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2,575 result(s) for "Lucas, Robert"
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The Oxford handbook of sociolinguistics
\"From its beginnings in the 1960s, sociolinguistics developed several different subfields with distinct methods and interests: the variationist tradition established by Labov, the anthropological tradition of Hymes, interactional sociolinguistics as developed by Gumperz, and the sociology of language represented by the work of Fishman. All of these areas have seen a great deal of growth in recent decades, and recent studies have led to a more broadly inclusive view of sociolinguistics. Hence there is a need for a handbook that will survey the main areas of the field, point out the lacunae in our existing knowledge base, and provide directions for future research. The Oxford Handbook of Sociolinguistics will differ from existing work in four major respects. First, it will emphasize new methodological developments, particularly the convergence of linguistic anthropology and variationist sociolinguistics. Second, it will include chapters on sociolinguistic developments in areas of the world that have been relatively neglected in the major journals. Third, its chapters are written by contributors who have worked in a range of languages and whose work addresses sociolinguistic issues in bi- and multilingual contexts, i.e. the contexts in which a majority of the world's population lives. Finally, it will include substantial material on the rapidly growing study of sign language sociolinguistics.\"--Publisher.
Recommendations for daytime, evening, and nighttime indoor light exposure to best support physiology, sleep, and wakefulness in healthy adults
Ocular light exposure has important influences on human health and well-being through modulation of circadian rhythms and sleep, as well as neuroendocrine and cognitive functions. Prevailing patterns of light exposure do not optimally engage these actions for many individuals, but advances in our understanding of the underpinning mechanisms and emerging lighting technologies now present opportunities to adjust lighting to promote optimal physical and mental health and performance. A newly developed, international standard provides a SI-compliant way of quantifying the influence of light on the intrinsically photosensitive, melanopsin-expressing, retinal neurons that mediate these effects. The present report provides recommendations for lighting, based on an expert scientific consensus and expressed in an easily measured quantity (melanopic equivalent daylight illuminance (melaponic EDI)) defined within this standard. The recommendations are supported by detailed analysis of the sensitivity of human circadian, neuroendocrine, and alerting responses to ocular light and provide a straightforward framework to inform lighting design and practice.
Knowledge Growth and the Allocation of Time
We analyze a model economy with many agents, each with a different productivity level. Agents divide their time between two activities: producing goods with the production-related knowledge they already have and interacting with others in search of new, productivity-increasing ideas. These choices jointly determine the economy’s current production level and its rate of learning and real growth. We construct the balanced growth path for this economy. We also study the allocation chosen by an idealized planner who takes into account and internalizes the external benefits of search. Finally, we provide three examples of alternative learning technologies and show that the properties of equilibrium allocations are quite sensitive to two of these variations.
Aquaman/Suicide Squad : sink Atlantis
\"After Aquaman's undersea kingdom rises to become a world power of the surface, the Suicide Squad must infiltrate the city and send it back to the depths or die trying. The epic crossover event is collected here in Aqauman/Suicide Squad: Sink Atlantis! Task Force X's objective: take out Aquaman's kingdom. But that's not their only job. There's something buried there that Amanda Waller wants, and this is her chance to claim it. Will the Squad realize this before it's too late? Or will Aquaman clash with Harley Quinn, Deadshot, Killer Croc and co. and destroy everything around them in the process?\"-- Provided by publisher.
Menu Costs and Phillips Curves
This paper develops a model of a monetary economy in which individual firms are subject to idiosyncratic productivity shocks as well as general inflation. Sellers can change price only by incurring a real “menu cost.” We calibrate this cost and the variance and autocorrelation of the idiosyncratic shock using a new U.S. data set of individual prices due to Klenow and Kryvtsov. The prediction of the calibrated model for the effects of high inflation on the frequency of price changes accords well with international evidence from various studies. The model is also used to conduct numerical experiments on the economy’s response to various shocks. In none of the simulations we conducted did monetary shocks induce large or persistent real responses.
Law abiding citizen
\"Jamie Foxx stars as an assistant DA who finds himself at the mercy of a spiteful vigilante (Gerard Butler) hell-bent on avenging the death of his wife and daughter, whose murderers are set free due to legal loopholes\"--Allmovie.com, March 16, 2020.
Human Capital and Growth
This paper describes a growth model with the property that human capital accumulation can account for all observed growth. The model is shown to be consistent with evidence on individual productivities as measured by census earnings data. The central hypothesis is that we learn more when we interact with more productive people.
Form vision from melanopsin in humans
Detection and discrimination of spatial patterns is thought to originate with photoreception by rods and cones. Here, we investigated whether the inner-retinal photoreceptor melanopsin could represent a third origin for form vision. We developed a 4-primary visual display capable of presenting patterns differing in contrast for melanopsin vs cones, and generated spectrally distinct stimuli that were indistinguishable for cones (metamers) but presented contrast for melanopsin. Healthy observers could detect sinusoidal gratings formed by these metamers when presented in the peripheral retina at low spatial (≤0.8 cpd) and temporal (≤0.45 Hz) frequencies, and Michelson contrasts ≥14% for melanopsin. Metameric gratings became invisible at lower light levels (<10 13 melanopsin photons cm −2  sr −1  s −1 ) when rods are more active. The addition of metameric increases in melanopsin contrast altered appearance of greyscale representations of coarse gratings and a range of everyday images. These data identify melanopsin as a new potential origin for aspects of spatial vision in humans. The perception of spatial patterns (form vision) is thought to rely on rod and cone cells in the retina. Here, the authors show that a third kind of retinal cell, melanopsin-expressing ganglion cells, can also detect form in humans, under particular conditions.
Human melanopsin forms a pigment maximally sensitive to blue light (λmax ≈ 479 nm) supporting activation of Gq/11 and Gi/o signalling cascades
A subset of mammalian retinal ganglion cells expresses an opsin photopigment (melanopsin, Opn4) and is intrinsically photosensitive. The human retina contains melanopsin, but the literature lacks a direct investigation of its spectral sensitivity or G-protein selectivity. Here, we address this deficit by studying physiological responses driven by human melanopsin under heterologous expression in HEK293 cells. Luminescent reporters for common second messenger systems revealed that light induces a high amplitude increase in intracellular calcium and a modest reduction in cAMP in cells expressing human melanopsin, implying that this pigment is able to drive responses via both Gq and Gi/o class G-proteins. Melanopsins from mouse and amphioxus had a similar profile of G-protein coupling in HEK293 cells, but chicken Opn4m and Opn4x pigments exhibited some Gs activity in addition to a strong Gq/11 response. An action spectrum for the calcium response in cells expressing human melanopsin had the predicted form for an opsin : vitamin A1 pigment and peaked at 479 nm. The G-protein selectivity and spectral sensitivity of human melanopsin is similar to that previously described for rodents, supporting the utility of such laboratory animals for developing methods of manipulating this system using light or pharmacological agents.