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Preeclampsia (PE) is considered as a disease of placental origin. However, the specific mechanism of placental abnormalities remains elusive. This study identified thrombospondin‐1 (THBS1) is downregulated in preeclamptic placentae and negatively correlated with blood pressure. Functional studies show that THBS1 knockdown inhibits proliferation, migration, and invasion and increases the cycle arrest and apoptosis rate of HTR8/SVneo cells. Importantly, THBS1 silencing induces necroptosis in HTR8/SVneo cells, accompanied by the release of damage‐associated molecular patterns (DAMPs). Necroptosis inhibitors necrostatin‐1 and GSK′872 restore the trophoblast survival while pan‐caspase inhibitor Z‐VAD‐FMK has no effect. Mechanistically, the results show that THBS1 interacts with transforming growth factor B‐activated kinase 1 (TAK1), which is a central modulator of necroptosis quiescence and affects its stability. Moreover, THBS1 silencing up‐regulates the expression of neuronal precursor cell‐expressed developmentally down‐regulated 4 (NEDD4), which acts as an E3 ligase of TAK1 and catalyzes K48‐linked ubiquitination of TAK1 in HTR8/SVneo cells. Besides, THBS1 attenuates PE phenotypes and improves the placental necroptosis in vivo. Taken together, the down‐regulation of THBS1 destabilizes TAK1 by activating NEDD4‐mediated, K48‐linked TAK1 ubiquitination and promotes necroptosis and DAMPs release in trophoblast cells, thus participating in the pathogenesis of PE. The down‐regulation of THBS1 can destabilize TAK1 via NEDD4‐mediated, K48‐linked TAK1 ubiquitination, resulting in the activation of the necroptosis and DAMPs release in trophoblast cells, thus participating in the pathogenesis of PE.

Background Advancements in information technology, have made hospital information systems (HIS) essential tools for clinical nursing. The integration of HIS into undergraduate nursing education is a growing expectation within healthcare institutions. To meet this demand, nursing educators have promoted the incorporation of HIS into curricula to foster educational innovation. In response, our research team developed the Nursing Simulation Teaching Information System (NSTIS) to facilitate nursing operations related to HIS. We designed a comprehensive training course for senior students to prepare them for clinical rotations, with case simulations as a central component. This study aimed to assess the effectiveness of NSTIS in the training course and refine both the system and teaching scheme based on student feedback. Methods A total of 114 nursing students were assigned to either the experimental ( n  = 55) or the control group ( n  = 59), with only 114 students completing the intervention. Both groups worked on the same simulation case. The experimental group used the NSTIS to obtain complete medical records, whereas the control group used traditional Microsoft Word documents and printed materials. With informed consent from the participants, data were collected using a self-designed classroom teaching effect questionnaire and a case workshop scoring form. Results The experimental group scored higher than the control group on the total scores of the self-designed teaching effect questionnaire, with significant differences observed in specific items related to teaching objective achievement and learning outcomes. Qualitative data indicated that the experimental group reported acquiring skills in HIS operation. Both groups recommended adjustments to the teaching structure to enrich the case study resources, while the control group expressed a desire for measures to enhance their learning motivation. Conclusion Integrating NSTIS into a comprehensive training course can help enhance the effectiveness of case simulations. Further improvements to the NSTIS and teaching strategies are necessary for effective teaching. Future research should explore whether the application of the NSTIS in comprehensive training courses can improve students’ abilities and investigate how to integrate the NSTIS into other courses. Trial registration Not applicable.

The current study sought to develop an instrument for measuring benefit finding in Chinese older adults with chronic diseases and establish its psychometric characteristics. Scale items were drafted based on a literature review, theoretical learning, the Benefit Finding Scale (BFS), the Post-Traumatic Growth Inventory, and results of interviews with 24 older adults with chronic diseases. The preliminary scale draft was constructed by performing a Delphi expert consultation and pretest with a small sample. Using the first draft of the scale, we surveyed 380 older adults with chronic diseases. The BFS for older adults with chronic diseases comprised 26 items. Using exploratory factor analysis, we identified six common factors that explained 66.86% of the variance. Item content validity index ranged from 0.818 to 1.000 and scale content validity index was 0.91. Cronbach's alpha of the scale was 0.924 and test–retest reliability was 0.902. The BFS for older adults with chronic diseases showed good validity and reliability and can be used as a measurement tool for benefit finding in the aforementioned population. [Research in Gerontological Nursing, 16(1), 44–52.]

