Explore the vast range of titles available.

Organic light-emitting diodes (OLEDs) exploiting simple binary emissive layers (EMLs) blending only emitters and hosts have natural advantages in low-cost commercialization. However, previously reported OLEDs based on binary EMLs hardly simultaneously achieved desired comprehensive performances, e.g., high efficiency, low efficiency roll-off, narrow emission bands, and high operation stability. Here, we report a molecular-design strategy. Such a strategy leads to a fast reverse intersystem crossing rate in our designed emitter h -BNCO-1 of 1.79×10 5  s −1 . An OLED exploiting a binary EML with h -BNCO-1 achieves ultrapure emission, a maximum external quantum efficiency of over 40% and a mild roll-off of 14% at 1000 cd·m −2 . Moreover, h -BNCO-1 also exhibits promising operational stability in an alternative OLED exploiting a compact binary EML (the lifetime reaching 95% of the initial luminance at 1000 cd m −2 is ~ 137 h). Here, our work has thus provided a molecular-design strategy for OLEDs with promising comprehensive performance. Multi-resonance thermally activated delayed fluorescent emitters composed of only period-2 elements are important for achieving comprehensive performances. Here, authors report hybridization of organoboron-nitrogen and carbonyl groups in the emitter to achieve a long device operational stability.

One‐dimensional semiconductor nanostructures have already been used for a variety of optoelectronic applications. Metal halide perovskites have emerged in recent years as promising high‐performance optoelectronic materials, but reports on 1D nanorods (NRs) of all‐inorganic halide perovskites are still scarce. This work demonstrates a synthetic strategy toward cesium‐based inorganic perovskite NRs by exploiting composition‐controlled crystal phase engineering. It is accomplished for Cd‐rich mixed‐cation CsPb1‐xCdxBr3 nanocrystals, where the initial 1D hexagonal perovskite phase drives the growth of the 1D NRs, as supported by first‐principles calculations. The band gaps of the resulting NRs are tunable by varying the Cd‐content, and the highly uniform CsPb0.08Cd0.92Br3 NRs (with an average length of 84 nm and width of 16 nm) exhibit a true blue‐color emission centered at 460 nm, with a high quantum yield of 48%. Moreover, this work also demonstrates the tunability of the Fermi levels in the films made of CsPb1‐xCdxBr3 alloyed nanocrystals, where samples with highest Cd content show an increase of the electron concentration and a related increase in the conductivity. It is shown that upon incorporation of sufficient levels of Cd2+ cations, the isotropic 3D cubic lattice of CsPbBr3 nanocrystals gives way to a transformation to the 1D anisotropic hexagonal lattice, which allows 1D growth of alloyed CsPb1‐xCdxBr3 nanorods to be realized whose bandgaps can be tailored all across the blue spectral range from 2.40 eV for x = 0.10 to 2.74 eV for x = 0.96.

The hematopoietic ecosystem comprises both cellular components such as hematopoietic stem cells (HSCs) and immune cells as well as non-cellular components including iron. Systemic iron overload, which leads to serious complications and affects both patients' quality of life and overall survival, is a common clinical challenge in patients with acute myeloid leukemia (AML). We previously elucidated the direct effects of iron overload on AML cells. It's worth noting that iron overload remodels the hematopoietic ecosystem. However, whether and how remodeled leukemic microenvironment with overloaded iron regulates normal HSCs and immune cells, especially leukemia-associated macrophages (LAMs), in AML have not been elucidated. The MLL-AF9-induced AML (MA9) cells were originated from c-kit BM cells enriched from C57BL/6J mice that infected with MSCV-MLL-AF9-GFP retrovirus. The MA9 AML mouse model was established by transplantation of MA9 cells into C57BL/6 mice. MA9 mice were administered with iron dextran every other day for a total of 6 times to established the iron overload MLL-AF9-induced AML mouse model (MA9/FE). HSC maintenance and differentiation was assessed by flow cytometry, cell proliferation, cell apoptosis, colony forming and competitive transplantation assays. LAM activation and function was analyzed by RNA-sequencing, flow cytometry and coculture assay. Intravenous clodronate liposome administration was employed to reduce LAMs in AML. Iron overload skewed myeloid differentiation of normal HSCs. Furthermore, iron overload affected LAMs in the AML microenvironment by promoting LAM polarization toward an M2 phenotype. Functionally, iron overload decreased the phagocytic function of LAMs against leukemia cells and inhibited LAM-induced T cell activation by acquiring a tolerogenic phenotype with aberrant immune checkpoints. Moreover, depletion of LAMs attenuated iron overload caused acceleration of AML progression. Collectively, this study reveals the significance of iron overload in remodeling hematopoietic ecosystem and affecting HSC and LAM function in AML, providing new insights into the multifaceted role of iron overload in leukemia.

