess guideline tolerability in an Asian population. From 2000, all stage I–IVA cervical carcinoma patients were treated following ABS guidelines. Early disease (FIGO stage I/II <4 cm) received 45 Gy whole-pelvis external-beam radiation (EBRT) at 1.8 Gy/fraction, while advanced-stage disease received 50.4 Gy: no central shielding was used. All patients were planned to receive chemotherapy during EBRT, cisplatin 40 mg/m2 weekly. All patients received 31.8-Gy HDR brachytherapy (six fractions of 5.3 Gy/fraction) to point A via three-channel applicators. Radiotherapy was completed within 8 weeks. Toxicity scoring used Common Toxicity Criteria. Nineteen of 21 (90.4%) patients (8 early, 13 advanced stage) received planned radiation, and 85.7% received planned chemotherapy. Median follow-up was 24 months (range 9–50 months). Three-year overall survival (S) was 79.1% and disease-free survival (DFS) was 64.8%. S/DFS for early and advanced stage was 85.7%/85.7% and 73.3%/47.1%, respectively. Complete response (CR) was achieved by 85.7% of patients, partial response 14.3%. For those in CR, there were no local failures. Acute cystitis occurred in 23.8%, proctitis 4.8%, and gastroenteritis 47.6%. Late cystitis occurred in 9.5%, gastroenteritis 4.8%, and genitourinary fistula (in the presence of progressive disease) 4.8%. No grade 3/4 treatment-related toxicity occurred. The ABS guidelines were well tolerated and efficacious in our study, although longer follow-up is required. Further studies are warranted to validate safety and efficacy of the recommendations.

Of the estimated 13,700 women in the United States in whom invasive cervical cancer was diagnosed in 1998, 1 nearly 5000 will ultimately die of the disease because of the inadequacies of current treatment. In the United States, cervical cancer disproportionately affects women who are members of minority groups and women of low socioeconomic status, partly because such women tend to have insufficient access to and knowledge of screening programs for cervical cancer. The nationwide use of such screening programs has greatly reduced the incidence of invasive cervical cancer. Women with early cervical cancer can be successfully treated with radical surgery. . . .

Objective: To summarize the characteristics of patients calling the 120 emergency number for pre-hospital first aid in Keyouqian Banner, Hinggan League. Methods: The clinical data of adult patients with pre-hospital first aid from 2016 to 2018 were retrospectively analyzed. Results: There were 2711 cases with pre-hospital first aid. Males significantly outnumbered females. Young and middle-aged patients comprised 81.5%. Patients were mainly Han and Mongolians. Most injuries and illnesses occurred at home and on the road. The time to arrival of medical services was 30.34 [+ or -] 28.29 minutes. The proportion of pre-hospital first aid for trauma was the highest, followed by diseases concerning the cardiovascular and neurological systems. The proportion of patients with improved medical conditions after onsite first aid was 43.3%, the proportion with unchanged conditions was 51.7%, and the total mortality rate was 3.9%. Conclusion: The disease spectrum, ethnic distribution, age at onset, and pre-hospital first aid capabilities for outpatients were analyzed. These results may facilitate the establishment of a pre-hospital first aid system for the local prevention and control of acute and critical illnesses, increase the success rate of the region's pre-hospital first aid services, and improve the prognosis. Keywords: Keyouqian Banner, Inner Mongolia, pre-hospital first aid, emergency medical service, epidemiological analysis