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\"The cost of absenteeism in organizational functioning has been widely acknowledged and extensively examined in the management disciplines of organizational behavior, organizational theory and strategy (Cascio & Boudreau, 2011). Yet, its alleged flip side \"presenteeeism\" (working while sick) has only recently attracted scholarly attention as a byproduct of organizational restructuring in the wake of the global economic recession, and subsequently as a factor in explaining worsening employee wellbeing, loss productivity, strained team dynamics, hampered implementation of management strategies, and depressed organizational functioning. In the past decade, the rapid advance of digital technologies, i.e. Information and Communication Technologies (ICT) has facilitated agile working and flexibility, but also fuelled the \"always on\" culture (McDowall & Kinman, 2017), which may be more potent in Asian societies working in harmony with the social values of diligence. Alongside this global transformation of \"work taking over life, any time anywhere\", presenteeism may have ceased to be just a work issue: cultural forces, social factors, managerial practices, employees' self-concept, values, motivations, psychological resources will all conspire to make it into a socio-cultural as much as an individual-personal act (of attending work given the circumstance). Unfortunately, the existing work on presenteeism is scattered across a wide range of academic disciplines and under a variety of topics, lacking the coherence and comprehensiveness to address the complexity underlying the phenomenon\"-- Provided by publisher.

Background Neuronal pyroptosis and neuroinflammation with excess microglial activation are widely involved in the early pathological process of ischemic stroke. Repetitive transcranial magnetic stimulation (rTMS), as a non-invasive neuromodulatory technique, has recently been reported to be anti-inflammatory and regulate microglial function. However, few studies have elucidated the role and mechanism of rTMS underlying regulating neuronal pyroptosis and microglial polarization. Methods We evaluated the motor function in middle cerebral artery occlusion/reperfusion (MCAO/r) injury mice after 1-week intermittent theta-burst rTMS (iTBS) treatment in the early phase with or without depletion of microglia by colony-stimulating factor 1 receptor (CSF1R) inhibitor treatment, respectively. We further explored the morphological and molecular biological alterations associated with neuronal pyroptosis and microglial polarization via Nissl, EdU, TTC, TUNEL staining, electron microscopy, multiplex cytokine bioassays, western blot assays, immunofluorescence staining and RNA sequencing. Results ITBS significantly protected against cerebral ischemia/reperfusion (I/R) injury-induced locomotor deficits and neuronal damage, which probably relied on the regulation of innate immune and inflammatory responses, as evidenced by RNA sequencing analysis. The peak of pyroptosis was confirmed to be later than that of apoptosis during the early phase of stroke, and pyroptosis was mainly located and more severe in the peri-infarcted area compared with apoptosis. Multiplex cytokine bioassays showed that iTBS significantly ameliorated the high levels of IL-1β, IL-17A, TNF-α, IFN-γ in MCAO/r group and elevated the level of IL-10. ITBS inhibited the expression of neuronal pyroptosis-associated proteins (i.e., Caspase1, IL-1β, IL-18, ASC, GSDMD, NLRP1) in the peri-infarcted area rather than at the border of infarcted core. KEGG enrichment analysis and further studies demonstrated that iTBS significantly shifted the microglial M1/M2 phenotype balance by curbing proinflammatory M1 activation (Iba1 + /CD86 + ) and enhancing the anti-inflammatory M2 activation (Iba1 + /CD206 + ) in peri-infarcted area via inhibiting TLR4/NFκB/NLRP3 signaling pathway. Depletion of microglia using CSF1R inhibitor (PLX3397) eliminated the motor functional improvements after iTBS treatment. Conclusions rTMS could alleviate cerebral I/R injury induced locomotor deficits and neuronal pyroptosis by modulating the microglial polarization. It is expected that these data will provide novel insights into the mechanisms of rTMS protecting against cerebral I/R injury and potential targets underlying neuronal pyroptosis in the early phase of stroke. Highlights rTMS significantly ameliorated cerebral ischemia/reperfusion injury-induced locomotor deficits and neuronal damage in the early phase probably through the anti-inflammatory mechanism. The peak of pyroptosis was later than that of apoptosis during the early phase of stroke, and pyroptosis was mainly located and more severe in the peri-infarcted area compared with apoptosis. rTMS inhibited neuronal pyroptosis in the peri-infarcted area rather than at the border of infarcted core. rTMS modulated microglial polarization in the peri-infarcted area via inhibiting TLR4/NFκB/NLRP3 signaling pathway. Depletion of microglia eliminated the motor functional improvements after rTMS treatment.

