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"Lu, Zheng"
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Structure and Function of Cationic and Ionizable Lipids for Nucleic Acid Delivery
Hereditary genetic diseases, cancer, and infectious diseases are affecting global health and become major health issues, but the treatment development remains challenging. Gene therapies using DNA plasmid, RNAi, miRNA, mRNA, and gene editing hold great promise. Lipid nanoparticle (LNP) delivery technology has been a revolutionary development, which has been granted for clinical applications, including mRNA vaccines against SARS-CoV-2 infections. Due to the success of LNP systems, understanding the structure, formulation, and function relationship of the lipid components in LNP systems is crucial for design more effective LNP. Here, we highlight the key considerations for developing an LNP system. The evolution of structure and function of lipids as well as their LNP formulation from the early-stage simple formulations to multi-components LNP and multifunctional ionizable lipids have been discussed. The flexibility and platform nature of LNP enable efficient intracellular delivery of a variety of therapeutic nucleic acids and provide many novel treatment options for the diseases that are previously untreatable.
Journal Article
Strain analysis and engineering in halide perovskite photovoltaics
Halide perovskites are a compelling candidate for the next generation of clean-energy-harvesting technologies owing to their low cost, facile fabrication and outstanding semiconductor properties. However, photovoltaic device efficiencies are still below practical limits and long-term stability challenges hinder their practical application. Current evidence suggests that strain in halide perovskites is a key factor in dictating device efficiency and stability. Here we outline the fundamentals of strain within halide perovskites relevant to photovoltaic applications and rationalize approaches to characterize the phenomenon. We examine recent breakthroughs in eliminating the adverse impacts of strain, enhancing both device efficiencies and operational stabilities. Finally, we discuss further challenges and outline future research directions for placing stress and strain studies at the forefront of halide perovskite research. An extensive understanding of strain in halide perovskites is needed, which would allow effective strain management and drive further enhancements in efficiencies and stabilities of perovskite photovoltaics.
This Review provides an outlook on current understanding of the role of strain on the performance and stability of perovskite solar cells, as well as on tools to characterize strain in halide perovskite films and on strain management strategies.
Journal Article
Color-stable highly luminescent sky-blue perovskite light-emitting diodes
Perovskite light-emitting diodes (PeLEDs) have shown excellent performance in the green and near-infrared spectral regions, with high color purity, efficiency, and brightness. In order to shift the emission wavelength to the blue, compositional engineering (anion mixing) and quantum-confinement engineering (reduced-dimensionality) have been employed. Unfortunately, LED emission profiles shift with increasing driving voltages due to either phase separation or the coexistence of multiple crystal domains. Here we report color-stable sky-blue PeLEDs achieved by enhancing the phase monodispersity of quasi-2D perovskite thin films. We selected cation combinations that modulate the crystallization and layer thickness distribution of the domains. The perovskite films show a record photoluminescence quantum yield of 88% at 477 nm. The corresponding PeLEDs exhibit stable sky-blue emission under high operation voltages. A maximum luminance of 2480 cd m
−2
at 490 nm is achieved, fully one order of magnitude higher than the previous record for quasi-2D blue PeLEDs.
Perovskite light-emitting diodes show promising color tunability and device performance but suffer from emission color shift at higher driving voltages. Here Xing et al. report color stable blue light-emitting diodes by drastically increasing the phase purity of the quasi-2D perovskite thin films.
Journal Article
The impact of market-incentive environmental regulation on the development of the new energy vehicle industry: a quasi-natural experiment based on China's dual-credit policy
Promoting new energy vehicles (NEVs) is considered to be one of the most effective ways to solve the increasingly serious problems of energy security and environmental pollution. Under the background of a gradual decline in the use of subsidy policy, the dual-credit policy (DCP), as a market-incentive environmental regulation, has been introduced to the process of policy development. This is of great significance in promoting NEVs and upgrading of the automobile industry. Based on data for 56 listed companies related to NEVs from 2012 to 2019, this study investigated the impact of the DCP on total factor productivity (TFP) under the framework of the propensity score matching difference-in-differences (PSM-DID) and further analyzed the mechanisms by how the DCP impacted on TFP. In addition, the heterogenous impacts of different firms were investigated. The results reveal three key findings. (1) After using instrumental variable to overcome endogenous problems and carrying out a series of robustness tests, the DCP can significantly improve firms’ TFP, and this effect is increasing annually. (2) The results of the mechanism analysis show that technological innovation, reputation enhancements, and the reduction of manager motivation have promotional effects on firms’ TFP. Besides, environmental tax can reduce the contribution of research and development (R&D) innovation to TFP. (3) In terms of regional and market structural levels, the promotional effect of the DCP on firms’ TFP in the eastern region is greater than that in the midwestern region. Furthermore, it has no significant effect on competitive firms, but plays a significant role in the improvement of oligopolistic firms’ TFP. This study supported the Porter Hypothesis that flexible market-incentive environmental regulation is likely to trigger positive productivity effects, and provided an empirical basis and latest information for promoting the accuracy and effectiveness of the DCP implementation.