Background Postmenopausal osteoporosis is a common bone disease and characterized by low bone mineral density. Aim This study aimed to reveal key genes associated with postmenopausal osteoporosis (PMO), and provide a theoretical basis for subsequent experiments. Methods The dataset GSE7429 was obtained from Gene Expression Omnibus. A total of 20 B cell samples (ten ones, respectively from postmenopausal women with low or high bone mineral density (BMD) were included in this dataset. Following screening of differentially expressed genes (DEGs), coexpression analysis of all genes was performed, and key genes in the coexpression network were screened using the random walk algorithm. Afterwards, functional and pathway analyses were conducted. Additionally, protein–protein interactions (PPIs) between DEGs and key genes were analyzed. Results A set of 308 DEGs (170 up-regulated ones and 138 down-regulated ones) between low BMD and high BMD samples were identified, and 101 key genes in the coexpression network were screened out. In the coexpression network, some genes had a higher score and degree, such as CSTA . The key genes in the coexpression network were mainly enriched in GO terms of the defense response (e.g., SERPINA1 and CST3 ), immune response (e.g., IL32 and CLEC7A ); while, the DEGs were mainly enriched in structural constituent of cytoskeleton (e.g., CYLC2 and TUBA1B ) and membrane-enclosed lumen (e.g., CCNE1 and INTS5 ). In the PPI network, CCNE1 interacted with REL ; and TUBA1B interacted with ESR1 . Conclusions A series of interactions, such as CSTA / TYROBP , CCNE1 / REL and TUBA1B / ESR1 might play pivotal roles in the occurrence and development of PMO.

One‐dimensional semiconductor nanostructures have already been used for a variety of optoelectronic applications. Metal halide perovskites have emerged in recent years as promising high‐performance optoelectronic materials, but reports on 1D nanorods (NRs) of all‐inorganic halide perovskites are still scarce. This work demonstrates a synthetic strategy toward cesium‐based inorganic perovskite NRs by exploiting composition‐controlled crystal phase engineering. It is accomplished for Cd‐rich mixed‐cation CsPb 1‐ x Cd x Br 3 nanocrystals, where the initial 1D hexagonal perovskite phase drives the growth of the 1D NRs, as supported by first‐principles calculations. The band gaps of the resulting NRs are tunable by varying the Cd‐content, and the highly uniform CsPb 0.08 Cd 0.92 Br 3 NRs (with an average length of 84 nm and width of 16 nm) exhibit a true blue‐color emission centered at 460 nm, with a high quantum yield of 48%. Moreover, this work also demonstrates the tunability of the Fermi levels in the films made of CsPb 1‐ x Cd x Br 3 alloyed nanocrystals, where samples with highest Cd content show an increase of the electron concentration and a related increase in the conductivity.

One-dimensional semiconductor nanostructures have already been used for a variety of optoelectronic applications. Metal halide perovskites have emerged in recent years as promising high-performance optoelectronic materials, but reports on 1D nanorods (NRs) of all-inorganic halide perovskites are still scarce. This work demonstrates a synthetic strategy toward cesium-based inorganic perovskite NRs by exploiting composition-controlled crystal phase engineering. It is accomplished for Cd-rich mixed-cation CsPb1- x Cd x Br3 nanocrystals, where the initial 1D hexagonal perovskite phase drives the growth of the 1D NRs, as supported by first-principles calculations. The band gaps of the resulting NRs are tunable by varying the Cd-content, and the highly uniform CsPb0.08Cd0.92Br3 NRs (with an average length of 84 nm and width of 16 nm) exhibit a true blue-color emission centered at 460 nm, with a high quantum yield of 48%. Moreover, this work also demonstrates the tunability of the Fermi levels in the films made of CsPb1- x Cd x Br3 alloyed nanocrystals, where samples with highest Cd content show an increase of the electron concentration and a related increase in the conductivity.One-dimensional semiconductor nanostructures have already been used for a variety of optoelectronic applications. Metal halide perovskites have emerged in recent years as promising high-performance optoelectronic materials, but reports on 1D nanorods (NRs) of all-inorganic halide perovskites are still scarce. This work demonstrates a synthetic strategy toward cesium-based inorganic perovskite NRs by exploiting composition-controlled crystal phase engineering. It is accomplished for Cd-rich mixed-cation CsPb1- x Cd x Br3 nanocrystals, where the initial 1D hexagonal perovskite phase drives the growth of the 1D NRs, as supported by first-principles calculations. The band gaps of the resulting NRs are tunable by varying the Cd-content, and the highly uniform CsPb0.08Cd0.92Br3 NRs (with an average length of 84 nm and width of 16 nm) exhibit a true blue-color emission centered at 460 nm, with a high quantum yield of 48%. Moreover, this work also demonstrates the tunability of the Fermi levels in the films made of CsPb1- x Cd x Br3 alloyed nanocrystals, where samples with highest Cd content show an increase of the electron concentration and a related increase in the conductivity.

