Explore the vast range of titles available.

Introduction This study analysed the causative factors and clinical characteristics of acute and chronic ocular sequelae of Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) treated at a large third-referral centre in a developed country (Hungary) over a 15-year period. Methods This was a retrospective review of patients with acute and/or chronic SJS/TEN who were managed between 2006 and 2020 at the Department of Ophthalmology of Semmelweis University in Budapest, Hungary. For each subject, clinical data, including patient demographics, clinical history, causative agents of SJS/TEN, and conservative and surgical treatment details, were reviewed. Results Ninety-six eyes of 48 patients were included (28 female; 58.3%); the age at disease onset was 32.1 ± 22.4 years. The most common causative factors were medicines ( n  = 36; 75.0%). Among these drugs, 29.2% were nonsteroidal anti-inflammatory drugs (NSAIDs) ( n  = 14), 20.8% were antibiotics ( n  = 10) and 14.6% were antiepileptic drugs ( n  = 7). In patients with chronic SJS/TEN, the most commonly found ocular sequelae were conjunctival hyperaemia in 45 (56.3%) eyes, symblepharon in 38 (47.5%) eyes, trichiasis/distichiasis in 37 (46.3%) eyes, corneal neovascularization in 31 (38.8%) eyes and corneal scarring in 29 (36.3%) eyes. In patients with chronic SJS/TEN, the most frequently used topical conservative treatment included antibiotics in 53 (66.3%) eyes, preservative-free artificial tears in 50 (62.5%) eyes and topical corticosteroids in 42 (52.5%) eyes of 40 patients. The most frequently performed ocular surgeries for managing chronic ocular sequelae in patients with SJS/TEN were epilation for trichiasis ( n  = 27; 33.8%), cataract surgery ( n  = 14; 17.5%), entropion surgery ( n  = 12; 15.0%), penetrating keratoplasty (PK) ( n  = 11; 13.8%) and amniotic membrane transplantation ( n  = 4; 5.0%). Conclusion Our results suggest that NSAIDs, antibiotics and antiepileptic drugs are the most common causative factors for SJS/TEN in Hungary. Like in other countries, in Hungary, the ocular management of patients with acute and chronic SJS/TEN is heterogeneous, and most cases do not follow modern therapeutic guidelines.

Recent literature draws attention to the fact that problematic Internet use is a growing health issue among adolescents worldwide. This study aimed to find the potential demographic, physical and psychopathological risk factors associated with severe problematic Internet use of adolescents. A total of 1,347 adolescents (45.1% males) were recruited from five high schools in three settlements. Students completed an online questionnaire and provided data about socio-demographics, physical activity, physical and psychopathological health, as well as about their Internet use habits (Problematic Internet Use Questionnaire). 1.9% of the respondents appeared to be severe, 20.4% moderate problematic Internet users. The complexity of the problem is manifested in the multifaceted relationships of factors. The multinomial regression analysis identified four significant risk factors for severe problematic internet use, namely depressive symptoms, loneliness, low level of father’s education level and low level of physical activity. The real severe problematic Internet use is not so common in adolescent students, however, together with moderate problematic Internet users, this number has significance. Psychopathological factors such as elevated depressive symptoms and loneliness should be considered when preventive programs are implemented and more attention should be taken on physical activity as an effective tool against addictive behavior.

This study aims to explore the associations between descriptive normative beliefs (DNB), alcohol use and negative consequences and test whether self-regulation (SR) moderates this relationship. The data was collected online from 1621 first-year university students in the Czech Republic, Hungary, Lithuania and Slovakia. The AUDIT, self-regulation questionnaire and questions regarding DNB were used. DNB were found to be positively associated with drinking across all the samples. The associations between DNB and alcohol use as well as between alcohol use and negative consequences were stronger among students with lower SR. The protective effect of SR on alcohol use and consequences combined with the theory of social influence may improve intervention accuracy and make it a promising target for intervention among young adults.

