Explore the vast range of titles available.

To analyze the trends and clinical significance of the platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), and monocyte/lymphocyte ratio (MLR) in hospitalized patients prior to death. A retrospective analysis was conducted on the PLR, NLR, and MLR of 341 hospitalized patients prior to death from January 2016 to October 2020 at Changzhou De'an Hospital, using inpatients with kidney disease and patients in rehabilitation as case-control groups, and hospital staff as a healthy control group, to statistically analyze relevant clinical data and test results. Significant differences were observed in the PLR, NLR, and MLR prior to death in hospitalized patients compared to those with kidney disease, those in recovery, and the healthy control group ( < 0.05). No statistically significant differences were found among different genders and age groups. The PLR, NLR, and MLR showed significant correlations with potential mortality risk, and middle-to-high performance in discriminating mortality events with area under the curve (AUC) values of 0.690, 0.866, 0.833 respectively for independent indicators. The PLR, NLR, and MLR significantly increased within 4 weeks, 1 week, and 48 h before death ( < 0.05). As the condition fluctuates, the PLR, NLR, and MLR exhibit fluctuating changes. The NLR was significantly higher in patients with malignant tumors and severe infections compared to those with cardiovascular and cerebrovascular diseases, and the sudden death group ( < 0.05). The PLR, NLR, and MLR significantly associate with mortality risk in hospitalized patients, and could serve as important identification parameters for mortality.

To examine prefrontal hemodynamic changes in patients with post-stroke anxiety (PSA), both at rest and during cognitive task engagement, with the aim of elucidating the underlying neural mechanisms of PSA and identifying potential neural correlates for clinical application. Fifty patients with PSA and 45 post-stroke patients without anxiety symptoms were recruited. PSA was diagnosed using the Hamilton Anxiety Rating Scale (HAMA ≥ 7), and comorbid depression was screened using the 17-item Hamilton Depression Rating Scale (HAMD-17 ≥ 8). Patients with significant cognitive impairment were excluded. Functional near-infrared spectroscopy (fNIRS) was used to measure resting-state functional connectivity in the frontopolar cortex (FPC) and dorsolateral prefrontal cortex (DLPFC), as well as task-evoked activation during the verbal fluency task (VFT). Demographic and clinical characteristics showed no significant differences between groups except for stroke type. Between-group comparisons were conducted to identify PSA-related differences in prefrontal network characteristics. Subgroup analyses were performed to explore the influence of comorbid depression on neural alterations. There were no significant differences between the PSA and non-PSA groups in demographic or clinical characteristics, including age, sex, and disease duration ( > 0.05). Compared to the non-PSA group, patients with PSA exhibited significantly reduced activation in the bilateral FPC during the VFT ( < 0.05). Within the PSA group, those with comorbid depression showed further reductions in activation in the bilateral FPC and the left DLPFC ( < 0.05). No significant differences in resting-state functional connectivity were observed between groups ( > 0.05). Reduced activation in the bilateral FPC may represent a key neural substrate associated with post-stroke anxiety. In addition, altered activation patterns in the bilateral FPC and left DLPFC may reflect neural correlates related to depressive symptoms in patients with PSA, providing candidate targets for future mechanistic and clinical studies.

Background To explore the efficacy of theta burst stimulation (TBS) on the cognitive function of chronic schizophrenia, and to analyze the effect of TBS on brain function using functional near-infrared spectroscopy (fNIRS). Methods One hundred stable chronic schizophrenia patients were selected and divided randomly into the experimental group (50 cases) and control group (50 cases). The experimental group received real TBS stimulation to the left dorsolateral prefrontal cortex (DLPFC) for 4 weeks, while the control group received sham stimulation to the same site. The Mini-mental State Examination (MMSE) and Mattis-dementia Rating Scale Second Edition (MDRS-2) were used to assess cognitive function. fNIRS was used to detect the changes in hemoglobin signal values during the verbal fluency task (VFT) before and after TBS intervention. Results Repeated measures analysis of variance showed that the interaction effect of group-by-time had a significant impact on MMSE, MDRS-2 total scores, MDRS-2 attention, MDRS-2 initiation/sustain, MDRS-2 concept formation, and MDRS-2 memory subscale scores for both groups of patients. Tests of within-subjects effects showed that significant improvements in MMSE, MDRS-2 total scores, MDRS-2 attention and memory subscale scores were found between the experimental group and control group after TBS, as well as in the experimental group before and after TBS. Multiple factor stepwise regression analyses found that the improvement of MDRS-2 total scores after the intervention was positively correlated with age in the experimental group. Based on fNIRS-VFT, the experimental group showed significant decrease in deoxyhemoglobin signal values in channel 47 (left dorsolateral prefrontal cortex) before and after the intervention. Conclusions TBS may have the potential to improve brain activity by enhancing the blood oxygen consumption of the stimulation target, as indicated by the fNIRS findings. Then, it may contribute to improvements in cognitive function of patients with chronic schizophrenia. However, the age of the patients may be an independent factor influencing the prediction of the treatment effect.

