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In order to deal with the new threat of low altitude slow small (LSS) targets in air defense operations and provide support for LSS target interception decision, we propose a simple and reliable LSS target threat assessment method. Based on the detection capability of LSS targets and their threat characteristics, this paper proposes a threat evaluation factor and threat degree quantization function in line with the characteristics of LSS targets. LSS targets not only have the same threat characteristics as traditional air targets but also have the unique characteristics of flexible mobility and dynamic mission planning. Therefore, we use analytic hierarchy process (AHP) and information entropy to determine the subjective and objective threat factor weights of LSS targets and use the optimization model to combine them to obtain more reliable evaluation weights. Finally, the effectiveness and credibility of the proposed method are verified by experimental simulation.

In the context of distributed defense, multi-sensor networks are required to be able to carry out reasonable planning and scheduling to achieve the purpose of continuous, accurate and rapid target detection. In this paper, a multi-sensor cooperative scheduling model based on the partially observable Markov decision process is proposed. By studying the partially observable Markov decision process and the posterior Cramer–Rao lower bound, a multi-sensor cooperative scheduling model and optimization objective function were established. The improvement of the particle filter algorithm by the beetle swarm optimization algorithm was studied to improve the tracking accuracy of the particle filter. Finally, the improved elephant herding optimization algorithm was used as the solution algorithm of the scheduling scheme, which further improved the algorithm performance of the solution model. The simulation results showed that the model could solve the distributed multi-sensor cooperative scheduling problem well, had higher solution performance than other algorithms, and met the real-time requirements.

To address the issue of jitter and oscillation of guidance command during multi-vehicle cooperative engagement with maneuvering platforms, this paper proposes a novel terminal guidance law with prescribed performance constraints for multiple cooperative vehicles, which explicitly considers both transient and steady-state performance. Firstly, based on the vehicle-target relative kinematics, with time and space as the main constraint indicators, a multi-vehicle cooperative guidance model is established in the inertial coordinate system. Secondly, combined with the sliding mode control theory, cooperative guidance laws are designed for both the line-of-sight (LOS) direction and the LOS normal direction, respectively, and the Lyapunov stability proof is given. Furthermore, to counteract the impact of target maneuvers on guidance performance, a non-homogeneous disturbance observer is designed to estimate target maneuver information that is difficult to obtain directly, which ensures that performance constraints are still satisfied under strong target maneuvering conditions. Simulation results demonstrate that the proposed guidance law enables multiple coordinated vehicles to successfully engage the target under different maneuvering modes, while satisfying the terminal time-space constraints. Compared with conventional sliding mode control methods exhibiting inherent chattering, the proposed approach employs a novel PPC-SMC hybrid structure to quantitatively constrain the transient convergence of cooperative errors. This structure enhances the multi-vehicle cooperative guidance performance by effectively eliminating chattering and oscillations in the guidance commands, thereby significantly improving the system’s transient behavior.

This article investigates a novel operational pattern for intercepting UAV clusters over the range of middle and far distances using mother-son missiles. To address the guidance issue of the mother-cabin in the operational pattern, a special cooperative guidance law, which takes into account acceleration constraint and satisfies the constraints of impact time, speed, and zero line of sight angle (LOS), is proposed. Based on consistency theory and sliding mode control theory, the proposed cooperative guidance law is specifically designed for the mother-cabin of the mother-son missile. This approach offers several advantages, including a simple structure and smooth controller output, and smooth flight trajectory. Finally, numerical simulations are presented to demonstrate the effectiveness and applicability of the cooperative guidance law.

The basolateral amygdala (BLA) and ventral hippocampal CA1 (vCA1) are cellularly and functionally diverse along their anterior–posterior and superficial-deep axes. Here, we find that anterior BLA (aBLA) and posterior BLA (pBLA) innervate deep-layer calbindin1-negative (Calb1−) and superficial-layer calbindin1-positive neurons (Calb1+) in vCA1, respectively. Photostimulation of pBLA–vCA1 inputs has an anxiolytic effect in mice, promoting approach behaviours during conflict exploratory tasks. By contrast, stimulating aBLA–vCA1 inputs induces anxiety-like behaviour resulting in fewer approaches. During conflict stages of the elevated plus maze task vCA1 Calb1+ neurons are preferentially activated at the open-to-closed arm transition, and photostimulation of vCA1 Calb1+ neurons at decision-making zones promotes approach with fewer retreats. In the APP/PS1 mouse model of Alzheimer’s disease, which shows anxiety-like behaviour, photostimulating the pBLA–vCA1 Calb1+ circuit ameliorates the anxiety in a Calb1-dependent manner. These findings suggest the pBLA–vCA1 Calb1+ circuit from heterogeneous BLA–vCA1 connections drives approach behaviour to reduce anxiety-like behaviour. Projections from the anterior and posterior basolateral amygdala (pBLA) to the ventral hippocampus CA1 (vCA1) are heterogenous. Here the authors show that activating the pathway from pBLA to vCA1 calbindin 1 positive neurons has an anxiolytic effect in approach-avoidance tasks in mice.