Background Within the frame of National Epidemiological Surveillance System, family physicians have an obligation to report infections and suspicions cases. The aim of this study was to evaluate the knowledge, attitudes, daily practice and the reporting activities of Hungarian family physicians regarding to infectious diseases. Methods A self-administered survey was developed, validated and used. The survey was completed by family physicians who had taken part in continuous medical educational programmes of all Hungarian medical faculties. The questionnaire, consisting demographic questions and 10 statements about their reporting habits were completed by 347 doctors, 8% of the total number of family physicians. The data were processed in a cross-sectional design with general linear model. Results According to the majority of responders, the current reporting system works efficiently. Rural physicians were mainly agreed, that reporting is not a simply obligation, it is a professional task as well. They were less hindered in daily work by reporting activities, waited less for laboratory confirmation before reporting, reported suspicious cases more frequently. Practitioner’s based in urban settlements preferred to await laboratory tests before reporting and were hindered less by failures of the electronic reporting system. Older physicians trusted more in the recent system and they wished to increase the number of reports. Female physicians have higher consciousness in epidemiology. They were mostly in agreement that even severe infectious diseases can be diagnosed at primary care level and their daily practices were less burdened by reporting duties. Conclusions Both the epidemiological knowledge of general practitioners’ and the electronic surveillance systems should be improved. There is a need to develope the electronic infrastructure of primary care. More and regular control is also expected by the health care authorities, beside the synthesis of professional and governmental expectations and regulations.

Life satisfaction, dimensions of internalized cultural values and self-efficacy related to emigration intentions for a long-term stay abroad of university students in five European countries. Aim: To explore the associations between emigration intentions of university students form five European countries in relation to several intrapersonal and emigration self-efficacy. The second aim is to explore the mediating role of self-efficacy in relation to internalized cultural values and emigration intentions. Sample and procedure: The sample consisted of 1223 students (females N=812, 66.4%, males N=411, 33.6%. M=21.95, SD=3.62) from five European countries. The data collection was completed via an online questionnaire (University of Antwerp, Belgium, Sofia University, Bulgaria, University of Miskolc, Hungary, Lithuanian University of Health Sciences, Lithuania, Pavol Jozef Šafárik University in Košice, Slovak Republic). The local ethics committee in every country approved the study Statistical analysis: Statistical analysis was performed in SPSS 21. Differences in intrapersonal were analysed by ANOVA with a Scheffe Post hoc test. Binary logistic regression with the method enter controlling for country and age was used as a method of analysis. Mediational analyses were explored by using Hayes PROCESS tool. Findings: The regression model explained between 29-38 percent of the variance. Those students with higher self–efficacy also with higher horizontal individualism were more likely to have emigration intentions compared to those with lower self-efficacy and HI, and those with lower satisfaction and vertical collectivism were more likely to have long-term emigration intentions compared to those with higher satisfaction and VC. Self-efficacy was found to mediate the relationship between horizontal dimensions of internalized cultural values and emigration intentions.

Background The study distinguishes the effect of type 2 diabetes and hypertension on cognitive functions when the two diseases are alone or when they occur together, compared to healthy individuals. Methods A total of 143 middle-aged adults were screened using the Wechsler Memory Scale – Revised psychometric test (verbal memory, visual memory, attention/concentration and delayed memory). Participants were divided into four groups based on their diseases: patients with type 2 diabetes (36), patients with hypertension (30), patients having both diseases (33), and healthy controls (44). Results This study found no differences among investigated groups in verbal and visual memory, however, hypertension and both-disease group performed unfavorably compared to patients with diabetes and to healthy individuals in attention/concentration and delayed memory. Conclusions The findings of this study suggest that there is a relationship between hypertension and cognitive dysfunction, whereas type 2 diabetes without consequences was not proved to have an association with cognitive decline in middle-aged people.

Background Adolescents with type 1 diabetes (T1D) can be faced with deterioration in glycemic control (GC), reduced health‐related quality of life (HRQoL), and other psychosocial problems. It is important to understand how the disease and its clinical conditions influence HRQoL and how adolescents are able to overcome the life adjustment difficulties. Objective To assess HRQoL of adolescents with T1D from demographic, clinical, personal, and behavioral point of view. Subjects A total of 229 adolescents with T1D (51.2% males) with a mean age of 15.35 (2.29) years old were recruited from three diabetes centers. The mean diabetes duration was 7.48 (3.87), the mean hemoglobin A1C (HbA1c) level was 10.3 (1.76) mmol/L. Methods A multicenter quantitative correlational design study was applied to investigate the influence of sex, age, diabetes duration, GC expressed by HbA1c, intensive insulin regimen, physical activity (PA), resilience (RS), and socioeconomic background on HRQoL. Results Presence of the diabetes symptoms and worry about the disease has negative impact on the patients' HRQoL. Stepwise multiple regression analyses indicated that insulin pump therapy, male sex, and higher level of RS were significantly related to an increase in HRQoL, whereas the higher level of PA, male sex, and better HRQoL was significantly related to positive change in RS. Patients treated with insulin pump therapy had significantly better HRQoL. Conclusions Significant association can be observed between HRQoL and RS. Supposedly, higher level of PA promotes higher level of RS that in turn helps increase HRQoL in adolescents with T1D. Treatment with insulin pump therapy also promotes better HRQoL.

