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"Luo, Jun"
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Does Mixed or Embedded Output Servitization in Manufacturing Promote Employment?
A goal of developing economies is to promote manufacturing output servitization, thereby increasing jobs and optimizing employment structure. This study analyzes the impact of manufacturing enterprises’ output servitization on employment and its mechanism in the downstream value chain, based on Chinese Industrial Enterprises Database, and uses mediation and moderation effect models for empirical testing. The results show: (1) Embedded servitization in manufacturing promotes employment growth, including highly-skilled labor growth, while mixed servitization has little effect on the employment of highly-skilled labor. Overall, manufacturing output servitization promotes both the employment of highly-skilled employees and total employment growth. (2) Enterprise and environmental characteristics affect manufacturing output servitization on employment. There are significant differences in the promotional effect of manufacturing output servitization on employment when enterprise ownership, industries, regions, and scales differ. (3) Increased profits, decreased transaction costs, and increased wages are possible channels for manufacturing enterprises to promote employment growth by manufacturing output servitization. (4) The marketization and internationalization degrees play an important role in regulating the impact of manufacturing output servitization on employment. The improvement of enterprises’ marketization and internationalization degrees will allow manufacturing output servitization to play a more significant role in promoting labor employment.
Journal Article
Concepts and status of Chinese space gravitational wave detection projects
Gravitational wave (GW) detection in space probes the GW spectrum that is inaccessible from the Earth. In addition to the LISA project led by the European Space Agency, and the DECIGO detector proposed by the Japan Aerospace Exploration Agency, two Chinese space-based GW observatories—TianQin and Taiji—are planned to be launched in the 2030s. TianQin has a unique concept in its design with a geocentric orbit. Taiji’s design is similar to LISA, but is more ambitious with a longer arm distance. Both facilities are complementary to LISA, considering that TianQin is sensitive to higher frequencies and Taiji probes similar frequencies but with a higher sensitivity. In this Perspective we explain the concepts of both facilities and introduce the development milestones of the TianQin and Taiji projects in testing key technologies to pave the way for future space-based GW detections. Considering that LISA, TianQin and Taiji have similar scientific goals, are all scheduled to be launched around the 2030s and will operate concurrently, we discuss possible collaborations among them to improve GW source localization and characterization.
The concepts and development milestones of the two Chinese space-based gravitational wave observatories, TianQin and Taiji, are introduced. Considering their similar goals and operation window with LISA, possible collaborations among them are discussed.
Journal Article
Development of AR-V7 as a putative treatment selection marker for metastatic castration-resistant prostate cancer
Prostate cancer cells demonstrate a remarkable ＂addiction＂ to androgen receptor （AR） signaling in all stages of disease progression. As such, suppression of AR signaling remains the therapeutic goal in systemic treatment of prostate cancer. A number of molecular alterations arise in patients treated with AR-directed therapies. These molecular alterations may indicate the emergence of treatment resistance and may be targeted for the development of novel agents for prostate cancer. The presence of functional androgen receptor splice variants may represent a potential explanation for resistance to abiraterone and enzalutamide, newer AR-directed agents developed to treat metastatic castration-resistant prostate cancer （mCRPC）. In the last 8 years, many androgen receptor splice variants have been identified and characterized. Among these, androgen receptor splice variant-7 （AR-V7） has been investigated extensively. In AR-V7, the entire COOH-terminal ligand-binding domain of the canonical AR is truncated and replaced with a variant-specific peptide of 16 amino acids. Functionally, AR-V7 is capable of mediating constitutive nuclear localization and androgen receptor signaling in the absence of androgens, or in the presence of enzalutamide. In this review, we will focus on clinical translational studies involving detection/measurement of AR-V7. Methods have been developed to detect AR-V7 in clinical mCRPC specimens. AR-V7 can be reliably measured in both tissue and circulating tumor cells derived from mCRPC patients, making it possible to conduct both cross-sectional and longitudinal clinical correlative studies. Current evidence derived from studies focusing on detection of AR-V7 in mCRPC support its potential clinical utility as a treatment selection marker.
Journal Article
Air-quality prediction based on the ARIMA-CNN-LSTM combination model optimized by dung beetle optimizer
Air pollution is a serious problem that affects economic development and people’s health, so an efficient and accurate air quality prediction model would help to manage the air pollution problem. In this paper, we build a combined model to accurately predict the AQI based on real AQI data from four cities. First, we use an ARIMA model to fit the linear part of the data and a CNN-LSTM model to fit the non-linear part of the data to avoid the problem of blinding in the CNN-LSTM hyperparameter setting. Then, to avoid the blinding dilemma in the CNN-LSTM hyperparameter setting, we use the Dung Beetle Optimizer algorithm to find the hyperparameters of the CNN-LSTM model, determine the optimal hyperparameters, and check the accuracy of the model. Finally, we compare the proposed model with nine other widely used models. The experimental results show that the model proposed in this paper outperforms the comparison models in terms of root mean square error (RMSE), mean absolute error (MAE) and coefficient of determination (R
2
). The RMSE values for the four cities were 7.594, 14.94, 7.841 and 5.496; the MAE values were 5.285, 10.839, 5.12 and 3.77; and the R
2
values were 0.989, 0.962, 0.953 and 0.953 respectively.
