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Mare basalts from lunar farside are pivotal for unraveling lunar nearside-farside dichotomies and global thermal history. The Chang’e-6 (CE-6) mission conducted the first sampling from a young basaltic unit within the Apollo basin on the lunar farside. Here, we performed comprehensive petrological and geochemical analyses on the CE-6 basalt clasts. The CE-6 basalt is a low-titanium basalt (about 5 wt% TiO2) depleted in KREEP components. The absence of olivine, particularly magnesium-rich olivine, suggests that the basaltic magma underwent extensive fractional crystallization. Thermodynamic modeling supports that there may be 10%–20% late-stage cumulates of magma ocean (clinopyroxene and ilmenite) present in the source region of CE-6 basalt. The magma derived from the partial melting of such lunar mantle may undergo fractional crystallization dominated by olivine and clinopyroxene within a shallow magma cg1hamber, followed by eruption. Modeling of the REE pattern further indicates that 3%–7% batch melting of a depleted lunar mantle source, combined with 21%–59% fractional crystallization, achieves the observed REE abundances of CE-6 basalt. The genesis of CE-6 basalt could be attributed to the synergistic influence of a readily fusible mantle source, resulting from the incorporation of late-stage cumulates, and the crust-mantle deformation induced by large impacts. This could serve as a paradigm for the formation of other young basalts on the Moon.

Background Pulmonary hypertension (PH) is a progressive disorder with high pulmonary arterial pressure, causing right ventricular dysfunction. Understanding PH’s molecular basis is vital for therapy development, but research on lactylation’s role in PH is limited and needs more investigation. Methods We integrated bulk RNA-seq datasets (GSE113439, GSE186996) and single-cell RNA-seq data (GSE210248) from PH patients and controls Differential expression analysis identified lactylation-associated hub genes. Functional enrichment (GO/KEGG), immune infiltration, and cell-cell communication analyses were performed. In vitro validation included RT-PCR and western blot on hypoxic pulmonary artery smooth muscle cells (PASMCs). Results We identified lymphocyte cytosolic protein 1 (LCP1) as a core lactylation-related hub gene, significantly upregulated in PH and validated in human/rat models. Single-cell profiling revealed elevated lactylation levels in vascular smooth muscle cells (VSMCs), T lymphocytes, and monocytes/macrophages within PH tissues. Cell communication analysis implicated TWEAK signaling from monocytes/macrophages to VSMCs as a driver of vascular remodeling. Metabolic pathways (e.g., glycolysis, bile acid metabolism) correlated strongly with lactylation activity. In vitro, hypoxia-induced LCP1 overexpression in PASMCs confirmed bioinformatic findings. Conclusion We analyzed lactylation - related genes in PH, identifying LCP1 as a key diagnostic marker, and described immune cell lactylation in PH patients, offering insights for future research.

China’s Tianwen-2 spacecraft was launched on 2025 May 29 and will arrive at the Earth quasi-satellite (469219) Kamo‘oalewa in 2026 July. We previously reported that Kamo‘oalewa develops an LL-chondrite-compositional, highly space-weathered surface. Here, using the light-curve data and the Cellinoid model, we modeled Kamo‘oalewa’s shape, rotation period, and pole orientation. We then estimated the global distribution of regolith critical size using the balance method of gravity, cohesive force, and centrifugal force. Furthermore, in the temperature range of 253.15−473.15 K, we measured the thermal parameters of laser-irradiated LL chondrite powder that best matches Kamo‘oalewa’s spectrum, estimating Kamo‘oalewa’s thermal inertia and skin depth (lower limit of regolith thickness). Using the radiative transfer mixing model, we also estimated the sub-micrometer-sized iron (SMFe0) content in Kamo‘oalewa’s regolith. Finally, using the MIT online spectral classification tool for the laser-irradiated LL chondrite powder, we obtained a virtual spectral type of Kamo‘oalewa. Our model gives a size of 68 × 46 × 39 m, a rotation period of 27.66 minutes, and a pole orientation of 134 .° 7 longitude and −11 .° 4 latitude for Kamo‘oalewa. Regolith grains with a size <2 cm can remain stable over 93.8% of the global surface area of Kamo‘oalewa. Laser-irradiated LL chondrite powder shows a low thermal inertia (163.14−232.31 J m−2 K−1 s−1/2), corresponding to a thermal skin depth of 3.1−3.5 mm on Kamo‘oalewa. An SMFe0 content of 0.29 ± 0.05 wt.% is required to match Kamo‘oalewa’s spectrum. The virtual spectral type of Kamo‘oalewa is given as “Sqw.”