The limited efficacy and poor tumor accumulation remain crucial challenges for radiotherapy against lung cancer. To address these limitations, we rationally developed a polyunsaturated fatty acid (PUFA)-based nanoreactor (DHA-N@M) camouflaged with macrophage cell membrane to improve tumoral distribution and achieve peroxynitrite-augment ferroptosis for enhanced radiotherapy against lung cancer. After nebulization, the nanoreactors exhibited superior pulmonary accumulation in orthotopic lung cancer-bearing mice, with 70-fold higher than intravenously injected nanoreactors at 12 h post-administration, and distributed deeply in the tumors. DHA-N@M selectively released nitric oxide (NO) in glutathione (GSH)-enriched tumor cells, with consumption of GSH and subsequent inactivation of glutathione peroxidase 4 (GPX4). Under radiation, NO reacted with radiotherapy-induced reactive oxygen species (ROS) to generate peroxynitrite (ONOO - ), resulting in redox homeostasis disruption. Combined with docosahexaenoic acid (DHA)-induced lipid metabolism disruption, overwhelming ferroptosis was induced both in vitro and in vivo. Notably, DHA-N@M mediated ferroptosis-radiotherapy significantly suppressed tumor growth with a 93.91% inhibition in orthotopic lung cancer models. Therefore, this design provides a nebulized ferroptosis-radiotherapy strategy for lung cancer.

Background/Aims: The correlation between platelet levels and clinical outcomes has received increasing attention, but it is not yet clear whether and how platelet levels affect the therapeutic response in non-small cell lung cancer (NSCLC). In the current study, we aimed to explore the role of platelet levels in responsive to platinum-based chemotherapy and investigated the underlying mechanism. Methods: We evaluated the possibility of platelet level as a biomarker for response to platinum-based therapy in NSCLC by retrospective analysis of NSCLC patients. Cell proliferation was evaluated using cell counter and flow cytometry. Cell capillary-like structures of HPMEC were estimated with ECMatrix. The effect of platelets on A549, H1299, and HPMEC apoptosis was measured by flow cytometry. A A549-bearing NOD/ SCID mice model was employed to determine whether platelets could counteract cisplatin-induced apoptosis in vivo. In vivo cell proliferation and apoptosis were evaluated with Ki-67 antibody and TUNEL staining respectively. The angiogenesis of tumor was estimated by CD31 microvessel density. The protein levels of Akt, Bad and Bcl-2 were assessed by western blot. To further examine platelet-driven effects of the chemotherapeutic response, we used platelet depletion and platelet transfusion in A549-bearing NOD/SCID mice. Results: Thrombocytosis at NSCLC diagnosis was associated with lower progression-free survival and median overall survival. Platelet levels before chemotherapy in the no response group were markedly higher than in the responsive group. Platelets rescued the inhibition of cell proliferation and angiogenesis and protected against cell apoptosis induced by cisplatin, platelets rescued cisplatin-induced apoptosis via the Akt/Bad/Bcl-2 signaling pathway under endoplasmic reticulum stress. Platelet transfusion decreased the therapeutic effect of cisplatin, while it was increased by platelet depletion. Conclusion: We confirmed an important anti-apoptosis mechanism mediated by platelets and found that platelets could counteract cisplatin-induced apoptosis. Reducing platelet levels or blocking platelet-based cytoprotection may represent new methods for improving the chemotherapeutic effect.

The existing steering device in the fruit and vegetable packaging assembly line cannot adjust the attitude of lettuce to a unified attitude, affecting the input and packaging process of the packaging machine. This study proposes an intelligent assembly line sorting method based on the visual positioning and model predictive control of a robotic ami. First, lightweight improvement based on the YOLOvS is realized, the lettuce stalk in the background of the conveyor belt is promptly identified, the image of the lettuce stalk in the anchor box area is processed, and the edge contour point set is determined to extract the pixel coordinates of the optimal grasp point and mirror inclination angle of the lettuce. For the intelligent assembly line system, a robot ami kinematics model is constructed and the robot kinematics inverse solutions are calculated. Additionally, the lettuce movement speeds are dynamically measured by the vision system. A combination of the model prediction control, dynamic tracking, and rapid sorting of the lettuce by the robot claw is realized. The results show that the average detection time of a single frame image in the visual positioning part is 0.014 s, which is reduced by 50%; the accuracy and recall are 98% and 95%, respectively. The detection time is significantly reduced by ensuring accuracy. Within the current speed range of the packaging assembly line conveyor belt, the manipulator can grasp lettuce at different speeds stably and fast; the average axial error, average radial error, and adjusted average inclination angle error are 0.71 cm, 1.02 cm, and 3.79°, respectively, verifying the high efficiency and stability of the model. The proposed method of this study enables application in the intelligent sorting operation of industrial assembly lines