Journal Article
Robust epitaxial growth of two-dimensional heterostructures, multiheterostructures, and superlattices
We report a general synthetic strategy for highly robust growth of diverse lateral heterostructures, multiheterostructures, and superlattices from two-dimensional (2D) atomic crystals. A reverse flow during the temperature-swing stage in the sequential vapor deposition growth process allowed us to cool the existing 2D crystals to prevent undesired thermal degradation and uncontrolled homogeneous nucleation, thus enabling highly robust block-by-block epitaxial growth. Raman and photoluminescence mapping studies showed that a wide range of 2D heterostructures (such as WS₂-WSe₂ and WS₂-MoSe₂), multiheterostructures (such as WS2-WSe2-MoS2 and WS2-MoSe2-WSe2), and superlattices (such as WS₂-WSe₂-WS₂-WSe₂-WS₂) were readily prepared with precisely controlled spatial modulation. Transmission electron microscope studies showed clear chemical modulation with atomically sharp interfaces. Electrical transport studies of WSe₂-WS₂ lateral junctions showed well-defined diode characteristics with a rectification ratio up to 10⁵.
Journal Article
Uncovering and tailoring hidden Rashba spin–orbit splitting in centrosymmetric crystals
Hidden Rashba and Dresselhaus spin splittings in centrosymmetric crystals with subunits/sectors having non-centrosymmetric symmetries (the R-2 and D-2 effects) have been predicted theoretically and then observed experimentally, but the microscopic mechanism remains unclear. Here we demonstrate that the spin splitting in the R-2 effect is enforced by specific symmetries, such as non-symmorphic symmetry in the present example, which ensures that the pertinent spin wavefunctions segregate spatially on just one of the two inversion-partner sectors and thus avoid compensation. We further show that the effective Hamiltonian for the conventional Rashba (R-1) effect is also applicable for the R-2 effect, but applying a symmetry-breaking electric field to a R-2 compound produces a different spin-splitting pattern than applying a field to a trivial, non-R-2, centrosymmetric compound. This finding establishes a common fundamental source for the R-1 effect and the R-2 effect, both originating from local sector symmetries rather than from the global crystal symmetry per se.
The Dresselhaus and Rashba effects have traditionally been expected only in non-centrosymmetric systems but recent work has shown that they can exist in some centrosymmetric materials. Here the authors show that the so-called hidden Rashba effect originates from wavefunction segregation enforced by local symmetries.
Journal Article
Doping strain induced bi-Ti3+ pairs for efficient N2 activation and electrocatalytic fixation
The electrochemical N
2
fixation to produce ammonia is attractive but significantly challenging with low yield and poor selectivity. Herein, we first used density function theory calculations to reveal adjacent bi-Ti
3+
pairs formed on anatase TiO
2
as the most active electrocatalytic centers for efficient N
2
lying-down chemisorption and activation. Then, by doping of anatase TiO
2
with Zr
4+
that has similar
d
-electron configuration and oxide structure but relatively larger ionic size, the adjacent bi-Ti
3+
sites were induced and enriched via a strained effect, which in turn enhanced the formation of oxygen vacancies. The Zr
4+
-doped anatase TiO
2
exhibited excellent electrocatalytic N
2
fixation performances, with an ammonia production rate (8.90 µg·h
−1
·cm
−2
) and a Faradaic efficiency of 17.3% at −0.45 V versus reversible hydrogen electrode under ambient aqueous conditions. Moreover, our work suggests a viewpoint to understand and apply the same-valance dopants in heterogeneous catalysis, which is generally useful but still poorly understood.
Electrocatalytic N
2
conversion to ammonia offers a low-carbon alternative to industrial ammonia production, although the rational design of active, efficient catalysts remains limited. Here, authors show Ti
3+
-pair sites in anatase TiO
2
to be active for aqueous N
2
electroreduction to ammonia.
Journal Article
CDKN2A is a prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma
Cyclin dependent kinase inhibitor 2A (CDKN2A) is an essential regulator of immune cell functionality, but the mechanisms whereby it drives immune infiltration in hepatocellular carcinoma (HCC) remain unclear. In the present study, we studied the association with CDKN2A expression and immune invasion with the risk of developing HCC. A totally of 2207 different genes were found between HCC and adjacent liver tissues from TCGA and GEO databases. CDKN2A was highly expressed in HCC and associated with poorer overall survival and disease-free survival. Notably, CDKN2A expression was positively correlated with infiltrating levels into purity, B cell, CD+8 T cell, CD+4 T cell, macrophage, neutrophil, and dendritic cells in HCC. CDKN2A expression showed strong correlations between diverse immune marker sets in HCC. These findings suggest that CDKN2A expression potentially contributes to regulation of tumor-associated macrophages and can be used as a prognostic biomarker for determining prognosis and immune infiltration in HCC.
Journal Article
Hidden spin polarization in inversion-symmetric bulk crystals
Spin–orbit coupling can induce spin polarization in nonmagnetic 3D crystals when the inversion symmetry is broken, as manifested by the bulk Rashba and Dresselhaus effects. We establish that these spin-polarization effects originate fundamentally from specific atomic site asymmetries, rather than, as generally accepted, from the asymmetry of the crystal space group. This understanding leads to the recognition that a previously overlooked hidden form of spin polarization should exist in centrosymmetric crystals. Although all energy bands must be doubly degenerate in centrosymmetric materials, we find that the two components of such doubly degenerate bands could have opposite polarizations, each spatially localized on one of the two separate sectors forming the inversion partners. We demonstrate such hidden spin polarizations in particular centrosymmetric crystals by first-principles calculations. This new understanding could considerably broaden the range of currently useful spintronic materials and enable the control of spin polarization by means of operations on the atomic scale.
Spin polarization due to spin–orbit coupling requires broken inversion symmetry. Now, calculations show that the effect arises from local site-asymmetry rather than global space-group asymmetry, and that a hitherto overlooked form of spin polarization should also exist in centrosymmetric structures.
Journal Article