Journal Article
Bright high-colour-purity deep-blue carbon dot light-emitting diodes via efficient edge amination
Deep-blue light-emitting diodes (LEDs) (emitting at wavelengths of less than 450 nm) are important for solid-state lighting, vivid displays and high-density information storage. Colloidal quantum dots, typically based on heavy metals such as cadmium and lead, are promising candidates for deep-blue LEDs, but these have so far had external quantum efficiencies lower than 1.7%. Here we present deep-blue light-emitting materials and devices based on carbon dots. The carbon dots produce emission with a narrow full-width at half-maximum (about 35 nm) with high photoluminescence quantum yield (70% ± 10%) and a colour coordinate (0.15, 0.05) closely approaching the standard colour Rec. 2020 (0.131, 0.046) specification. Structural and optical characterization, together with computational studies, reveal that amine-based passivation accounts for the efficient and high-colour-purity emission. Deep-blue LEDs based on these carbon dots display high performance with a maximum luminance of 5,240 cd m−2 and an external quantum efficiency of 4%, notably exceeding that of previously reported quantum-tuned solution-processed deep-blue LEDs.Deep-blue high-colour-purity light-emitting materials are developed by using amine-based edge passivation. The light-emitting diodes based on the carbon dots exhibit a maximum luminance of 5,240 cd m–2 and an external quantum efficiency of 4%.
Journal Article
Efficient and stable solution-processed planar perovskite solar cells via contact passivation
Planar perovskite solar cells (PSCs) made entirely via solution processing at low temperatures (<150°C) offer promise for simple manufacturing, compatibility with flexible substrates, and perovskite-based tandem devices. However, these PSCs require an electron-selective layer that performs well with similar processing. We report a contact-passivation strategy using chlorine-capped TiO₂ colloidal nanocrystal film that mitigates interfacial recombination and improves interface binding in low-temperature planar solar cells. We fabricated solar cells with certified efficiencies of 20.1 and 19.5% for active areas of 0.049 and 1.1 square centimeters, respectively, achieved via low-temperature solution processing. Solar cells with efficiency greater than 20% retained 90% (97% after dark recovery) of their initial performance after 500 hours of continuous room-temperature operation at their maximum power point under 1-sun illumination (where 1 sun is defined as the standard illumination at AM1.5, or 1 kilowatt/square meter).
Journal Article
Myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment and their targeting in cancer therapy
The advent of immunotherapy represents a significant breakthrough in cancer treatment, with immune checkpoint inhibitors (ICIs) targeting PD-1 and CTLA-4 demonstrating remarkable therapeutic efficacy. However, patient responses to immunotherapy vary significantly, with immunosuppression within the tumor microenvironment (TME) being a critical factor influencing this variability. Immunosuppression plays a pivotal role in regulating cancer progression, metastasis, and reducing the success rates of immunotherapy. Myeloid-derived suppressor cells (MDSCs), due to their potent immunosuppressive capabilities, emerged as major negative regulators within the TME, facilitating tumor immune evasion by modulating various immune cells. In addition to their immunosuppressive functions, MDSCs also promote tumor growth and metastasis through non-immunological mechanisms, such as angiogenesis and the formation of pre-metastatic niches. Consequently, MDSCs in the TME are key regulators of cancer immune responses and potential therapeutic targets in cancer treatment. This review describes the origins and phenotypes of MDSCs, their biological roles in tumor progression, and regulatory mechanisms, with a focus on current therapeutic approaches targeting tumor-associated MDSCs. Furthermore, the synergistic effects of targeting MDSCs in combination with immunotherapy are explored, aiming to provide new insights and directions for cancer therapy.
Journal Article
Home Bias and Local Contagion
Our paper analyzes the geographical preferences of hedge fund investors and the implication of these preferences for hedge fund performance. We find that funds of hedge funds overweigh their investments in hedge funds located in the same geographical areas and that funds with a stronger local bias exhibit superior performance. Local bias also gives rise to excess flow comovement and extreme return clustering within geographic areas. Overall, our results suggest that while funds of funds benefit from local advantages, their local bias also creates market segmentation that can destabilize the underlying hedge funds.
Journal Article