Background: Hypertensive cerebral small vessel disease (HT-CSVD) is a cerebrovascular clinical, imaging and pathological syndrome caused by hypertension (HT). The condition manifests with lesions in various vessels including intracranial small/arterioles, capillaries, and small/venules. Hypertensive cerebral small vessel disease has complex and diverse clinical manifestations. For instance, it can present as an acute stroke which progresses to cause cognitive decline, affective disorder, unstable gait, dysphagia, or abnormal urination. Moreover, hypertensive cerebral small vessel disease causes 25–30% of all cases of ischemic strokes and more than 50% of all cases of single or mixed dementias. The 1-year recurrence rate of stroke in cerebral small vessel disease patients with hypertension is 14%. In the early stage of development, the symptoms of hypertensive cerebral small vessel disease are concealed and often ignored by patients and even clinicians. Patients with an advanced hypertensive cerebral small vessel disease manifest with severe physical and mental dysfunction. Therefore, this condition has a substantial economic burden on affected families and society. Naotaifang (NTF) is potentially effective in improving microcirculation and neurofunction in patients with ischemic stroke. In this regard, this multicenter randomized controlled trial (RCT) aims to furtherly evaluate the efficacy and safety of naotaifang capsules on hypertensive cerebral small vessel disease. Methods: This study is a multicenter, randomized, double-blind, placebo-controlled clinical trial. A total of 388 eligible subjects were recruited from the First Hospital of Hunan University of Chinese Medicine, Hunan Academy of Chinese Medicine Affiliated Hospital, the First Hospital of Shaoyang University, the First Traditional Chinese Medicine Hospital of Changde, and Jiangmen Wuyi Hospital of Traditional Chinese Medicine from July 2020 to April 2022. After a 4-week run-in period, all participants were divided into the intervention group (represented by Y-T, N-T) and control group (represented by Y-C, N-C); using a stratified block randomized method based on the presence or absence of brain damage symptoms in hypertensive cerebral small vessel disease (represented by Y and N). The Y-T and N-T groups were administered different doses of naotaifang capsules, whereas Y-C and N-C groups received placebo treatment. These four groups received the treatments for 6 months. The primary outcome included Fazekas scores and dilated Virchow-robin spaces (dVRS) grades on magnetic resonance imaging (MRI). The secondary outcomes included the number of lacunar infarctions (LI) and cerebral microbleeds (CMB) on magnetic resonance imaging, clinical blood pressure (BP) level, traditional Chinese medicine (TCM) syndrome scores, mini-mental state examination (MMSE) scale, and safety outcomes. Fazekas scores, dilated Virchow-robin spaces grades, and the number of lacunar infarctions and cerebral microbleeds on magnetic resonance imaging were tested before enrollment and after 6 months of treatment. The clinical blood pressure level, traditional Chinese medicine syndrome scores, mini-mental state examination scale and safety outcomes were tested before enrollment, after 3-month, 6-month treatment and 12th-month follow-up respectively. Conclusion: The protocol will comfirm whether naotaifang capsules reduce Fazekas scores, dilated Virchow-robin spaces grades, and the number of lacunar infarctions and cerebral microbleeds, clinical blood pressure, increase mini-mental state examination scores, traditional Chinese medicine syndrome scores of Qi deficiency and blood stasis (QDBS), and improve the quality of life of subjects. The consolidated evidence from this study will shed light on the benefits of Chinese herbs for hypertensive cerebral small vessel disease, such as nourishing qi, promoting blood circulation and removing blood stasis, and dredging collaterals. However, additional clinical trials with large samples and long intervention periods will be required for in-depth research. Clinical Trial registration: www.chictr.org.cn , identifier ChiCTR1900024524.

Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious and pathogenic infectious disease caused by the porcine reproductive and respiratory syndrome virus (PRRSV). It manifests as reproductive disorders in sows and respiratory disorders in piglets. PRRSV infects swine herds with symptoms such as abortions, stillbirths, and mummified fetuses in gestating sows. Piglets mainly experience abdominal respiration and respiratory symptoms. To date, the prevention of PRRS relies primarily on vaccination and the implementation of various preventive and control measures. Swine deaths caused by PRRS have resulted in significant economic losses to the pig industry worldwide. Non-structural protein 10 (NSP10) has helicase and adenosine triphosphatase (ATPase) activities that unwind DNA and RNA and play important roles in viral replication and transcription. Hence, it can be potentially used to develop novel reagents for the detection of PPRSV. This article reviews genetic variations, interaction with viral and host proteins, effects on PRRSV replication, immunomodulation, apoptosis, and viral virulence of NSP10, with the aim of providing a theoretical basis for the prevention and control of PRRS and drug development in the future.