To enhance the economic viability of wind energy in cold regions and ensure the safe operational management of wind farms, this paper proposes a short-term wind turbine blade icing wind power prediction method that combines principal component analysis (PCA) and fractional Lévy stable motion (fLsm). By applying supervisory control and data acquisition (SCADA) data from wind turbines experiencing icing in a mountainous area of Yunnan Province, China, the model comprehensively considers long-range dependence (LRD) and self-similar features. Adopting a combined pattern of previous-day predictions and actual measurement data, the model predicts the power under near-icing conditions, thereby enhancing the credibility and accuracy of icing forecasts. After validation and comparison with other prediction models (fBm, CNN-Attention-GRU, XGBoost), the model demonstrates a remarkable advantage in accuracy, achieving an accuracy rate and F1 score of 96.86% and 97.13%, respectively. This study proves the feasibility and wide applicability of the proposed model, providing robust data support for reducing wind turbine efficiency losses and minimizing operational risks.

Passion fruit (Passiflora edulis), a commercially vital tropical crop, faces flowering instability due to photoperiod-sensitive flowering patterns, particularly under the cloudy, rainy climates of subtropical regions. To mitigate floral suppression during unfavorable light conditions, this study implemented a dual-modality strategy combining 16 h daily supplementary lighting (460 nm blue + 630 nm red spectrum) and foliar application of a high-phosphorus-containing nutrient, the Plant-Prod (nitrogen–phosphorus–potassium = 10:52:10) grown in field ‘Qinmi No. 9’. The treatment significantly stimulated lateral branch formation, internode elongation, flower retention, stage IV flower bud development, and enhanced photosynthetic efficiency. Physiological analyses revealed that the treatment increased the net photosynthetic rate (Pn), reduced the intercellular carbon dioxide concentration (Ci), and enhanced stomatal conductance (Gs), indicating the improvement of carbon assimilation. Controlled seedling trials further confirmed these effects, with treated groups exhibiting accelerated lateral branching and stress resilience. This integrated approach, combining optimized supplemental lighting and precision phosphorus fertilization, offers a practical and scalable strategy to stabilize passion fruit yields in climate-variable regions, with immediate potential for commercial orchards and greenhouse production.

This paper presents a new metal-contact RF MEMS switch based on an Al-Sc alloy. The use of an Al-Sc alloy is intended to replace the traditional Au-Au contact, which can greatly improve the hardness of the contact, and thus improve the reliability of the switch. The multi-layer stack structure is adopted to achieve the low switch line resistance and hard contact surface. The polyimide sacrificial layer process is developed and optimized, and the RF switches are fabricated and tested for pull-in voltage, S-parameters, and switching time. The switch shows high isolation of more than 24 dB and a low insertion loss of less than 0.9 dB in the frequency range of 0.1–6 GHz.

GaN-based light-emitting diodes (LEDs) structures with microstripes of InGaN/GaN quantum wells were grown on the Si(111) planes of microscale V-grooved Si(100) substrate by metal–organic vapor-phase epitaxy. This microstriped microfacet structure is composed of two semipolar (1 1 ¯ 01) planes and two polar (0001) planes. The indium (In) composition and thickness of quantum wells grown on semipolar (1 1 ¯ 01) plane differ from polar (0001) plane, causing the variation of local emission wavelength along the planes. Using the cathodoluminescence (CL) techniques, it was found that the emission wavelength is longer at the top of the (0002) planes, whereas it is shorter at the bottom of the (0002) plane and the (1 1 ¯ 01) plane. The continuous change in the properties of the quantum wells results in a uniform multicolored emission band. The results show that unique structures could uniformly activate multicolored light to realize the integrated light emission over the most visible spectrum. In some situations, this arrangement can emit white light. This method can be used to produce integrated white-light sources for monolithically integrated white-light-emitting diodes.

Vertebrate limb regeneration in adulthood is a fascinating phenomenon unique to salamanders, requiring precise coordination and interaction of various cell types. Connective tissue (CT) constitutes a major component of the limb and serves as the primary reservoir of positional information during regeneration. However, the role and extent of CT cell contribution remain largely undefined. Here we develop an inducible Cre-LoxP-mediated tBid cell ablation system in axolotls and demonstrate efficient elimination of targeted muscle tissue and muscle stem cells through transient electroporation or genetic approach. Ablation of CT cells at early regeneration stages results in delayed regeneration and loss of proximal limb segments (e.g., upper and lower limb), with minimal impact on hand differentiation. CT ablation during development yields similar defects, supporting an essential role for CT cells in determining the positional identity of developing and regenerating limb structures. Further single-cell RNA-sequencing (scRNA-seq) reveals a progressive proximal-to-distal transition among CT cells and identifies distinct CT subtypes contributing to proximal and distal segments. CT ablation reduces differentiated CT1-a subpopulation maintaining proximal identity throughout regeneration, and delays distal transformation in proliferative CT1 progenitors. These cellular shifts likely explain the observed morphological deficits. Moreover, differentiated CT1 cells enhance interactions with surrounding cells after CT ablation to modulate adaptive proliferation in other populations (e.g., muscle stem cells). Our work establishes a tBid-based ablation strategy for functional studies of CT and other cell types in axolotls and demonstrates pivotal roles of CT cells in limb regeneration.