يتناول كتاب (الصين تربط العالم : الخلفية التي تستند إليها مبادرة الحزام والطريق) والذي قام بتأليفه (وانغ ييوي) في حوالي (350) صفحة من القطع المتوسط موضوع (العلاقات الاقتصادية الخارجية للصين) مستعرضا أبرز المحتويات التالية : الفصل الأول : العالم المترابط، الفصل الثاني : مبادرة الحزام والطريق : منطق العولمة، الفصل الثالث : مبادرة الحزام والطريق : منطق الحضارة، الفصل الرابع : مبادرة الحزام والطريق : المنطق الاستراتيجي.‪‪‪‪‪‪‪‪‪‪

The aim of this study was to test the flow from long working hours to sickness presenteeism behavior and its outcomes for employees, while integrating intrinsic and extrinsic work value orientations as moderators in the process. We employed a two-wave design with a five-month interval. Data were obtained from 275 employees in Taiwan. The results of latent moderated structural equations (LMS) revealed that long working hours were positively associated with presenteeism, which in turn was negatively related to employees’ well-being and job performance. Furthermore, the negative indirect effect of working long hours on job performance via presenteeism was weaker for those with a higher intrinsic work value orientation. The negative indirect effect of working long hours on well-being via presenteeism was weaker for those with a higher extrinsic work value orientation. We demonstrated that the long-term impact of presenteeism behavior could be understood by viewing work value orientations as resource gains to compensate resource depletion in a demanding work context. This resource dynamism is pivotal to realizing the functional or dysfunctional outcomes of presenteeism behavior. Theoretical and managerial implications of the findings for employees’ well-being and organizational effectiveness are discussed.

Ethnopharmacological relevance: The genus Polygonatum Tourn, ex Mill. contains numerous chemical components, such as steroidal saponins, polysaccharides, flavonoids, alkaloids, and others, it possesses diverse pharmacological activities, such as anti-aging, anti-tumor, immunological regulation, as well as blood glucose management and fat reducing properties. Aim of the review: This study reviews the current state of research on the systematic categorization, chemical composition, pharmacological effects, and processing changes of the plants belonging to the genus Polygonatum, to provide a theoretical foundation for their scientific development and rational application. Materials and methods: The information was obtained by searching the scientific literature published between 1977 and 2022 on online databases (including PubMed, CNKI, SciFinder, and Web of Science) and other sources (such as the Chinese Pharmacopoeia 2020 edition, and Chinese herbal books). Results: The genus Polygonatum contains 79 species, and 233 bioactive chemical compounds were identified in them. The abundance of pharmacological activities, such as antioxidant activities, anti-fatigue activities, anti-inflammatory activities, etc., were revealed for the representatives of this genus. In addition, there are numerous processing methods, and many chemical constituents and pharmacological activities change after the unappropriated processing. Conclusions: This review summarizes the taxonomy classification, chemical composition, pharmacological effects, and processing of the plants belonging to the genus Polygonatum, providing references and research tendencies for plant-based drug development and further clinical applications.

Heavy metal contamination in herbal medicines is a global threat to human beings especially at levels above known threshold concentrations. The concentrations of five heavy metals cadmium (Cd), lead (Pb), arsenic (As), mercury (Hg) and copper (Cu) were investigated using Inductively Coupled Plasma Optical Mass Spectrometry (ICP-MS) with 1773 samples around the world. According to Chinese Pharmacopoeia, 30.51% (541) samples were detected with at least one over-limit metal. The over-limit ratio for Pb was 5.75% (102), Cd at 4.96% (88), As at 4.17% (74), Hg at 3.78% (67), and of Cu, 1.75% (31). For exposure assessment, Pb, Cd, As, and Hg have resulted in higher than acceptable risks in 25 kinds of herbs. The maximal Estimated Daily Intake of Pb in seven herbs, of Cd in five, of Hg in four, and As in three exceeded their corresponding Provisional Tolerable Daily Intakes. In total 25 kinds of herbs present an unacceptable risk as assessed with the Hazard Quotient or Hazard Index. Additionally, the carcinogenic risks were all under acceptable limits. Notably, As posed the highest risk in all indicators including Estimated Daily Intake, Hazard Index, and carcinogenic risks. Therefore further study on enrichment effect of different states of As and special attention to monitoring shall be placed on As related contamination.

Continuous speech is organized into a hierarchy of rhythms. Accurate processing of this rhythmic hierarchy through the interactions of auditory and motor systems is fundamental to speech perception and production. In this mini-review, we aim to evaluate the implementation of behavioral auditory-motor synchronization paradigms when studying rhythm processing in speech. First, we present an overview of the classic finger-tapping paradigm and its application in revealing differences in auditory-motor synchronization between the typical and clinical populations. Next, we highlight key findings on rhythm hierarchy processing in speech and non-speech stimuli from finger-tapping studies. Following this, we discuss the potential caveats of the finger-tapping paradigm and propose the speech-speech synchronization (SSS) task as a promising tool for future studies. Overall, we seek to raise interest in developing new methods to shed light on the neural mechanisms of speech processing.