Many studies have been published in recent years regarding the fact that moderate wine consumption, as a part of a balanced diet can have a beneficial effect on human health. The biologically active components of wine continue to be the subject of intense research today. In this study, the bioactive molecules of Hungarian aszú from the Tokaj wine region were analyzed using high-performance liquid chromatography (HPLC) and investigated in an in vitro model system of endothelial cells induced by bacterial-derived lipopolysaccharide. The HPLC measurements were performed on a reversed phased column with gradient elution. The non-cytotoxic concentration of the active substance was determined based on 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide (MTT)-, apoptosis, and necrosis assays. The antioxidant effect of the extract was determined by evaluating its ability to eliminate ROS. The expressions of the interleukin-(IL)1α, IL1-β, IL-6, and IL-8 pro-inflammatory cytokines and nitric oxide synthase (eNOS) at the mRNA level were evaluated using a quantitative polymerase chain reaction (qPCR). We found that the lipopolysaccharides (LPS)-induced increases in the expressions of the investigated cytokines were significantly suppressed by Hungarian aszú extract, excluding IL-6. In our experimental setup, our treatment had a positive effect on the eNOS expression, which was impaired as a result of the inflammatory manipulation. In our experimental model, the Hungarian aszú extract decreased the LPS-induced increases in the expression of the investigated cytokines and eNOS at the mRNA level, which presumably had a positive effect on the endothelial dysfunction caused by inflammation due to its strong antioxidant and anti-inflammatory effects. Collectively, this research contributes to a more thorough understanding of the bioactive molecules of aszú from the Tokaj wine region.

This study aimed to evaluate the health-related quality of life (HRQoL) of adolescents with type 1 diabetes (T1DM) on the basis of the pediatric quality of life inventory™ (PedsQL™) generic and diabetes-specific modules, and to compare it to that of healthy peers. This retrospective case-control study involved 650 participants between ages of 13 and 19 years including 296 adolescents with T1DM from four diabetes centers and 354 healthy peers matched for age and gender from three different cities of the country. Participants completed the validated PedsQL™ for assessing the HRQoL. The analysis included an independent t-test to compare the means of the total and subscales of the PedsQL™ between boys and girls as well as between a healthy group and a group with T1DM. Gender differences in exercise, insulin therapy modalities were evaluated with the Pearson χ -test. Adolescents with T1DM have similar HRQoL in all domains when compared to their healthy counterparts. Females report worse HRQoL regardless of the presence of the disease. Insulin pump therapy facilitates better glycemic control and HRQoL. Regular exercise positively correlates with the generic HRQoL in both groups; however, it has no relationship with glycemic control. Optimal metabolic control and improved HRQoL are the eventual goals of diabetes management. Despite the difficulties, adolescents with diabetes can manage their disease well and live normal lives, similar to their healthy peers. Although diabetes-related problems exist, it seems that regular exercise and staying physically active, as well as promoting insulin pump therapy where it is applicable are related to favorable HRQoL.

This study investigated whether culture can affect self- and proxy-reports of perceived diabetes-specific health-related quality of life of children and adolescents with type 1 diabetes when taking into account glycemic control, gender and age. A total of 416 patients aged between 8 and 18years – 84 (Greece), 135 (Hungary) and 197 (Kuwait) – and their parents completed the Pediatric Quality of Life Inventory™ 3.0. Diabetes Module. Gender and age did not have any effect on perceived diabetes-specific health-related quality of life. Significant differences were detected among countries in self- and proxy-reports of diabetes-specific health-related quality of life when controlling for glycemic control. More specifically, Greek patients with type 1 diabetes and their parents reported significantly worse disease-specific health-related quality of life than their peers from Kuwait and Hungary. Moreover, culture affected the level of agreement between self- and proxy-reports with parents from Kuwait underestimating their children's diabetes-specific health-related quality of life. The impact of culture on self- and proxy-reports of diabetes-specific health-related quality of life warrants further investigation, since it might suggest the need for differential psychosocial treatment.