DNA modifications such as 5-methylcytosine （5mC） and 5-hydroxymethylcytosine （5hmC） are epigenetic marks known to affect global gene efpression in mammals. Given their prevalence in the human genome, close correlation with gene expression and high chemical stability, these DNA epigenetic marks could serve as ideal biomarkers for cancer diagnosis. Taking advantage of a highly sensitive and selective chemical labeling technology, we report here the genome-wide profiling of 5hmC in circulating cell-free DNA （cfDNA） and in genomic DNA （gDNA） of paired tumor and adjacent tissues collected from a cohort of 260 patients recently diagnosed with colorectal, gastric, pancreatic, liv- er or thyroid cancer and normal tissues from 90 healthy individuals. 5hmC was mainly distributed in transcriptionally active regions coincident with open chromatin and permissive histone modifications. Robust cancer-associated 5hmC signatures were identified in cfDNA that were characteristic for specific cancer types. 5hmC-based biomarkers of cir- culating cfDNA were highly predictive of colorectal and gastric cancers and were superior to conventional biomarkers and comparable to 5hmC biomarkers from tissue biopsies. Thus, this new strategy could lead to the development of effective, minimally invasive methods for diagnosis and prognosis of cancer from the analyses of blood samples.

Recognition of structure prototypes from tremendous known inorganic crystal structures has been an important subject beneficial for material science research and new materials design. The existing databases of inorganic crystal structure prototypes were mostly constructed by classifying materials in terms of the crystallographic space group information. Herein, we employed a distinct strategy to construct the inorganic crystal structure prototype database, relying on the classification of materials in terms of local atomic environments (LAE) accompanied by unsupervised machine learning method. Specifically, we adopted a hierarchical clustering approach onto all experimentally known inorganic crystal structures data to identify structure prototypes. The criterion for hierarchical clustering is the LAE represented by the state-of-the-art structure fingerprints of the improved bond-orientational order parameters and the smooth overlap of atomic positions. This allows us to build up a LAE-based Inorganic Crystal Structure Prototype Database (LAE-ICSPD) containing 15,613 structure prototypes with defined stoichiometries. In addition, we have developed a Structure Prototype Generator Infrastructure (SPGI) package, which is a useful toolkit for structure prototype generation. Our developed SPGI toolkit and LAE-ICSPD are beneficial for investigating inorganic materials in a global way as well as accelerating materials discovery process in the data-driven mode.

Atomically thin, two-dimensional (2D) indium selenide (InSe) has attracted considerable attention due to large tunability in the band gap (from 1.4 to 2.6 eV) and high carrier mobility. The intriguingly high dependence of band gap on layer thickness may lead to novel device applications, although its origin remains poorly understood, and generally attributed to quantum confinement effect. In this work, we demonstrate via first-principles calculations that strong interlayer coupling may be mainly responsible for this phenomenon, especially in the fewer-layer region, and it could also be an essential factor influencing other material properties of {\\beta}-InSe and {\\gamma}-InSe. Existence of strong interlayer coupling manifests itself in three aspects: (i) indirect-to-direct band gap transitions with increasing layer thickness; (ii) fan-like frequency diagrams of the shear and breathing modes of few-layer flakes; (iii) strong layer-dependent carrier mobilities. Our results indicate that multiple-layer InSe may be deserving of attention from FET-based technologies and also an ideal system to study interlayer coupling, possibly inherent in other 2D materials.