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"Luke, David"
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The effects of microdose LSD on time perception: a randomised, double-blind, placebo-controlled trial
RationalePrevious research demonstrating that lysergic acid diethylamide (LSD) produces alterations in time perception has implications for its impact on conscious states and a range of psychological functions that necessitate precise interval timing. However, interpretation of this research is hindered by methodological limitations and an inability to dissociate direct neurochemical effects on interval timing from indirect effects attributable to altered states of consciousness.MethodsWe conducted a randomised, double-blind, placebo-controlled study contrasting oral administration of placebo with three microdoses of LSD (5, 10, and 20 μg) in older adults. Subjective drug effects were regularly recorded and interval timing was assessed using a temporal reproduction task spanning subsecond and suprasecond intervals.ResultsLSD conditions were not associated with any robust changes in self-report indices of perception, mentation, or concentration. LSD reliably produced over-reproduction of temporal intervals of 2000 ms and longer with these effects most pronounced in the 10 μg dose condition. Hierarchical regression analyses indicated that LSD-mediated over-reproduction was independent of marginal differences in self-reported drug effects across conditions.ConclusionsThese results suggest that microdose LSD produces temporal dilation of suprasecond intervals in the absence of subjective alterations of consciousness.
Journal Article
A single-center, retrospective study of COVID-19 features in children: a descriptive investigation
Background
Compared to adults, there are relatively few studies on COVID-19 infection in children, and even less focusing on the unique features of COVID-19 in children in terms of laboratory findings, locations of computerized tomography (CT) lesions, and the role of CT in evaluating clinical recovery. The objective of this study is to report the results from patients at Wuhan Children’s Hospital, located within the initial center of the outbreak.
Methods
Clinical, imaging, and laboratory data of 76 children were collected retrospectively and analyzed with the Fisher exact test and Cox regression statistical methods.
Results
Among 50 children with a positive COVID-19 real-time reverse-transcriptase polymerase chain reaction (PCR), five had negative PCR results initially but showed positive results in subsequent tests. Eight (16%) patients had lymphopenia, seven (14%) with thrombocytopenia, four (8%) with lymphocytosis, two (4%) with thrombocytosis, ten (20%) with elevated C-reactive protein, four (8%) with hemoglobin above, and six (12%) with below standard reference values. Seven (14%) of the 50 had no radiologic evidence of disease on chest CT. For the 43 patients who had abnormal CT findings, in addition to previously reported patterns of ground-glass opacity (67%), local patchy shadowing (37%), local bilateral patchy shadowing (21%), and lesion location of lower lobes (65%), other CT features include that an overwhelming number of pediatric patients had lesions in the subpleural area (95%) and 22 of the 28 lower lobe lesions were in the posterior segment (78%). Lesions in most of the 15 patients (67%) who received chest CT at discharge were not completely absorbed, and 26% of these pediatric patients had CT lesions that were either unchanged or worse.
Conclusions
There were a few differences between COVID-19 children and COVID-19 adults in terms of laboratory findings and CT characteristics. CT is a powerful tool to detect and characterize COVID-19 pneumonia but has little utility in evaluating clinical recovery for children. These results oppose current COVID-19 hospital discharge criteria in China, as one requirement is that pulmonary imaging must show significant lesion absorption prior to discharge. These differences between pediatric and adult cases of COVID-19 may necessitate pediatric-specific discharge criteria.
Journal Article
Extended difficulties following the use of psychedelic drugs: A mixed methods study
Long-term adverse experiences following psychedelic use can persist for weeks, months, or even years, and are relatively unexplored in psychedelic research. Our convergent mixed-method study gained quantitative and qualitative data from 608 participants who reported extended difficulties following psychedelic experiences. Data was gathered on the context of use, the nature and duration of the challenges they experienced (including a written description of these), plus a range of possible risk factors and perceived causes. The most common forms of extended difficulty were feelings of anxiety and fear, existential struggle, social disconnection, depersonalization and derealization. For approximately one-third of the participants, problems persisted for over a year, and for a sixth, they endured for more than three years. It was found that a shorter duration of difficulties was predicted by knowledge of dose, drug type and lower levels of difficulty reported during the psychoactive experience, while a narrower range of difficulties was predicted by taking the drug in a guided setting. Implications for psychedelic harm reduction are discussed.
Journal Article
WikiLeaks : inside Julian Assange's war on secrecy
Traces the history of the online organization WikiLeaks, which released thousands of previously secret or classified documents from numerous government agencies, and examines its impact on world politics and freedom of information.
Book
Geographies of Identity in Nineteenth-Century Japan
In this pioneering study, David L. Howell looks beneath the surface structures of the Japanese state to reveal the mechanism by which markers of polity, status, and civilization came together over the divide of the Meiji Restoration of 1868. Howell illustrates how a short roster of malleable, explicitly superficial customs—hairstyle, clothing, and personal names— served to distinguish the \"civilized\" realm of the Japanese from the \"barbarian\" realm of the Ainu in the Tokugawa era. Within the core polity, moreover, these same customs distinguished members of different social status groups from one another, such as samurai warriors from commoners, and commoners from outcasts.
eBook
Blonde ambition
\"An ambitious young woman (Jessica Simpson) attempting to navigate her way through the cutthroat corporate world becomes the unwitting pawn of two unscrupulous executives seeking to topple and replace the powerful head of an international conglomerate. Penelope Ann Miller, Luke Wilson, Andy Dick, Rachel Leigh Cook, and Jamie Kennedy co-star in director Scott Marshall's loose remake of the Mike Nichols' 1988 comedy Working Girl\"--Allmovie.com, viewed September 12, 2017.
DVD
Changes in Mental Status and Dyspnea Followed by Pulseless Electrical Activity
Following back surgery a man developed extensive pulmonary emboli that proved fatal.
Journal Article