Lunar soil samples from young maria (formed <3.0 billion years ago (Ga)) preserve key records of recent space weathering history in the Earth–Moon system. China’s Chang’e-6 mission returned the first farside soil samples from a young mare (∼2.8 Ga) at the northeastern South Pole–Aitken basin. We present preliminary results on the space weathering properties of the Chang’e-6 soils. The glassy agglutinate content in the Chang’e-6 soils is approximately 30%, significantly lower than the 50%–70% observed in the mature Apollo soils from older maria (>3.0 Ga) and higher than the ∼21% found in the Chang’e-5 soils from younger mare (∼2.0 Ga). However, our spectroscopic study reveals that the Chang’e-6 soils are well developed, with high maturity, weak absorption, and a red-sloped continuum, similar to the characteristics of the mature soils from the Apollo and Chang’e-5 landing sites. Orbital observations indicate more mature surface than in the returned samples from young mare regions, likely due to the destruction of an optically mature veneer by spacecraft. The optically mature veneer reveals deficiencies in remote sensing and emphasizes the importance of sample return missions. The thinner optically mature veneer and lower abundance of glassy agglutinate in younger maria suggest reduced gardening cycles and changes in impactor properties (such as rate and size) after 3.0 Ga. This is important for understanding how the relative contributions of space weathering agents change over time and the evolution of impactors in the inner solar system.

Super-enhancers (SEs) represent a distinct category of cis-regulatory elements notable for their robust transcriptional activation capabilities. In tumor cells, SEs intricately regulate the expression of oncogenes and pivotal cancer-associated signaling pathways, offering significant potential for cancer treatment. However, few studies have systematically discussed the crucial role of SEs in hepatocellular carcinoma (HCC), which is one of the most common liver cancers with late-stage diagnosis and limited treatment methods for advanced disease. Herein, we first summarize the identification methods and the intricate processes of formation and organization of super-enhancers. Subsequently, we delve into the roles and molecular mechanisms of SEs within the framework of HCC. Finally, we discuss the inhibitors targeting the key SE-components and their potential effects on the treatment of HCC. In conclusion, this review meticulously encapsulates the distinctive characteristics of SEs and underscores their pivotal roles in the context of hepatocellular carcinoma, presenting a novel perspective on the potential of super-enhancers as emerging therapeutic targets for HCC.

The Nectarian-aged Crisium basin exhibits an extremely thin crust and complicated lunar geological history. This large multi-ring impact basin is characterized by prolonged lunar volcanism ranging from the Imbrian age to the Eratosthenian period, forming the high-Ti mare unit, low-Ti mare basalts, and very low-Ti mare unit. We produced an updated geological map of the Crisium basin and defined four mare units (Im1: 3.74 Ga; Im2: 3.49 Ga; Im3: 3.56 Ga; EIm: 2.49 Ga) in terms of distinct composition and mineralogy. Olivine was widely determined in the Ti-rich Im1, implying the hybridization source in the lunar mantle with the occurrence of small-scale convective overturn. The major phase of low-Ti basaltic volcanism occurred c.a. 3.5 Ga, forming Im2 and Im3 in the western area. The youngest mare unit (EIm) has slight variations of pyroxene compositions, implying a decrease of calcic content of basaltic volcanisms with time. Later, distal material transports from large impact events in highlands could complicate the mixing of local mare basalts in the Copernicus age, especially the Im3 unit. The identified olivine-bearing outcrops and widely Mg-rich materials (Mg# > 70, where Mg# = molar 100 × Mg/(Mg + Fe)) in the western highlands, assumed to be the occurrence of the Mg-suite candidates, require future lunar exploration missions to validate.

Objective: Rare study of the non-coding and regulatory regions of the genome limits our ability to decode the mechanisms of fatty liver hemorrhage syndrome (FLHS) in chickens.Methods: Herein, we constructed the high-fat diet-induced FLHS chicken model to investigate the genome-wide active enhancers and transcriptome by H3K27ac target chromatin immunoprecipitation sequencing (ChIP-seq) and RNA sequencing (RNA-Seq) profiles of normal and FLHS liver tissues. Concurrently, an integrative analysis combining ChIP-seq with RNA-Seq and a comparative analysis with chicken FLHS, rat non-alcoholic fatty liver disease (NAFLD) and human NAFLD at the transcriptome level revealed the enhancer and super enhancer target genes and conservative genes involved in metabolic processes.Results: In total, 56 and 199 peak-genes were identified in upregulated peak-genes positively regulated by H3K27ac (Cor (peak-gene correlation) ≥0.5 and log2(FoldChange) ≥1) (PP) and downregulated peak-genes positively regulated by H3K27ac (Cor (peak-gene correlation) ≥0.5 and log2(FoldChange)≤–1) (PN), respectively; then we screened key regulatory targets mainly distributing in lipid metabolism (PCK1, APOA4, APOA1, INHBE) and apoptosis (KIT, NTRK2) together with MAPK and PPAR signaling pathway in FLHS. Intriguingly, PCK1 was also significantly covered in up-regulated super-enhancers (SEs), which further implied the vital role of PCK1 during the development of FLHS.Conclusion: Together, our studies have identified potential therapeutic biomarkers of PCK1 and elucidated novel insights into the pathogenesis of FLHS, especially for the epigenetic perspective.