BackgroundMost women suffer from perineal trauma during childbirth, whether it is natural tears or episiotomy.ObjectivesTo perform a systematic review and network meta-analysis investigating the effectiveness of different PFMT relevant strategies in the prevention of perineal trauma.Search strategyPubMed, Embase, the Cochrane Library, CINAHL, CNKI, CBM, WANFANG DATABASE, and ClinicalTrials.gov were searched for citations published in any language from inception to 1 July 2021.Selection criteriaRandomized controlled trials (RCTs) of PFMT relevant prevention strategies for preventing perineal trauma during childbirth.Data collection and analysisData were independently extracted by two reviewers. Relative treatment effects were estimated using network meta-analysis (NMA).Main resultsOf 12 632 citations searched, 21 RCTs were included. Comparing with usual care, “PFMT combine with perineal massage” and PFMT alone showed more superiority in intact perineum (RR = 5.37, 95% CI: 3.79 to 7.60, moderate certainty; RR = 2.58, 95% CI 1.34–4.97, moderate certainty, respectively), episiotomy (RR = 0.26, 95% CI 0.14–0.49, very low certainty; RR = 0.63, 95% CI 0.45–0.90, very low certainty, respectively), and OASIS (RR = 0.35, 95% CI 0.16–0.78, moderate certainty; RR = 0.49, 95% CI 0.28–0.85, high certainty, respectively). “PFMT combine with perineal massage” showed superiority in reducing perineal tear (RR = 0.41, 95% CI 0.20–0.85, moderate certainty).ConclusionsIn view of the results, antenatal “PFMT combine with perineal massage” and PFMT were effective strategies for the prevention of perineal trauma.

This article has been retracted at the request of Mona Shattell, PhD, RN, FAAN, Editor, Journal of Psychosocial Nursing and Mental Health Services. I would like to formally request that the article entitled, “Influence of the Left-Behind Experience on Self-Efficacy of College Students,” (posted for Online Advanced Release, August 22, 2018, doi:10.3928/02793695-20180815-02) be retracted. The integrity of the measure used has been compromised. Mona Shattell, PhD, RN, FAAN

The left-behind experience refers to the experience of children who were taken care of by caregivers in their hometowns for ≥6 months before reaching age 18, as one or both parents left the rural hometown for better paying jobs in bigger cities. The current study was conducted with college students to test the effect of the left-behind experience on self-efficacy. The General Self-Efficacy Scale and a questionnaire designed by the authors were adopted for a survey of 200 Chinese college students in their final year of university. Of 200 students, 72 (36%) students had ≥6 months of left-behind experience before reaching age 18. Results did not show statistically significant difference in self-efficacy between college students with or without left-behind experience (p > 0.05). In addition, researchers found no significant difference in self-efficacy between college students with left-behind experience from different backgrounds. Further research and focus on this area is necessary. [Journal of Psychosocial Nursing and Mental Health Services, xx(x), xx-xx.].

To reduce the structural deterioration of mass concrete structures from temperature cracks, and lower energy consumption caused by the traditional mass concrete hydration heat cooling process, this paper reports the preparation of concrete temperature-controlled phase change aggregate (PCA) by a vacuum compaction method using light and high-strength black ceramite and No. 58 fully refined paraffin wax as phase change material (PCM), and the encapsulation technology of the aggregate by using superfine cement and epoxy resin. Further, through laboratory tests, the cylinder compressive strength, thermal stability and mixing breakage rate of the encapsulated PCA were tested, and the differences in mechanical properties such as compressive strength, flexural strength and splitting tensile strength between phase change aggregate concrete (PCAC) and ordinary concrete were studied. A test method was designed to test the heat storage effect of PCA, and the temperature control effect of PCAC was analyzed based on the law of conservation of energy. The research conclusions are as follows: (1) Both superfine cement and epoxy resin shells increase the strength of the aggregate, with the epoxy resin increasing it more than the superfine cement. The thermal stabilization of the PCA is good after encapsulation of superfine cement and epoxy resin. However, PCA encapsulated in superfine cement is more easily crushed than that encapsulated in epoxy resin. (2) Under the condition of water bath heating and semi-insulation, when the water bath temperature reaches 85 °C, the temperature difference between the PCA and the common stone aggregate can be up to 6 °C. Based on the law of energy conservation, the test results will be converted to mass concrete with the same volume of aggregate mixture;, the difference of PCAC and ordinary concrete temperature can be up to 10 °C, so the temperature control effect is significant. (3) The mechanical properties of PCAC with 100% aggregate replacement rate compared to ordinary concrete are reduced to varying degrees, and the performance decline of the epoxy-encapsulated PCA is smaller than that encapsulated with superfine cement; in an actual project, it is possible to improve the concrete grade to make up for this defect.

Doc number: 160 Abstract Background: Ziziphus jujuba Mill. is nutritious and used as food and medicine for more than two thousand years. It has many pharmacological effects, such as elimination of fatigue, dilation of blood vessels, etc. The polysaccharide in it is one of the bioactive substances. In this paper, the ultrasonic extraction effects on the yield and activity of polysaccharide were studied. Results: The optimum ultrasonic extraction conditions were investigated based on a Box-Behnken statistical experimental design. Response surface methodology (RSM) of three factors (ultrasonic power, extraction time and extraction temperature) and three levels was employed to optimize the yield and the antioxidant activity of the polysaccharides. The experimental data were fitted to quadratic response surface models using multiple regression analysis. The best extraction conditions were 120 W, 15 min. and 55°C for highest yield, and 80 W, 15 min. and 40°C for highest hydroxyl radical scavenging activity. Conclusion: The study showed that high ultrasonic power was good for obtaining high yield but bad for keeping the antioxidant activity of the polysaccharides.