Plant protein phosphatase 2C (PP2C) play important roles in response to salt stress by influencing metabolic processes, hormone levels, growth factors, etc. Members of the PP2C family have been identified in many plant species. However, they are rarely reported in peanut. In this study, 178 PP2C genes were identified in peanut, which were unevenly distributed across the 20 chromosomes, with segmental duplication in 78 gene pairs. AhPP2Cs could be divided into 10 clades (A-J) by phylogenetic analysis. AhPP2C s had experienced segmental duplications and strong purifying selection pressure. 22 miRNAs from 14 different families were identified, targeting 57 AhPP2C genes. Gene structures and motifs analysis exhibited PP2C s in subclades AI and AII had high structural and functional similarities. Phosphorylation sites of AhPP2C45 / 59 / 134 / 150 / 35 / 121 were predicted in motifs 2 and 4, which located within the catalytic site at the C-terminus. We discovered multiple MYB binding factors and ABA response elements in the promoter regions of the six genes ( AhPP2C45 / 59 / 134 / 150 / 35 / 121 ) by cis -elements analysis. GO and KEGG enrichment analysis confirmed AhPP2C-A genes in protein binding, signal transduction, protein modification process response to abiotic stimulus through environmental information processing. Based on RNA-Seq data of 22 peanut tissues, clade A AhPP2C s showed a varying degree of tissue specificity, of which, AhPP2C35 and AhPP2C121 specifically expressed in seeds, while AhPP2C45 / 59 / 134 / 150 expressed in leaves and roots. qRT-PCR indicated that AhPP2C45 and AhPP2C134 displayed significantly up-regulated expression in response to salt stress. These results indicated that AhPP2C45 and AhPP2C134 could be candidate PP2Cs conferring salt tolerance. These results provide further insights into the peanut PP2C gene family and indicate PP2Cs potentially involved in the response to salt stress, which can now be further investigated in peanut breeding efforts to obtain cultivars with improved salt tolerance.

Sperm cryopreservation is an effective fertility preservation method for cancer patients before anticancer treatments. However, there are little data on fertility preservation in large cohorts of patients with cancer in southern China. This retrospective cross-sectional study aimed to assess the fertility preservation status of 1034 newly diagnosed male patients with cancer in the Human Sperm Bank of Guangdong Province in southern China (Guangzhou, China). Of these, 302 patients had reproductive system tumors, mostly testicular cancers (99.0%), and 732 had other tumors, including lymphoma (33.1%), gastrointestinal cancer (16.3%), nasopharyngeal carcinoma (15.7%), leukemia (7.7%), sarcoma (3.6%), and others (23.6%). Patients with reproductive system tumors had lower sperm concentration and prefreezing and post-thawing progressive motility than those with non-reproductive system tumors (all P < 0.001). Differences in sperm concentration, progressive motility, and normal morphology rate were observed between patients with and without anticancer surgery before sperm cryopreservation (all P < 0.05). As of April 30, 2022, 63 patients used their cryopreserved sperm for assisted reproductive technology treatments and 39 pregnancies were achieved. This study provides valuable data on the fertility preservation status in newly diagnosed cancer patients in southern China, demonstrating that patients with reproductive system tumors had poor sperm quality for their pretreatment fertility preservation.

This study is guided by the pivotal yet underexplored question, “How does the resilience developed through the motherhood experience, particularly within the mother/child relationship, translate into a mother’s approach to her relationships with followers in a professional context?” This study delves into the impact of resilience fostered through motherhood on leadership styles, especially in professional interactions with subordinates. Adopting the grounded theory methodology, we collected qualitative data through in-depth interviews with 28 female leaders, each a mother of at least one child. We followed a grounded theory analytic procedure to systematically organize data and examine the intricacies of maternal leadership and its process-oriented resilience development. Our research uncovers a three-stage resilience-strengthening process among maternal leaders. The three stages involve the emergence of challenges, followed by the development of transformative resilience, culminating in the significant impact on inclusive leadership styles and the evolution of leader–follower relationships. This study contributes to the academic discourse in three key ways. First, it offers unique insights into how the challenges and adversities inherent in motherhood can be transformative for leadership development. Second, by identifying and detailing a three-stage process of resilience development in maternal leaders, the research provides a nuanced understanding of how personal experiences influence professional leadership capabilities. Third, the study broadens the current discourse on inclusive leadership by incorporating the maternal perspective, a relatively underexplored area, particularly in the context of transformed leader/follower relationships.