China’s first Mars exploration mission, named Tianwen-1, landed on Mars on 15 May 2021. The Mars Surface Composition Detector (MarSCoDe) payload onboard the Zhurong rover applied the laser-induced breakdown spectroscopy (LIBS) technique to acquire chemical compositions of Martian rocks and soils. The quantitative interpretation of MarSCoDe-LIBS spectra needs to establish a LIBS spectral database that requires plenty of terrestrial geological standards. In this work, we selected 316 terrestrial standards including igneous rocks, sedimentary rocks, metamorphic rocks, and ores, whose chemical compositions, rock types, and chemical weathering characteristics were comparable to those of Martian materials from previous orbital and in situ detections. These rocks were crushed, ground, and sieved into powders less than <38 μm and pressed into pellets to minimize heterogeneity at the scale of laser spot. The chemical compositions of these standards were independently measured by X-ray fluorescence (XRF). Subsequently, the LIBS spectra of MAL standards were acquired using an established LIBS system at Shandong University (SDU-LIBS). In order to evaluate the performance of these standards in LIBS spectral interpretation, we established multivariate models using partial least squares (PLS) and least absolute shrinkage and selection (LASSO) algorithms to predict the abundance of major elements based on SDU-LIBS spectra. The root mean squared error (RMSE) values of these models are comparable to those of the published models for MarSCoDe, ChemCam, and SuperCam, suggesting these PLS and LASSO models work well. From our research, we can conclude that these 316 MAL targets are good candidates to acquire geochemistry information based on the LIBS technique. These targets could be regarded as geological standards to build a LIBS database using a prototype of MarSCoDe in the near future, which is critical to obtain accurate chemical compositions of Martian rocks and soils based on MarSCoDe-LIBS spectral data.

The Mg-pyroxene annulus in the South Pole–Aitken (SPA) basin holds crucial information about the lunar crustal evolution, yet its mineralogy and origin remain debate. Here we analyzed the mineralogy, exogenic ejecta, and soil evolution of the 2.8-billion-year-old Chang’e-6 samples from the SPA basin by Raman spectroscopic technique. The Chang’e-6 soils contain mare basalts and noritic exogenous ejecta (31–40 vol%), likely from Chaffee S crater. The derived mineralogy (63–67 vol% plagioclase and 25–27 vol% low-Ca pyroxene) of Mg-pyroxene annulus indicates a ferrous noritic lithology, attributed to a mixture of differentiated norite from the SPA impact melt sheet and re-deposited SPA crust (61–63 vol%). Ejecta accumulation facilitated glass formation, while small impacts induced quartz metamorphism, mixing mature basaltic soil with fresh ejecta, and leading to the fine-grained CE-6 soil. These findings provide new insights into the origin of SPA mafic anomalies and farside mare soil evolution. Young mare soils formed by impact-driven mixing of local basalt with noritic ejecta from Mg-rich pyroxene annulus of the lunar South PoleAitken basin, according to mineralogical observations of Chang’e-6 farside lunar samples.

Background Metabolic dysfunction-associated steatotic liver disease (MASLD) disrupts core hepatic physiological functions, with super-enhancers (SEs) playing a pivotal role in orchestrating the expression of genes associated with disease pathogenesis. This study aimed to elucidate the regulatory mechanisms of SEs in MASLD pathogenesis. Methods We conducted genome-wide H3K27ac profiling and Rank Ordering of SEs (ROSE) in a high-fat diet (HFD)-induced rat model to characterize histone modification and SE reprograming. Integrative analysis of ChIP-Seq and RNA-Seq, combined with transcription factor (TF) binding analysis and siRNA knockdown, was performed to investigate the regulatory mechanisms of SEs, while single-cell RNA sequencing analysis revealed cell-type-specific expression patterns. In vitro experiments further evaluated JQ1-mediated SE inhibition using human and rat hepatocyte cell lines. Results We observed significant H3K27ac remodeling and transcriptional reprogramming in both MASLD patients and HFD-induced rat models, highlighting epigenetic dysregulation in MASLD progression. Nineteen differential active SEs were identified in the rat model, with SULT1B1 emerging as a core SE-associated gene. Mechanistic analyses revealed that the TF C/EBPβ promotes SULT1B1 transcription through H3K27ac modification. Single-cell analysis further localized this regulatory axis specifically to hepatocytes. Functionally, targeted inhibition of the SE suppressed SULT1B1 expression and significantly mitigated lipid accumulation in both human and rat hepatocytes, supporting its pathogenic role in MASLD. Conclusions Our study establishes a mechanistic link between epigenetic-driven SULT1B1 overexpression and MASLD pathogenesis, highlighting SE mediated H3K27ac/C/EBPβ/ SULT1B1 axis emerges as a critical regulatory pathway in MASLD, which may offer new therapeutic targets and strategies for treating metabolic liver diseases.